Feature Reviews in Cytokines

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: 30 January 2026 | Viewed by 1572

Special Issue Editor

Special Issue Information

Dear Colleagues,

This Special Issue will feature a selection of up-to-date review articles related to cytokines, with a particular emphasis on the usefulness of cytokine determination in healthy individuals and patients with civilization diseases.

Cytokines are proteins that play a key role in regulating the immune and inflammatory responses. Understanding their functions can lead to the development of new treatment and prevention strategies. Many civilization diseases—such as neurodegenerative diseases, cancers, obesity, type 2 diabetes, cardiovascular diseases, and autoimmune disorders—are associated with immunological disorders and the initiation of inflammatory state. Therefore, we are seeking new indicators/biomarkers that allow for early detection and thus improve the prognosis of survival for patients with selected civilization diseases.

This Special Issue welcomes review articles discussing various aspects of the role of cytokines in the processes leading to the development of various diseases, as well as their usefulness in detecting, differentiating, and treating these conditions. 

Dr. Monika Zajkowska
Guest Editor

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Keywords

  • cytokines
  • neurodegenerative disease
  • cancer
  • diabetes
  • obesity
  • immunological disorder
  • cardiovascular disease
  • diagnosis
  • biomarker
  • treatment

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Published Papers (2 papers)

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Review

31 pages, 1574 KB  
Review
Linking Metabolic Disorders and Immune System Phenomena in Schizophrenia: The Role of Adipose Tissue and Inflammation
by Aleksandra Julia Oracz, Mateusz Zwierz, Maciej Naumowicz, Stefan Modzelewski, Maria Suprunowicz and Napoleon Waszkiewicz
Biomedicines 2025, 13(9), 2308; https://doi.org/10.3390/biomedicines13092308 - 20 Sep 2025
Viewed by 210
Abstract
Emerging evidence highlights the role of chronic low-grade inflammation and dysregulated cytokines in both obesity and schizophrenia, suggesting overlapping immune system pathways that contribute to cognition and nervous system inflammation. Excess adipose tissue functions as an active endocrine organ, releasing pro-inflammatory mediators that [...] Read more.
Emerging evidence highlights the role of chronic low-grade inflammation and dysregulated cytokines in both obesity and schizophrenia, suggesting overlapping immune system pathways that contribute to cognition and nervous system inflammation. Excess adipose tissue functions as an active endocrine organ, releasing pro-inflammatory mediators that may serve as potential biomarkers, while the use of antipsychotic agents in schizophrenia further modifies cytokine profiles and immune responses. A key knowledge gap lies in understanding how adipose-related inflammation modifies the severity of psychotic symptoms, cognitive deficits, and the efficacy of antipsychotic medications. This review aims to present excess adipose tissue as a potential contributor to the development of SCZ or a modifier of treatment efficacy, emphasizing the role of immune imbalance, inflammatory pathways, and metabolic dysfunction. By synthesizing current findings, we aim to present obesity not only as a frequent comorbidity in schizophrenia but also as a potential driver of neuroinflammation and disease progression. Here, we demonstrate that excess adiposity may perpetuate a vicious cycle linking metabolic dysfunction, immune activation, and psychiatric symptomatology. Situating these findings within a broader context, the review underscores the clinical need for inflammation-informed, individualized management strategies that integrate psychiatric care with metabolic monitoring. Ultimately, clarifying the shared inflammatory pathways of obesity and schizophrenia may open new avenues for biomarker development and targeted interventions. Full article
(This article belongs to the Special Issue Feature Reviews in Cytokines)
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13 pages, 265 KB  
Review
The Role of Cytokines in Degenerative Retinal Diseases: A Comprehensive Review
by Rubens Camargo Siqueira and Cinara Cássia Brandão
Biomedicines 2025, 13(7), 1724; https://doi.org/10.3390/biomedicines13071724 - 15 Jul 2025
Cited by 3 | Viewed by 735
Abstract
Degenerative retinal diseases, such as age-related macular degeneration (AMD), diabetic retinopathy (DR), and retinitis pigmentosa (RP), are the leading causes of vision loss worldwide. Inflammation plays a crucial role in the pathogenesis of these diseases, with cytokines acting as key mediators of neuroinflammation, [...] Read more.
Degenerative retinal diseases, such as age-related macular degeneration (AMD), diabetic retinopathy (DR), and retinitis pigmentosa (RP), are the leading causes of vision loss worldwide. Inflammation plays a crucial role in the pathogenesis of these diseases, with cytokines acting as key mediators of neuroinflammation, vascular dysfunction, and cellular degeneration. This review explores the complex role of cytokines in degenerative retinal diseases, highlighting their involvement in disease progression, cellular interactions, and potential therapeutic strategies. Understanding the cytokine network within the retina may provide novel insights into targeted interventions for these debilitating conditions. Full article
(This article belongs to the Special Issue Feature Reviews in Cytokines)
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