Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
4.7
3.0
Journals
Diagnostics
Special Issues
Advances in Oral Diseases Diagnosis and Management: 2nd Edition
share announcement

Advances in Oral Diseases Diagnosis and Management: 2nd Edition

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: closed (31 March 2025) | Viewed by 11597

Special Issue Editors

Dr. Dimitris Tatsis

E-Mail Website
Guest Editor
Fourth Surgical Department, Faculty of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece
Interests: oral pathology; oral implantology; oral diseases; maxillofacial surgery; implant dentistry
Special Issues, Collections and Topics in MDPI journals
Dr. Konstantinos Paraskevopoulos

E-Mail Website
Guest Editor
Department of Oral and Maxillofacial Surgery, Specialized Cancer Treatment and Reconstruction Centre, General Hospital "George Papanikolaou", Aristotle University of Thessaloniki, Thessaloniki, Greece
Interests: oral and maxillofacial surgery; surgical oncology; neck; cancer therapy; head and neck surgery; cancer diagnostics; oral cancer; oncology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Globally, oral diseases pose a serious threat to public health because they affect people of all ages and place a heavy strain on healthcare systems. Oral potentially malignant disorders, oral cancer, autoimmune diseases, and various infections of the oral cavity are among these conditions. To avoid problems and enhance patient outcomes, oral disease diagnosis and care are crucial.

The field of oral illness detection and management has undergone a revolution due to the emergence of new technologies and diagnostic techniques. These developments have resulted in the discovery of new risk factors and biomarkers for oral disorders, enhanced imaging methods, and the creation of more efficient and individualised treatment modalities.

The enormous impact that oral diseases can have on a person's quality of life serves as a reminder of the significance of early detection and treatment of oral diseases. A person's ability to eat, speak, and interact socially can be hampered by poor oral health, which can also cause pain, discomfort, and embarrassment. Moreover, systemic health issues including cardiovascular disease, diabetes, and respiratory infections can all be impacted by dental illnesses.

Advances in the diagnosis and treatment of oral disorders aim to increase the precision and efficacy of diagnosis, prevent and control oral diseases, and lessen their negative effects on patients' general health and wellbeing. The area of oral health is becoming more interdisciplinary with the development of new instruments and methods, including the components of molecular biology, genetics, and microbiology, among others. Additionally, there is a growing emphasis on patient-centred care, recognizing the unique needs and preferences of each individual. In summary, advances in oral disease diagnosis and management are critical for improving oral and overall health outcomes, reducing healthcare costs, and enhancing quality of life.

Dr. Dimitris Tatsis
Dr. Konstantinos Paraskevopoulos
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • oral potentially malignant disorders
  • oral cancer
  • oral infections
  • auto-immune disorders
  • temporomandibular joint disorders
  • osteomyelitis
  • medication-related osteonecrosis of the jaws

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (11 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review, Other

22 pages, 1313 KiB  
Article
Mucoscopic Features of Oral Lichen Planus: A Retrospective Comparative Study with Inflammatory Mimickers
by Mihaela Paula Toader, Oana Mihaela Condurache Hritcu, Cristina Colac Botoc, Antonia Elena Hutanu, Catalina Anca Munteanu, Roxana Paraschiva Ciobanu, Stefan Vasile Toader, Alin Gabriel Colac, Victor Vlad Costan, Elena Porumb Andrese and Daciana Elena Branisteanu
Diagnostics 2025, 15(9), 1084; https://doi.org/10.3390/diagnostics15091084 - 24 Apr 2025
Abstract
Background/Objectives: Oral lichen planus (OLP) is a chronic inflammatory mucocutaneous disorder with a recognized potential for malignant transformation. While histopathological examination remains the diagnostic gold standard, mucoscopy has emerged as a valuable non-invasive tool for assessing striae patterns, vascular features, and pigmentary [...] Read more.
Background/Objectives: Oral lichen planus (OLP) is a chronic inflammatory mucocutaneous disorder with a recognized potential for malignant transformation. While histopathological examination remains the diagnostic gold standard, mucoscopy has emerged as a valuable non-invasive tool for assessing striae patterns, vascular features, and pigmentary alterations. This study aimed to evaluate the mucoscopic characteristics of OLP across different oral mucosal sites and to compare them with other inflammatory oral conditions, assessing their diagnostic relevance. Methods: A retrospective comparative study was conducted on 106 patients, including 33 with histopathologically confirmed OLP and 73 with other inflammatory oral conditions (pemphigus vulgaris, chronic cheilitis, hyperplastic oral candidiasis, leukoplakia, squamous cell carcinoma, pachyonychia congenita, morsicatio buccarum). Mucoscopic evaluation focused on the buccal mucosa, vermilion, and lingual mucosa. Features assessed included background color, white striae patterns, vascular morphology, the presence of erosions, and other features like blunting of the lingual papillae and scales on the vermilion. Statistical analysis was carried out using SPSS 29.0. Results: Reticular striae were highly specific to OLP, particularly on the buccal mucosa (90.9%, p < 0.001). Leukoplakia-like lesions were most prevalent on the lingual mucosa and significantly associated with dotted (p = 0.027) and looped vessels (p = 0.002). Erosions correlated significantly with both dotted (p < 0.001) and linear vessels (p = 0.011), especially in lingual and vermilion lesions. In comparison, control group lesions displayed significantly more globular structures (p < 0.001), veil-like patterns (p < 0.001), and diffuse vascular distributions (p = 0.018), particularly in cheilitis and candidiasis cases. Conclusions: Mucoscopy reveals distinct site-specific patterns in OLP, supporting its role as a non-invasive diagnostic aid. Comparative analysis highlights its utility in differentiating OLP from other inflammatory oral conditions and in identifying lesions with features suggestive of malignant potential. These findings support the integration of mucoscopy into routine clinical practice and warrant further validation through larger, prospective studies. Full article
(This article belongs to the Special Issue Advances in Oral Diseases Diagnosis and Management: 2nd Edition)
10 pages, 1395 KiB  
Article
Discrepancy in the Histological Diagnoses of Oral Lichen Planus Based on WHO Criteria Versus the Newly Proposed Diagnostic Set of the American Academy of Oral and Maxillofacial Pathology
by Maria Zaharieva Mutafchieva and Desislava Atanasova Tashkova
Diagnostics 2025, 15(5), 558; https://doi.org/10.3390/diagnostics15050558 - 26 Feb 2025
Viewed by 1568
Abstract
Background/Objectives: The diagnosis of oral lichen planus (OLP) is challenging because many other oral diseases demonstrate similar clinical and microscopic features. Clinicopathological discrepancy and inter- and intraobserver variability in the histological assessment of OLP have been shown in the literature, as there [...] Read more.
Background/Objectives: The diagnosis of oral lichen planus (OLP) is challenging because many other oral diseases demonstrate similar clinical and microscopic features. Clinicopathological discrepancy and inter- and intraobserver variability in the histological assessment of OLP have been shown in the literature, as there are no unified diagnostic criteria for the disease. In 2016, the American Academy of Oral and Maxillofacial Pathology (AAOMP) proposed a new diagnostic set for OLP. The aim of the study was to assess the reliability of the AAOMP histological criteria in diagnosing OLP. Methods: In this retrospective study, 34 histological sections, once diagnosed as OLP, were revised by a second pathologist using the WHO criteria. Then, all specimens were analyzed for the presence (P) or absence (A) of the criteria listed in the AAOMP diagnostic set. The reproducibility of the histological diagnosis of OLP when applying the different sets of diagnostic criteria was assessed. Results: From the AAOMP diagnostic criteria, hydropic degeneration was found in 35.2%, lymphocytic exocytosis in 32.3%, mild epithelial dysplasia in 2.9%, verrucous epithelial architectural change in 0% and band-like lymphocytic infiltrate, confined to the epithelium-lamina propria interface in 55.8% of the samples. Reproducibility of the histological diagnosis of OLP was achieved in only 19.3% of the cases when applying the 1978 WHO criteria versus the newly proposed AAOMP criteria. Conclusions: A large number of OLP cases failed to meet the AAOMP histological criteria in the present study. Further studies are needed to assess the validity of the proposed diagnostic set. Full article
(This article belongs to the Special Issue Advances in Oral Diseases Diagnosis and Management: 2nd Edition)
►▼ Show Figures

Figure 1

10 pages, 269 KiB  
Article
Comparative Clinical and Histopathological Study of Oral Leukoplakia in Smokers and Non-Smokers
by Andrei-Eduard Șerban, Ioanina Părlătescu, Elena Milanesi, Iulia Andreea Pelisenco, Maria Dobre, Mariana Costache, Șerban Țovaru and Paula Perlea
Diagnostics 2025, 15(4), 502; https://doi.org/10.3390/diagnostics15040502 - 19 Feb 2025
Viewed by 382
Abstract
Background/Objectives: Oral leukoplakia (OLK) is an oral mucosal lesion classified in the oral potentially malignant disorder group and is associated with an increased risk of malignant transformation (MT). The aim of this study was to compare the clinical and histopathological features of two [...] Read more.
Background/Objectives: Oral leukoplakia (OLK) is an oral mucosal lesion classified in the oral potentially malignant disorder group and is associated with an increased risk of malignant transformation (MT). The aim of this study was to compare the clinical and histopathological features of two OLK groups, a group of smokers and a group of non-smokers. Methods: In this retrospective study, a cohort of 154 patients with OLK was divided into two groups based on the presence of smoking as a major risk factor. OLK diagnoses were established via clinical and histopathological examination. Results: Females were more abundant in the non-smoking group than in the smoking group, where males were more abundant (p < 0.001). The average age of the smokers was lower than that of the non-smokers (p = 0.003). In the smokers, the buccal mucosa was most frequently affected, while in the non-smokers, the gums and the tongue were primarily involved (p = 0.016). In female smokers, involvement of the buccal area and multiple-site involvement were statistically significantly more frequently observed compared to that in female non-smokers (p = 0.006). Non-dysplastic lesions were predominant in both groups, with severe dysplasia observed more frequently in the non-smokers than in the smokers. MT was higher in the non-smoker group compared to that in the smoker group. Conclusions: OLK in smokers is different from OLK in non-smokers concerning female gender involvement, site location, the number of lesions, and the MT rate. Full article
(This article belongs to the Special Issue Advances in Oral Diseases Diagnosis and Management: 2nd Edition)
13 pages, 2191 KiB  
Article
Assessment of a Bioimpedance-Based Method for the Diagnosis of Oral Cancer
by Kristina Horvat Šikonja, Ivica Richter, Marko Velimir Grgić, Krešimir Gršić, Dinko Leović, Lovorka Batelja Vuletić and Vlaho Brailo
Diagnostics 2024, 14(24), 2894; https://doi.org/10.3390/diagnostics14242894 - 23 Dec 2024
Viewed by 753
Abstract
Background/Objectives: Oral cancer (OC) is a disease with poor prognosis mainly due to late diagnosis. There is considerable interest in the use and development of rapid, point of care (POC) non-invasive methods that can accelerate the diagnostic process. Bioimpedance (BI) is resistance to [...] Read more.
Background/Objectives: Oral cancer (OC) is a disease with poor prognosis mainly due to late diagnosis. There is considerable interest in the use and development of rapid, point of care (POC) non-invasive methods that can accelerate the diagnostic process. Bioimpedance (BI) is resistance to the passage of electric currents through tissue that reflects structural changes in the tissue. The aim of this study was to determine the spectrum of BI values in patients with oral cancer, to compare them with other oral lesions and healthy controls, and to determine the diagnostic value of the BI-based method for diagnosis of OC. Methods: Ninety-three participants divided into three groups participated in this study. The first group (31 participants) consisted of patients with histologically confirmed OC, the second group (31 participants) consisted of patients with an active reticular form of oral lichen planus (positive controls; OLP) and the third group (31 participants) consisted of healthy controls. In OC and OLP patients, BI was measured at three points (non-ulcerated lesional mucosa, clinically unaffected perilesional mucosa and unaffected mucosa on the contralateral side). In healthy controls, BI was measured on a healthy mucosa in the corresponding anatomical region. Measurements were performed at nine frequencies (1, 2, 5, 7, 10, 20, 70 and 100 kHz). Results: In OC patients, BI values in the lesion were significantly lower than BI values in clinically intact perilesional mucosa and the unaffected contralateral side at all frequencies. Furthermore, BI values of the clinically intact perilesional mucosa were significantly lower than the BI values of the healthy contralateral mucosa at frequencies of 1 kHz, 2 kHz, 5 kHz, 7 kHz and 10 kHz. Patients with OC had significantly lower BI values compared to patients with OLP and individuals with healthy oral mucosa at all frequencies. Conclusions: This study demonstrated the very good to excellent ability of this method to detect OC lesions, which needs to be confirmed by further studies on a larger number of participants. Full article
(This article belongs to the Special Issue Advances in Oral Diseases Diagnosis and Management: 2nd Edition)
►▼ Show Figures

Figure 1

11 pages, 1613 KiB  
Article
Quantitative Evaluation of Enamel Thickness in Maxillary Central Incisors in Different Age Groups Utilizing Cone Beam Computed Tomography a Retrospective Analysis
by Kinga Mária Jánosi, Diana Cerghizan, Izabella Éva Mureșan, Alpár Kovács, Andrea Szász, Emese Rita Markovics, Krisztina Ildikó Mártha and Silvia Izabella Pop
Diagnostics 2024, 14(22), 2518; https://doi.org/10.3390/diagnostics14222518 - 11 Nov 2024
Viewed by 944
Abstract
Background/Objectives: The presence of enamel on the tooth surface is crucial for the long-term success of minimally invasive adhesive restorations such as dental veneers. Our study aims to evaluate the enamel thickness in the incisal, middle, and cervical portions of the labial surface [...] Read more.
Background/Objectives: The presence of enamel on the tooth surface is crucial for the long-term success of minimally invasive adhesive restorations such as dental veneers. Our study aims to evaluate the enamel thickness in the incisal, middle, and cervical portions of the labial surface of the upper central incisors using cone beam computed tomography (CBCT). This imaging method provides detailed and accurate three-dimensional images with a low radiation dose, allowing an accurate assessment of enamel thickness. The analysis aims to identify variations in enamel thickness depending on the age and different levels of the labial tooth surface. Methods: 800 CBCT scans performed for diagnostic or therapeutic purposes on patients aged 18–60 years were analyzed. The data were gathered from the imaging archives of private practitioners from Targu Mures and the “George Emil Palade” University of Medicine, Pharmacy, Science, and Technology of Targu Mures. Enamel thickness measurements were conducted using the OnDemand3D Communicator CBCT evaluation program, with subsequent statistical analysis performed using GraphPad Instat Prism software. Results: Results showed significant variation in enamel thickness between the incisal, middle, and cervical segments of the labial surface of the upper central incisors. A decrease in enamel thickness with age has been observed. In patients aged 18–40, mean values of enamel thickness 1 mm and 3 mm above the cementoenamel junction (CEJ) were 0.48 ± 0.092, respectively, 0.819 ± 0.158. In patients over 40, the mean values were 0.454 ± 0.116 and 0.751 ± 0.067 at 1 mm, respectively, 3 mm above the CEJ. Statistically significant differences were found between the two age groups at 1 mm and 3 mm above the CEJ, with p < 0.0001 and p = 0.0214. Conclusions: A statistically significant decrease can be observed in enamel thickness in almost the entire labial surface of the upper central incisors with aging. The varied thickness of the enamel at different tooth levels requires individualized planning for each patient to maximize the long-term aesthetic and functional results. Full article
(This article belongs to the Special Issue Advances in Oral Diseases Diagnosis and Management: 2nd Edition)
►▼ Show Figures

Figure 1

14 pages, 2313 KiB  
Article
Application of Targeted Optical Coherence Tomography in Oral Cancer: A Cross-Sectional Preliminary Study
by Vera Panzarella, Fortunato Buttacavoli, Vito Rodolico, Laura Maniscalco, Alberto Firenze, Viviana De Caro, Rodolfo Mauceri, Simona E. Rombo and Giuseppina Campisi
Diagnostics 2024, 14(19), 2247; https://doi.org/10.3390/diagnostics14192247 - 9 Oct 2024
Viewed by 1363
Abstract
Background/Objectives: The diagnosis of oral potentially malignant disorders (OPMDs) and oral squamous cell carcinoma (OSCC) represent a significant challenge in oral medicine. Optical coherence tomography (OCT) shows promise for evaluating oral tissue microstructure but lacks standardized diagnostic protocols tailored to the structural variability [...] Read more.
Background/Objectives: The diagnosis of oral potentially malignant disorders (OPMDs) and oral squamous cell carcinoma (OSCC) represent a significant challenge in oral medicine. Optical coherence tomography (OCT) shows promise for evaluating oral tissue microstructure but lacks standardized diagnostic protocols tailored to the structural variability and lesions of oral mucosa. Methods: This cross-sectional observational study aims to evaluate the diagnostic accuracy of targeted biopsy-based and site-coded OCT protocols for common OPMDs and OSCC. Adult patients clinically diagnosed with OPMDs, including oral leukoplakia (OL), oral lichen planus (OLP), and OSCC were enrolled. Clinical and OCT evaluation before and after punch scalpel-site registration preceding diagnostic biopsy on the target site was performed. Blinded observers analyzed the OCT scans for OCT-based diagnoses. Sensitivity, specificity, and diagnostic accuracy for OCT evaluations before and after punch scalpel-site registration were statistically compared with histological findings. Results: A dataset of 2520 OCT scans and 210 selected images from 21 patients was obtained. Sensitivity and specificity post-target site registration were high for OSCC (98.57%, 100.00%), OL (98.57%, 98.57%), and OLP (97.14%, 98.57%). The positive predictive values ranged from 97.14% to 100.00%, while negative predictive values ranged from 98.57% to 99.29%. Inter-observer agreements were strong for OSCC (0.84) and moderate for OL (0.54) and OLP (0.47–0.49). Targeted OCT scans significantly improved diagnostic accuracy for all conditions (p < 0.001). Conclusions: This preliminary study supports using site-targeted OCT scans followed by a site-targeted punch biopsy, enhancing precision in oral diagnostics. This approach is foundational for developing pioneering automated algorithms guiding oral cancer and pre-cancer diagnosis via OCT imaging. Full article
(This article belongs to the Special Issue Advances in Oral Diseases Diagnosis and Management: 2nd Edition)
►▼ Show Figures

Figure 1

12 pages, 1982 KiB  
Article
Influencing Factors Regarding the Severity of Peri-Implantitis and Peri-Implant Mucositis
by Csilla Benedek, Bernadette Kerekes-Máthé, Liana Bereșescu, Imola Zsuzsa Buka, Zsuzsanna Bardocz-Veres, Ildikó Geréb, Krisztina Ildikó Mártha and Kinga Mária Jánosi
Diagnostics 2024, 14(14), 1573; https://doi.org/10.3390/diagnostics14141573 - 19 Jul 2024
Cited by 3 | Viewed by 1837
Abstract
The scientific literature is increasingly focused on peri-implant mucositis and peri-implantitis, which are biological outcomes of dental implant treatment. Background/Objectives: The present study aimed to evaluate the two most critical complications of dental implantation, peri-implant mucositis and peri-implantitis, through the prism of different [...] Read more.
The scientific literature is increasingly focused on peri-implant mucositis and peri-implantitis, which are biological outcomes of dental implant treatment. Background/Objectives: The present study aimed to evaluate the two most critical complications of dental implantation, peri-implant mucositis and peri-implantitis, through the prism of different influencing factors. Methods: We followed 40 patients, with a total number of 92 dental implants, divided into three age groups: under 35 years, between 35 and 55 years, and older than 55 years. Patients were also divided into groups according to the time since implant placement: 1–3 years, 4–7 years, and more than 7 years. The patients were examined, and periodontal pocket depth, peri-implant pocket depth, Löe–Silness gingival index, mucosal thickness, and keratinized mucosal width were recorded; bone resorption was measured on radiographs using a 2D image analysis method; and a questionnaire was also conducted. Results: Bone resorption was highest in the 35–55 age group (3.09 ± 0.04 mm) and for implants placed 4–7 years ago (3.39 ± 0.12 mm). Females had a mean bone resorption of 3.4 ± 0.15 mm and males of 2.45 ± 0.07 mm. Statistically, there was a significant difference only in the Löe–Silness index: the 35–55 age group had the highest values (p = 0.04). Conclusions: There were no statistically significant differences between the time since implant placement and the degree of bone resorption, nor between sexes. Peri-implant inflammation may occur at any age, regardless of the lifetime of the implants. Full article
(This article belongs to the Special Issue Advances in Oral Diseases Diagnosis and Management: 2nd Edition)
►▼ Show Figures

Figure 1

Review

Jump to: Research, Other

12 pages, 209 KiB  
Review
Prognosis, Controversies and Assessment of Bone Erosion or Invasion of Oral Squamous Cell Carcinoma
by Ahmed Ata Alfurhud
Diagnostics 2025, 15(1), 104; https://doi.org/10.3390/diagnostics15010104 - 4 Jan 2025
Viewed by 883
Abstract
Objectives: To discuss the prognostic outcomes, controversies and assessment of bone erosion or invasion of oral squamous cell carcinoma (OSCC). Methods: A structured literature review was conducted to critically analyse relevant evidence. The Web of Science database was searched using specific keywords [...] Read more.
Objectives: To discuss the prognostic outcomes, controversies and assessment of bone erosion or invasion of oral squamous cell carcinoma (OSCC). Methods: A structured literature review was conducted to critically analyse relevant evidence. The Web of Science database was searched using specific keywords aligned with the review question. After identifying initial studies, their references were also reviewed to include any additional relevant publications, ensuring a comprehensive evaluation of the available evidence. Results: The search identified 11 relevant studies, including 5 from the initial search and 6 from reference review. The significance of bone involvement is unclear in OSCC, with varying definitions of cortical bone erosion and medullary bone infiltration contributing to conflicting results regarding the prognostic significance of bone involvement. The majority of evidence stems from retrospective cohort studies without clear study criteria and a lack of power to draw valid conclusions. Conclusions: There are currently a lack of high-quality studies assessing bone invasion in OSCC. While there appears to be some evidence that medullary bone infiltration is prognostic, further well-designed studies are warranted. Full article
(This article belongs to the Special Issue Advances in Oral Diseases Diagnosis and Management: 2nd Edition)
14 pages, 2602 KiB  
Review
Clinical and Morphological Aspects of Aggressive Salivary Gland Mixed Tumors: A Narrative Review
by Alexandra Corina Faur, Alina Maria Șișu, Laura Andreea Ghenciu, Roxana Iacob, Emil Robert Stoicescu, Ovidiu Alin Hațegan and Mărioara Cornianu
Diagnostics 2024, 14(17), 1942; https://doi.org/10.3390/diagnostics14171942 - 3 Sep 2024
Viewed by 1406
Abstract
Salivary gland tumors are a rare and heterogeneous group of neoplasms of the head and neck region. The mixed category of these tumors include the following entities: pleomorphic adenoma (PA), carcinoma ex pleomorphic adenoma (CEPA), salivary carcinosarcoma (CS), and metastasizing PA (MPA). The [...] Read more.
Salivary gland tumors are a rare and heterogeneous group of neoplasms of the head and neck region. The mixed category of these tumors include the following entities: pleomorphic adenoma (PA), carcinoma ex pleomorphic adenoma (CEPA), salivary carcinosarcoma (CS), and metastasizing PA (MPA). The most common benign tumor of the salivary glands is PA. Metastasis and malignant degeneration have been reported in cases of PA of a salivary gland origin. Judging by their behavior, MPA, CEPA, and CS can be considered aggressive tumors. Invasive CEPA has been identified in the parotid gland more frequently. MPA and CS cases reported in the current literature are rare. In this paper, we present, narratively, the clinico-morphological features of this group of mixed tumors. Full article
(This article belongs to the Special Issue Advances in Oral Diseases Diagnosis and Management: 2nd Edition)
►▼ Show Figures

Figure 1

Other

Jump to: Research, Review

14 pages, 1058 KiB  
Systematic Review
Metabolomics Applications for Diagnosing Peri-Implantitis: A Systematic Review of In Vivo Studies
by Ana-Maria Condor, Andreea Kui, Daniela Cornelia Condor, Marius Negucioiu, Smaranda Dana Buduru and Patricia Ondine Lucaciu
Diagnostics 2025, 15(8), 990; https://doi.org/10.3390/diagnostics15080990 - 14 Apr 2025
Viewed by 299
Abstract
Background/Objectives: Peri-implantitis is a prevalent inflammatory condition affecting dental implants, leading to increased treatment costs, patient dissatisfaction, and potential implant failure. Novel biomarker-based approaches may contribute to early detection, thereby decreasing the burden of the disease. The aim of this review was [...] Read more.
Background/Objectives: Peri-implantitis is a prevalent inflammatory condition affecting dental implants, leading to increased treatment costs, patient dissatisfaction, and potential implant failure. Novel biomarker-based approaches may contribute to early detection, thereby decreasing the burden of the disease. The aim of this review was to assess in vivo studies using metabolomics to identify the metabolic profiles and potential biomarkers of peri-implantitis. Methods: The protocol for this study was registered with PROSPERO (CRD42025634865). Five databases and grey literature sources (PubMed, Scopus, Web of Science, ProQuest, and Google Scholar) were searched using keywords related to metabolomics and peri-implantitis. Studies were selected by independent, inter-calibrated researchers. Data were extracted using predefined, custom forms. The risk of bias was assessed using the ROBINS-I tool. Results: An electronic literature search retrieved 543 articles, of which five were selected. All studies were published within the last five years of the search. All but one study used untargeted metabolomics, and all studies identified metabolites associated with peri-implantitis or distinct metabolomic profiles of peri-implantitis. SCFAs and lysine metabolites were recurring in the results, confirming the findings of previous metabolomic studies on periodontal disease. Conclusions: Metabolomics has not been widely used to study peri-implantitis. Evidence from existing studies confirms the findings of metabolomics studies on periodontitis. Several metabolites related to PI are associated with immune response, tissue degradation, and cellular energy pathways. Integrating -omics technologies into peri-implantitis diagnosis may facilitate biomarker discovery and improve early detection strategies. Full article
(This article belongs to the Special Issue Advances in Oral Diseases Diagnosis and Management: 2nd Edition)
►▼ Show Figures

Figure 1

4 pages, 2330 KiB  
Interesting Images
Extensive Synovial Chondromatosis of the Temporomandibular Joint Extending to the Cranial Base
by Chi-Heon Sung, Seo-Young An, Hae-Seo Park, Wonae Lee and Moon-Young Kim
Diagnostics 2024, 14(20), 2311; https://doi.org/10.3390/diagnostics14202311 - 17 Oct 2024
Viewed by 957
Abstract
A 42-year-old male presented to the Department of Oral and Maxillofacial Surgery with the chief complaint of pain and stiffness in the right temporomandibular joint (TMJ). The patient’s height was 174 cm and his body weight was 65 kg. The patient’s occupation was [...] Read more.
A 42-year-old male presented to the Department of Oral and Maxillofacial Surgery with the chief complaint of pain and stiffness in the right temporomandibular joint (TMJ). The patient’s height was 174 cm and his body weight was 65 kg. The patient’s occupation was heavy equipment operator. According to the patient, the pain had initiated a week prior to his first visit and was exacerbated during mastication. Evaluation of the range of motion revealed extensive crepitus along the right TMJ. The active and passive range of motion were measured at 45 mm and 42 mm, respectively, indicating adequate mouth-opening capacity. Occlusion was also favorable, and no other clinical symptoms were shown intraorally. Full article
(This article belongs to the Special Issue Advances in Oral Diseases Diagnosis and Management: 2nd Edition)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-11
Back to TopTop