Skin Cancers as a Paradigm Shift: From Pathobiology to Treatment
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".
Deadline for manuscript submissions: 30 August 2024 | Viewed by 14026
Special Issue Editors
Interests: keratinocyte skin cancer; minimally invasive treatment modalities
Interests: medical image analysis; machine learning; computer aided skin diagnostics; treatment evaluation
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues
We are pleased to announce this Special Issue in Cancers which has the scope to provide a comprehensive update on the current knowledge pertaining to skin cancers, as delineated by the title and the relevant aims.
It is well-established that in humans, compared to other body tissues and organs, most malignant and non-malignant neoplasms affect the skin and, in particular, the epidermis. Additionally, the development of malignant skin cancers is relatively slower and has a comparatively better prognosis than cancers of other tissue origins. Histogenetically, malignant skin neoplasms originate predominately from the permanently residing cells of the skin epithelium (keratinocytes, melanocytes, Merkel cells), and less commonly from the transiently cycling populations of Langerhans cells and lymphocytes, as well as from cellular components of the dermal and subdermal compartments of the skin, including the endothelia. On the other hand, ultraviolet radiation (UVR) is an established complete carcinogen for the skin, responsible for >90% of all skin cancers and with a particular impact on epidermal cancers. Notably, most skin carcinogenesis occurs in a spatially restricted tissue niche, the single cell layer of the basal epidermis, which, however, is expanded on the whole skin surface and is thus subjected to a significantly varying degree to the environmental carcinogen UVR during life. Thus, human skin neoplasms, particularly UVR-induced keratinocyte skin cancers, are a suitable model for studying two key dogmas of contemporary oncology: Multifocal carcinogenesis within cutaneous cancerization fields and multistage carcinogenesis. Furthermore, the relatively slow progression of the majority of the ensuing cutaneous pre-cancers and cancers, as well as the accessibility of the skin to medical interventions, emphasize the role of dermato-oncology as an ideal scientific and clinical area for the evaluation of emerging concepts of innovative non- to minimally invasive modalities for the diagnosis, treatment, and follow-up of cancer.
This Special Issue aims to:
- Update the current knowledge on the epidemiology and pathobiology of skin cancers;
- Address recent developments in the non-invasive imaging-based approaches to the diagnosis, treatment evaluation, and follow-up of skin cancer, also incorporating novel advents from the field of artificial intelligence;
- Investigate the potential of minimally invasive therapeutic modalities for treating selected types of skin neoplasms or addressing the specific treatment demands of certain patient populations.
In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following: epidemiology, pathobiology of skin cancer, minimally invasive diagnostics and treatment, artificial intelligence/machine learning in dermato-oncology, and therapeutic issues in selected populations (e.g., immunocompromised, older-old, etc.)
We look forward to receiving your contributions.
Dr. Ioannis D. Bassukas
Dr. Panagiota Spyridonos
Dr. Georgios Gaitanis
Guest Editors
Manuscript Submission Information
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Keywords
- skin cancer
- pathobiology
- diagnosis
- artificial intelligence
- machine learning
- treatment
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