Neurodegenerative Diseases: From Molecular Mechanisms to Pathophysiology
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 20 December 2024 | Viewed by 48
Special Issue Editor
Interests: oxysterols; very-long-chain fatty acids; lipid metabolism; diet, peroxisomes; biotherapies; inflammation; cancer; cell cycle and apoptosis; autophagy; biological membranes; oxidative damage; biomarkers; neurodegenerative diseases
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Special Issue Information
Dear Colleagues,
Neurodegenerative diseases are defined as the progressive degeneration or death of neurons in the central or peripheral nervous system. Genetic, environmental, and lifestyle factors all contribute to the development of neurodegenerative diseases. Most neurodegenerative diseases remain incurable despite treatment and slowing of progression.
Common processes contributing to neuronal degeneration exist, but the molecular mechanisms of neurodegenerative diseases remain complex and varied. Neurodegenerative processes and neuronal disorders can also occur peripherally, outside the brain, for example, in the spinal cord, retina, and enteric nervous system. These phenomes can either reflect and/or affect what is happening in the brain. The consequences of these conditions are often characterized by progressive decline and abnormalities in perceptual, cognitive, motor, behavioral, and social abilities.
Neurodegenerative diseases are a major threat to public health. These diseases generally occur in the elderly. However, longer life expectancy and lower fertility rates are leading to an increase in the prevalence of these disorders in middle age and a worsening health and economic burden for society.
We, therefore, need to know as much as possible about the molecular mechanisms involved in these diseases, both common and specific to each pathology. A better understanding of the functioning of the blood–brain barrier and its specific features is also important in the search for new drugs. In short, we need to know more about the pathophysiology of these neurodegenerative diseases.
Dr. Anne Vejux
Guest Editor
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Keywords
- neurodegenerative diseases
- molecular mechanisms
- physiology
- cell death
- autophagy
- oxidative stress
- inflammation
- genetic factors
- diet
- cognitive functions
- exosomes
- blood–brain barrier
- immunity
