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Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue polices and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Key Molecules in Traditional Medicine: From Molecular Mechanisms to Therapies Strategies

edited by

Seungtae Kim

and

Sunoh Kwon

submission deadline 31 Jan 2025 | 2 articles | Viewed by 2313 | Submission Open

Keywords: natural compounds; traditional medicine; biomolecules in medicinal herbs; molecular changes caused by traditional medicine treatments

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Recent Advances in the Isolation, Chemical and Biological Characterization and Synthesis of Bioactive Metabolites from Plants

edited by

Antonio Evidente

and

Stefano Superchi

submission deadline 31 Jan 2025 | 2 articles | Viewed by 2068 | Submission Open

Keywords: plants; bioactive metabolite; natural analogues; chemical and biological characterization; synthesis; synthetic intermediates and derivatives

(This special issue belongs to the Section Natural and Bio-derived Molecules)

New Insights into Neuroimmunology

edited by

Marc André Lécuyer

submission deadline 31 Jan 2025 | 1 articles | Viewed by 2067 | Submission Open

Keywords: neuroimmunology (in health and disease); multiple sclerosis (MS); experimental autoimmune encephalomyelitis (EAE); acute disseminated encephalomyelitis (ADEM); neuromyelitis optica spectrum disorders (NMOSD); transverse myelitis; anti-NMDA receptor encephalitis (NMDAR encephalitis); paraneoplastic autoimmune diseases; neurodegenerative diseases with immunological components; Parkinson’ s disease; Alzheimer’ s disease; neuroinfections

(This special issue belongs to the Section Cellular Biochemistry)

The Role of Glia in Alzheimer's Disease

edited by

Sriram Balusu

submission deadline 31 Jan 2025 | 1 articles | Viewed by 1850 | Submission Open

Keywords: Alzheimer's disease; neurodegeneration; glial cells

(This special issue belongs to the Section Molecular Medicine)

The Role of CD36 in Human Health and Disease

edited by

Laura Cristina Ceafalan

and Mihail E. Hinescu

submission deadline 31 Jan 2025 | 1 articles | Viewed by 1349 | Submission Open

Keywords: CD36; lipid scavenger; cell-to-matrix adhesion; metastasis; neoangiogenesis; biomarker

(This special issue belongs to the Section Molecular Medicine)

Selected Papers from the 3rd International Electronic Conference on Biomolecules

edited by

Vladimir N. Uversky

and

Piero Crespo

submission deadline 31 Jan 2025 | Viewed by 1180 | Submission Open

New Insights into RNA-Binding Proteins

edited by

Marko Noerenberg

submission deadline 31 Jan 2025 | 1 articles | Viewed by 917 | Submission Open

Keywords: RNA-binding protein; RBP; RNA; riboregulation; RNA interactome; protein– RNA interaction; protein– RNA complex; ribonucleoprotein

(This special issue belongs to the Section Biomacromolecules: Proteins)

Non-coding RNAs in Human Diseases: Roles and Mechanisms of Action

edited by Lei Jin

submission deadline 31 Jan 2025 | Viewed by 404 | Submission Open

Keywords: non-coding RNAs; human diseases; diagnostic markers; therapeutic targets; prognostic indicators

(This special issue belongs to the Section Molecular Genetics)

Computational Intelligence in Structure and Function Prediction and Modeling of Proteins—2nd Edition

edited by

Jian Zhang

Bi Zhao

and Haiting Chai

submission deadline 31 Jan 2025 | Viewed by 309 | Submission Open

Keywords: protein tertiary structure; protein folding; protein functions; intrinsic disorder; drug discovery; protein– drug interaction; computational intelligent algorithms; artificial intelligence for proteomics; high-throughput proteomics

(This special issue belongs to the Section Bioinformatics and Systems Biology)

Pathogenesis and Therapies of SARS-CoV-2

edited by

Grzegorz Przybylski

and Piotr Kopiński

submission deadline 31 Jan 2025 | Viewed by 237 | Submission Open

Keywords: ARDS in COVID-19; COVID-19 therapies; COVID-19 vaccines; immune systems in COVID-19; long-COVID pathogenesis; SARS-Cov-2 genomics; SARS-Cov-2 variants; T-cells in COVID-19

Heterocyclic Compounds as Novel Anti-cancer Agents and Their Mechanisms of Action

edited by Chandra Mishra and

Dnyaneshwar N. Garad

submission deadline 31 Jan 2025 | Viewed by 232 | Submission Open

Keywords: heterocyclic compounds; anticancer; synthetic; natural

(This special issue belongs to the Section Molecular Medicine)

Mitochondria and Central Nervous System Disorders: 3rd Edition

edited by

Marta Zaninello

and

Camilla Bean

submission deadline 31 Jan 2025 | Viewed by 200 | Submission Open

Keywords: mitochondria; metabolism; neurodegeneration; neuroinflammation; ageing; central nervous system

(This special issue belongs to the Section Molecular Biology)

The Role of Nanoparticles in Tumor Treatment

edited by

Carla Vitorino

submission deadline 31 Jan 2025 | Viewed by 104 | Submission Open

Keywords: nanoparticles; cancer therapy; nanotechnology

(This special issue belongs to the Section Chemical Biology)

The Production and Destruction of Phytohormones by Microorganisms: Their Roles in the Promotion of Plant Growth and Resistance

edited by Guzel Kudoyarova

submission deadline 31 Jan 2025 | Viewed by 88 | Submission Open

Keywords: plant-growth-promoting bacteria (PGPB); mycorrhizae; auxins; cytokines; ethylene; abscisic acid; gibberellins; jasmonates; brassinolides; water relations; mineral nutrition; antioxidant system; protection against pathogens; salicylic acid; ethylene

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Molecular Insights into the Mechanism of Antipsychotic Drugs

edited by Serdar Dursun and

Massimo Tusconi

submission deadline 15 Feb 2025 | 2 articles | Viewed by 2833 | Submission Open

Keywords: psychotropic medications; antipsychotic drugs; schizophrenia; molecular mechanisms

(This special issue belongs to the Section Molecular Biology)

The Role of Scaffold Proteins in Human Diseases

edited by László Buday and

Virag Vas

submission deadline 15 Feb 2025 | 1 articles | Viewed by 1147 | Submission Open

Keywords: scaffold proteins; cellular signalling; protein– protein interactions; protein domains; human diseases; drug targets; protein complex formation; pathogenic alterations

(This special issue belongs to the Section Biomacromolecules: Proteins)

New Advances of Cannabinoid Receptors in Health and Disease: 2nd Edition

edited by

Balapal S. Basavarajappa

submission deadline 15 Feb 2025 | Viewed by 109 | Submission Open

Keywords: neurodegeneration; alcohol; addiction; signaling; structure– function

(This special issue belongs to the Section Molecular Biology)

Exploring Novel Molecular Pathways and Emerging Treatments for Myotonic Dystrophy

edited by

Arturo Lopez-Castel

submission deadline 15 Feb 2025 | Viewed by 77 | Submission Open

Keywords: gene therapy; repurposing; therapeutic oligonucleotides; personalized medicine; biomarkers

(This special issue belongs to the Section Molecular Medicine)

Molecular Mechanisms and Novel Treatments of Stroke

edited by Saif Ahmad and Naseem Akhter

submission deadline 15 Feb 2025 | Viewed by 53 | Submission Open

Keywords: ischemic stroke; molecular mechanisms; neuroinflammation; signaling pathways; therapeutic approaches

(This special issue belongs to the Section Molecular Biology)

Mitochondria as a Target for Tissue Repair and Regeneration

edited by

Igor A. Prudovsky

submission deadline 20 Feb 2025 | Viewed by 59 | Submission Open

Keywords: mitochondria; trauma; tissue repair; regeneration; inflammation; mitochondrial DAMPs; mitochondrial biogenesis; mitophagy

Oxygen Homeostasis, Oxidative Stress, and Inflammation in Kidney Health and Disease

edited by

David Hoogewijs

and

Liang-Jun Yan

submission deadline 20 Feb 2025 | Viewed by 58 | Submission Open

Keywords: acute kidney injury; chronic kidney disease; diabetic nephropathy/diabetic kidney disease; inflammation; hypoxia; redox homeostasis; redox imbalance; oxidative stress; mitochondrial dysfunction

(This special issue belongs to the Section Molecular Biology)

Research into Bioactive Natural Compounds: New Molecules, Bioinspired Syntheses, Biotechnological Methods and Bioassays—Celebrating the Pioneering Work of Prof. Alejandro Fernandez Barrero

edited by

José Francisco Quílez del Moral

and

Azucena González Coloma

submission deadline 28 Feb 2025 | 5 articles | Viewed by 4887 | Submission Open

Keywords: natural products; bioactivity; organic synthesis; biotecnnology; structural elucidation

(This special issue belongs to the Section Natural and Bio-derived Molecules)

The Role of Vascular Dysfunction in Neuronal Degeneration and Cognitive Impairment (2nd Edition)

edited by

David Lominadze

submission deadline 28 Feb 2025 | 3 articles | Viewed by 4055 | Submission Open

Keywords: blood cells; plasma components; vascular wall components; neurovascular unit; neuroinflammation; cognitive decline

(This special issue belongs to the Section Molecular Biology)

Esophageal Diseases: Molecular Basis and Therapeutic Approaches

edited by

Hiroshi Nakagawa

and Amanda B. Muir

submission deadline 28 Feb 2025 | 3 articles | Viewed by 3287 | Submission Open

(This special issue belongs to the Section Molecular Medicine)

New Insights into Mechanisms and Therapeutics for Cardiovascular Disorders

edited by

Mohsin Saleet Jafri

Carola Yvette Förster

and Tarun W. Dasari

submission deadline 28 Feb 2025 | 2 articles | Viewed by 3131 | Submission Open

Keywords: brain heart-axis; heart & stroke; stress-induced cardiomyopathy; cardiovascular disease

(This special issue belongs to the Section Molecular Medicine)

Chemoinformatics and Molecular Modeling of Pharmacologically Active Biomolecules: A Themed Issue in Honor of Prof. José L. Medina-Franco

edited by Carlos A. Velázquez-Martínez and

Martín González-Andrade

submission deadline 28 Feb 2025 | 1 articles | Viewed by 2825 | Submission Open

Keywords: drug design; molecular modelling; chemoinformatics; materials science; big data; machine learning; predictive modeling; toxicology

(This special issue belongs to the Section Bioinformatics and Systems Biology)

Amyloid-Beta and Alzheimer’s Disease

edited by

Fumiaki Ito

and

Toshifumi Akizawa

submission deadline 28 Feb 2025 | 2 articles | Viewed by 2599 | Submission Open

Keywords: Alzheimer's disease (AD); amyloid-beta (Aβ ); neurotoxicity of Aβ ; Tau protein; Aβ phagocytosis; Aβ clearance; autophagy– lysosome system; anti-Aβ monoclonal antibodies; neuroinflammation in AD; glial cells in AD

(This special issue belongs to the Section Cellular Biochemistry)

The Role of Amyloid in Neurological Disorders

edited by

Marny Fedrigo

and Tamara Berno

submission deadline 28 Feb 2025 | 2 articles | Viewed by 2579 | Submission Open

Keywords: amyloid-beta; neurodegenerative disorders; aducanumab; oligomers; cross-amyloid intraction

(This special issue belongs to the Section Biomacromolecules: Proteins)

New Insights into Mesothelioma Immunotherapy

edited by

Licun Wu

submission deadline 28 Feb 2025 | 1 articles | Viewed by 2480 | Submission Open

Keywords: mesothelioma/malignant pleural mesothelioma (MPM)/peritoneal mesothelioma; immunotherapy; immunology; immune profiling; immune response; immunosuppression; immune checkpoint/inhibitor; immune score; tumor immune microenvironment; epithelial-mesenchymal transition (EMT) gene signature

(This special issue belongs to the Section Cellular Biochemistry)

Role of TRAF1 in Regulating Inflammation and Cell Survival

edited by Ali Abdul-Sater

submission deadline 28 Feb 2025 | 2 articles | Viewed by 2051 | Submission Open

Keywords: TRAF1; inflammation; inflammasome; TNFRs; apoptosis; cellular survival

(This special issue belongs to the Section Biological Factors)

Diet and Immune Response

edited by

Hanne Frøkiær

submission deadline 28 Feb 2025 | 1 articles | Viewed by 1957 | Submission Open

(This special issue belongs to the Section Molecular Medicine)

The Genomics Era: From Reference Genomes to Pan-Genomic Approach, 2nd Edition

edited by

Chiara Scapoli

submission deadline 28 Feb 2025 | 1 articles | Viewed by 1686 | Submission Open

Keywords: pangenome; genome evolution; graph-based pangenome; core and dispensable genomes; human genomics; metagenomics; transcriptome; structural variation

(This special issue belongs to the Section Molecular Genetics)

Biochemistry of Wine and Beer, 3rd Edition

edited by

Encarna Gómez-Plaza

and

Rocio Gil-Muñoz

submission deadline 28 Feb 2025 | 1 articles | Viewed by 510 | Submission Open

Keywords: grape biochemistry; barley and malt biochemistry; role of prefermentative enzymatic reactions; wine and beer’ s fermentation process; aging reactions; phenolic compounds; aroma compounds; protein and nitrogen compounds

(This special issue belongs to the Section Biological Factors)

Cannabinoids in Neurobehavioral Modulation

edited by

Francisco Navarrete

and

María S. García Gutiérrez

submission deadline 28 Feb 2025 | Viewed by 312 | Submission Open

Keywords: cannabinoids; neurobehavior; brain diseases; therapeutic; translational

(This special issue belongs to the Section Molecular Biology)

Inflammation and Hemostasis: 2nd Edition

edited by

Zsuzsa Bagoly

submission deadline 28 Feb 2025 | Viewed by 249 | Submission Open

(This special issue belongs to the Section Molecular Medicine)

Bcl-2 Family Proteins in Human Health and Diseases

edited by

Ladislav Anděra

and

Shazib Pervaiz

submission deadline 28 Feb 2025 | Viewed by 247 | Submission Open

Keywords: Bcl-2; cancer; signaling; therapy; apoptosis; mitochondria

(This special issue belongs to the Section Biomacromolecules: Proteins)

Redox Balance and Proteostasis Surveillance in Neurodegenerative Disorders

edited by

Fabio Di Domenico

and

Antonella Tramutola

submission deadline 28 Feb 2025 | Viewed by 237 | Submission Open

Keywords: redox homeostasis; oxidative stress; antioxidant response; proteostasis; protein folding; protein oxidation; unfolded protein response; ubiquitin proteosome system; autophagy; neurodegeneration

(This special issue belongs to the Section Molecular Medicine)

State of the Art and Perspectives in Retinal Pigment Epithelium

edited by

Paola Secchiero

and

Elisabetta Melloni

submission deadline 28 Feb 2025 | Viewed by 200 | Submission Open

Keywords: retinal pigment epithelium; innovative treatments/therapeutic approaches; retinal diseases; bioactive molecules; eye delivery strategy

(This special issue belongs to the Section Cellular Biochemistry)

Molecular and Genetic Basis of Neurodegenerative Diseases

edited by Teresa M. Gunn and Andrea Grindeland

submission deadline 28 Feb 2025 | Viewed by 179 | Submission Open

Keywords: neurodegeneration; neurodegenerative diseases; protein misfolding; protein trafficking; mitochondrial dysfunction; oxidative stress; neuronal homeostasis; neuroinflammation

(This special issue belongs to the Section Molecular Biology)

Antimicrobial Peptides in Nature: Inspiration for Rationally Designed Antimicrobials

edited by

Mire Zloh

and Rachael Dickman

submission deadline 28 Feb 2025 | Viewed by 155 | Submission Open

Keywords: antimicrobial resistance; antimicrobial peptides; rational design of peptides; antimicrobial peptide synthesis; peptidomimetic antimicrobial agents

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Cellular Quiescence and Dormancy

edited by

Jürg Bähler

submission deadline 28 Feb 2025 | Viewed by 145 | Submission Open

Keywords: quiescent cells; dormant cells; biostasis; diapause; spores; dauer larva

(This special issue belongs to the Section Molecular Genetics)

Advances in Purinergic Signaling Research: From Molecular Biology to Human Diseases

edited by Ricardo Rodrigues

submission deadline 28 Feb 2025 | Viewed by 140 | Submission Open

Keywords: ATP; adenosine; P1 receptors; P2 receptors; P2X receptors; P2Y receptors; ecto-nucleotidases

(This special issue belongs to the Section Molecular Biology)

Inflammation—The Surprising Bridge between Diseases

edited by

Manuela Ciocoiu

Minerva Codruta Badescu

and

Iris Bararu-Bojan

submission deadline 28 Feb 2025 | Viewed by 137 | Submission Open

Keywords: low-grade inflammation; lung inflammation; atherosclerosis; ischemic heart disease; peripheral artery disease; inflammatory bowel disease; fatty liver disease; inflammatory rheumatic diseases; cancer

Application of Bioinformatics in Medicine

edited by