Age-Related Macular Degeneration: From Mechanisms to Therapy

Dear Colleagues,

Age-related macular degeneration (AMD) is a common retinal disease that leads to irreversible central vision loss in the elderly population. AMD is influenced by several genetic and environmental factors, such as genetic alterations, aging, cigarette smoking, and oxidative stress, ultimately leading to local inflammation and cell death in the retina. AMD is diagnosed as either dry type, which is characterized by the accumulation of lipofuscin and deposition of drusen in the Bruch’s membrane, or wet-AMD with choroidal neovascularization. However, the molecular understanding of RPE dysfunction, the mechanism for extracellular deposit accumulation, and neovascularization remain unclear.

This Special Issue invites original articles and reviews focusing on the broad topic of molecular mechanism, in vitro/in vivo models, and experimental/clinical evidence for novel therapies for AMD.

Dr. Kwang Won Jeong
Guest Editor

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