Table of Contents
Genes, Volume 8, Issue 1 (January 2017)
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Cover Story (view full-size image) Mec1/ATR serves as a foreman inside a yeast cell, overseeing the DNA double-stranded break (DSB) [...] Read more. Mec1/ATR serves as a foreman inside a yeast cell, overseeing the DNA double-stranded break (DSB) repair process. The Mec1-mediated DNA damage response results in cells undergoing aerobic fermentation instead of respiration. Mec1/ATR promotes the THO/TREX complex to translocate to the cytoplasm in response to torsional stress. Mec1, together with the chromatin remodeling factors Ino80 and Paf1, also functions to remove RNA Pol II from the template to preserve replication fork integrity when replication and transcription are in conflict. View this paper