Ion Channels and Neurological Disease
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Pharmaceutical Science".
Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 22761
Special Issue Editor
Interests: ion channels; neurobiophysics; neuronal activity; neurodegenerative disease
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
We are pleased to invite you to contribute to this Special Issue in Life on the topic "Ion Channels and Neurological Disease".
Ion channels are key elements in the control of membrane physiology and neurotransmission as ionic fluxes assure the neuronal signal propagation across and between neurons through synaptic transmission. Pathophysiology of ion channels may originate from either mutations of gene-encoding components of the channel structure (channelopathy) or secondary dysfunctions—both conditions affect intrinsic excitability in the cell and synaptic functions leading to pathophysiological signs of diseases. Most of the currently known neurodegenerative diseases (NDDs) report alterations in neuronal excitability due to dysfunction of molecular and/or functional features in ion channels. In the majority of NDDs, the pathogenic role of ion channels has been widely demonstrated either for channelopathies or secondary dysfunction. Nevertheless, the link between ion channel alterations underlying neuronal excitability and disease onset has been neglected in some disorders, while for others, research is increasing rapidly.
The aim of this Special Issue is to provide new achievements in the research on pathophysiological changes and structural altered phenotypes in ion channel misfunction. A particular interest could be addressed to drug screening and targeting in order to propose putative therapeutic avenues (including also nutraceutics and/or ethnopharmacology) that can be developed to treat or alleviate these incurable diseases. Multi- and inter-disciplinary research contributions, possibly combining structural, functional, and pharmacological approaches with different methods/techniques, including clinical ones, will be greatly appreciated.
Dr. Carlo Musio
Guest Editor
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Keywords
- ion channels
- neurodegenerative diseases
- neurodegeneration
- cellular and animal models
- neuronal excitability
- neuronal activity
- structural and functional correlates
- computational modeling
- pathophysiology and pathogenesis
- channelopaties
- altered currents
- neuropharmacology and ethnopharmacology
- drug screening, delivery and targeting
- pharmacological treatments
- molecular therapeutic options
- neuroprotection
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