Latest Research in Cartilaginous Neoplasms
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Molecular Cancer Biology".
Deadline for manuscript submissions: closed (15 September 2023) | Viewed by 3328
Special Issue Editor
Interests: understanding the role of developmentally important processes in repair and pathologies involving the musculoskeletal system; pathobiology of musculoskeletal tumors; bone and skin repair and the role of hematopoietic cells in regeneration, metabolism in musculoskeletal tumors, and the role of cellular heterogeneity in sarcomas
Special Issue Information
Dear Colleagues,
Cartilage tumors are the most common types of bone lesions, occurring in 5% of the population. They range from benign lesions, such an enchondromas and osteochondromas, to malignant chondrosarcomas. Benign cartilaginous lesions can progress to chondrosarcomas. Benign lesions can cause disabilities, due to pain, deformity, and joint dysfunction. There have been significant advances in our understanding of cartilage tumors in the past several years. The identification of the genetic mechanism that causes benign cartilage tumors, modeling these lesions in mice, and understanding how these mutations alter cell behavior have all identified possible new therapeutics. Next-generation sequencing identified novel genetic changes that are common in chondrosarcoma. New findings in epigenetics, metabolism, DNA repair, bioinformatics, and next-generation genetic analysis have identified new therapies, some of which have been translated to clinical trials. This Special Issue will cover many of these recent advances, identifying future directions for translational research.
Dr. Benjamin A. Alman
Guest Editor
Manuscript Submission Information
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Keywords
- enchondroma
- chondrosarcoma
- osteochondroma
- Ext
- IDH
- mouse models
- epigenetics
- metabolomics
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