Molecular Mechanisms of Renal Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (28 August 2023) | Viewed by 29741
Special Issue Editors
Interests: renal diseases; diabetic nephropathy; kidney injury; nephrology; renal disease; biomarkers; renal; endothelial dysfunction; endothelial cells; kidney
Special Issue Information
Dear Colleagues,
Renal fibrosis is a major outcome of kidney diseases, which affect nearly 10% of the population and contribute to the increased number of deaths and the surcharge of the national health systems worldwide. Renal disease can originate from different causes, such as diabetes, hypertension, immune or toxic stimuli. However, it involves common pathological mechanisms, such as chronic inflammation and the development of renal fibrosis, ultimately leading to the impairment of renal function.
Fibrosis initially appears as a normal response to injury, where activated fibroblasts produce high amounts of the extracellular matrix (ECM) in the context of a wound-healing process in order to assist in the repair of the damaged tissue. In the case of a repetitive injury, chronic wound healing leads to an excessive accumulation of ECM, which fails to be resolved by the remodeling mechanisms and leads to organ dysfunction. To understand the mechanisms of renal failure, great attention was paid to pro-inflammatory and pro-fibrotic agents, such as angiotensin II, TGF-β, CTGF, PDGF, and MCP-1.
Despite the fact that drugs targeting some of these mediators are currently used in subgroups of renal patients, no major improvement has been made in specifically targeting the renal disease. The scope of this Special Issue is to assemble original articles or reviews promoting the latest advances on the roles of newly identified mediators of renal dysfunction and emphasize their potential as novel promising therapeutic targets to fight renal disease.
Dr. Christos Chatziantoniou
Dr. Christos E. Chadjichristos
Guest Editors
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Keywords
- chronic kidney disease
- acute renal failure
- fibrosis
- tissue repair
- inflammation
- hypertension
- diabetes
- IgAN
- lupus
- TGFb
- chemokines
- renal biomarkers
- renal organoids
- nanoparticles
- miRNA
- tissue-specific drug delivery
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