Integrated Photonic Digital PCR Techniques

Dear Colleagues,

PCR technology has developed over several decades and through three generations due to the utilization of various techniques. As the world has recently experienced COVID-19, PCR technology has become necessary for rapid and early diagnosis. Recently, quantitative analysis has become possible with the development of a fast molecular diagnosis and digital PCR, and the expectations of molecular diagnosis have increased as ultra-fast digital PCR technology has been developed using light energy and energy conversion technologies. Photonic digital PCR is a molecular analysis technique that enables the precise quantification and amplification of DNA or RNA molecules in a sample. This method offers exceptional sensitivity and accuracy by partitioning the sample into thousands of individual reaction volumes, each containing a limited number of target molecules. Through the utilization of advanced microfluidics and optical detection systems, photonic digital PCR allows for the absolute quantification of nucleic acids without the need for a standard curve. Accordingly, this Special Issue seeks to showcase research papers, short communications, and review articles that focus on: (1) (portable) photonic dPCR development using new technologies, (2) demonstrations using highly infectious pathogens, and (3) on-site demonstrations using portable devices.

Dr. Kyung Ho Kim
Prof. Dr. Oh-seok Kwon
Guest Editors

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• photonic PCR
• energy conversion
• molecular diagnosis
• nanotechnology