You are currently viewing a new version of our website. To view the old version click .

Brain Sciences, Volume 9, Issue 10

October 2019 - 47 articles

  • Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
  • You may sign up for email alerts to receive table of contents of newly released issues.
  • PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Reader to open them.
Cover Story: Autism spectrum disorder (ASD) is a complex neuropsychiatric disorder characterized by deficits in social interactions, communication, language and in a limited repertoire of activities and interests. Genetic, epigenetic and environmental factors contribute to the onset of ASD. This work aims to provide an overview of the animal models of ASD and the role of the different miRNAs involved in this disorder. The results of this study showed that miRNA-125b, miRNA-132, miRNA-146a, miRNA-146b, miRNA-137, miRNA-134, miRNA-358 134-5p, miRNA-138-5p, miRNA-34a, miRNA-181c and miRNA-30d regulate the expression of several genes directly involved in ASD. On the basis of these observations, researchers have identified miRNAs as important biomarkers to discover new targets for ASD treatment. View this paper

Articles (47)

  • Article
  • Open Access
6 Citations
4,594 Views
15 Pages

22 October 2019

Tonal languages make use of pitch variation for distinguishing lexical semantics, and their melodic richness seems comparable to that of music. The present study investigated a novel priming effect of melody on the pitch processing of Mandarin speech...

  • Article
  • Open Access
4 Citations
3,938 Views
17 Pages

Assessing the Effects of Cytoprotectants on Selective Neuronal Loss, Sensorimotor Deficit and Microglial Activation after Temporary Middle Cerebral Occlusion

  • Julius V. Emmrich,
  • Sohail Ejaz,
  • David J. Williamson,
  • Young T. Hong,
  • Sergey Sitnikov,
  • Tim D. Fryer,
  • Franklin I. Aigbirhio,
  • Heike Wulff and
  • Jean-Claude Baron

22 October 2019

Although early reperfusion after stroke salvages the still-viable ischemic tissue, peri-infarct selective neuronal loss (SNL) can cause sensorimotor deficits (SMD). We designed a longitudinal protocol to assess the effects of cytoprotectants on SMD,...

  • Article
  • Open Access
34 Citations
5,837 Views
15 Pages

Integrated Analysis of microRNA and mRNA Expression Profiles: An Attempt to Disentangle the Complex Interaction Network in Attention Deficit Hyperactivity Disorder

  • Nicoletta Nuzziello,
  • Francesco Craig,
  • Marta Simone,
  • Arianna Consiglio,
  • Flavio Licciulli,
  • Lucia Margari,
  • Giorgio Grillo,
  • Sabino Liuni and
  • Maria Liguori

22 October 2019

Attention Deficit Hyperactivity Disorder (ADHD) is a childhood-onset neurodevelopmental disorder, whose etiology and pathogenesis are still largely unknown. In order to uncover novel regulatory networks and molecular pathways possibly related to ADHD...

  • Article
  • Open Access
30 Citations
5,093 Views
34 Pages

22 October 2019

An improved computer-aided diagnosis (CAD) system is proposed for the early diagnosis of Alzheimer’s disease (AD) based on the fusion of anatomical (magnetic resonance imaging (MRI)) and functional (8F-fluorodeoxyglucose positron emission tomog...

  • Perspective
  • Open Access
55 Citations
9,818 Views
12 Pages

The Neuroprotective Effects of Melatonin: Possible Role in the Pathophysiology of Neuropsychiatric Disease

  • Jung Goo Lee,
  • Young Sup Woo,
  • Sung Woo Park,
  • Dae-Hyun Seog,
  • Mi Kyoung Seo and
  • Won-Myong Bahk

21 October 2019

Melatonin is a hormone that is secreted by the pineal gland. To date, melatonin is known to regulate the sleep cycle by controlling the circadian rhythm. However, recent advances in neuroscience and molecular biology have led to the discovery of new...

  • Article
  • Open Access
33 Citations
4,565 Views
14 Pages

Overexpression of Macrophage Migration Inhibitory Factor and Its Homologue D-Dopachrome Tautomerase as Negative Prognostic Factor in Neuroblastoma

  • Eugenio Cavalli,
  • Emanuela Mazzon,
  • Santa Mammana,
  • Maria Sofia Basile,
  • Salvo Danilo Lombardo,
  • Katia Mangano,
  • Placido Bramanti,
  • Ferdinando Nicoletti,
  • Paolo Fagone and
  • Maria Cristina Petralia

19 October 2019

Neuroblastoma (NB) represents one of the most frequent pediatric solid tumors. Macrophage migration inhibitory factor (MIF) is a cytokine exerting multiple biological functions. More recently, a second member of the MIF family of cytokine has been id...

  • Article
  • Open Access
6 Citations
3,019 Views
10 Pages

Is It Easy to Synchronize Our Minds When We Are Forced to Cooperate?

  • Ángel Romero-Martínez,
  • Alejandro Rodríguez and
  • Luis Moya-Albiol

18 October 2019

There is increasing scientific interest in elucidating the biological mechanisms underlying cooperative behaviors. Humans have developed a high degree of complexity in their cooperativity, which has been defined as hyper-cooperativity. An interesting...

  • Review
  • Open Access
84 Citations
11,291 Views
18 Pages

A Review of Neurostimulation for Epilepsy in Pediatrics

  • Keith Starnes,
  • Kai Miller,
  • Lily Wong-Kisiel and
  • Brian Nils Lundstrom

18 October 2019

Neurostimulation for epilepsy refers to the application of electricity to affect the central nervous system, with the goal of reducing seizure frequency and severity. We review the available evidence for the use of neurostimulation to treat pediatric...

  • Article
  • Open Access
18 Citations
4,114 Views
9 Pages

Diagnostic Issues of Asymptomatic Neurosyphilis in HIV-Positive Patients: A Retrospective Study

  • Giancarlo Ceccarelli,
  • Cristian Borrazzo,
  • Alessandro Lazzaro,
  • Giuseppe Pietro Innocenti,
  • Luigi Celani,
  • Eugenio Nelson Cavallari,
  • Claudia Pinacchio,
  • Letizia Santinelli,
  • Claudio Maria Mastroianni and
  • Gabriella d’Ettorre

17 October 2019

Introduction: Asymptomatic neurosyphilis (ANS) is a disease that is difficult to diagnose in people living with HIV (PLWH). The European Guidelines on the management of syphilis suggest that ANS should be suspected and thus the lumbar puncture (LP) s...

  • Article
  • Open Access
13 Citations
4,470 Views
14 Pages

Pre- and Post-Treatment with Novel Antiepileptic Drug Oxcarbazepine Exerts Neuroprotective Effect in the Hippocampus in a Gerbil Model of Transient Global Cerebral Ischemia

  • Ji Hyeon Ahn,
  • Bich Na Shin,
  • Joon Ha Park,
  • Tae-Kyeong Lee,
  • Young Eun Park,
  • Jae-Chul Lee,
  • Go Eun Yang,
  • Myoung Cheol Shin,
  • Jun Hwi Cho and
  • Kyu Chang Lee
  • + 2 authors

17 October 2019

Oxcarbazepine, an antiepileptic drug, has been reported to modulate voltage-dependent sodium channels, and it is commonly used in epilepsy treatment. In this study, we investigated the neuroprotective effect of oxcarbazepine in the hippocampus after...

of 5

Get Alerted

Add your email address to receive forthcoming issues of this journal.

XFacebookLinkedIn
Brain Sci. - ISSN 2076-3425Creative Common CC BY license