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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic. The journal’s Editor-in-Chief and/or designated EBM will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Advances in Proteins and Photosynthesis Dynamics
edited by Ilya B. Kovalenko
submission deadline 15 May 2024 | Viewed by 244 | Submission Open
Keywords: photosynthesis; electron transport; molecular dynamics; proteins; protein-protein interaction; conformational changes; reaction center; mobile electron carrier
(This special issue belongs to the Section Biochemistry)
Advancements in Osteoarthritis and Cartilage Regeneration: Pathophysiology and Molecular Mechanisms
edited by
submission deadline 15 May 2024 | Viewed by 240 | Submission Open
Keywords: osteoarthritis; cartilage regeneration; bioinformatics
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Role of Mitochondria in Cancer
edited by Hirofumi Arakawa, Takeshi Uchiumi and
submission deadline 15 May 2024 | Viewed by 238 | Submission Open
Keywords: metabolism; apoptosis; fusion and fission; mitochondrial DNA; mitochondrial RNA; mitochondrial proteins; mitophagy; lipid; cardiolipin; phase separation; oxidative phosphorylation; proteostasis; mitochondrial quality control; TFAM; anti-cancer drug; imaging; cancer therapy; cancer diagnosis; Warburg effect
(This special issue belongs to the Section Molecular Oncology)
Pathology of Gliomas
edited by and James Battiste
submission deadline 15 May 2024 | Viewed by 236 | Submission Open
Keywords: adult and pediatric gliomas; in-silico predicted biomarkers for gliomas; genetic heterogeneity; histological grades; molecular-targeted molecular imaging
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Researches in Hypertension
edited by
submission deadline 15 May 2024 | Viewed by 234 | Submission Open
(This special issue belongs to the Section Molecular Genetics and Genomics)
Modulatory Mutagenic Impacts on Photo-/Biophysical Performance of Fluorescent Proteins
edited by
submission deadline 15 May 2024 | Viewed by 230 | Submission Open
Keywords: fluorescent protein; molecular imaging; near-infrared fluorescence (NIR); protein bioengineering; optical reporter
(This special issue belongs to the Section Molecular Biophysics)
Tumor Microenvironment and Non-coding RNAs: Where We Are Now and Where We Are Going To
edited by
submission deadline 15 May 2024 | Viewed by 229 | Submission Open
Keywords: tumor microenvironment; non-coding RNAs; molecular networks
(This special issue belongs to the Section Molecular Oncology)
Cell Energetics and Ascorbic Acid: Cancer Treatment with Vitamin C
edited by
submission deadline 15 May 2024 | Viewed by 190 | Submission Open
Keywords: vitamin C; ATP synthase; carcinogenesis; molecular pathway; biological; cell energetics; ascorbic acid; cancer treatment
(This special issue belongs to the Section Molecular Pharmacology)
Chitin: Structure, Modifications and Applications
edited by and
submission deadline 15 May 2024 | Viewed by 185 | Submission Open
Keywords: chitin; nanotechnology; chemical modification; chitin-based biomaterials
(This special issue belongs to the Section Macromolecules)
mTOR Signaling in Anti-cancer Therapy Research
edited by
submission deadline 15 May 2024 | Viewed by 167 | Submission Open
Keywords: mTOR; cancer; apoptosis; autophagy; cancer metabolism
(This special issue belongs to the Section Molecular Biology)
Advanced Molecular Progression of Norovirus
edited by
submission deadline 15 May 2024 | Viewed by 156 | Submission Open
Keywords: human norovirus; norovirus surrogates; virus-host interaction; viral receptors; assay development
(This special issue belongs to the Section Molecular Microbiology)
Short and Long-Term Profound Acid Inhibition: Indications and Concerns
edited by
submission deadline 15 May 2024 | Viewed by 151 | Submission Open
Keywords: gastric acid; gastric cancer; gastric neuroendocrine tumours; gastric juice; gastrin; Helicobacter pylori; oesophageal reflux disease; pepsin; peptic ulcer disease; gastric cancer histology and classification; rebound acid hypersecretion
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Sleep Apnea and Intermittent Hypoxia
edited by Zoran Đogaš
submission deadline 15 May 2024 | Viewed by 134 | Submission Open
Keywords: sleep-disordered breathing; respiration; inflammation; molecular and neurophysiological mechanisms of sleep; sleep apnea; intermittent hypoxia
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Advance in Cheminformatics and Nanoinformatics: Pioneering Solutions for Modern Challenges submission deadline 15 May 2024 | Viewed by 130 | Submission Open
Keywords: cheminformatics; nanoinformatics; precision toxicology; personalized medicine; precision agriculture; COVID-19; drug discovery; computational toxicology; nanosafety; nano-QSAR; deep learning; artificial intelligence; nanotoxicology; nanomedicine; data mining; big data; QSAR/QSPR; in silico modeling; web applications; predictive toxicogenomics; biokinetics; risk assessment; software tools
(This special issue belongs to the Section Molecular Informatics)
Advanced Research on Regenerative Medicine submission deadline 18 May 2024 | 4 articles | Viewed by 4779 | Submission Open
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Cardiovascular Diseases: Molecular Mechanisms and Potential Therapy
edited by
submission deadline 20 May 2024 | 16 articles | Viewed by 19934 | Submission Open
Keywords: cardiovascular diseases; pathogenic mechanisms; genetics; cardiomyopathy; myocardial infarction; cardiac fibrosis; pharmacogenomics; drug discovery
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Mechanisms of Heavy Metal Toxicity 2.0
edited by
submission deadline 20 May 2024 | 9 articles | Viewed by 14195 | Submission Open
Keywords: heavy metal; metal compound; metallothionein; cellular defense mechanism; metal transporter  
(This special issue belongs to the Section Molecular Toxicology)
Recent Advances in Autoimmune and Inflammatory Disorders
edited by
submission deadline 20 May 2024 | 5 articles | Viewed by 12959 | Submission Open
Keywords: autoimmunity; autoimmune disease; inflammation; inflammatory disease; cellular pathways; molecular mechanisms; pathogenesis; therapy
(This special issue belongs to the Section Molecular Immunology)
Novel Molecular Research in Skin Inflammation submission deadline 20 May 2024 | 5 articles | Viewed by 12556 | Submission Open
Keywords: immune-mediated skin diseases; psoriasis; suppurative hidradenitis; atopic dermatitis; acne vulgaris; acne rosacea; lichen sclerosus; chronic spontaneous urticaria; allergic contact eczema; neutrophilic dermatoses; systemic sclerosis; bullous diseases; chronic graft versus host diseases
(This special issue belongs to the Section Molecular Immunology)
Sympathetic Nerves and Cardiovascular Diseases 2.0
edited by and
submission deadline 20 May 2024 | 4 articles | Viewed by 11028 | Submission Open
Keywords: sympathetic nerve activity; renal denervation; heart disease; stroke; atherosclerosis; hypertension; vascular remodeling; diabetes; metabolic syndrome; kidney disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Stem Cells in Health and Disease 2.0 submission deadline 20 May 2024 | 10 articles | Viewed by 10641 | Submission Open
Keywords: stem cell regulation; differentiation; pluripotency; reprogramming; stem cell therapy; cancer stem cell/tumor-initiating cell; therapy resistance; regenerative medicine; metabolic plasticity
(This special issue belongs to the Section Molecular Biology)
Pharmacogenetics and Personalized Medicine 3.0 submission deadline 20 May 2024 | 7 articles | Viewed by 10627 | Submission Open
Keywords: pharmacogenetics and pharmacogenomics; personalized medicine; lncRNA; miRNA; circRNA; methylation; epigenetics; microbiome; liquid biopsy; circulating biomarkers
(This special issue belongs to the Section Molecular Pharmacology)
A Molecular Perspective on Reproductive Health submission deadline 20 May 2024 | 10 articles | Viewed by 9097 | Submission Open
Keywords: reproductive function; molecular bases; male; female; reproductive pathology; reproductive physiology
(This special issue belongs to the Section Biochemistry)
Gut Microbiota Derived Metabolites in Cardiovascular Health and Disease
edited by Zeneng Wang
submission deadline 20 May 2024 | 4 articles | Viewed by 8800 | Submission Open
Keywords: gut microbiota-derived metabolites such as: short-chain fatty acids; trimethylamine n-oxide; amide lipid; aromatic amino acid derivatives; polyamines; hydrogen sulfide; lipopolysaccharide; polyphenols; secondary bile acids; receptor recognition and signal transduction induced by metabolites; metabolites initiating atherosclerosis; microbial enzymes catalyzing biosynthesis of the metabolites; inhibitors; prebiotic and probiotic modulation of the metabolite production; transcriptomic; proteomic; metabolic profile changes induced by metabolites
(This special issue belongs to the Section Molecular Microbiology)
Molecular Advances in Ovarian Cancer
edited by
submission deadline 20 May 2024 | 7 articles | Viewed by 8736 | Submission Open
Keywords: pathogenesis; tumor microenvironment; ovarian cancer
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Lysophosphatidic Acid Signaling in Health and Disease
edited by and
submission deadline 20 May 2024 | 6 articles | Viewed by 7578 | Submission Open
(This special issue belongs to the Section Biochemistry)
Biomaterials and Their Composites for Biomedical Applications and Beyond submission deadline 20 May 2024 | 5 articles | Viewed by 7415 | Submission Open
Keywords: biomaterials; bio-composite materials; biomedical applications; nerve-tissue engineering; 3D/4D printing; biomedical engineering; nanomedicine; biocompatibility; cytotoxicity factors
(This special issue belongs to the Section Materials Science)
Disorders in Brain Development and Nervous System: Key Molecules and Pathology
edited by
submission deadline 20 May 2024 | 5 articles | Viewed by 7400 | Submission Open
Keywords: neurogenesis; neurotrophic factors; synapse formation; neuronal circuit formation; nutrition; specific genes for brain development; pathology of the affected brain
(This special issue belongs to the Section Molecular Neurobiology)
Biosensors for the Early Diagnosis of High-Impact Human Diseases
edited by
submission deadline 20 May 2024 | 5 articles | Viewed by 7361 | Submission Open
Keywords: early-stage diagnosis; high-impact human disease; biosensors; liquid biopsy; MEMs; point-of-care platform; artificial-intelligence-assisted diagnosis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms Involved in Sperm Development, Maturation, and Fertilization 2.0 submission deadline 20 May 2024 | 8 articles | Viewed by 6834 | Submission Open
Keywords: sperm physiology; seminal plasma; extracellular vesicles; reproduction; spermatogenesis; capacitation; fertility
(This special issue belongs to the Section Molecular Biology)
Recent Advances in Skin Diseases
edited by
submission deadline 20 May 2024 | 4 articles | Viewed by 6633 | Submission Open
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Research Progress on Glioblastoma
edited by
submission deadline 20 May 2024 | 5 articles | Viewed by 6457 | Submission Open
Keywords: glioblastoma; glioma stem cells; signaling pathways; tumor heterogeneity; tumor microenvironment; microglia; molecular pathways; immunotherapies
(This special issue belongs to the Section Molecular Oncology)
Novel Molecular and Cellular Biology Approaches in the Assessment of Radiation Effects
edited by
submission deadline 20 May 2024 | 5 articles | Viewed by 5315 | Submission Open
Keywords: ionizing radiation; cytoplasmic targets of radiation; radiation induced bystander effects; extracellular vesicles; dna damage and repair; biomarkers; miRNA; proteomics; liquid biopsy; radiation carcinogenesis; radiation fibrosis
(This special issue belongs to the Section Molecular Biology)
Molecular and Translational Research on Bone Tumors 2.0 submission deadline 20 May 2024 | 1 articles | Viewed by 5000 | Submission Open
Keywords: primary bone tumours; metastatic bone tumour; therapy; biomarkers; epigenetic factors; immune-oncology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Drug Repurposing: Emerging Approaches to Drug Discovery
edited by
submission deadline 20 May 2024 | 3 articles | Viewed by 4902 | Submission Open
Keywords: repurposed drugs; network medicine; systems medicine; drug design; therapeutic strategies; drug repurposing in the era of artificial intelligence; drug repositioning; machine learning
(This special issue belongs to the Section Molecular Informatics)
Research on Bone Cells in Health and Disease
edited by
submission deadline 20 May 2024 | 5 articles | Viewed by 4462 | Submission Open
Keywords: osteoclasts; osteoblasts; osteocytes; osteoporosis; bone tumors; periodontitis; rheumatoid arthritis; bone remodeling
(This special issue belongs to the Section Molecular Biology)
Recent Advances on Fluorine Chemistry
edited by
submission deadline 20 May 2024 | 6 articles | Viewed by 4449 | Submission Open
Keywords: fluorine; оrganofluorine compounds; fluorine-containing building blocks; fluorine introduction; defluorination; fluorocarbons; fluorine NMR; fluorine biocatalysis; trifluoromethyl; lipophilicity; fluorine drugs
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Aldehyde Dehydrogenase in Cancer
edited by and Beata Želazowska-Rutkowska
submission deadline 20 May 2024 | 2 articles | Viewed by 4434 | Submission Open
Keywords: aldehyde dehydrogenase; molecular regulation; molecular tumor pathology; gene polymorphism; gene expression; polymorphism; ALDH isoenzymes; ALDH inhibitors; therapeutic targets; prognosis; cancer stem cell; stem cell marker; biomarker; retinoic acid; oxidative stress; toxic aldehydes; tumor microenvironment; angiogenesis; metastasis
(This special issue belongs to the Section Molecular Oncology)
The Role of Lutein for Human Health submission deadline 20 May 2024 | 3 articles | Viewed by 4333 | Submission Open
Keywords: lutein; retina degeneration; antioxidants; cognitive functions; xanthophylls; carotenoids; AMD
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Biopolymers in Drug and Gene Delivery Systems 3.0
edited by
submission deadline 20 May 2024 | 4 articles | Viewed by 4168 | Submission Open
Keywords: biopolymers; drug delivery; gene delivery; biodegradable polymers; biocompatible polymers; nanomedicine
(This special issue belongs to the Section Macromolecules)
New Targeted Therapeutic Strategies of Multiple Myeloma submission deadline 20 May 2024 | 2 articles | Viewed by 4133 | Submission Open
Keywords: multiple myeloma; uncontrolled proliferation; plasmacells; immunoglobulins; natural drug therapies; immunotherapy; B cells; T cells; immunosuppressive cells; chemotherapeutics; molecular checkpoints; stem cell transplantation (ASCT); current status in MM therapy; new immunomodulatory drug/nutural compounds; monoclonal antibodies; osteoclast activity and bone resorption
(This special issue belongs to the Section Molecular Immunology)
Tissue-Engineered Skin Substitutes: The State-of-the-Art and Future Perspectives
edited by
submission deadline 20 May 2024 | 3 articles | Viewed by 3848 | Submission Open
Keywords: tissue-engineered skin; skin tissue scaffolds; skin substitutes; vascularization; pigmentation; wound healing; 3D printing; full-thickness wounds; clinical perspectives; skin regeneration; scar-free skin healing; immuno-inflammation; hypertrophic scars; keloids macrophages
(This special issue belongs to the Section Molecular Biology)
Transcriptional Therapy and Nucleic Acid-Based Therapeutics: From Molecular Targets to Preclinical Studies 2.0
edited by
submission deadline 20 May 2024 | 3 articles | Viewed by 3847 | Submission Open
Keywords: antisense oligonucleotide (ASO); RNA interference (RNAi); CRISPR/Cas9; miRNA; nucleic acid-based therapeutics; long non-coding RNA; splicing modification; transcript-targeted therapy; cancer therapy; genetic diseases
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Cancer Stem Cells in Solid Tumors
edited by
submission deadline 20 May 2024 | 2 articles | Viewed by 3830 | Submission Open
Keywords: CSC characterization; genetic and epigenetic regulators of CSCs; tumor microenvironment; energy/oxidative metabolism; exosomes; microRNAs; treatment resistance; targeting CSCs; differentiation therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Metalloproteins: How Metals Shape Protein Structure and Function submission deadline 20 May 2024 | 4 articles | Viewed by 3829 | Submission Open
Keywords: transition metals; metal clusters; structure; catalysis; regulation; electron transfer; metalloenzymes; metal transporters; metal sensors; heavy metal toxicity
(This special issue belongs to the Section Molecular Biophysics)
Genetic and Epigenetic Determinants of Age-Related Traits: New Challenges and Insights submission deadline 20 May 2024 | 2 articles | Viewed by 3474 | Submission Open
Keywords: genetics; epigenetics; age-related traits; health; chronic diseases; data integration; disease risk; aging
(This special issue belongs to the Section Molecular Genetics and Genomics)
Epigenetics and Beyond: New Advances in Drug Discovery submission deadline 20 May 2024 | 2 articles | Viewed by 3429 | Submission Open
Keywords: epigenetic modifications; epigenetic targets; drug design; drug discovery; cancer; infectious disease; immunology; inflammation; neurological diseases; fibrosis; wound repair and regeneration
(This special issue belongs to the Section Molecular Pharmacology)
Molecular Insights in Circadian Rhythm and Metabolism
edited by
submission deadline 20 May 2024 | 3 articles | Viewed by 3122 | Submission Open
Keywords: circadian clock; cell synchrony; bioactive; polyphenol; oxidative stress; metabolic syndrome
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Advances in Protein–Ligand Interactions
edited by Dong-Jun Yu
submission deadline 20 May 2024 | 3 articles | Viewed by 3075 | Submission Open
Keywords: drug design; binding specificity; molecular docking; ligand screening; structural biology; protein– protein interactions; protein– ligand interactions; protein– lipid complexes; protein– nucleic acid interactions
(This special issue belongs to the Section Macromolecules)
Molecular Mechanisms and Immunotherapy of Soft Tissue and Bone Sarcomas
edited by and
submission deadline 20 May 2024 | 1 articles | Viewed by 3003 | Submission Open
(This special issue belongs to the Section Molecular Oncology)
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