MicroRNA Signaling in Human Diseases 2.0
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (15 March 2023) | Viewed by 13805
Special Issue Editor
2. Hopital Antoine Beclere (APHP), 92140 Clamart, France
Interests: infectious diseases; microbiology; host-response; clostridioides difficile; inflammation cell signaling; flagella; TLR5 signaling; miRNA
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
An increasing interest in non-coding RNAs has developed in recent years. In particular, research on microRNAs, small natural sequences of 21 to 24 nucleotides, first identified in 1993, has made a leap forward with the identification of more than 2000 different miRNAs in humans, but also in animals and plants. Originating from the transcription of independent genes (canonical pathway) or introns of genes encoding proteins (alternative pathway) throughout genomes, these miRNAs are involved in a huge variety of biological processes including development, differentiation, response to stress, homeostasis, cell death, inflammation, and the host immune response. Moreover, a strong implication of miRNAs in a variety of human pathologies has been widely described in the literature. These small molecules have also aroused great interest because of their enormous therapeutic potential. In fact, their specific mechanism of action on target genes suggests their use as therapeutic candidates for human diseases through new approaches using nucleic acids. However, faced with these major challenges, it is important to fully understand the complex mechanisms of inhibition through the partial complementarity of transcription of miRNAs as well as the specific cell signaling pathways specifically regulated by miRNAs in cells. This Special Issue will be dedicated to the role of miRNAs in cell physiology and human pathology. All studies which help to enrich knowledge on the intimate mechanisms of gene regulation exerted by miRNAs and signaling pathways involving miRNAs in different physiological and pathological situations will be welcome.
Prof. Dr. Imad Kansau
Guest Editor
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Keywords
- microRNAs
- inhibition of gene expression
- miRNA targets
- seed sequence
- cell signaling
- immune response
- innate immune response
- TLR signaling pathways
- regulation of gene expression
- miRNA mimics
- miRNA antagonist
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