Polymer Based Bio-Sensors II

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Polymer Applications".

Deadline for manuscript submissions: closed (20 November 2020) | Viewed by 3240

Special Issue Editor


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Guest Editor
Korea Research Institutes for Bioscience and Biotechnology, Daejeon 305-806, Republic of Korea
Interests: conductive nanomaterials; interfacing chemistry; optical nanomaterials; electronics; chem/bio sensors; optical sensors; point-of-care test
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Special Issue Information

Dear Colleagues,

The inherent biocompatibility and the unique optical, electrical, and mechanical properties of polymers have attracted attention from various fields, such as energy, as well as environmental and bioapplications. Especially, polymer-based biosensors, including enzyme-, tissue-, DNA-, aptamer-, and protein-based biosensors, have been rapidly developed, owing to their high performances. There are various detection methodologies for polymer-based biosensors, including electrochemical, optical, field-effect transistor, lateral flow assay, etc. Moreover, polymer-related materials, such as conducting polymer nanomaterials, polymer composites, polymer beads, and hybrids, have been designed and created. Although biosensors with these conventional polymers showed high-performance sensing properties, the challenges remain to enhance a maximum detectable level (MDL) of biosensors: (i) enlarged surface to volume ratios; (ii) development of interfacing chemistry, including surface modification and interfacial adhesion; (iii) high stability from surrounding environments; (iv) novel sensing systems, and so on. In addition, industrial approaches with high reliability in a multitude of fields are also important issues. Notably, polymer-based biosensors for healthcare monitoring have been investigated and integrated into smart devices to collect a large amount of sensing data.
This Special Issue invites original papers and reviews reporting on recent progress in the following areas:

- Fabrication methods of the polymers with enlarged surface areas and their biosensor applications;
- Chemical and physical surface modification of polymers to improve sensing performances;
- Next-generation polymer-based biosensors;
- Integration process of polymer-based biosensors into smart devices and their point-of-care test;
- Properties of polymer-based biosensors;
- Biological properties of polymer-based biosensors.

Dr. Oh Seok Kwon
Guest Editor

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Keywords

  • Polymers
  • Composites
  • Beads
  • Hybrids
  • Hard-template
  • Soft-template
  • Biosensors
  • Immunoassay
  • Field-effect transistor
  • Electrochemical sensor
  • Optical sensor
  • Rapid Kit
  • Mobile networks
  • Point-of-care test
  • Interfacing chemistry
  • Biomolecular detection
  • Surface modification

Published Papers (1 paper)

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Research

12 pages, 1075 KiB  
Article
In Situ Enhanced Raman and Photoluminescence of Bio-Hybrid Ag/Polymer Nanoparticles by Localized Surface Plasmon for Highly Sensitive DNA Sensors
by Seokho Kim, Bo-Hyun Kim, Young Ki Hong, Chunzhi Cui, Jinho Choi, Dong Hyuk Park and Sung Ho Song
Polymers 2020, 12(3), 631; https://doi.org/10.3390/polym12030631 - 10 Mar 2020
Cited by 8 | Viewed by 2940
Abstract
We experimentally demonstrate the simultaneous enhancement of Raman and photoluminescence (PL) of core-shell hybrid nanoparticles consisting of Ag (core) and polydiacetylene (PDA, shell) through the assistance of localized surface plasmon (LSP) effect for the effective biosensor. Core-shell nanoparticles (NPs) are fabricated in deionized [...] Read more.
We experimentally demonstrate the simultaneous enhancement of Raman and photoluminescence (PL) of core-shell hybrid nanoparticles consisting of Ag (core) and polydiacetylene (PDA, shell) through the assistance of localized surface plasmon (LSP) effect for the effective biosensor. Core-shell nanoparticles (NPs) are fabricated in deionized water through a sequential process of reprecipitation and self-assembly. The Raman signal of PDA on core-shell NPs is enhanced more than 100 times. Also, highly enhanced photoluminescence is observed on Ag/PDA hybrid NPs after coupling of the complementary t-DNA with p-DNA which are immobilized on PDA shell. This indicates that the core Ag affects the Raman and PL of PDA through the LSP resonance, which can be caused by the energy and/or charge transfer caused by the LSP coupling and the strong electromagnetic field near Ag NP surface. Only electrons present on the surface interact with the PDA shell, not involving the electrically neutral part of the electrons inside the Ag NP. Furthermore, this work shows that as prepared Ag/PDA NPs functionalized by probe DNA can sense the target DNA with an attomolar concentration (100 attomole). Full article
(This article belongs to the Special Issue Polymer Based Bio-Sensors II)
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