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Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Immunofluorescent Techniques in Animal Stem Cell Research

edited by

Jaromír Vašíček

and Andrea Svoradová

submission deadline 30 Jun 2025 | Viewed by 204 | Submission Open

Keywords: animal stem cells; fluorescence/confocal microscopy; flow cytometry; fluorescence-activated cell sorting; fluorescent protein assay; stem cell markers; cell therapy; drug screening; exosomes; DNA analysis

(This special issue belongs to the Section Molecular Biology)

Regulation Mechanisms of Autophagy in Aging

edited by

Patricia Gomez-Suaga

submission deadline 30 Jun 2025 | Viewed by 181 | Submission Open

Keywords: autophagy; cellular senescence; protein aggregation; mitochondrial dysfunction; aging

(This special issue belongs to the Section Cellular Biochemistry)

Advances in Nano-Based Drug Delivery Systems

edited by

Amalendu P. Ranjan

Nirupama A. Sabnis

and

Zacharias Suntres

submission deadline 30 Jun 2025 | Viewed by 158 | Submission Open

Keywords: drug delivery system; nanotechnology; nanomedicine; nanocarriers; nanoparticles; nanoformulation; biomolecules

(This special issue belongs to the Section Molecular Medicine)

The Role of Glycosaminoglycans and Proteoglycans in Human Disease

edited by

Umesh Desai

submission deadline 30 Jun 2025 | Viewed by 151 | Submission Open

Keywords: glycosaminoglycans (GAGs); proteoglycans (PGs); diseases; mechanisms; molecules

(This special issue belongs to the Section Molecular Biology)

Multiple Myeloma: From Pathophysiology to Novel Therapeutic Approaches

edited by

Cirino Botta

submission deadline 30 Jun 2025 | Viewed by 149 | Submission Open

Keywords: multiple myeloma; tumor immunology; MGUS; sMM

Nano-Based Tumor Therapy: State-of-the-Art and Future Prospects

edited by

Maria Virtudes Céspedes

submission deadline 30 Jun 2025 | Viewed by 138 | Submission Open

Keywords: nano-based cancer therapy; personalized nanoparticle; cancer care strategies; tumor treatment

Novel Drug Targets and RNA Epigenetics in Cancer Therapy

edited by Manjeet K. Rao

submission deadline 30 Jun 2025 | Viewed by 135 | Submission Open

Keywords: RNA modifications; cancer epigenetics; novel drug targets; RNA therapeutics; tumorigenesis

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Fibrinogen and Fibrin in Human Diseases

edited by

Abha Sahni

submission deadline 30 Jun 2025 | Viewed by 131 | Submission Open

Keywords: fibrinogen; fibrin; inflammation; cardiovascular; neurological; endothelium; thrombosis; hemostasis; fibrosis

(This special issue belongs to the Section Molecular Biology)

Molecular and Cellular Mechanisms of Aortic Aneurysms

edited by Maria Giovanna Scioli

submission deadline 30 Jun 2025 | Viewed by 129 | Submission Open

Keywords: aorthopaties; thoracic and abdominal aneurysms; pathogenetic mechanisms; aortic wall degeneration; biomarkers; targeted therapies

(This special issue belongs to the Section Molecular Biology)

Cysteine and Selenocysteine in Antioxidant Defense, Protein Synthesis and Signaling Pathways

edited by

Maria Wrobel

and

Halina Jurkowska

submission deadline 30 Jun 2025 | Viewed by 124 | Submission Open

Keywords: cysteine; selenocysteine; taurine; hydrogen sulfide; hydrogen selenide; selenoproteins; sulfurtransferases; H2S precursors; antioxidants; diseases related to sulfur metabolism

(This special issue belongs to the Section Molecular Biology)

Insights into Mitochondria in Psychiatric Disorders

edited by Ji Geng

submission deadline 30 Jun 2025 | Viewed by 123 | Submission Open

Keywords: mitochondria; depression; schizophrenia; autism; neurodevelopmental disorders

(This special issue belongs to the Section Cellular Biochemistry)

The Impact of Epigenetic Reprogramming Induced by Environmental Factors on Aging

edited by

Min Hi Park

submission deadline 30 Jun 2025 | Viewed by 88 | Submission Open

Keywords: aging ; environmental factors ; DNA methylation ; histone modification ; non-coding RNA

Integrating Genetics, Immune Dysregulation, and the Gut Microbiome: Advances in Elucidating IBD Pathophysiology and Emerging Therapeutic Strategies

edited by Peter W. Jurutka and

Todd R. Sandrin

submission deadline 1 Jul 2025 | 2 articles | Viewed by 3329 | Submission Open

Keywords: microbiome; biomarkers; Crohn’ s disease; ulcerative colitis; indeterminate colitis; multiomics; gastrointestinal (GI disease); immunology; gut– brain axis; neuropsychology

(This special issue belongs to the Section Molecular Genetics)

Structural Biology of Protein

edited by

Nabanita Saikia

submission deadline 10 Jul 2025 | 1 articles | Viewed by 1367 | Submission Open

Keywords: structural characterization; protein structure– function paradigm; biophysical techniques; computational methods; conformational dynamics; drug discovery; protein– protein interactions

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

PARPs in Cell Death and PARP Inhibitors in Cancers: 2nd Edition

edited by

María Isabel Rodríguez

and

Josefa León

submission deadline 10 Jul 2025 | 1 articles | Viewed by 1196 | Submission Open

Keywords: PARPs; PARP inhibitors; cancers; cell death; DNA repair

(This special issue belongs to the Section Molecular Medicine)

Embryo Implantation: New Molecular Insights in Endometrial Receptivity, Trophoblast Invasion and Signaling

edited by

Hans-Werner Denker

, Evdokia Dimitriadis and Lois A. Salamonsen

submission deadline 15 Jul 2025 | 4 articles | Viewed by 3768 | Submission Open

Keywords: embryo implantation; endometrial receptivity; trophoblast invasion; signaling

(This special issue belongs to the Section Molecular Reproduction)

Molecular Pathology, Diagnostics and Therapeutics of Retinal Diseases: 2nd Edition

edited by

Antonio Ferreras

submission deadline 15 Jul 2025 | Viewed by 150 | Submission Open

Keywords: retina; macula; macular edema; inflammatory mediators; optical coherence tomography; retinal imaging; biochemical marker; biomarker; pharmacological targeting

Muscular Dystrophy: From Molecular Basis to Therapies: 2nd Edition

edited by

Francesca Sciandra

and

Kinga I. Gawlik

submission deadline 15 Jul 2025 | Viewed by 144 | Submission Open

Keywords: muscular dystrophies; muscle regeneration; extracellular matrix; satellite cells; therapeutic approaches; animal models; clinical trials

Molecular Mechanisms, Novel Diagnostics and Treatments of Gynecologic Cancer

edited by Panneerdoss Subbarayalu

submission deadline 15 Jul 2025 | Viewed by 81 | Submission Open

Keywords: biomarker; cancer biology; novel drug targets and therapeutics; cancer stem cells; tumorigenesis

Immune Responses in Type 1 Diabetes

edited by

Eddie A. James

and Sally C. Kent

submission deadline 20 Jul 2025 | 4 articles | Viewed by 2804 | Submission Open

Keywords: type 1 diabetes; insulitis; immune response

(This special issue belongs to the Section Molecular Biology)

Mitochondria as a Target for Tissue Repair and Regeneration

edited by

Igor A. Prudovsky

submission deadline 21 Jul 2025 | Viewed by 271 | Submission Open

Keywords: mitochondria; trauma; tissue repair; regeneration; inflammation; mitochondrial DAMPs; mitochondrial biogenesis; mitophagy

(This special issue belongs to the Section Molecular Biology)

Gametogenesis and Gamete Interaction, 2nd Edition

edited by

Hitoshi Sawada

submission deadline 25 Jul 2025 | 3 articles | Viewed by 3648 | Submission Open

Keywords: gametogenesis and meiosis; sperm attraction and activation; gamete interaction and recognition; species specificity and self/nonself-recognition in hermaphrodites; acrosome reaction sperm penetration of egg coat; gamete membrane fusion; polyspermy block; egg activation

(This special issue belongs to the Section Molecular Reproduction)

Inflammatory Mechanisms and Molecular Targets in Neurological Disorders: Effects of Neuroprotective Drugs

edited by

Jose Joaquin Merino

submission deadline 30 Jul 2025 | Viewed by 300 | Submission Open

Keywords: neuroinflammation; neurological disorders; molecular targets; therapeutic strategies; neuroimmunology

(This special issue belongs to the Section Molecular Medicine)

Biogenic Amines, Their Receptors and Transporters in Health and Disease: Commemorative Issue in Honor of Professor Marc G. Caron (1946–2022)

edited by

Raul Gainetdinov

Bruno Giros

, Jean Martin Beaulieu and Stephen S.G. Ferguson

submission deadline 31 Jul 2025 | 16 articles | Viewed by 44311 | Submission Open

Keywords: dopamine; serotonin; norepinephrine; epinephrine; histamine; trace amines; beta-phenylethylamine; GPCR; TAAR

(This special issue belongs to the Section Biological Factors)

Recent Developments in Mesenchymal Stem Cells

edited by

Antonietta Rosa Silini

and

Enrico Ragni

submission deadline 31 Jul 2025 | 8 articles | Viewed by 15986 | Submission Open

Keywords: mesenchymal stromal cell; regenerative medicine; secretome

(This special issue belongs to the Section Cellular Biochemistry)

Mitochondrial ROS in Health and Disease

edited by

Frank Krause

submission deadline 31 Jul 2025 | 5 articles | Viewed by 11082 | Submission Open

Keywords: aging; apoptosis; respiratory chain; redox signaling; paclitaxel

(This special issue belongs to the Section Chemical Biology)

Recent Advances in Cellular and Molecular Mechanisms of Cardiovascular and Metabolic Diseases: 2nd Edition

edited by

Adriana Georgescu

submission deadline 31 Jul 2025 | 6 articles | Viewed by 10900 | Submission Open

Keywords: cardiovascular disease; dyslipidemia; diabetes; obesity; inflammation; oxidative stress; biomarkers; microRNA; extracellular vesicles; cardiopulmonary disease

(This special issue belongs to the Section Molecular Biology)

Therapeutic Potential of Natural Products in Metabolic Diseases

edited by

Atanas G. Atanasov

Ronan Lordan

and

Ren-You Gan

submission deadline 31 Jul 2025 | 4 articles | Viewed by 10109 | Submission Open

Keywords: natural products; metabolic disorders; diabetes mellitus; dietary constituents; phytotherapy; integrative medicine; obesity; dyslipidemia; non-alcoholic fatty liver disease (NAFLD); metabolic dysfunction-associated steatohepatitis (MASH); nutraceuticals; supplements

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Molecular, Cellular, and Blood Biomarkers in Diagnosis, Prognosis, Monitoring, and Treatment

edited by

Jordi Camps

, Isabel Fort Gallifa and Xavier Gabaldó Barrios

submission deadline 31 Jul 2025 | 6 articles | Viewed by 8234 | Submission Open

Keywords: biomarkers; infectious diseases; laboratory medicine; non-communicable diseases

(This special issue belongs to the Section Molecular Biology)

Molecular Insights into the Mechanism of Antipsychotic Drugs

edited by Serdar Dursun and

Massimo Tusconi

submission deadline 31 Jul 2025 | 2 articles | Viewed by 6368 | Submission Open

Keywords: psychotropic medications; antipsychotic drugs; schizophrenia; molecular mechanisms

(This special issue belongs to the Section Molecular Biology)

Computational Analysis and Conformational Modeling for Protein Structure and Interaction

edited by

Clement Agoni

and

Indrani Bera

submission deadline 31 Jul 2025 | 6 articles | Viewed by 5756 | Submission Open

Keywords: protein structure prediction; drug discovery targeting proteins; structural bioinformatics; molecular dynamics simulations; protein– protein interactions; protein– ligand binding; conformational dynamics; molecular docking studies

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Molecular Advances in Inflammatory Bowel Disease

edited by

Antonietta Gerarda Gravina

and

Raffaele Pellegrino

submission deadline 31 Jul 2025 | 2 articles | Viewed by 4711 | Submission Open

Keywords: inflammatory bowel disease; Crohn’ s disease; ulcerative colitis; biologics; quality of life; diagnostic markers; prognostic markers; drug monitoring; antibodies

(This special issue belongs to the Section Molecular Medicine)

Molecular and Toxicological Profiling of Drugs of Abuse—in Honor of Professor Félix Carvalho

edited by

João Pedro Silva

and

Vera Marisa Costa

submission deadline 31 Jul 2025 | 3 articles | Viewed by 4004 | Submission Open

Keywords: toxicodynamic; toxicokinetic; amphetamine-type stimulants; cannabis and cannabinoids; cocaine; hallucinogens; new psychoactive substances; opioids; immune modulation

(This special issue belongs to the Section Molecular Medicine)

Omics Data Integration: Focusing on Molecular Biomarkers for Cancers and Diseases

edited by Cinzia Franchin

submission deadline 31 Jul 2025 | 3 articles | Viewed by 3986 | Submission Open

Keywords: omics data analysis; omics data integration; biomarker discovery; bioinformatics; cancers

(This special issue belongs to the Section Bioinformatics and Systems Biology)

Cannabinoids in Neurobehavioral Modulation

edited by

Francisco Navarrete

and

María S. García Gutiérrez

submission deadline 31 Jul 2025 | 3 articles | Viewed by 3551 | Submission Open

Keywords: cannabinoids; neurobehavior; brain diseases; therapeutic; translational

(This special issue belongs to the Section Molecular Biology)

Advances in Cardiometabolic Health

edited by

Pamela Senesi

and

Anna Ferrulli

submission deadline 31 Jul 2025 | 2 articles | Viewed by 3530 | Submission Open

Keywords: obesity; cardiovascular diseases; biomarkers; lifestyle interventions; personalized medicine

(This special issue belongs to the Section Cellular Biochemistry)

The Role of Scaffold Proteins in Human Diseases

edited by László Buday and

Virag Vas

submission deadline 31 Jul 2025 | 2 articles | Viewed by 3183 | Submission Open

Keywords: scaffold proteins; cellular signalling; protein– protein interactions; protein domains; human diseases; drug targets; protein complex formation; pathogenic alterations

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Genetic and Genomic Biomarkers in Cancer Diagnosis, Prognosis, and Treatment Prediction

edited by

Jianli Dong

submission deadline 31 Jul 2025 | 2 articles | Viewed by 1436 | Submission Open

Keywords: laboratory genetics and genomics; genetic and genomic biomarkers; diagnostic; prognostic; predictive; companion diagnosis; targeted therapy; nucleic acid

(This special issue belongs to the Section Molecular Biomarkers)

Artificial Intelligence (AI) in Biomedicine: 2nd Edition

edited by

Le Nguyen Quoc Khanh

submission deadline 31 Jul 2025 | 1 articles | Viewed by 1405 | Submission Open

Keywords: bioinformatics and biomedical informatics; biomedical image processing; cancer genomics; data analysis and big data; data mining and text mining; e-Health machine learning and deep learning; molecular biology and medicine; natural language processing; single-cell sequencing analysis

(This special issue belongs to the Section Molecular Medicine)

Advancing Molecular Regulation in Brain Injury Research: Mechanisms, Diagnosis, and Rehabilitation

edited by Guanglin Zhang and

Pavan Thapak

submission deadline 31 Jul 2025 | 1 articles | Viewed by 868 | Submission Open

Keywords: brain injury; biomarkers; neurodegeneration; neuroplasticity; neuroimaging; microbial dysbiosis; gut– brain axis; cognitive rehabilitation

(This special issue belongs to the Section Molecular Biology)

Chronic Heart Failure: From Molecular Mechanisms to Therapies Strategies

edited by

Josep Comín-Colet

and

Marta Tajes

submission deadline 31 Jul 2025 | 2 articles | Viewed by 716 | Submission Open

Keywords: chronic heart failure; pathophysiology; comorbidities; new therapies; molecular pathways

(This special issue belongs to the Section Molecular Medicine)

Advanced Biomaterials for Healing Oral Tissues

edited by Miki Taketomi Saito and

Rafael R. Lima

submission deadline 31 Jul 2025 | 1 articles | Viewed by 472 | Submission Open

Keywords: biocompatible materials; biopolymers; dental implants; materials testing; pharmaceutical preparations; regeneration; regenerative medicine; tissue scaffolds; wound healing

(This special issue belongs to the Section Bio-Engineered Materials)

Single-Molecule Protein Electronics

edited by

Stuart Lindsay

and Bintian Zhang

submission deadline 31 Jul 2025 | 1 articles | Viewed by 451 | Submission Open

Keywords: protein electronics; molecular electronics; single-molecule conductance; protein detection; protein sensing; label-free detection; conductance gating in proteins; electron transport mechanisms in proteins; coherence and dephasing in proteins; role of water in protein conductance; extended electronic states in proteins; hopping conductance in proteins; long-range hopping in proteins; electrode– protein interfaces; charge injection barriers at protein– electrode interfaces; proteins as electronic devices; protein assemblies as electronic devices; DNA electronics; electron transport in DNA; DNA– electrode interfaces; charge injection at a DNA– electrode interface; barrier to charge injection at a DNA– electrode interface

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Role of Glutathione Peroxidase in Health and Disease

edited by R Steve Esworthy

submission deadline 31 Jul 2025 | Viewed by 396 | Submission Open

Keywords: GPX1; GPX2; GPX3; GPX4; GPX5; GPX6; GPX7; GPX8; selenium; cancer; pathology

(This special issue belongs to the Section Molecular Medicine)

Molecular and Cellular Mechanisms of Megakaryocyte and Platelet Production

edited by Pedro J. Real and

Laura Gutiérrez

submission deadline 31 Jul 2025 | Viewed by 386 | Submission Open

Keywords: megakaryocytes; platelets; omics; platelet disorders; inflammation

(This special issue belongs to the Section Cellular Biochemistry)

The Production and Destruction of Phytohormones by Microorganisms: Their Roles in the Promotion of Plant Growth and Resistance

edited by Guzel Kudoyarova

submission deadline 31 Jul 2025 | Viewed by 343 | Submission Open

Keywords: plant-growth-promoting bacteria (PGPB); mycorrhizae; auxins; cytokines; ethylene; abscisic acid; gibberellins; jasmonates; brassinolides; water relations; mineral nutrition; antioxidant system; protection against pathogens; salicylic acid; ethylene

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Advances in Liver Transplantation and Hepatocellular Carcinoma

edited by

Paolo De Simone

submission deadline 31 Jul 2025 | Viewed by 285 | Submission Open

Keywords: biomolecular markers of liver graft quality; the prediction role of biomolecular markers in liver transplantation; biomolecular markers of graft viability in the setting of machine perfusion technology; biomolecular markers of liver graft dysfunction; HCC biomarkers: AFP; PIVKA; and SPIK; the role of inflammation and immunity; standards of biomolecular HCC diagnosis; biomolecular-based diagnostic algorithms for HCC; biomolecular-based screening and prevention algorithms; advantages and pitfalls of existing biomolecular diagnosis

(This special issue belongs to the Section Molecular Biomarkers)

Molecular Mechanisms and Novel Treatments of Stroke

edited by Saif Ahmad and Naseem Akhter

submission deadline 31 Jul 2025 | Viewed by 284 | Submission Open

Keywords: ischemic stroke; molecular mechanisms; neuroinflammation; signaling pathways; therapeutic approaches

(This special issue belongs to the Section Molecular Biology)

Elucidating the Roles of Chromatin in Genomic Processes

edited by

Daniel M. Czajkowsky

and Meijun Liu

submission deadline 31 Jul 2025 | Viewed by 280 | Submission Open

Keywords: nucleosome positioning and occupancy; histone modifications; histone variants; nucleosome chaperones; nucleosome remodelers; insulator proteins; CTCF and cohesin; cis-regulatory elements; 3D genome structure; chromatin dynamics

Obesity-Related Diseases in Children: Molecular Basis and Therapeutic Approaches

edited by