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Drug Treatment for Bacterial Infections
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Drug Treatment for Bacterial Infections

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".

Deadline for manuscript submissions: 31 July 2024 | Viewed by 1521

Special Issue Editor

Prof. Dr. Janusz Madaj

E-Mail Website
Guest Editor
Department of Organic Chemistry, Faculty of Chemistry, University of Gdańsk, Gdańsk, Poland
Interests: carbohydrates; synthesis and analysis of sugar derivatives; vancomycin and its derivatives; sugar hydrazides; cationic sugar compounds; biological activity of sugar derivatives

Special Issue Information

Dear Colleagues,

Bacterial infections, next to viral and fungal infections, are a major threat, especially to human health. Thanks to their ability to mutate, they can quickly create new strains that are resistant to the antibiotics used, which is a significant challenge in the treatment of infections caused by them. Pharmacological treatment of bacterial infections therefore requires the right approach. On the one hand, drug therapy should be conducted responsibly to reduce the risk of drug resistance. On the other hand, it is still necessary to search for new substances that will prove to be more effective and less toxic than the currently used antibiotics. Interesting results in the treatment of bacterial infections are also brought by the use of combination drugs containing more than one active substance.

The possibility of using targeted therapy to treat inflammatory foci is extremely interesting. New forms of drugs that allow the release of the drug substance at the site of infection would allow for a reduction in the dose of the drug and its more effective action.

All new research and review articles on drug therapy for bacterial infections, from new uses of approved drugs, to new drug substances and combination drugs, and further to new drug formulations, are welcome in this Special Issue.

Prof. Dr. Janusz Madaj
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bacterial infection
  • antibiotic-resistant bacteria
  • new agents in the treatment of bacterial infections
  • optimization of the use of already registered drugs
  • single antibacterial agents
  • combined antibacterial agents
  • new drug forms

Published Papers (2 papers)

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Research

15 pages, 1410 KiB  
Article
Oxolane Ammonium Salts (Muscarine-Like)—Synthesis and Microbiological Activity
by Patrycja Bogdanowicz, Janusz Madaj, Piotr Szweda, Artur Sikorski, Justyna Samaszko-Fiertek and Barbara Dmochowska
Int. J. Mol. Sci. 2024, 25(4), 2368; https://doi.org/10.3390/ijms25042368 - 17 Feb 2024
Viewed by 587
Abstract
Commercially available 2-deoxy-D-ribose was used to synthesize the appropriate oxolane derivative—(2R,3S)-2-(hydroxymethyl)oxolan-3-ol—by reduction and dehydration/cyclization in an acidic aqueous solution. Its monotosyl derivative, as a result of the quaternization reaction, allowed us to obtain eight new muscarine-type derivatives containing a [...] Read more.
Commercially available 2-deoxy-D-ribose was used to synthesize the appropriate oxolane derivative—(2R,3S)-2-(hydroxymethyl)oxolan-3-ol—by reduction and dehydration/cyclization in an acidic aqueous solution. Its monotosyl derivative, as a result of the quaternization reaction, allowed us to obtain eight new muscarine-type derivatives containing a quaternary nitrogen atom and a hydroxyl group linked to the oxolane ring. Their structure was fully confirmed by the results of NMR, MS and IR analyses. The crystal structure of the pyridinium derivative showed a high similarity of the conformation of the oxolane ring to previously published crystal structures of muscarine. Two reference strains of Gram-negative bacteria (Escherichia coli ATCC 25922 and Pseudomonas aeruginosa ATCC 27853), two reference strains of Gram-positive staphylococci (Staphylococcus aureus ATCC 25923 and Staphylococcus aureus ATCC 29213) and four reference strains of pathogenic yeasts of the genus Candida spp. (Candida albicans SC5314, Candida glabrata DSM 11226, Candida krusei DSM 6128 and Candida parapsilosis DSM 5784) were selected for the evaluation of the antimicrobial potential of the synthesized compounds. The derivative containing the longest (decyl) chain attached to the quaternary nitrogen atom turned out to be the most active. Full article
(This article belongs to the Special Issue Drug Treatment for Bacterial Infections)
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18 pages, 3687 KiB  
Article
Radiosynthesis and Bioevaluation of 99mTc-Labeled Isocyanide Ubiquicidin 29-41 Derivatives as Potential Agents for Bacterial Infection Imaging
by Yuhao Jiang, Peiwen Han, Guangxing Yin, Qianna Wang, Junhong Feng, Qing Ruan, Di Xiao and Junbo Zhang
Int. J. Mol. Sci. 2024, 25(2), 1045; https://doi.org/10.3390/ijms25021045 - 15 Jan 2024
Viewed by 677
Abstract
To develop a novel 99mTc-labeled ubiquicidin 29-41 derivative for bacterial infection single-photon emission computed tomography (SPECT) imaging with improved target-to-nontarget ratio and lower nontarget organ uptake, a series of isocyanide ubiquicidin 29-41 derivatives (CNnUBI 29-41, n = 5–9) with different carbon linkers [...] Read more.
To develop a novel 99mTc-labeled ubiquicidin 29-41 derivative for bacterial infection single-photon emission computed tomography (SPECT) imaging with improved target-to-nontarget ratio and lower nontarget organ uptake, a series of isocyanide ubiquicidin 29-41 derivatives (CNnUBI 29-41, n = 5–9) with different carbon linkers were designed, synthesized and radiolabeled with the [99mTc]Tc(I)+ core, [99mTc][Tc(I)(CO)3(H2O)3]+ core and [99mTc][Tc(V)N]2+ core. All the complexes are hydrophilic, maintain good stability and specifically bind Staphylococcus aureus in vitro. The biodistribution in mice with bacterial infection and sterile inflammation demonstrated that [99mTc]Tc-CN5UBI 29-41 was able to distinguish bacterial infection from sterile inflammation, which had an improved abscess uptake and a greater target-to-nontarget ratio. SPECT imaging study of [99mTc]Tc-CN5UBI 29-41 in bacterial infection mice showed that there was a clear accumulation in the infection site, suggesting that this radiotracer could be a potential radiotracer for bacterial infection imaging. Full article
(This article belongs to the Special Issue Drug Treatment for Bacterial Infections)
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