Special Issues

Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue polices and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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New Insights into Cytochrome P450s, 2nd Edition
edited by
submission deadline 31 Dec 2024 | 1 articles | Viewed by 1005 | Submission Open
Keywords: cytochrome P450 (P450); cytochrome b5; NADPH-P450 oxidoreductase (CPR); heme; flavin; P450 structure; P450 catalytic activities; prokaryotic P450; eukaryotic P450; viral P450; drug metabolism; detoxification; plant secondary metabolisms; membrane protein– protein complex; AlphaFold; AlphaFold2; regulation of P450 transcription; catalytic cavities; substrate access channels; prediction of protein– protein complexes; P450 interaction on P450– CPR complexes; tripartite P450– CPR– cytochrome b5 complex
(This special issue belongs to the Section Chemical Biology)
The Next Generation of Proteomics for Precision Medicine: Second Edition
edited by
submission deadline 31 Dec 2024 | 1 articles | Viewed by 983 | Submission Open
Keywords: proteomics; biomarkers; next-generation protein sequencing; diagnostics; protein quantitative trait locus; systems biology; precision medicine
(This special issue belongs to the Section Biomacromolecules: Proteins)
Integrating Genetics, Immune Dysregulation, and the Gut Microbiome: Advances in Elucidating IBD Pathophysiology and Emerging Therapeutic Strategies
edited by Peter W. Jurutka and
submission deadline 31 Dec 2024 | 1 articles | Viewed by 859 | Submission Open
Keywords: microbiome; biomarkers; Crohn’ s disease; ulcerative colitis; indeterminate colitis; multiomics; gastrointestinal (GI disease); immunology; gut– brain axis; neuropsychology
(This special issue belongs to the Section Molecular Genetics)
Molecular and Toxicological Profiling of Drugs of Abuse—in Honor of Professor Félix Carvalho submission deadline 31 Dec 2024 | Viewed by 594 | Submission Open
Keywords: toxicodynamic; toxicokinetic; amphetamine-type stimulants; cannabis and cannabinoids; cocaine; hallucinogens; new psychoactive substances; opioids; immune modulation
(This special issue belongs to the Section Molecular Medicine)
Bioactive Molecules: Structures, Functions and Potential Uses for Cancer Prevention and Targeted Therapies (2nd Edition)
edited by
submission deadline 31 Dec 2024 | Viewed by 491 | Submission Open
Keywords: small molecules; biomolecules; molecular targeting; natural products; cancer management
(This special issue belongs to the Section Molecular Structure and Dynamics)
Innovative Biomolecular Structure Analysis Techniques
edited by Tzanko I. Doukov
submission deadline 31 Dec 2024 | Viewed by 430 | Submission Open
Keywords: macromolecular crystallography; room temperature crystallography; protein ensembles; NMR; MD simulations
(This special issue belongs to the Section Molecular Structure and Dynamics)
State-of-the-Art Protein X-Ray Crystallography
edited by Wu-Pei Su and
submission deadline 31 Dec 2024 | Viewed by 338 | Submission Open
Keywords: ab initio phasing methods; X-ray crystallography; protein structural determination; image reconstruction from Fourier amplitudes; iterative projection algorithms; phasing with deep learning methods
(This special issue belongs to the Section Molecular Structure and Dynamics)
New Insights into Autacoids in Disease
edited by
submission deadline 31 Dec 2024 | Viewed by 320 | Submission Open
Keywords: angiotensin; bradykinin; endothelin; prostaglandins; thromboxanes; leukotrienes; serotonin; histamine; angiotensin-converting enzyme; angiotensin receptor; renin; kininogen; kallikrein; cyclooxygenase; phospholipase A2
(This special issue belongs to the Section Molecular Medicine)
Molecular Biomarkers in Cardiology 2024
edited by
submission deadline 31 Dec 2024 | Viewed by 301 | Submission Open
Keywords: cardiovascular diseases; cardiovascular pathology and histology; carotid plaques and histology; endothelium and endothelial dysfunction; veins diseases; arrhythmias; heart
(This special issue belongs to the Section Molecular Biomarkers)
Molecular and Biochemical Mechanisms of Age-Related Macular Degeneration, Neuroophthalmological Diseases and Uveitis
edited by
submission deadline 31 Dec 2024 | Viewed by 297 | Submission Open
Keywords: retina; neovascularization; age-related macular degeneration; uveal tissue; neuro-ocular diseases
(This special issue belongs to the Section Molecular Medicine)
Antitumor Agents from Natural Sources 2024 submission deadline 31 Dec 2024 | Viewed by 293 | Submission Open
Keywords: antitumor agents; natural sources; cancer prevention and therapy
(This special issue belongs to the Section Natural and Bio-derived Molecules)
The Role of Oxidative Stress in Ovarian Cancer submission deadline 31 Dec 2024 | Viewed by 283 | Submission Open
Keywords: ovarian cancer; reactive oxygen species (ROS); metastasis; antioxidant; oxidative stress; chemotherapeutic resistance; inflammation
(This special issue belongs to the Section Molecular Medicine)
Barrier Formation and Homeostasis in the Vertebrate Brain
edited by , and
submission deadline 31 Dec 2024 | Viewed by 277 | Submission Open
Keywords: brain endothelial cell; pericytes; choroid plexus; retina; lymphatic; blood; astrocytes; oligodendrocytes; brain ventricle; microglia
(This special issue belongs to the Section Cellular Biochemistry)
Recent Advances in Adduct Science
edited by Yukari Totsuka and Haruhiko Sugimura
submission deadline 31 Dec 2024 | Viewed by 276 | Submission Open
Keywords: adductomics; protein- or nucleic acid-adducts; biomarkers; exposome; genomic mutations; disease etiology; preventive strategies; drug discovery; risk assessment
Molecular Effects of Environmental Pollutants on Health of Human, Animals and Plants 2.0
edited by
submission deadline 31 Dec 2024 | Viewed by 271 | Submission Open
Keywords: health damage; reproductive health; environmental pollution; epigenetics; human; animals and plants
(This special issue belongs to the Section Natural and Bio-derived Molecules)
The Role of MDM2 in Tumor Biology and Cancer Therapy submission deadline 31 Dec 2024 | Viewed by 269 | Submission Open
Keywords: MDM2; p53; targeted therapy; imunotherapy; drug resistance
(This special issue belongs to the Section Molecular Genetics)
Novel Antimicrobial Strategies for Animal Health submission deadline 31 Dec 2024 | Viewed by 264 | Submission Open
Keywords: antimicrobial alternatives; antimicrobial resistance; animal health; infectious disease
(This special issue belongs to the Section Molecular Medicine)
The Role of Non-coding RNAs in Health and Disease submission deadline 31 Dec 2024 | Viewed by 259 | Submission Open
Keywords: non-coding RNA; microRNA (miRNA); long noncoding RNA (lncRNA); circular RNA (circRNA); gene expression regulation; epigenetic modifications
(This special issue belongs to the Section Molecular Genetics)
The Endoplasmic Reticulum Stress in Yeast and Fungal Cells
edited by
submission deadline 31 Dec 2024 | Viewed by 254 | Submission Open
Keywords: unfolded protein response; yeast; fungi; endoplasmic reticulum; protein production
(This special issue belongs to the Section Molecular Biology)
Regeneration of Annelids: From Reorganization of Lost Body Parts to Cellular and Molecular Biological Background
edited by
submission deadline 31 Dec 2024 | Viewed by 238 | Submission Open
Keywords: regeneration; body plan; dedifferentiation; stem cells; morphallaxis; epimorphosis; neuro-immune interactions
(This special issue belongs to the Section Cellular Biochemistry)
Applications of NMR Spectroscopy in Structure-Based Drug Discovery
edited by Alexander L. Breeze and Reto Walser
submission deadline 31 Dec 2024 | Viewed by 229 | Submission Open
Keywords: NMR; structural biology; structure-based drug discovery; fragment screening; lead generation
(This special issue belongs to the Section Molecular Structure and Dynamics)
Alcohol-Related Organ Damage: Mechanisms, Outcomes, and Treatment Modalities submission deadline 31 Dec 2024 | Viewed by 223 | Submission Open
Keywords: alcoholic liver disease (ALD); steatohepatitis; fibrosis; cirhosis; parenhymal and non-parenhymal liver cells; brain; gut; lungs; immune responses; oxidative stress; methylation; viral infections; post-translational protein modifications; treatment of ALD
(This special issue belongs to the Section Molecular Medicine)
Combination Therapies Involving MicroRNA Modulation: Synergistic Approaches for Enhanced Anticancer Effects submission deadline 31 Dec 2024 | Viewed by 218 | Submission Open
Keywords: microRNA (miRNA); targeted therapy; cancer
Bioinspired and Biomimicking Materials for Biomedical Applications: Second Edition
edited by
submission deadline 31 Dec 2024 | Viewed by 215 | Submission Open
Keywords: biomedical and biological imaging; biophotonics; biosensors; cell-based therapy; delivery systems; theranostics
Role of Glutathione Peroxidase in Health and Disease
edited by R Steve Esworthy
submission deadline 31 Dec 2024 | Viewed by 205 | Submission Open
Keywords: GPX1; GPX2; GPX3; GPX4; GPX5; GPX6; GPX7; GPX8; selenium; cancer; pathology
(This special issue belongs to the Section Molecular Medicine)
The Development of Translational Cancer Research: In Honor of a Pioneering Professor, Ulrik Ringborg
edited by Ingemar Ernberg and Stephan Mielke
submission deadline 31 Dec 2024 | Viewed by 204 | Submission Open
Keywords: translational cancer research; tumor cell biology; precision cancer medicine
(This special issue belongs to the Section Molecular Medicine)
Transcription Factor E2F in Normal and Cancer Cells
edited by
submission deadline 31 Dec 2024 | Viewed by 199 | Submission Open
Keywords: E2F; RB; p53; cancer; tumor suppression
(This special issue belongs to the Section Biological Factors)
Peptide and Metabolite Self-Assembly: Physiology, Pathology, Biomaterials and Their Biomedical Applications
edited by and
submission deadline 31 Dec 2024 | Viewed by 195 | Submission Open
Keywords: peptide and metabolite; self-assembly; physiology and pathology; biomaterials; biomedicine
(This special issue belongs to the Section Molecular Structure and Dynamics)
Biomolecules from Natural Products: Anti-inflammatory and Anti-allergic Activities: 2nd Edition
edited by
submission deadline 31 Dec 2024 | Viewed by 185 | Submission Open
Keywords: anti-inflammation; anti-allergic; natural product; anti-aging
(This special issue belongs to the Section Natural and Bio-derived Molecules)
Tumour Suppressor Genes: The Guardians of Cell Integrity
edited by
submission deadline 31 Dec 2024 | Viewed by 172 | Submission Open
Keywords: cell cycle; cell growth; cell integrity; cell proliferation; DNA damage; genome integrity; protein homeostasis; migration; invasion; metastasis; apoptosis; autophagy
(This special issue belongs to the Section Molecular Biology)
Protein Misfolding Diseases: Molecular Mechanisms and Therapeutic Strategies
edited by Priyanka Joshi and Michele Perni
submission deadline 31 Dec 2024 | Viewed by 162 | Submission Open
Keywords: protein aggregation; protein misfolding; biomolecular condensation; chemical kinetics; cellular homeostasis; small molecules; antibody therapeutics; drug discovery; neurodegeneration; neurodegenerative diseases
(This special issue belongs to the Section Molecular Structure and Dynamics)
Molecular Mechanisms in New Strategies for Longevity
edited by
submission deadline 31 Dec 2024 | Viewed by 134 | Submission Open
Keywords: longevity; atherosclerosis; lipids; exercise; foods
Elucidating the Roles of Chromatin in Genomic Processes
edited by and Meijun Liu
submission deadline 31 Dec 2024 | Viewed by 129 | Submission Open
Keywords: nucleosome positioning and occupancy; histone modifications; histone variants; nucleosome chaperones; nucleosome remodelers; insulator proteins; CTCF and cohesin; cis-regulatory elements; 3D genome structure; chromatin dynamics
Prebiotics and Probiotics in Health and Disease: Looking at the Future submission deadline 7 Jan 2025 | 1 articles | Viewed by 1404 | Submission Open
Keywords: probiotics; live biotherapeutic product (LBP); next-generation probiotic (NGP); prebiotic; synbiotic/symbiotic; pharmabiotics; post-biotics; paraprobiotic/ghost probiotics/inactivated probiotics; probioceuticals/probiotaceuticals; biogenic; gut balance; gut– brain axis; vaginal homeostasis; vaginal microbiota modification or augmentation; oral microbiota; skin microbiota; new therapeutic approaches using bacteria; psychobiotics
(This special issue belongs to the Section Molecular Medicine)
Zinc in Health and Disease Conditions: 2nd Edition
edited by
submission deadline 10 Jan 2025 | 5 articles | Viewed by 7027 | Submission Open
Keywords: zinc; physiology; disease; regulation/modulation; function; pathology
(This special issue belongs to the Section Molecular Medicine)
Biosynthesis and Function of Thyroid Hormones
edited by and Eva K. Wirth
submission deadline 10 Jan 2025 | Viewed by 214 | Submission Open
Keywords: thyroid gland; thyroid follicle; TH release; iodide; deiodinase; TH transmembrane transport; TH receptors; intracellular TH binding proteins; thyroglobulin; sodium– iodide symporter; thyroperoxidase; dual oxidase; thyroid-relevant trace elements
(This special issue belongs to the Section Biological Factors)
Extracellular Vesicles as Biomarkers of Diseases submission deadline 15 Jan 2025 | 7 articles | Viewed by 9649 | Submission Open
Keywords: extracellular vesicles; metabolic syndrome; cancer; cardiovascular diseases; neurodegenerative diseases; biomarkers
(This special issue belongs to the Section Molecular Biomarkers)
The Value of Natural Compounds as Therapeutic Agents: 2nd Edition submission deadline 15 Jan 2025 | 4 articles | Viewed by 7297 | Submission Open
Keywords: natural compound; acute and chronic conditions; cell proliferation; cell death; cell differentiation
(This special issue belongs to the Section Natural and Bio-derived Molecules)
Molecular Mechanisms of Human Skin Aging
edited by
submission deadline 15 Jan 2025 | 3 articles | Viewed by 4635 | Submission Open
Keywords: skin aging; UV; extracellular matrix; fibroblast; prevention
(This special issue belongs to the Section Molecular Medicine)
Learn from Machine Learning: The Identification of Biomarkers and Therapeutic Targets in Neurodegeneration
edited by and
submission deadline 15 Jan 2025 | 2 articles | Viewed by 4320 | Submission Open
Keywords: machine learning; neurodegeneration; biomarkers; therapeutic targets; data mining
(This special issue belongs to the Section Molecular Medicine)
Circular RNAs: Functions, Applications and Prospects: 2nd Edition
edited by and Feiya Li
submission deadline 15 Jan 2025 | 2 articles | Viewed by 3603 | Submission Open
Keywords: circular RNAs; circRNA; function; application; disease
(This special issue belongs to the Section Biomacromolecules: Nucleic Acids)
Cellular and Molecular Biology of Neurodevelopment
edited by
submission deadline 15 Jan 2025 | Viewed by 148 | Submission Open
Keywords: neural stem cells; neuroblasts; neurons; glia; microglia; molecular pathways; genes; mutations; pharmacology; toxicology; neurodevelopment; neurodevelopmental disorders
(This special issue belongs to the Section Molecular Biology)
Sterol Biosynthesis and Function in Organisms
edited by Hubert Schaller
submission deadline 20 Jan 2025 | 5 articles | Viewed by 6381 | Submission Open
Keywords: sterol; biosynthesis; function; organisms
(This special issue belongs to the Section Molecular Biology)
Physiological and Pathological Functions of Crystallins
edited by and John Clark
submission deadline 20 Jan 2025 | 1 articles | Viewed by 2243 | Submission Open
Keywords: crystallin; small heat shock protein chaperone; transparency; phase separation; aging; age related disease; cataract; cancer; schizophrenia; fertility
(This special issue belongs to the Section Biomacromolecules: Proteins)
Immune Responses in Type 1 Diabetes
edited by and Sally C. Kent
submission deadline 20 Jan 2025 | Viewed by 494 | Submission Open
Keywords: type 1 diabetes; insulitis; immune response
(This special issue belongs to the Section Molecular Biology)
Synaptogenesis, Synaptic Plasticity and Brain Disorders
edited by Rubén Deogracias
submission deadline 20 Jan 2025 | Viewed by 249 | Submission Open
Keywords: synaptic plasticity; neuron; brain disorders; brain damage
(This special issue belongs to the Section Molecular Biology)
Structural Proteomics–Structural Biology Led by Advancements in Mass Spectrometry Techniques
edited by , Corie Ralston and
submission deadline 20 Jan 2025 | Viewed by 139 | Submission Open
Keywords: hydroxyl radical protein footprinting MS (XFP; FPOP); hydrogen/deuterium exchange MS (HDX-MS); cross-linking MS (XL-MS); covalent labeling MS; top-down MS; native MS
(This special issue belongs to the Section Bioinformatics and Systems Biology)
More than Just Adhesion: Recognition Molecules, a Theme Issue Honoring Professor Melitta Schachner
edited by
submission deadline 25 Jan 2025 | 1 articles | Viewed by 2576 | Submission Open
Keywords: cell adhesion molecules; extracellular matrix; glycans; nervous system regeneration; nervous system development
(This special issue belongs to the Section Biological Factors)
Biogenic Amines, Their Receptors and Transporters in Health and Disease: Commemorative Issue in Honor of Professor Marc G. Caron (1946–2022)
edited by , , Jean Martin Beaulieu and Stephen S.G. Ferguson
submission deadline 31 Jan 2025 | 15 articles | Viewed by 34722 | Submission Open
Keywords: dopamine; serotonin; norepinephrine; epinephrine; histamine; trace amines; beta-phenylethylamine; GPCR; TAAR
(This special issue belongs to the Section Biological Factors)
Novel Materials for Biomedical Applications: 2nd Edition submission deadline 31 Jan 2025 | 8 articles | Viewed by 16785 | Submission Open
Keywords: micro-/nanocarriers; synthesis or conjugation of biomaterials; drug delivery; targeted therapy/immunotherapy for combinatorial treatment; regenerative medicine/tissue engineering
(This special issue belongs to the Section Biological and Bio- Materials)
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