Bioengineering

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25 pages, 4581 KiB

Open AccessArticle

Artificial Intelligence Procedure for the Screening of Genetic Syndromes Based on Voice Characteristics

by Federico Calà, Lorenzo Frassineti, Elisabetta Sforza, Roberta Onesimo, Lucia D’Alatri, Claudia Manfredi, Antonio Lanata and Giuseppe Zampino

Bioengineering 2023, 10(12), 1375; https://doi.org/10.3390/bioengineering10121375 - 29 Nov 2023

Cited by 1 | Viewed by 1574

Abstract

Perceptual and statistical evidence has highlighted voice characteristics of individuals affected by genetic syndromes that differ from those of normophonic subjects. In this paper, we propose a procedure for systematically collecting such pathological voices and developing AI-based automated tools to support differential diagnosis. [...] Read more.

Perceptual and statistical evidence has highlighted voice characteristics of individuals affected by genetic syndromes that differ from those of normophonic subjects. In this paper, we propose a procedure for systematically collecting such pathological voices and developing AI-based automated tools to support differential diagnosis. Guidelines on the most appropriate recording devices, vocal tasks, and acoustical parameters are provided to simplify, speed up, and make the whole procedure homogeneous and reproducible. The proposed procedure was applied to a group of 56 subjects affected by Costello syndrome (CS), Down syndrome (DS), Noonan syndrome (NS), and Smith–Magenis syndrome (SMS). The entire database was divided into three groups: pediatric subjects (PS; individuals < 12 years of age), female adults (FA), and male adults (MA). In line with the literature results, the Kruskal–Wallis test and post hoc analysis with Dunn–Bonferroni test revealed several significant differences in the acoustical features not only between healthy subjects and patients but also between syndromes within the PS, FA, and MA groups. Machine learning provided a k-nearest-neighbor classifier with 86% accuracy for the PS group, a support vector machine (SVM) model with 77% accuracy for the FA group, and an SVM model with 84% accuracy for the MA group. These preliminary results suggest that the proposed method based on acoustical analysis and AI could be useful for an effective, non-invasive automatic characterization of genetic syndromes. In addition, clinicians could benefit in the case of genetic syndromes that are extremely rare or present multiple variants and facial phenotypes. Full article

(This article belongs to the Special Issue Monitoring and Analysis of Human Biosignals)

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10 pages, 1817 KiB

Open AccessArticle

EEG Connectivity Diversity Differences between Children with Autism and Typically Developing Children: A Comparative Study

by Jiannan Kang, Hongxiang Xie, Wenqin Mao, Juanmei Wu, Xiaoli Li and Xinling Geng

Bioengineering 2023, 10(9), 1030; https://doi.org/10.3390/bioengineering10091030 - 1 Sep 2023

Cited by 2 | Viewed by 1557

Abstract

Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by deficits in social interaction and communication, and repetitive or stereotyped behaviors. Previous studies have reported altered brain connectivity in ASD children compared to typically developing children. In this study, we investigated the diversity [...] Read more.

Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by deficits in social interaction and communication, and repetitive or stereotyped behaviors. Previous studies have reported altered brain connectivity in ASD children compared to typically developing children. In this study, we investigated the diversity of connectivity patterns between children with ASD and typically developing children using phase lag entropy (PLE), a measure of the variability of phase differences between two time series. We also developed a novel wavelet-based PLE method for the calculation of PLE at specific scales. Our findings indicated that the diversity of connectivity in ASD children was higher than that in typically developing children at Delta and Alpha frequency bands, both within brain regions and across hemispheric brain regions. These findings provide insight into the underlying neural mechanisms of ASD and suggest that PLE may be a useful tool for investigating brain connectivity in ASD. Full article

(This article belongs to the Special Issue Monitoring and Analysis of Human Biosignals)

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17 pages, 4523 KiB

Open AccessArticle

Continuous Motion Estimation of Knee Joint Based on a Parameter Self-Updating Mechanism Model

by Jiayi Li, Kexiang Li, Jianhua Zhang and Jian Cao

Bioengineering 2023, 10(9), 1028; https://doi.org/10.3390/bioengineering10091028 - 31 Aug 2023

Viewed by 1319

Abstract

Estimation of continuous motion of human joints using surface electromyography (sEMG) signals has a critical part to play in intelligent rehabilitation. Traditional methods always use sEMG signals as inputs to build regression or biomechanical models to estimate continuous joint motion variables. However, it [...] Read more.

Estimation of continuous motion of human joints using surface electromyography (sEMG) signals has a critical part to play in intelligent rehabilitation. Traditional methods always use sEMG signals as inputs to build regression or biomechanical models to estimate continuous joint motion variables. However, it is challenging to accurately estimate continuous joint motion in new subjects due to the non-stationarity and individual differences in sEMG signals, which greatly limits the generalisability of the method. In this paper, a continuous motion estimation model for the human knee joint with a parameter self-updating mechanism based on the fusion of particle swarm optimization (PSO) and deep belief network (DBN) is proposed. According to the original sEMG signals of different subjects, the method adaptively optimized the parameters of the DBN model and completed the optimal reconstruction of signal feature structure in high-dimensional space to achieve the optimal estimation of continuous joint motion. Extensive experiments were conducted on knee joint motions. The results suggested that the average root mean square errors (RMSEs) of the proposed method were 9.42° and 7.36°, respectively, which was better than the results obtained by common neural networks. This finding lays a foundation for the human–robot interaction (HRI) of the exoskeleton robots based on the sEMG signals. Full article

(This article belongs to the Special Issue Monitoring and Analysis of Human Biosignals)

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21 pages, 2032 KiB

Open AccessArticle

WA-ResUNet: A Focused Tail Class MRI Medical Image Segmentation Algorithm

by Haixia Pan, Bo Gao, Wenpei Bai, Bin Li, Yanan Li, Meng Zhang, Hongqiang Wang, Xiaoran Zhao, Minghuang Chen, Cong Yin and Weiya Kong

Bioengineering 2023, 10(8), 945; https://doi.org/10.3390/bioengineering10080945 - 8 Aug 2023

Cited by 2 | Viewed by 1724

Abstract

Medical image segmentation can effectively identify lesions in medicine, but some small and rare lesions cannot be well identified. Existing studies do not take into account the uncertainty of the occurrence of diseased tissue, and the problem of long-tailed distribution of medical data. [...] Read more.

Medical image segmentation can effectively identify lesions in medicine, but some small and rare lesions cannot be well identified. Existing studies do not take into account the uncertainty of the occurrence of diseased tissue, and the problem of long-tailed distribution of medical data. Meanwhile, the grayscale image obtained from Magnetic Resonance Imaging (MRI) detection has problems, such as the features being difficult to extract and invalid features being difficult to distinguish. In order to solve these problems, we propose a new weighted attention ResUNet (WA-ResUNet) and a class weight formula based on the number of images contained in the class, which improves the performance of the model in the low-frequency class and the overall effect of the model by improving the degree of attention paid to the valid features and invalid ones and rebalancing the learning efficiency among the classes. We evaluated our method on an uterine MRI dataset and compared it with the ResUNet. WA-ResUNet increased Intersection over Union (IoU) in the low-frequency class (Nabothian cysts) by 21.87%, and the overall mIoU increased by more than 6.5%. Full article

(This article belongs to the Special Issue Monitoring and Analysis of Human Biosignals)

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13 pages, 2203 KiB

Open AccessArticle

Prediction of Sleep Apnea Events Using a CNN–Transformer Network and Contactless Breathing Vibration Signals

by Yuhang Chen, Shuchen Yang, Huan Li, Lirong Wang and Bidou Wang

Bioengineering 2023, 10(7), 746; https://doi.org/10.3390/bioengineering10070746 - 21 Jun 2023

Cited by 1 | Viewed by 1822

Abstract

It is estimated that globally 425 million subjects have moderate to severe obstructive sleep apnea (OSA). The accurate prediction of sleep apnea events can offer insight into the development of treatment therapies. However, research related to this prediction is currently limited. We developed [...] Read more.

It is estimated that globally 425 million subjects have moderate to severe obstructive sleep apnea (OSA). The accurate prediction of sleep apnea events can offer insight into the development of treatment therapies. However, research related to this prediction is currently limited. We developed a covert framework for the prediction of sleep apnea events based on low-frequency breathing-induced vibrations obtained from piezoelectric sensors. A CNN-transformer network was utilized to efficiently extract local and global features from respiratory vibration signals for accurate prediction. Our study involved overnight recordings of 105 subjects. In five-fold cross-validation, we achieved an accuracy of 85.9% and an F1 score of 85.8%, which are 3.5% and 5.3% higher than the best-performed classical model, respectively. Additionally, in leave-one-out cross-validation, 2.3% and 3.8% improvements are observed, respectively. Our proposed CNN-transformer model is effective in the prediction of sleep apnea events. Our framework can thus provide a new perspective for improving OSA treatment modes and clinical management. Full article

(This article belongs to the Special Issue Monitoring and Analysis of Human Biosignals)

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21 pages, 4445 KiB

Open AccessArticle

Detecting Safety Anomalies in pHRI Activities via Force Myography

by Umme Zakia and Carlo Menon

Bioengineering 2023, 10(3), 326; https://doi.org/10.3390/bioengineering10030326 - 5 Mar 2023

Cited by 1 | Viewed by 1965

Abstract

The potential application of using a wearable force myography (FMG) band for monitoring the occupational safety of a human participant working in collaboration with an industrial robot was studied. Regular physical human–robot interactions were considered as activities of daily life in pHRI (pHRI-ADL) [...] Read more.

The potential application of using a wearable force myography (FMG) band for monitoring the occupational safety of a human participant working in collaboration with an industrial robot was studied. Regular physical human–robot interactions were considered as activities of daily life in pHRI (pHRI-ADL) to recognize human-intended motions during such interactions. The force myography technique was used to read volumetric changes in muscle movements while a human participant interacted with a robot. Data-driven models were used to observe human activities for useful insights. Using three unsupervised learning algorithms, isolation forest, one-class SVM, and Mahalanobis distance, models were trained to determine pHRI-ADL/regular, preset activities by learning the latent features’ distributions. The trained models were evaluated separately to recognize any unwanted interactions that differed from the normal activities, i.e., anomalies that were novel, inliers, or outliers to the normal distributions. The models were able to detect unusual, novel movements during a certain scenario that was considered an unsafe interaction. Once a safety hazard was detected, the control system generated a warning signal within seconds of the event. Hence, this study showed the viability of using FMG biofeedback to indicate risky interactions to prevent injuries, improve occupational health, and monitor safety in workplaces that require human participation. Full article

(This article belongs to the Special Issue Monitoring and Analysis of Human Biosignals)

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18 pages, 1946 KiB

Open AccessArticle

The Back Muscle Surface Electromyography-Based Fatigue Index: A Digital Biomarker of Human Neuromuscular Aging?

by Gerold Ebenbichler, Richard Habenicht, Peter Blohm, Paolo Bonato, Josef Kollmitzer, Patrick Mair and Thomas Kienbacher

Bioengineering 2023, 10(3), 300; https://doi.org/10.3390/bioengineering10030300 - 27 Feb 2023

Cited by 1 | Viewed by 2452

Abstract

As part of our quest for digital biomarkers of neuromuscular aging, and encouraged by recent findings in healthy volunteers, this study investigated if the instantaneous median frequency (IMDF) derived from back muscle surface electromyographic (SEMG) data monitored during cyclic back extensions could reliably [...] Read more.

As part of our quest for digital biomarkers of neuromuscular aging, and encouraged by recent findings in healthy volunteers, this study investigated if the instantaneous median frequency (IMDF) derived from back muscle surface electromyographic (SEMG) data monitored during cyclic back extensions could reliably differentiate between younger and older individuals with cLBP. A total of 243 persons with cLBP participated in three experimental sessions: at baseline, one to two days after the first session, and then again approximately six weeks later. During each session, the study participants performed a series of three isometric maximal voluntary contractions (MVC) of back extensors using a dynamometer. These were followed by an isometric back extension at 80% MVC, and—after a break—25 slow cyclic back extensions at 50% MVC. SEMG data were recorded bilaterally at L5 (multifidus), L2 (longissimus dorsi), and L1 (iliocostalis lumborum). Linear mixed-effects models found the IMDF-SEMG time-course changes more rapidly in younger than in older individuals, and more prominently in male participants. The absolute and relative reliabilities of the SEMG time–frequency representations were well compared between older and younger participants. The results indicated an overall good relative reliability, but variable absolute reliability levels. IMDF-SEMG estimates derived from cyclic back extensions proved to be successful in reliably detecting differences in back muscle function in younger vs. older persons with cLBP. These findings encourage further research, with a focus on assessing whether an IMDF-SEMG-based index could be utilized as a tool to achieve the preclinical detection of back muscle aging, and possibly predict the development of back muscle sarcopenia. Full article

(This article belongs to the Special Issue Monitoring and Analysis of Human Biosignals)

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17 pages, 3830 KiB

Open AccessArticle

Word Structure Tunes Electrophysiological and Hemodynamic Responses in the Frontal Cortex

by Fei Gao, Lin Hua, Yuwen He, Jie Xu, Defeng Li, Juan Zhang and Zhen Yuan

Bioengineering 2023, 10(3), 288; https://doi.org/10.3390/bioengineering10030288 - 23 Feb 2023

Cited by 4 | Viewed by 2647

Abstract

To date, it is still unclear how word structure might impact lexical processing in the brain for languages with an impoverished system of grammatical morphology such as Chinese. In this study, concurrent electroencephalogram (EEG) and functional near-infrared spectroscopy (fNIRS) recordings were performed to [...] Read more.

To date, it is still unclear how word structure might impact lexical processing in the brain for languages with an impoverished system of grammatical morphology such as Chinese. In this study, concurrent electroencephalogram (EEG) and functional near-infrared spectroscopy (fNIRS) recordings were performed to inspect the temporal and spatial brain activities that are related to Chinese word structure (compound vs. derivation vs. non-morphological) effects. A masked priming paradigm was utilized on three lexical conditions (compound constitute priming, derivation constitute priming, and non-morphological priming) to tap Chinese native speakers’ structural sensitivity to differing word structures. The compound vs. derivation structure effect was revealed by the behavioral data as well as the temporal and spatial brain activation patterns. In the masked priming task, Chinese derivations exhibited significantly enhanced brain activation in the frontal cortex and involved broader brain networks as compared with lexicalized compounds. The results were interpreted by the differing connection patterns between constitute morphemes within a given word structure from a spreading activation perspective. More importantly, we demonstrated that the Chinese word structure effect showed a distinct brain activation pattern from that of the dual-route mechanism in alphabetic languages. Therefore, this work paved a new avenue for comprehensively understanding the underlying cognitive neural mechanisms associated with Chinese derivations and coordinate compounds. Full article

(This article belongs to the Special Issue Monitoring and Analysis of Human Biosignals)

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17 pages, 2610 KiB

Open AccessEditor’s ChoiceArticle

Unsupervised Learning-Based Non-Invasive Fetal ECG Muti-Level Signal Quality Assessment

by Xintong Shi, Kohei Yamamoto, Tomoaki Ohtsuki, Yutaka Matsui and Kazunari Owada

Bioengineering 2023, 10(1), 66; https://doi.org/10.3390/bioengineering10010066 - 4 Jan 2023

Cited by 3 | Viewed by 2834

Abstract

Objective: To monitor fetal health and growth, fetal heart rate is a critical indicator. The non-invasive fetal electrocardiogram is a widely employed measurement for fetal heart rate estimation, which is extracted from the electrodes placed on the surface of the maternal abdomen. The [...] Read more.

Objective: To monitor fetal health and growth, fetal heart rate is a critical indicator. The non-invasive fetal electrocardiogram is a widely employed measurement for fetal heart rate estimation, which is extracted from the electrodes placed on the surface of the maternal abdomen. The qualities of the fetal ECG recordings, however, are frequently affected by the noises from various interference sources. In general, the fetal heart rate estimates are unreliable when low-quality fetal ECG signals are used for fetal heart rate estimation, which makes accurate fetal heart rate estimation a challenging task. So, the signal quality assessment for the fetal ECG records is an essential step before fetal heart rate estimation. In other words, some low-quality fetal ECG signal segments are supposed to be detected and removed by utilizing signal quality assessment, so as to improve the accuracy of fetal heart rate estimation. A few supervised learning-based fetal ECG signal quality assessment approaches have been introduced and shown to accurately classify high- and low-quality fetal ECG signal segments, but large fetal ECG datasets with quality annotation are required in these methods. Yet, the labeled fetal ECG datasets are limited. Proposed methods: An unsupervised learning-based multi-level fetal ECG signal quality assessment approach is proposed in this paper for identifying three levels of fetal ECG signal quality. We extracted some features associated with signal quality, including entropy-based features, statistical features, and ECG signal quality indices. Additionally, an autoencoder-based feature is calculated, which is related to the reconstruction error of the spectrograms generated from fetal ECG signal segments. The high-, medium-, and low-quality fetal ECG signal segments are classified by inputting these features into a self-organizing map. Main results: The experimental results showed that our proposal achieved a weighted average F1-score of 90% in three-level fetal ECG signal quality classification. Moreover, with the acceptable removal of detected low-quality signal segments, the errors of fetal heart rate estimation were reduced to a certain extent. Full article

(This article belongs to the Special Issue Monitoring and Analysis of Human Biosignals)

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17 pages, 1693 KiB

Open AccessArticle

Fetal Arrhythmia Detection Based on Labeling Considering Heartbeat Interval

by Sara Nakatani, Kohei Yamamoto and Tomoaki Ohtsuki

Bioengineering 2023, 10(1), 48; https://doi.org/10.3390/bioengineering10010048 - 30 Dec 2022

Cited by 8 | Viewed by 2528

Abstract

Arrhythmia is one of the causes of sudden infant death, and it is very important to detect fetal arrhythmia for fetal well-being. Fetal electrocardiogram (FECG) is one of the methods to detect a heartbeat. Fetal arrhythmia can be detected based on the heartbeat [...] Read more.

Arrhythmia is one of the causes of sudden infant death, and it is very important to detect fetal arrhythmia for fetal well-being. Fetal electrocardiogram (FECG) is one of the methods to detect a heartbeat. Fetal arrhythmia can be detected based on the heartbeat detection results from FECG signals such as heartbeat intervals. However, the accuracy of arrhythmia detection easily degrades depending on the accuracy of heartbeat detection. In this paper, we propose a deep learning-based fetal arrhythmia detection method using FECG signals. Recently, arrhythmia detection methods using adult ECG signals have achieved a high arrhythmia detection accuracy based on deep learning. Motivated by this fact, in the proposed method, the acquired FECG signals are segmented, and the segments are input into a deep learning model that classifies them into normal or arrhythmia ones. Based on the classification results of multiple segments, a subject is judged as a healthy or arrhythmia subject. Each segment of the training data is divided into three categories based on the estimated heartbeat interval: (i) normal, (ii) arrhythmia, and (iii) a segment that could be both normal and arrhythmic. Only segments labeled as normal or arrhythmia are used for training a deep learning model to achieve a higher classification accuracy of the model. Through these procedures, the proposed method detects fetal arrhythmia with fewer effects of heartbeat detection results. The experimental results show that the proposed method achieves 96.2% accuracy, 100% specificity, and 100% recall, improving the values of conventional methods based on heartbeat detection and feature detection. Full article

(This article belongs to the Special Issue Monitoring and Analysis of Human Biosignals)

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15 pages, 631 KiB

Open AccessArticle

Assessment of Remote Vital Sign Monitoring and Alarms in a Real-World Healthcare at Home Dataset

by Nicole Zahradka, Sophie Geoghan, Hope Watson, Eli Goldberg, Adam Wolfberg and Matt Wilkes

Bioengineering 2023, 10(1), 37; https://doi.org/10.3390/bioengineering10010037 - 28 Dec 2022

Cited by 3 | Viewed by 2397

Abstract

The importance of vital sign monitoring to detect deterioration increases during healthcare at home. Continuous monitoring with wearables increases assessment frequency but may create information overload for clinicians. The goal of this work was to demonstrate the impact of vital sign observation frequency [...] Read more.

The importance of vital sign monitoring to detect deterioration increases during healthcare at home. Continuous monitoring with wearables increases assessment frequency but may create information overload for clinicians. The goal of this work was to demonstrate the impact of vital sign observation frequency and alarm settings on alarms in a real-world dataset. Vital signs were collected from 76 patients admitted to healthcare at home programs using the Current Health (CH) platform; its wearable continuously measured respiratory rate (RR), pulse rate (PR), and oxygen saturation (SpO₂). Total alarms, alarm rate, patient rate, and detection time were calculated for three alarm rulesets to detect changes in SpO₂, PR, and RR under four vital sign observation frequencies and four window sizes for the alarm algorithms’ median filter. Total alarms ranged from 65 to 3113. The alarm rate and early detection increased with the observation frequency for all alarm rulesets. Median filter windows reduced alarms triggered by normal fluctuations in vital signs without compromising the granularity of time between assessments. Frequent assessments enabled with continuous monitoring support early intervention but need to pair with settings that balance sensitivity, specificity, clinical risk, and provider capacity to respond when a patient is home to minimize clinician burden. Full article

(This article belongs to the Special Issue Monitoring and Analysis of Human Biosignals)

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13 pages, 4425 KiB

Open AccessArticle

Respiratory-Induced Amplitude Modulation of Forcecardiography Signals

by Jessica Centracchio, Emilio Andreozzi, Daniele Esposito and Gaetano D. Gargiulo

Bioengineering 2022, 9(9), 444; https://doi.org/10.3390/bioengineering9090444 - 7 Sep 2022

Cited by 17 | Viewed by 2162

Abstract

Forcecardiography (FCG) is a novel technique that records the weak forces induced on the chest wall by cardio-respiratory activity, by using specific force sensors. FCG sensors feature a wide frequency band, which allows us to capture respiration, heart wall motion, heart valves opening [...] Read more.

Forcecardiography (FCG) is a novel technique that records the weak forces induced on the chest wall by cardio-respiratory activity, by using specific force sensors. FCG sensors feature a wide frequency band, which allows us to capture respiration, heart wall motion, heart valves opening and closing (similar to the Seismocardiogram, SCG) and heart sounds, all simultaneously from a single contact point on the chest. As a result, the raw FCG sensors signals exhibit a large component related to the respiratory activity, referred to as a Forcerespirogram (FRG), with a much smaller, superimposed component related to the cardiac activity (the actual FCG) that contains both infrasonic vibrations, referred to as LF-FCG and HF-FCG, and heart sounds. Although respiration can be readily monitored by extracting the very low-frequency component of the raw FCG signal (FRG), it has been observed that the respiratory activity also influences other FCG components, particularly causing amplitude modulations (AM). This preliminary study aimed to assess the consistency of the amplitude modulations of the LF-FCG and HF-FCG signals within the respiratory cycle. A retrospective analysis was performed on the FCG signals acquired in a previous study on six healthy subjects at rest, during quiet breathing. To this aim, the AM of LF-FCG and HF-FCG were first extracted via a linear envelope (LE) operation, consisting of rectification followed by low-pass filtering; then, the inspiratory peaks were located both in the LE of LF-FCG and HF-FCG, and in the reference respiratory signal (FRG). Finally, the inter-breath intervals were extracted from the obtained inspiratory peaks, and further analyzed via statistical analyses. The AM of HF-FCG exhibited higher consistency within the respiratory cycle, as compared to the LF-FCG. Indeed, the inspiratory peaks were recognized with a sensitivity and positive predictive value (PPV) in excess of 99% in the LE of HF-FCG, and with a sensitivity and PPV of 96.7% and 92.6%, respectively, in the LE of LF-FCG. In addition, the inter-breath intervals estimated from the HF-FCG scored a higher R² value (0.95 vs. 0.86) and lower limits of agreement (± 0.710 s vs. ±1.34 s) as compared to LF-FCG, by considering those extracted from the FRG as the reference. The obtained results are consistent with those observed in previous studies on SCG. A possible explanation of these results was discussed. However, the preliminary results obtained in this study must be confirmed on a larger cohort of subjects and in different experimental conditions. Full article

(This article belongs to the Special Issue Monitoring and Analysis of Human Biosignals)

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Review

Jump to: Research

28 pages, 3743 KiB

Open AccessEditor’s ChoiceReview

Advancement in the Cuffless and Noninvasive Measurement of Blood Pressure: A Review of the Literature and Open Challenges

by Mohammad Mahbubur Rahman Khan Mamun and Ahmed Sherif

Bioengineering 2023, 10(1), 27; https://doi.org/10.3390/bioengineering10010027 - 24 Dec 2022

Cited by 13 | Viewed by 5436

Abstract

Hypertension is a chronic condition that is one of the prominent reasons behind cardiovascular disease, brain stroke, and organ failure. Left unnoticed and untreated, the deterioration in a health condition could even result in mortality. If it can be detected early, with proper [...] Read more.

Hypertension is a chronic condition that is one of the prominent reasons behind cardiovascular disease, brain stroke, and organ failure. Left unnoticed and untreated, the deterioration in a health condition could even result in mortality. If it can be detected early, with proper treatment, undesirable outcomes can be avoided. Until now, the gold standard is the invasive way of measuring blood pressure (BP) using a catheter. Additionally, the cuff-based and noninvasive methods are too cumbersome or inconvenient for frequent measurement of BP. With the advancement of sensor technology, signal processing techniques, and machine learning algorithms, researchers are trying to find the perfect relationships between biomedical signals and changes in BP. This paper is a literature review of the studies conducted on the cuffless noninvasive measurement of BP using biomedical signals. Relevant articles were selected using specific criteria, then traditional techniques for BP measurement were discussed along with a motivation for cuffless measurement use of biomedical signals and machine learning algorithms. The review focused on the progression of different noninvasive cuffless techniques rather than comparing performance among different studies. The literature survey concluded that the use of deep learning proved to be the most accurate among all the cuffless measurement techniques. On the other side, this accuracy has several disadvantages, such as lack of interpretability, computationally extensive, standard validation protocol, and lack of collaboration with health professionals. Additionally, the continuing work by researchers is progressing with a potential solution for these challenges. Finally, future research directions have been provided to encounter the challenges. Full article

(This article belongs to the Special Issue Monitoring and Analysis of Human Biosignals)

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