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Chemosensors
Special Issues
Fluorescent Probe for Sensing and Bioimaging
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Fluorescent Probe for Sensing and Bioimaging

A special issue of Chemosensors (ISSN 2227-9040). This special issue belongs to the section "Optical Chemical Sensors".

Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 10562

Special Issue Editors

Prof. Dr. Lintao Zeng

E-Mail Website
Guest Editor
School of Light Industry and Food Engineering, Guangxi University, Nanning 530004, China
Interests: fluorescent probes; chemosensor; bio-imaging; organic functional materials
Prof. Dr. Minhuan Lan

E-Mail Website
Guest Editor
College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China
Interests: chemical sensing; biological imaging; photocatalytic
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Ever since the discovery of organic fluorescent compounds in the late nineteenth century, efforts have been made to “see” the behaviors of specific biomolecules in living systems by using these dyes as labels, and as a novel kind of promising fluorescent probes for high-performance sensors and bioimaging because of their strong luminescence, good photostability, and excellent biocompatibility.

Fluorescent probes with a highly sought reversible feature can provide a real-time monitor of the concentration dynamics (increases and decreases) of such chemical species, and thus are ideally suited to understand the physiological function. They have been developed rapidly due to their wide application in various fields.

This Special Issue will provide a forum for the latest research activities in the field of fluorescent/luminescent probe. Both review articles and original research papers are solicited in, though not limited to, the following areas:

  1. Fluorescent/luminescent probe for sensing or imaging;
  2. Emerging application of fluorescent/luminescent material;
  3. Fluorescence/colorimetric analysis;
  4. The mechanism research on the biomedical.

Prof. Dr. Lintao Zeng
Prof. Dr. Minhuan Lan
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Chemosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • fluorescent/luminescent probe
  • fluorescent sensors
  • bioimaging
  • fluorescent/luminescent material

Published Papers (6 papers)

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Research

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11 pages, 7222 KiB  
Article
A Red-Emitting Fluorescence Probe for Rapid Detecting Exogenous and Endogenous Peroxynitrite in Living Cells with High Sensitivity and Selectivity
by Bing Jin, Jing Liu, Longsheng Jin, Weishuai Liu and Xiangjun Liu
Chemosensors 2023, 11(11), 555; https://doi.org/10.3390/chemosensors11110555 - 06 Nov 2023
Viewed by 1351
Abstract
Peroxynitrite (ONOO−) has been revealed to play crucial roles in many physiological and pathological processes, and many diseases were proven to be associated with its misregulated production. The development of fluorescent probes meets the need for tracking ONOO− and gives [...] Read more.
Peroxynitrite (ONOO−) has been revealed to play crucial roles in many physiological and pathological processes, and many diseases were proven to be associated with its misregulated production. The development of fluorescent probes meets the need for tracking ONOO− and gives a better understanding of its diverse mechanisms. In this work, a red-emitting fluorescent probe BP-ONOO was synthesized via functionalization of the rhodol-like fluorophore with a reactive site of hydrazide. The probe BP-ONOO exhibited high sensitivity, excellent selectivity, and short response time (less than 4 s) towards ONOO− under neutral or weak alkaline conditions. These attractive properties favor its application in real-time imaging of ONOO− in living cells, and the probe has been successfully applied for imaging the concentration levels of ONOO− in RAW 264.7 macrophage cells under drug stimulation. Full article
(This article belongs to the Special Issue Fluorescent Probe for Sensing and Bioimaging)
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10 pages, 16821 KiB  
Communication
Ratiometric Fluorescence Probe Based on Deep-Red Emissive CdTe Quantum Dots and Eu3+ Hybrid for Oxytetracycline Detection
by Siyi Tan, Qin Wang, Qiuxia Tan, Shaojing Zhao, Lei Huang, Benhua Wang, Xiangzhi Song and Minhuan Lan
Chemosensors 2023, 11(1), 62; https://doi.org/10.3390/chemosensors11010062 - 13 Jan 2023
Cited by 4 | Viewed by 1616
Abstract
Oxytetracycline (OTC) is an environmental pollutant caused by the abuse of antibiotics, and its content in water is closely related to human health. Therefore, the development of a simple, rapid, and accurate method to detect OTC has become desirable. In this work, a [...] Read more.
Oxytetracycline (OTC) is an environmental pollutant caused by the abuse of antibiotics, and its content in water is closely related to human health. Therefore, the development of a simple, rapid, and accurate method to detect OTC has become desirable. In this work, a ratiometric fluorescence probe based on deep red emissive CdTe quantum dots (QDs) modified by mercaptopropionic acid and Eu3+ is developed to accurately and rapidly detect OTC in water. After the addition of OTC, the photoluminescence intensity of CdTe QDs at 698 nm remains almost unchanged, while the peak at 617 nm intensifies within 40 s due to the coordination of Eu3+ with OTC. An excellent linear relationship is present between the photoluminescence intensity ratio of I617/I698 and the concentration of OTC. The limit of detection of the probe towards OCT is 5.4 nM. In addition, the probe shows good selectivity and anti-interference ability for OTC in the presence of other antibiotics, including other antibiotics, ions, and amino acids. The probe has been successfully applied to detect OTC in actual samples, demonstrating its potential for environmental application. Full article
(This article belongs to the Special Issue Fluorescent Probe for Sensing and Bioimaging)
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19 pages, 6734 KiB  
Article
Unusual ‘Turn-on’ Ratiometric Response of Fluorescent Porphyrin-Pyrene Dyads to the Nitroaromatic Compounds
by Irina I. Shepeleva, Kirill P. Birin, Daria A. Polivanovskaia, Alexander G. Martynov, Alexander V. Shokurov, Aslan Yu. Tsivadze, Sofiya L. Selektor and Yulia G. Gorbunova
Chemosensors 2023, 11(1), 43; https://doi.org/10.3390/chemosensors11010043 - 03 Jan 2023
Cited by 2 | Viewed by 1859
Abstract
Detection of nitroaromatic compounds (NAC) is an important task since these substances are hazardous to both the biosphere and the society. Fluorescent sensors developed for NAC detection usually demonstrate a ‘turn-off’ response to the analyte, while ‘turn-on’ sensors are rarely reported. Here, we [...] Read more.
Detection of nitroaromatic compounds (NAC) is an important task since these substances are hazardous to both the biosphere and the society. Fluorescent sensors developed for NAC detection usually demonstrate a ‘turn-off’ response to the analyte, while ‘turn-on’ sensors are rarely reported. Here, we present a showcase report on new pyrene-imidazoporphyrin dyads that demonstrate an unusual analytic response to NAC with clear ‘turn-on’ behavior followed by an unexpected appearance of a new band, which can be ascribed to exciplex emission. The porphyrin backbone of the dyad also allows registration of its own fluorescence, providing an internal reference signal for ratiometric detection. The association constants in the order of 104 M−1 are reported. Full article
(This article belongs to the Special Issue Fluorescent Probe for Sensing and Bioimaging)
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11 pages, 2651 KiB  
Article
Umbelliferone-Based Fluorescent Probe for Selective Recognition of Hydrogen Sulfide and Its Bioimaging in Living Cells and Zebrafish
by Yuyu Fang, Fan Luo, Zhixing Cao, Cheng Peng and Wim Dehaen
Chemosensors 2022, 10(10), 427; https://doi.org/10.3390/chemosensors10100427 - 17 Oct 2022
Cited by 3 | Viewed by 1743
Abstract
Hydrogen sulfide (H2S) plays a crucial role in a variety of physiological and pathological processes, similar to other gaseous signaling molecules. The significant pathophysiological functions of H2S have sparked a great deal of interest in the creation of fluorescent [...] Read more.
Hydrogen sulfide (H2S) plays a crucial role in a variety of physiological and pathological processes, similar to other gaseous signaling molecules. The significant pathophysiological functions of H2S have sparked a great deal of interest in the creation of fluorescent probes for H2S monitoring and imaging. Using 3-cyanoumbelliferone as the push–pull fluorophore and a dinitrophenyl substituent as the response site, herein we developed a umbelliferone-based fluorescent probe 1 for H2S, which exhibited a remarkable turn-on fluorescence response with a low detection limit (79.8 nM), high sensitivity and selectivity. The H2S-sensing mechanism could be attributed to the cleavage of the ether bond between the dinitrophenyl group and the umbelliferone, leading to the recovery of an intermolecular charge transfer (ICT) process. Moreover, the probe had negligible cytotoxicity and good cell membrane permeability, which was successfully applied to image H2S in MCF-7 cells and zebrafish. Full article
(This article belongs to the Special Issue Fluorescent Probe for Sensing and Bioimaging)
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Review

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47 pages, 8839 KiB  
Review
The Art of Fluorescence Imaging with Chemical Sensors: The Next Decade 2012–2022
by Michael Schäferling and Vladimir Ondrus
Chemosensors 2024, 12(3), 31; https://doi.org/10.3390/chemosensors12030031 - 23 Feb 2024
Viewed by 1287
Abstract
Imaging methods by the means of optical sensors are applied in diverse scientific areas such as medical research and diagnostics, aerodynamics, environmental analysis, or marine research. After a general introduction to the field, this review is focused on works published between 2012 and [...] Read more.
Imaging methods by the means of optical sensors are applied in diverse scientific areas such as medical research and diagnostics, aerodynamics, environmental analysis, or marine research. After a general introduction to the field, this review is focused on works published between 2012 and 2022. The covered topics include planar sensors (optrodes), nanoprobes, and sensitive coatings. Advanced sensor materials combined with imaging technologies enable the visualization of parameters which exhibit no intrinsic color or fluorescence, such as oxygen, pH, CO2, H2O2, Ca2+, or temperature. The progress on the development of multiple sensors and methods for referenced signal read out is also highlighted, as is the recent progress in device design and application formats using model systems in the lab or methods for measurements’ in the field. Full article
(This article belongs to the Special Issue Fluorescent Probe for Sensing and Bioimaging)
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19 pages, 3197 KiB  
Review
Fluorescent Protein-Based Metal Biosensors
by Ki Hyun Nam
Chemosensors 2023, 11(4), 216; https://doi.org/10.3390/chemosensors11040216 - 30 Mar 2023
Cited by 2 | Viewed by 1999
Abstract
Fluorescent proteins (FPs) are optical probes that are used to track the functions of genetically encoded target molecules in molecular and cellular biology. FPs have intrinsic photophysical properties generated by the chromophore and its surrounding amino acid sequences. The intensity of the fluorescence [...] Read more.
Fluorescent proteins (FPs) are optical probes that are used to track the functions of genetically encoded target molecules in molecular and cellular biology. FPs have intrinsic photophysical properties generated by the chromophore and its surrounding amino acid sequences. The intensity of the fluorescence emission of FPs can be changed using external factors such as pH or metal ions. Additionally, the fluorescence intensity of FPs can be reduced or quenched using specific transition metal ions, suggesting that they are attractive probes for measuring metal ion levels. A spectroscopical analysis of the metal-induced fluorescence quenching of several FPs revealed that they exhibited intrinsic fluorescence quenching behavior with specific metal ions. The quenchable metal-binding site of FP has been determined using chemical modification, crystal structure, and modeling, providing insights into the molecular mechanism and FP engineering. In this review, studies on the change in the fluorescence activity of FPs mediated by metal ions are comprehensively compared and reviewed, and the requirements for the development of fluorescent protein-based metal biosensors in the future are discussed. Full article
(This article belongs to the Special Issue Fluorescent Probe for Sensing and Bioimaging)
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