Special Issues

Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Mechanisms and Pathophysiology of Gliomas
edited by Fengchao Lang
submission deadline 31 Aug 2025 | Viewed by 122 | Submission Open
Keywords: gliomas; cell cycle; epigenetic modifications; metabolic reprogramming; tumor microenvironment; targeted therapies
(This special issue belongs to the Section Molecular Biology)
Probiotics and Their Metabolites, 2nd Edition submission deadline 31 Aug 2025 | Viewed by 117 | Submission Open
Keywords: probiotics; metabolites; functionality; biochemical aspects; biophysical aspects; physicochemical approach; molecular mechanism; interaction; synergy; adhesion; colonization; stability; prebiotics; postbiotics; synbiotics; viability; formulation; rational design; human health; animal health; plant health
Tumor Genomics and Liquid Biopsy in Cancer Biology
edited by
submission deadline 31 Aug 2025 | Viewed by 116 | Submission Open
Keywords: circulating tumor DNA (ctDNA); circulating tumor cells (CTCs); exosomes and extracellular vesicles; circulating free RNAs and microRNAs; tumor heterogeneity; mechanisms of metastasis; tumor clonal evolution; drug resistance; tumor microenvironment; multi-omics integration
(This special issue belongs to the Section Molecular Biology)
Small Aquatic Organisms as a Model for Predictive Toxicology and Stress Mechanisms
edited by Tetsuhiro Kudoh
submission deadline 31 Aug 2025 | Viewed by 100 | Submission Open
Keywords: fish model; zebrafish model; chemical toxicology
Cellular and Molecular Mechanisms in Cardiorenal Syndrome
edited by , María Carmen Ruiz Fuentes and Maria José Espigares Huete
submission deadline 31 Aug 2025 | Viewed by 100 | Submission Open
Keywords: cardiorenal syndrome; renal failure; heart; kidney; heart failure
(This special issue belongs to the Section Molecular Biology)
DNA Damage Response for Targeted Cancer Therapy: Molecular Basis and Mechanisms Pathways
edited by
submission deadline 31 Aug 2025 | Viewed by 61 | Submission Open
Keywords: DNA repair; targeted cancer therapy; DNA damage response; predictive factors; gene editing; personalized cancer therapy
(This special issue belongs to the Section Molecular Biology)
Updates on Molecular Mechanisms of Lysosomal Storage Disease submission deadline 31 Aug 2025 | Viewed by 59 | Submission Open
Keywords: lysosomal storage disease (LSD); molecular mechanisms of LSD; genetic analyses; genotype– phenotype correlation in LSD; molecular biomarkers in LSD; gene therapy in LSD
(This special issue belongs to the Section Biological Factors)
Advances in Antiviral Drug Development
edited by Angel S. Galabov
submission deadline 31 Aug 2025 | Viewed by 50 | Submission Open
Keywords: viral inhibitors; mechanism of action; antiviral tests
Hyaluronic Acid and Proteoglycans: Basic and Biomedical Applications: 2nd Edition
edited by
submission deadline 31 Aug 2025 | Viewed by 49 | Submission Open
Keywords: hyaluronic acid; proteoglycans; GAGs; extracellular matrix; hyaluronic acid and proteoglycans in disease; cancer; inflammation; angiogenesis; vascular homeostasis and damage; arthritis and arthrosis; glycobiology
Genetics and Molecular Mechanisms of Parkinson's Disease
edited by
submission deadline 31 Aug 2025 | Viewed by 43 | Submission Open
Keywords: Parkinson’ s disease; genetics; molecular mechanisms; neurodegeneration
(This special issue belongs to the Section Molecular Genetics)
Advances in Nano-Based Drug Delivery: Unveiling the Next Frontier submission deadline 15 Sep 2025 | 1 articles | Viewed by 2713 | Submission Open
Keywords: targeted drug delivery; smart nanoformulation; controlled drug release; biocompatible nanocarriers; extracellular vesicles; immunotherapy
(This special issue belongs to the Section Bio-Engineered Materials)
Roles of Alpha-1 Antitrypsin in Human Health and Disease Models
edited by
submission deadline 15 Sep 2025 | 1 articles | Viewed by 1491 | Submission Open
Keywords: alpha-1 antitrypsin; serine proteinase inhibitor (SERPIN); autoimmunity; inflammation; aging; cancer
(This special issue belongs to the Section Molecular Medicine)
Molecular Insights into Treatment and Prognosis of Autoimmune Bullous Diseases
edited by Kristina Seiffert-Sinha and Animesh A. Sinha
submission deadline 15 Sep 2025 | Viewed by 338 | Submission Open
Keywords: autoimmunity; blistering; gene expression; immunome; keratinocyte; pathomechanism; proteome; skin
(This special issue belongs to the Section Molecular Medicine)
Recent Advances in Bioactive Compounds from Microalgae submission deadline 15 Sep 2025 | Viewed by 52 | Submission Open
Keywords: microalgae; bioactive compounds; biomolecules; innovations
Dysregulated Cytokine Signals in Human Disease
edited by
submission deadline 25 Sep 2025 | Viewed by 249 | Submission Open
Keywords: cytokine; signaling; dysregulation; immunity; development; disease
(This special issue belongs to the Section Molecular Medicine)
Molecular Aspects of Diseases Origin and Development
edited by
submission deadline 30 Sep 2025 | 5 articles | Viewed by 12606 | Submission Open
(This special issue belongs to the Section Molecular Medicine)
Diabetes, Overweight and Obesity: From Molecular Mechanisms to Therapies Strategies
edited by and
submission deadline 30 Sep 2025 | 7 articles | Viewed by 12156 | Submission Open
Keywords: diabetes mellitus; overweight; obesity; molecular mechanisms; microbiome; liver metabolism; advanced therapy
(This special issue belongs to the Section Molecular Medicine)
The Role of Vascular Dysfunction in Neuronal Degeneration and Cognitive Impairment (2nd Edition)
edited by
submission deadline 30 Sep 2025 | 6 articles | Viewed by 9400 | Submission Open
Keywords: blood cells; plasma components; vascular wall components; neurovascular unit; neuroinflammation; cognitive decline
(This special issue belongs to the Section Molecular Biology)
Prebiotics and Probiotics in Health and Disease: Looking at the Future submission deadline 30 Sep 2025 | 5 articles | Viewed by 8534 | Submission Open
Keywords: probiotics; live biotherapeutic product (LBP); next-generation probiotic (NGP); prebiotic; synbiotic/symbiotic; pharmabiotics; post-biotics; paraprobiotic/ghost probiotics/inactivated probiotics; probioceuticals/probiotaceuticals; biogenic; gut balance; gut– brain axis; vaginal homeostasis; vaginal microbiota modification or augmentation; oral microbiota; skin microbiota; new therapeutic approaches using bacteria; psychobiotics
(This special issue belongs to the Section Molecular Medicine)
Amyloid-Beta and Alzheimer’s Disease submission deadline 30 Sep 2025 | 6 articles | Viewed by 8101 | Submission Open
Keywords: Alzheimer's disease (AD); amyloid-beta (Aβ ); neurotoxicity of Aβ ; Tau protein; Aβ phagocytosis; Aβ clearance; autophagy– lysosome system; anti-Aβ monoclonal antibodies; neuroinflammation in AD; glial cells in AD
(This special issue belongs to the Section Cellular Biochemistry)
Recent Advances in the Role of Translation Machinery and Translational Control in the Cardiovascular System
edited by Peng Yao and
submission deadline 30 Sep 2025 | 3 articles | Viewed by 4788 | Submission Open
Keywords: translational control; translation machinery; RNA-binding protein; non-coding RNA
(This special issue belongs to the Section Molecular Medicine)
The Structure and Function of Neurotransmitter Receptors and Transporters: From Molecular Biology to Translational Research
edited by Riccardo Fesce
submission deadline 30 Sep 2025 | 1 articles | Viewed by 4251 | Submission Open
Keywords: neurotransmitters; receptors; neurotransporters; structure– function relationship; neuropharmacology
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
Health and Environmental Effect of Advanced Materials and Fine Particles: 2nd Edition
edited by
submission deadline 30 Sep 2025 | 1 articles | Viewed by 4217 | Submission Open
Keywords: advanced materials; fine particles; nanoparticles; nanomaterials; ultrafine particles; health effect; environmental effect; risk assessment; toxicity; exposure; biomaterials
(This special issue belongs to the Section Molecular Medicine)
Pathogenesis and Neuropathology of Alzheimer's Disease submission deadline 30 Sep 2025 | 3 articles | Viewed by 3778 | Submission Open
Keywords: Alzheimer disease; pathogenesis; neuropathology; diagnosis; neurodegenerative diseases; microRNA as diagnostic marker; the important modulatory action of DNA repair enzyme DNA-PKcs in synaptic plasticity
(This special issue belongs to the Section Molecular Medicine)
Oxidative Stress and Inflammation in Aging and Cancer: Biological Bases, Therapeutic Strategies and Opportunities
edited by
submission deadline 30 Sep 2025 | 1 articles | Viewed by 3139 | Submission Open
Keywords: ROS; inflammatory compounds; oxidative stress; chronic inflammation; aging; cancer; immunomodulation; antioxidant strategies; exercise; nutrition
(This special issue belongs to the Section Biological Factors)
Lipids Metabolism in Cardiovascular Disease
edited by Anand K. Rohatgi
submission deadline 30 Sep 2025 | 1 articles | Viewed by 2651 | Submission Open
Keywords: lipid; lipoprotein; vascular disease; therapy; atherosclerosis
(This special issue belongs to the Section Molecular Medicine)
Mitochondria and Central Nervous System Disorders: 3rd Edition submission deadline 30 Sep 2025 | 2 articles | Viewed by 2540 | Submission Open
Keywords: mitochondria; metabolism; neurodegeneration; neuroinflammation; ageing; central nervous system
(This special issue belongs to the Section Molecular Biology)
Redox Balance and Proteostasis Surveillance in Neurodegenerative Disorders submission deadline 30 Sep 2025 | 1 articles | Viewed by 2314 | Submission Open
Keywords: redox homeostasis; oxidative stress; antioxidant response; proteostasis; protein folding; protein oxidation; unfolded protein response; ubiquitin proteosome system; autophagy; neurodegeneration
(This special issue belongs to the Section Molecular Medicine)
Molecular Mechanisms and Therapeutic Targets in Leukaemia
edited by and
submission deadline 30 Sep 2025 | 1 articles | Viewed by 1317 | Submission Open
Keywords: leukaemia; blood; genetics; genomics; chromosome
(This special issue belongs to the Section Molecular Medicine)
Biomarkers of Cardiovascular and Cerebrovascular Diseases, 2nd Edition submission deadline 30 Sep 2025 | 3 articles | Viewed by 1248 | Submission Open
Keywords: biomarkers; cardiovascular disease; cerebrovascular disease; cardiovascular therapy; diagnosis
(This special issue belongs to the Section Molecular Biomarkers)
Experimental and Bioinformatic Approaches for Biomarker Discovery in Disease: From Molecular Mechanisms to Therapeutic Challenges submission deadline 30 Sep 2025 | 1 articles | Viewed by 1091 | Submission Open
Keywords: biomarker; molecular biology; bioinformatics
(This special issue belongs to the Section Bioinformatics and Systems Biology)
Recent Advances in Anti-Tumor Metal Complexes and Drug Delivery Systems: 2nd Edition
edited by Jasmina Dimitrić Marković, and
submission deadline 30 Sep 2025 | 1 articles | Viewed by 838 | Submission Open
Keywords: transition metal complexes; synthesis; structural characterization; biological activity; in silico methods; drug delivery
Stem Cells in Musculoskeletal Tissue Engineering
edited by and
submission deadline 30 Sep 2025 | 1 articles | Viewed by 796 | Submission Open
Keywords: tissue regeneration; stem cell; cell reporgramming; iPSCs
(This special issue belongs to the Section Bio-Engineered Materials)
Cellular Quiescence and Dormancy
edited by
submission deadline 30 Sep 2025 | 1 articles | Viewed by 763 | Submission Open
Keywords: quiescent cells; dormant cells; biostasis; diapause; spores; dauer larva
(This special issue belongs to the Section Molecular Genetics)
Breast Cancer: Molecular Pathology, Drug Resistance and Novel Treatment Strategies
edited by
submission deadline 30 Sep 2025 | Viewed by 467 | Submission Open
Keywords: breast cancer; mechanism of resistance; targeted therapy resistance; ER+; HER2; TNBC; tumor microenvironment; recurrence; metastasis; tumor evasion
(This special issue belongs to the Section Molecular Medicine)
State of the Art and Perspectives in Retinal Pigment Epithelium submission deadline 30 Sep 2025 | Viewed by 450 | Submission Open
Keywords: retinal pigment epithelium; innovative treatments/therapeutic approaches; retinal diseases; bioactive molecules; eye delivery strategy
(This special issue belongs to the Section Cellular Biochemistry)
Role of Postbiotics on Health Maintenance and Recovery
edited by
submission deadline 30 Sep 2025 | 1 articles | Viewed by 333 | Submission Open
Keywords: human microbiota; postbiotics; lantibiotics; SCFAs; SCFAs receptors; immune regulation; synbiotics; psychobiotics; dysbiosis; TMAO
(This special issue belongs to the Section Molecular Biology)
Mechanisms, Biology and Regulation of Proteasomes—in Memory of Professor Alfred L. Goldberg (1942–2023)
edited by and Alexander John Dear
submission deadline 30 Sep 2025 | Viewed by 245 | Submission Open
Keywords: proteasomes; ubiquitin; protease mechanisms; protease inhibitors; ATPases; muscle atrophy; antigen presentation
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
Identifying New Therapeutic Targets for Psychiatric Disease Using Transcriptomics and Epigenomics submission deadline 30 Sep 2025 | Viewed by 162 | Submission Open
Keywords: epigenomics; psychiatric disease; psychiatry; therapeutic target; transcriptomics
(This special issue belongs to the Section Molecular Genetics)
DNA Damage and Repair in Cancer Treatment submission deadline 30 Sep 2025 | Viewed by 149 | Submission Open
Keywords: ionizing radiation; DNA damage; DNA repair; genomic instability; patient radioprotection; tumour radiosensitization; radiation-induced carcinogenesis
(This special issue belongs to the Section Molecular Biology)
Omics in Entomology: Unraveling the Molecular Mechanisms of Insects submission deadline 30 Sep 2025 | Viewed by 122 | Submission Open
Keywords: entomology; medical entomology; forensic entomology; agricultural entomology; omics
(This special issue belongs to the Section Molecular Genetics)
Extracellular Vesicles and Their Roles in Cancer Progression submission deadline 30 Sep 2025 | Viewed by 82 | Submission Open
Keywords: extracellular vesicles; tumor microenvironment; biomolecule profiling; multi-omics; cancer biomarkers
(This special issue belongs to the Section Molecular Biology)
New Insights into Hormonal Control of Plant Growth and Development
edited by
submission deadline 30 Sep 2025 | Viewed by 55 | Submission Open
Keywords: plant hormones; auxins; cytokinin; gibberellins; ethylene; abscisic acid; jasmonic acid; salicylic acid; peptide hormones; growth and development
(This special issue belongs to the Section Molecular Biology)
Bionanomaterials: Synthesis, Characterization, Toxicity and Biomedical Applications, 3rd Edition submission deadline 30 Sep 2025 | Viewed by 53 | Submission Open
Keywords: nanoparticles; nano-alloys; graphene; nanotubes; hybrid nanomaterials; green synthesis; cytotoxicity; systemic toxicity; modulation of the biological impact; nanomaterials as diagnostic and therapeutic platforms; potential applications in medicine
(This special issue belongs to the Section Bio-Engineered Materials)
Epigenetic Regulation of Vascular Smooth Muscle Cells During Development and Disease submission deadline 30 Sep 2025 | Viewed by 52 | Submission Open
Keywords: vascular smooth muscle cells; cell phenotypic change; epigenetics; gene expression regulation; cell differentiation
(This special issue belongs to the Section Molecular Biology)
Cell Death and Clearance
edited by and Jascinta Santavanond
submission deadline 30 Sep 2025 | Viewed by 51 | Submission Open
Keywords: cell death; apoptosis; efferocytosis; cell clearance
(This special issue belongs to the Section Molecular Medicine)
Metabolic Syndrome and Type 2 Diabetes: From Molecular Pathogenesis to Novel Therapies
edited by
submission deadline 30 Sep 2025 | Viewed by 51 | Submission Open
Keywords: metabolic syndrome; type 2 diabetes; insulin resistance; molecular pathogenesis; novel therapies
(This special issue belongs to the Section Molecular Medicine)
T Cell Ca2+ Signal Dynamics: An Emerging Landscape for Therapeutic Strategies
edited by David W. Thomas and
submission deadline 30 Sep 2025 | Viewed by 48 | Submission Open
Keywords: T cell signaling; Ca signaling; TCR-activated signals; ER Ca release; ER Ca stores; store-operated Ca influx; ER Ca store depletion signals
(This special issue belongs to the Section Cellular Biochemistry)
Metallic Nanoparticles: Biosynthesis and Therapeutic Potential submission deadline 30 Sep 2025 | Viewed by 48 | Submission Open
Keywords: silver nanoparticle; antibacterial agent; green synthesis; therapeutics
(This special issue belongs to the Section Biological Factors)
Cellular Signaling and Cardiovascular Diseases: From NF-κB to Golgi Dynamics
edited by
submission deadline 30 Sep 2025 | Viewed by 47 | Submission Open
Keywords: cardiovascular diseases; NF-κ B signaling; vascular cells; epigenetic regulation; vascular inflammation; intercellular crosstalk; Golgi dynamics  
(This special issue belongs to the Section Cellular Biochemistry)
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