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Pathogens, Volume 10, Issue 4

April 2021 - 114 articles

Cover Story: Human skin-colonizing bacteria can have double “personalities”, which muddles the distinction between commensals and pathogens. Coagulase-negative staphylococci (CoNS) are part of the normal skin microbiota, but can also act as opportunistic pathogens, e.g., in prosthetic joint infections (PJIs). The anaerobic CoNS species Staphylococcus saccharolyticus is a frequent colonizer of human skin. Its pathogenic potential is so far unclear. In our study, we describe the clinical features of seven hip and shoulder PJIs that were associated with S. saccharolyticus. Whole genome sequencing revealed two subspecies of S. saccharolyticus, one of which was exclusively associated with hip PJIs. Our study suggests that S. saccharolyticus has the potential to cause PJIs that were previously regarded as aseptic loosening of prosthetic joint devices. View this paper
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Articles (114)

  • Article
  • Open Access
5 Citations
2,798 Views
14 Pages

Phenotypic and Phylogenetic Characterization of Cu Homeostasis among Xylella fastidiosa Strains

  • Qing Ge,
  • Ranlin Liu,
  • Paul A. Cobine,
  • Neha Potnis and
  • Leonardo De La Fuente

Xylella fastidiosa is a bacterial pathogen causing severe diseases and asymptomatic colonization in more than 600 plants worldwide. Copper (Cu) is a widely used antimicrobial treatment for various plant diseases, including those affecting X. fastidio...

  • Communication
  • Open Access
16 Citations
3,623 Views
9 Pages

Antimicrobial Peptides Pom-1 and Pom-2 from Pomacea poeyana Are Active against Candidaauris, C. parapsilosis and C. albicans Biofilms

  • Heinz Fabian Raber,
  • Jetmira Sejfijaj,
  • Ann-Kathrin Kissmann,
  • Andreas Wittgens,
  • Melaine Gonzalez-Garcia,
  • Annia Alba,
  • Antonio A. Vázquez,
  • Fidel E. Morales Vicente,
  • Julio Pérez Erviti and
  • Dennis Kubiczek
  • + 4 authors

Recently two peptides isolated from the Cuban freshwater snail Pomacea poeyana (Pilsbry, 1927) were described to have antimicrobial activity against bacterial pathogens. Here we show considerable activities of Pom-1 and Pom-2 to reduce the viability...

  • Case Report
  • Open Access
1 Citations
3,894 Views
7 Pages

Cerebral toxoplasmosis occurs mainly in immunocompromised hosts as a reactivation of latent Toxoplasma gondii infection. In the diagnostic process, magnetic resonance imaging (MRI), serum testing, and biopsy are used. We describe a case of a 43-year-...

  • Article
  • Open Access
8 Citations
2,809 Views
11 Pages

TREM1 rs2234237 (Thr25Ser) Polymorphism in Patients with Cutaneous Leishmaniasis Caused by Leishmania guyanensis: A Case-Control Study in the State of Amazonas, Brazil

  • José do Espírito Santo Júnior,
  • Tirza Gabrielle Ramos de Mesquita,
  • Luan Diego Oliveira da Silva,
  • Felipe Jules de Araújo,
  • Josué Lacerda de Souza,
  • Thaís Carneiro de Lacerda,
  • Lener Santos da Silva,
  • Cláudio Marcello da Silveira Júnior,
  • Krys Layane Guimarães Duarte Queiroz and
  • Diogo Matos dos Santos
  • + 6 authors

Background: Leishmaniasis is an infectious disease caused by Leishmania parasites. A Th1 immune response is necessary in the acute phase to control the pathogen. The triggering receptor expressed on myeloid cells (TREM)-1 is a potent amplifier of inf...

  • Review
  • Open Access
19 Citations
6,650 Views
17 Pages

Gene Regulation of Biofilm-Associated Functional Amyloids

  • Khushal Khambhati,
  • Jaykumar Patel,
  • Vijaylaxmi Saxena,
  • Parvathy A and
  • Neha Jain

Biofilms are bacterial communities encased in a rigid yet dynamic extracellular matrix. The sociobiology of bacterial communities within a biofilm is astonishing, with environmental factors playing a crucial role in determining the switch from plankt...

  • Article
  • Open Access
5 Citations
4,215 Views
11 Pages

Ameobae belonging to the genus Acanthamoeba are responsible for the human diseases Acanthamoeba keratitis (AK) and granulomatous amoebic encephalitis (GAE). The treatment of these illnesses is hampered by the existence of a resistance stage (cysts)....

  • Article
  • Open Access
8 Citations
2,831 Views
8 Pages

Maximising Productivity and Eliminating Campylobacter in Broilers by Manipulating Stocking Density and Population Structure Using ‘Biosecurity Cubes’

  • Genevieve Greene,
  • Leonard Koolman,
  • Paul Whyte,
  • Helen Lynch,
  • Aidan Coffey,
  • Brigid Lucey,
  • John Egan,
  • Lisa O’Connor and
  • Declan Bolton

This study investigates the effect of stocking density and population dynamics on broiler growth rates and productivity, while further validating the ability of the biosecurity cubes (BC) to protect birds from Campylobacter. In our methodology, six B...

  • Article
  • Open Access
12 Citations
3,354 Views
17 Pages

High Biofilm Formation of Non-Smooth Candida parapsilosis Correlates with Increased Incorporation of GPI-Modified Wall Adhesins

  • Ana Esther Moreno-Martínez,
  • Emilia Gómez-Molero,
  • Pablo Sánchez-Virosta,
  • Henk L. Dekker,
  • Albert de Boer,
  • Elena Eraso,
  • Oliver Bader and
  • Piet W. J. de Groot

Candida parapsilosis is among the most frequent causes of candidiasis. Clinical isolates of this species show large variations in colony morphotype, ranging from round and smooth to a variety of non-smooth irregular colony shapes. A non-smooth appear...

  • Article
  • Open Access
54 Citations
9,395 Views
16 Pages

Evaluation of Essential Oils and Extracts of Rose Geranium and Rose Petals as Natural Preservatives in Terms of Toxicity, Antimicrobial, and Antiviral Activity

  • Chrysa Androutsopoulou,
  • Spyridoula D. Christopoulou,
  • Panagiotis Hahalis,
  • Chrysoula Kotsalou,
  • Fotini N. Lamari and
  • Apostolos Vantarakis

Essential oils (EOs) and extracts of rose geranium (Pelargonium graveolens) and petals of rose (Rosa damascena) have been fully characterized in terms of composition, safety, antimicrobial, and antiviral properties. They were analyzed against Escheri...

  • Case Report
  • Open Access
5 Citations
3,413 Views
10 Pages

Myopericarditis Associated with COVID-19 in a Pediatric Patient with Kidney Failure Receiving Hemodialysis

  • Marcela Daniela Ionescu,
  • Mihaela Balgradean,
  • Catalin Gabriel Cirstoveanu,
  • Ioana Balgradean,
  • Loredana Ionela Popa,
  • Carmen Pavelescu,
  • Andrei Capitanescu,
  • Elena Camelia Berghea and
  • Cristina Filip

The outbreak of COVID-19 can be associated with cardiac and pulmonary involvement and is emerging as one of the most significant and life-threatening complications in patients with kidney failure receiving hemodialysis. Here, we report a critically i...

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Pathogens - ISSN 2076-0817Creative Common CC BY license