Prostate-Specific Membrane Antigen (PSMA)
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".
Deadline for manuscript submissions: closed (10 December 2022) | Viewed by 51246
Special Issue Editor
Interests: PSMA Imaging and Therapy; Circulating Tumor Cells (CTC); Prostate Cancer
Special Issue Information
Dear Colleagues,
This Special Issue is about Prostate-Specific Membrane Antigen (PSMA), which has been the subject of a huge number of studies during the last 25 years. PSMA is a transmembrane protein, highly expressed by prostate epithelial cells and strongly upregulated in prostate cancer. PSMA expression levels are directly correlated to androgen independence, metastasis, and prostate cancer progression.
PSMA targeted imaging and therapy have significantly changed the management of patients with prostate cancer: Prospective studies could show the superiority of PSMA PET compared to conventional imaging modalities for the staging of prostate cancer. Moreover, within the last decades, different radiolabeled ligands have been used for therapy in Phase I and II studies with extremely promising response rates in end stage prostate cancer patients. Lately, one of those ligands has been under evaluation in a Phase III trial (VISION).
This special issue will highlight the importance of the radio targeted diagnostic and therapy in prostate cancer using PSMA ligands.
Prof. Kambiz Rahbar
Guest Editor
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Keywords
- PSMA
- PET
- Radioligand therapy
- CRPC
- CTC
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