Special Issue "Diabetes, Obesity and the Gut Microbiome"
Deadline for manuscript submissions: closed (31 October 2017)
Dr. Gerard E. Mullin
Department of Medicine, Division of Gastroenterology & Hepatology, Johns Hopkins University School of Medicine/ 600 N Wolfe Street, Baltimore, Maryland 21287, USA
The gut microbiome is an interactive network of trillions of microbes that synergize to provide epigenetic regulation of the host and impacting a number of crucial physiological functions. Establishment of the gut microbiome is influenced by the mode of birth, breastfeeding, provision of prebiotic foods, antibiotics, host genetics, and more. Environmental factors cause perturbations in the biodiversity of the gut microbial communities occur throughout the lifecycle, however, the interplay between diet and host genetics determines the outcome: health or disease. Diabetes and obesity are complex chronic diseases that have reduced gut microbial biodiversity that contribute towards their pathophysiologies including insulin resistance, systemic inflammation, increased gut permeability, appetite dysregulation, distorted thermodynamics among other changes. Bacteria causing weight gain are thought to induce the expression of genes related to lipid and carbohydrate metabolism thereby leading to greater energy harvest from the diet. Intricate fecal transplantation experiments in genetically manipulated mice have exquisitely demonstrated the interaction of genes and environment to produce metabolic outcomes that can either prevent to promote these chronic diseases. Novel therapies for these chronic diseases will be advanced by a deeper understanding of epigenetic modulation of host metabolism by the gut microbiome in health and in obesity and diabetes.
In this Special Issue, we would like to invite submissions of original research or review articles on any topic related to “Diabetes, Obesity, and the Gut Microbiome”. We look forward to receiving your contributions.
Dr. Gerard E. Mullin
Prof. Laura Matarese
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Gut Microbiome
- Insulin resistance
- Animal Models
- Fecal transplantation