Multi-Target Profile of Antioxidant Compounds, including Repurposing and Combination Strategies
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: 30 September 2024 | Viewed by 5310
Special Issue Editor
Interests: docking; nucleic acids; drug design; molecular modeling; molecular dynamics; virtual screening; drug repurposing; natural products
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cancer, neurodegenerative disorders and stroke are just some examples of multifactorial diseases and often oxidative stress is a common event that occurs. Currently, there is no efficient and effective cure for these diseases; consequently, researchers have taken advantage of the multi-targeting drug approach to design molecules which may be developed as useful agents for their treatment. In this scenario, in silico techniques are considered as useful and powerful tools to enhance rational drug design in the medicinal chemistry field. The discovery, design, synthesis and biological evaluation of multi-targeting molecules combining antioxidant and/or anti-inflammatory properties are expected to be beneficial in the treatment of different multifactorial diseases.
The aim of the current Special Issue is to cover promising, recent, and novel research trends in the polypharmacologic field, focusing on antioxidant compounds. In particular, advancements in the design and synthesis of novel polypharmacological agents, especially those that highlight new strategies and approaches, are appreciated. Additionally, repurposing or the discovery of new mechanisms of action for antioxidants compounds are considered.
We welcome original research, review, mini review and perspective articles on themes including, but not limited to:
- the development of new multi-target antioxidant entities;
- multi-target rational drug design of antioxidant molecules;
- drug repurposing proposals of antioxidant compounds;
- discovery of off-target effects for antioxidant compounds;
- application of different approaches to polypharmacology;
- rational design and synthesis of hybrid compounds.
Dr. Roberta Rocca
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- polypharmacology
- multi-target ligands
- rational drug design
- repurposing
- off-target effects
- computational techniques
