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Micromachines, Volume 12, Issue 1

2021 January - 98 articles

Cover Story: While sorting cells based on their membrane or internal structures has important implications for cell biology, these properties usually do not translate into common properties that have been used for sorting, for example, size, shape, or deformability. We show that by combining electrokinetics with deterministic lateral displacement (DLD) in a microfluidics device, it is possible to sort cells continuously based on differences in their membrane and internal structures. Using heat to deactivate cells, which changes their viability and structure, we demonstrate sorting of a mixture of viable and non-viable cells for two different cell types. We expect our work to form the basis for the development of simple, low-cost, continuous label-free methods that can separate cells and bioparticles based on their intrinsic properties. View this paper.
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Articles (98)

  • Article
  • Open Access
27 Citations
5,253 Views
9 Pages

19 January 2021

Microalgae separation technology is essential for both executing laboratory-based fundamental studies and ensuring the quality of the final algal products. However, the conventional microalgae separation technology of micropipetting requires highly s...

  • Article
  • Open Access
4 Citations
4,120 Views
12 Pages

Parallel Recordings of Transmembrane hERG Channel Currents Based on Solvent-Free Lipid Bilayer Microarray

  • Ryusuke Miyata,
  • Daisuke Tadaki,
  • Daichi Yamaura,
  • Shun Araki,
  • Madoka Sato,
  • Maki Komiya,
  • Teng Ma,
  • Hideaki Yamamoto,
  • Michio Niwano and
  • Ayumi Hirano-Iwata

19 January 2021

The reconstitution of ion-channel proteins in artificially formed bilayer lipid membranes (BLMs) forms a well-defined system for the functional analysis of ion channels and screening of the effects of drugs that act on these proteins. To improve the...

  • Feature Paper
  • Article
  • Open Access
4 Citations
5,177 Views
18 Pages

Micropatterning of Substrates for the Culture of Cell Networks by Stencil-Assisted Additive Nanofabrication

  • Anita Previdi,
  • Claudio Piazzoni,
  • Francesca Borghi,
  • Carsten Schulte,
  • Leandro Lorenzelli,
  • Flavio Giacomozzi,
  • Alessio Bucciarelli,
  • Antonio Malgaroli,
  • Jacopo Lamanna and
  • Paolo Milani
  • + 4 authors

18 January 2021

The fabrication of in vitro neuronal cell networks where cells are chemically or electrically connected to form functional circuits with useful properties is of great interest. Standard cell culture substrates provide ensembles of cells that scarcely...

  • Article
  • Open Access
18 Citations
3,756 Views
6 Pages

Development of a CMOS-Compatible Carbon Nanotube Array Transfer Method

  • Chun Fei Siah,
  • Lucas Yu Xiang Lum,
  • Jianxiong Wang,
  • Simon Chun Kiat Goh,
  • Chong Wei Tan,
  • Liangxing Hu,
  • Philippe Coquet,
  • Hong Li,
  • Chuan Seng Tan and
  • Beng Kang Tay

18 January 2021

Carbon nanotubes (CNTs) have, over the years, been used in research as a promising material in electronics as a thermal interface material and as interconnects amongst other applications. However, there exist several issues preventing the widespread...

  • Review
  • Open Access
65 Citations
9,136 Views
21 Pages

Recent Advances in Three-Dimensional Multicellular Spheroid Culture and Future Development

  • Honglin Shen,
  • Shuxiang Cai,
  • Chuanxiang Wu,
  • Wenguang Yang,
  • Haibo Yu and
  • Lianqing Liu

18 January 2021

Three-dimensional multicellular spheroids (MCSs) have received extensive attention in the field of biomedicine due to their ability to simulate the structure and function of tissues in vivo more accurately than traditional in vitro two-dimensional mo...

  • Article
  • Open Access
16 Citations
3,803 Views
11 Pages

Utilization of a Gas-Sensing System to Discriminate Smell and to Monitor Fermentation during the Manufacture of Oolong Tea Leaves

  • Ting-Shiang Tseng,
  • Mei-Hui Hsiao,
  • Po-An Chen,
  • Shu-Yen Lin,
  • Shih-Wen Chiu and
  • Da-Jeng Yao

17 January 2021

The operational duration of shaking tea leaves is a critical factor in the manufacture of oolong tea; this duration influences the formation of its flavor and fragrance. The current method to control the duration of fermentation relies on the olfacto...

  • Article
  • Open Access
15 Citations
3,287 Views
14 Pages

16 January 2021

Cavities are typical features in aeronautical structural parts and molds. For high-speed milling of multi-cavity parts, a reasonable processing sequence planning can significantly affect the machining accuracy and efficiency. This paper proposes an i...

  • Article
  • Open Access
4 Citations
4,434 Views
12 Pages

Sidewall Slope Control of InP Via Holes for 3D Integration

  • Jongwon Lee,
  • Kilsun Roh,
  • Sung-Kyu Lim and
  • Youngsu Kim

16 January 2021

This is the first demonstration of sidewall slope control of InP via holes with an etch depth of more than 10 μm for 3D integration. The process for the InP via holes utilizes a common SiO2 layer as an InP etch mask and conventional inductively co...

  • Article
  • Open Access
29 Citations
5,895 Views
13 Pages

3D-Printed Microfluidic Droplet Generator with Hydrophilic and Hydrophobic Polymers

  • Chandler A. Warr,
  • Hunter S. Hinnen,
  • Saroya Avery,
  • Rebecca J. Cate,
  • Gregory P. Nordin and
  • William G. Pitt

16 January 2021

Droplet generation has been widely used in conventional two-dimensional (2D) microfluidic devices, and has recently begun to be explored for 3D-printed droplet generators. A major challenge for 3D-printed devices is preventing water-in-oil droplets f...

  • Article
  • Open Access
7 Citations
4,614 Views
15 Pages

Long-Term Human Hematopoietic Stem Cell Culture in Microdroplets

  • Pilar Carreras,
  • Itziar González,
  • Miguel Gallardo,
  • Alejandra Ortiz-Ruiz,
  • Maria Luz Morales,
  • Jessica Encinas and
  • Joaquín Martínez-López

16 January 2021

We previously reported a new approach for micromanipulation and encapsulation of human stem cells using a droplet-based microfluidic device. This approach demonstrated the possibility of encapsulating and culturing difficult-to-preserve primary human...

  • Article
  • Open Access
24 Citations
3,852 Views
15 Pages

Modeling and Compensation for Asymmetrical and Dynamic Hysteresis of Piezoelectric Actuators Using a Dynamic Delay Prandtl–Ishlinskii Model

  • Wen Wang,
  • Fuming Han,
  • Zhanfeng Chen,
  • Ruijin Wang,
  • Chuanyong Wang,
  • Keqing Lu,
  • Jiahui Wang and
  • Bingfeng Ju

16 January 2021

Piezoelectric actuators are widely used in micro- and nano-manufacturing and precision machining due to their superior performance. However, there are complex hysteresis nonlinear phenomena in piezoelectric actuators. In particular, the inherent hyst...

  • Feature Paper
  • Article
  • Open Access
13 Citations
4,222 Views
16 Pages

A Tunable-Gain Transimpedance Amplifier for CMOS-MEMS Resonators Characterization

  • Rafel Perelló-Roig,
  • Jaume Verd,
  • Sebastià Bota and
  • Jaume Segura

15 January 2021

CMOS-MEMS resonators have become a promising solution thanks to their miniaturization and on-chip integration capabilities. However, using a CMOS technology to fabricate microelectromechanical system (MEMS) devices limits the electromechanical perfor...

  • Feature Paper
  • Review
  • Open Access
80 Citations
11,914 Views
36 Pages

Carbon Dots: An Emerging Smart Material for Analytical Applications

  • Smita Das,
  • Lightson Ngashangva and
  • Pranab Goswami

15 January 2021

Carbon dots (CDs) are optically active carbon-based nanomaterials. These nanomaterials can change their light emission properties in response to various external stimuli such as pH, temperature, pressure, and light. The CD’s remarkable stimuli-respon...

  • Article
  • Open Access
6 Citations
3,438 Views
19 Pages

15 January 2021

This study investigated the effects of different substrates on the mechanical properties of Ti-60at%Ni shape memory alloys (SMA). Two types of samples were prepared for this experiment: (1) a Ti-60at%Ni deposited on SiNx, and (2) a Ti-60at%Ni deposit...

  • Article
  • Open Access
9 Citations
2,728 Views
10 Pages

15 January 2021

In the fast tool servo (FTS) system for microstructure surface cutting, the dynamic voltage hysteresis of piezoelectric actuators (PEAs) and the cutting force produced in the manufacturing affect the driving accuracy and the cutting performance. For...

  • Article
  • Open Access
34 Citations
6,230 Views
12 Pages

3D Printed Shape Memory Polymers Produced via Direct Pellet Extrusion

  • Trenton Cersoli,
  • Alexis Cresanto,
  • Callan Herberger,
  • Eric MacDonald and
  • Pedro Cortes

15 January 2021

Shape memory polymers (SMPs) are materials capable of changing their structural configuration from a fixed shape to a temporary shape, and vice versa when subjected to a thermal stimulus. The present work has investigated the 3D printing process of a...

  • Article
  • Open Access
76 Citations
5,750 Views
11 Pages

Temperature-Controlled Crystal Size of Wide Band Gap Nickel Oxide and Its Application in Electrochromism

  • Muyang Shi,
  • Tian Qiu,
  • Biao Tang,
  • Guanguang Zhang,
  • Rihui Yao,
  • Wei Xu,
  • Junlong Chen,
  • Xiao Fu,
  • Honglong Ning and
  • Junbiao Peng

14 January 2021

Nickel oxide (NiO) is a wide band gap semiconductor material that is used as an electrochromic layer or an ion storage layer in electrochromic devices. In this work, the effect of annealing temperature on sol-gel NiO films was investigated. Fourier t...

  • Article
  • Open Access
11 Citations
3,343 Views
13 Pages

14 January 2021

The field of inertial microfluidics has been significantly advanced in terms of application to fluid manipulation for biological analysis, materials synthesis, and chemical process control. Because of their superior benefits such as high-throughput,...

  • Review
  • Open Access
62 Citations
13,975 Views
22 Pages

Bending Setups for Reliability Investigation of Flexible Electronics

  • Rafat Saleh,
  • Maximilian Barth,
  • Wolfgang Eberhardt and
  • André Zimmermann

13 January 2021

Flexible electronics is a rapidly growing technology for a multitude of applications. Wearables and flexible displays are some application examples. Various technologies and processes are used to produce flexible electronics. An important aspect to b...

  • Article
  • Open Access
18 Citations
4,557 Views
25 Pages

13 January 2021

The demands for indoor positioning in location-based services (LBS) and applications grow rapidly. It is beneficial for indoor positioning to combine attitude and heading information. Accurate attitude and heading estimation based on magnetic, angula...

  • Feature Paper
  • Article
  • Open Access
8 Citations
3,783 Views
15 Pages

Double-Deck Metal Solenoids 3D Integrated in Silicon Wafer for Kinetic Energy Harvester

  • Nianying Wang,
  • Ruofeng Han,
  • Changnan Chen,
  • Jiebin Gu and
  • Xinxin Li

12 January 2021

A silicon-chip based double-deck three-dimensional (3D) solenoidal electromagnetic (EM) kinetic energy harvester is developed to convert low-frequency (<100 Hz) vibrational energy into electricity with high efficiency. With wafer-level micro elect...

  • Article
  • Open Access
18 Citations
3,102 Views
9 Pages

12 January 2021

Lactobacillus brevis is the most common bacteria that causes beer spoilage. In this work, a novel electrochemical immunosensor was fabricated for ultra-sensitive determination of L. brevis. Gold nanoparticles (AuNPs) were firstly electro-deposited on...

  • Article
  • Open Access
15 Citations
3,957 Views
17 Pages

Effect of Strain Rate on the Deformation Characteristic of AlN Ceramics under Scratching

  • Shang Gao,
  • Honggang Li,
  • Renke Kang,
  • Yu Zhang and
  • Zhigang Dong

12 January 2021

To clarify the influence mechanism of strain rate effect on deformation characteristics of aluminum nitride (AlN) ceramics, some varied-velocity nanoscratching tests were carried out using a Berkovich indenter in this paper. The deformation character...

  • Feature Paper
  • Article
  • Open Access
14 Citations
5,990 Views
14 Pages

12 January 2021

We designed a kirigami structure with a particular shape at both ends to provide a large uniform deformation region when stretched. When a kirigami structure is stretched, non-deformation regions, where the regions’ cuts do not open, and non-uniform...

  • Article
  • Open Access
6 Citations
3,324 Views
12 Pages

Micro Direct Methanol Fuel Cell Based on Reduced Graphene Oxide Composite Electrode

  • Chaoran Liu,
  • Sanshan Hu,
  • Lu Yin,
  • Wenli Yang,
  • Juan Yu,
  • Yumin Xu,
  • Lili Li,
  • Gaofeng Wang and
  • Luwen Wang

11 January 2021

The effect of an anode composite electrode on the performance of a micro direct methanol fuel cell (μDMFC) is analyzed from sample preparation configurations and discussed in detail, with a specific focus on the catalyst layer and the micro-porous...

  • Article
  • Open Access
5 Citations
3,312 Views
10 Pages

Experimental Study of Bubble Formation from a Micro-Tube in Non-Newtonian Fluid

  • Georgia Kontaxi,
  • Yorgos G. Stergiou and
  • Aikaterini A. Mouza

11 January 2021

Over the last few years, microbubbles have found application in biomedicine. In this study, the characteristics of bubbles formed when air is introduced from a micro-tube (internal diameter 110 μm) in non-Newtonian shear thinning fluids are studie...

  • Article
  • Open Access
45 Citations
8,407 Views
13 Pages

11 January 2021

Even though computer vision has been developing, edge detection is still one of the challenges in that field. It comes from the limitations of the complementary metal oxide semiconductor (CMOS) Image sensor used to collect the image data, and then im...

  • Article
  • Open Access
25 Citations
3,943 Views
21 Pages

9 January 2021

Non-conductive structural ceramics are receiving ever-increasing attention due to their outstanding physical and mechanical properties and their critical applications in aerospace and biomedical industries. However, conventional mechanical machining...

  • Article
  • Open Access
11 Citations
3,309 Views
10 Pages

9 January 2021

The zebrafish is acknowledged as a reliable species of choices for biomechanical-related investigations. The definite quantification of the hydrodynamic flow physics caused by behavioral patterns, particularly in the zebrafish tail beat, is critical...

  • Article
  • Open Access
24 Citations
4,927 Views
16 Pages

9 January 2021

Micromirrors based on micro-electro-mechanical systems (MEMS) technology are widely employed in different areas, such as optical switching and medical scan imaging. As the key component of MEMS LiDAR, electromagnetic MEMS torsional micromirrors have...

  • Article
  • Open Access
6 Citations
5,252 Views
11 Pages

The Wafer-Level Integration of Single-Crystal LiNbO3 on Silicon via Polyimide Material

  • Xiangyu Yang,
  • Wenping Geng,
  • Kaixi Bi,
  • Linyu Mei,
  • Yaqing Li,
  • Jian He,
  • Jiliang Mu,
  • Xiaojuan Hou and
  • Xiujian Chou

9 January 2021

In situ measurements of sensing signals in space platforms requires that the micro-electro-mechanical system (MEMS) sensors be located directly at the point to be measured and in contact with the subject to be measured. Traditional radiation-tolerant...

  • Review
  • Open Access
38 Citations
7,903 Views
28 Pages

8 January 2021

Wide-bandgap (WBG) material-based switching devices such as gallium nitride (GaN) high electron mobility transistors (HEMTs) and silicon carbide (SiC) metal-oxide-semiconductor field-effect transistors (MOSFETs) are considered very promising candidat...

  • Article
  • Open Access
19 Citations
4,445 Views
13 Pages

7 January 2021

Energy leakage via anchors in substrate plates impairs the quality factor (Q) in microelectromechanical system (MEMS) resonators. Most phononic crystals (PnCs) require complicated fabrication conditions and have difficulty generating a narrow bandgap...

  • Article
  • Open Access
11 Citations
3,603 Views
13 Pages

Design and Manufacturing of a High-Sensitivity Cutting Force Sensor Based on AlSiCO Ceramic

  • Taobo Gong,
  • You Zhao,
  • Yulong Zhao,
  • Lukang Wang,
  • Yu Yang and
  • Wei Ren

7 January 2021

On-line cutting force measurement is an effective way to monitor processing quality, improve processing accuracy, and protect the tool. In high-speed and ultra-precision machining, status monitoring is particularly necessary to ensure machining accur...

  • Review
  • Open Access
23 Citations
8,095 Views
22 Pages

7 January 2021

The development of biosensors that measure various biosignals from our body is an indispensable research field for health monitoring. In recent years, as the demand to monitor the health conditions of individuals in real time have increased, wearable...

  • Article
  • Open Access
27 Citations
4,653 Views
13 Pages

6 January 2021

Silicon carbide (SiC) has promising potential for pressure sensing in a high temperature and harsh environment due to its outstanding material properties. In this work, a 4H-SiC piezoresistive pressure chip fabricated based on femtosecond laser techn...

  • Feature Paper
  • Article
  • Open Access
25 Citations
4,613 Views
16 Pages

Capacitive Field-Effect Biosensor Studying Adsorption of Tobacco Mosaic Virus Particles

  • Melanie Jablonski,
  • Arshak Poghossian,
  • Robin Severins,
  • Michael Keusgen,
  • Christina Wege and
  • Michael J. Schöning

6 January 2021

Plant virus-like particles, and in particular, tobacco mosaic virus (TMV) particles, are increasingly being used in nano- and biotechnology as well as for biochemical sensing purposes as nanoscaffolds for the high-density immobilization of receptor m...

  • Article
  • Open Access
10 Citations
3,694 Views
15 Pages

6 January 2021

This paper reports on a bidirectional Knudsen pump (KP) with a 3D-printed thermal management platform; the pump is intended principally for microscale gas chromatography applications. Knudsen pumps utilize thermal transpiration, where non-viscous flo...

  • Article
  • Open Access
22 Citations
5,294 Views
13 Pages

6 January 2021

With the k-ε renormalization group turbulence model, the drag reduction mechanism of three- dimensional spherical crown microstructure of different protruding heights distributing on the groove surface was studied in this paper. These spheric...

  • Article
  • Open Access
7 Citations
3,616 Views
11 Pages

Stamping Nanoparticles onto the Electrode for Rapid Electrochemical Analysis in Microfluidics

  • Jiyoung Son,
  • Edgar C. Buck,
  • Shawn L. Riechers and
  • Xiao-Ying Yu

6 January 2021

Electrochemical analysis is an efficient way to study various materials. However, nanoparticles are challenging due to the difficulty in fabricating a uniform electrode containing nanoparticles. We developed novel approaches to incorporate nanopartic...

  • Article
  • Open Access
7 Citations
3,363 Views
18 Pages

Analysis of Parametric and Subharmonic Excitation in Push-Pull Driven Disk Resonator Gyroscopes

  • Kai Wu,
  • Kuo Lu,
  • Qingsong Li,
  • Yongmeng Zhang,
  • Ming Zhuo,
  • Sheng Yu,
  • Xuezhong Wu and
  • Dingbang Xiao

6 January 2021

For micro-electromechanical system (MEMS) resonators, once the devices are fabricated and packaged, their intrinsic quality factors (Q) will be fixed and cannot be changed, which seriously limits the further improvement of the resonator’s perfo...

  • Article
  • Open Access
8 Citations
3,949 Views
11 Pages

5 January 2021

In this study, the soft-type and hard-type lead zirconate titanate (PZT) ceramics were compared in order to create an optimal system for ultrasonic dispersion of nanoparticles, and sound pressure energy for each PZT ceramic was analyzed and closely e...

  • Article
  • Open Access
7 Citations
3,094 Views
12 Pages

5 January 2021

Introduction: The Jozef Stefan Institute developed a personal portable electrocardiogram (ECG) sensor Savvy that works with a smartphone, and this was used in our study. This study aimed to analyze the usefulness of telecardiology at the primary heal...

  • Article
  • Open Access
4 Citations
3,714 Views
9 Pages

Efficient Lipid Bilayer Formation by Dipping Lipid-Loaded Microperforated Sheet in Aqueous Solution

  • Nobuo Misawa,
  • Satoshi Fujii,
  • Koki Kamiya,
  • Toshihisa Osaki and
  • Shoji Takeuchi

5 January 2021

This paper describes a method for a bilayer lipid membrane (BLM) formation using a perforated sheet along with an open chamber. Microscopic observation of the formed membrane showed a typical droplet interface bilayer. We proved that the formed membr...

  • Article
  • Open Access
11 Citations
3,771 Views
14 Pages

Exploring a New Adaptive Routing Based on the Dijkstra Algorithm in Optical Networks-on-Chip

  • Yan-Li Zheng,
  • Ting-Ting Song,
  • Jun-Xiong Chai,
  • Xiao-Ping Yang,
  • Meng-Meng Yu,
  • Yun-Chao Zhu,
  • Yong Liu and
  • Yi-Yuan Xie

5 January 2021

The photoelectric hybrid network has been proposed to achieve the ultrahigh bandwidth, lower delay, and less power consumption for chip multiprocessor (CMP) systems. However, a large number of optical elements used in optical networks-on-chip (ONoCs)...

  • Article
  • Open Access
11 Citations
3,626 Views
10 Pages

Ultrafast Parallel Micro-Gap Resistance Welding of an AuNi9 Microwire and Au Microlayer

  • He Zhang,
  • Shang Wang,
  • Bingying Wu,
  • Weiwei Zhang,
  • Chunjin Hang and
  • Yanhong Tian

3 January 2021

Welding between an AuNi9 microwire and Au microlayer is of great importance for fabricating electrical contact structures for high precision inertial devices, satellite slip ring brushes, robots, etc. In this paper, the achievement of parallel micro-...

  • Feature Paper
  • Article
  • Open Access
39 Citations
8,338 Views
10 Pages

3 January 2021

The sneak path current (SPC) is the inevitable issue in crossbar memory array while implementing high-density storage configuration. The crosstalks are attracting much attention, and the read accuracy in the crossbar architecture is deteriorated by t...

  • Article
  • Open Access
13 Citations
4,711 Views
12 Pages

2 January 2021

Circulating tumor cells (CTCs) have been considered as an alternative to tissue biopsy for providing both germline-specific and tumor-derived genetic variations. Single-cell analysis of CTCs enables in-depth investigation of tumor heterogeneity and i...

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Micromachines - ISSN 2072-666X