Signaling Pathway Regulation in Neuroblastoma Oncogenesis
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Molecular Cancer Biology".
Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 1751
Special Issue Editor
Interests: pediatric oncology; neuroblastoma; basic tumor biology research and translational studies; cancer metastasis and in particular the crosstalk between tumor and its microenvironment via exosomes
Special Issue Information
Dear Colleagues,
Despite overall progress in the treatment of children with high-risk neuroblastoma, 5-year survival remains below 50%. Indeed, most of these patients present metastatic disease at diagnosis and have a high rate of relapse. Thus, a deeper understanding of the deregulated signaling pathways and complex networks of cellular interactions in the tumor microenvironment is needed if the community is to develop more effective therapeutic strategies to cure children with high-risk neuroblastoma.
The dynamic interaction between different tumor cell populations and the tumor microenvironments, together with stromal and immune system components, can be mediated by the bi-directional release and uptake of secreted factors. This can modulate tumor initiation, drug resistance and progression, sustaining the malignant features of the tumor.
In this context, we invite studies that investigate the various aspects of signaling pathways in neuroblastoma, the interactions with tumor microenvironment, metastasis, and targeted therapeutic strategies in this field. In this Topic, both original research articles and reviews are welcome.
Dr. Angela Di Giannatale
Guest Editor
Manuscript Submission Information
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Keywords
- neuroblastoma
- signaling pathway
- tumor microenvironment
- crosstalk
- exosomes
- biomarkers
- targeted therapy
