Special Issues

Life publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue polices and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in Non-alcoholic Fatty Liver Disease: Pathophysiology, Diagnosis, and Emerging Therapies submission deadline 26 Apr 2025 | Viewed by 672 | Submission Open
Keywords: non-alcoholic fatty liver disease (NAFLD); metabolic dysfunction-associated fatty liver disease (MAFLD); steatohepatitis; metabolic syndrome; insulin resistance; apoptosis/cell death
Recent Insights in the Pathogenesis, Diagnosis, Prognosis and Treatment of Glomerular Disorders
edited by Adrian Constantin Covic and
submission deadline 29 Apr 2025 | Viewed by 5 | Submission Open
Keywords: glomerular disorders; pathology; kidney biopsy; immunology; immunosuppresion; vasculitis
(This special issue belongs to the Section Medical Research)
Alternative Pharmacological Approaches for Septic Shock Management: Beyond Traditional Amine-Based Therapies
edited by Guglielmo Consales and
submission deadline 30 Apr 2025 | 1 articles | Viewed by 1137 | Submission Open
Keywords: decatecholaminisation; non-amine-based therapy; beta blockers; hormone replacement; levosimendan; Angiotensin II; sepsis; septic shock; septic cardiomyopathy
(This special issue belongs to the Section Pharmaceutical Science)
G Protein-Coupled Receptors: Molecular Mechanisms Involved in Receptor Activation and Selectivity: Second Edition submission deadline 30 Apr 2025 | 1 articles | Viewed by 666 | Submission Open
Keywords: G protein-coupled receptors; chemokines; dimerization; beta arrestin; biased agonist; pain; inflammation; neuroinflammation
(This special issue belongs to the Section Genetics and Genomics)
New Diagnostic and Therapeutic Developments in Eye and Systemic Diseases
edited by Zhihong Jewel Hu
submission deadline 30 Apr 2025 | 1 articles | Viewed by 611 | Submission Open
Keywords: eye diseases; systemic diseases; oculomics; ocular imaging; eye surgery; retina; cornea; glaucoma; refractive surgery; OCT; OCTA
(This special issue belongs to the Section Medical Research)
Physical Rehabilitation for Musculoskeletal Disorders
edited by You Gyoung Yi
submission deadline 30 Apr 2025 | Viewed by 164 | Submission Open
Keywords: physical rehabilitation; musculoskeletal disorders; pain management; range of motion; muscle strengthening; mobility enhancement; physical therapy; manual therapy; AI in rehabilitation
(This special issue belongs to the Section Medical Research)
Gynecologic Oncology: Recent Advances and Future Perspectives
edited by Theodoros A. Panoskaltsis and
submission deadline 30 Apr 2025 | Viewed by 136 | Submission Open
Keywords: gynecologic cancer; gynecologic oncology; biomarkers in gynecology
(This special issue belongs to the Section Medical Research)
Characterization, Bioactivity Evaluation and Utilization of Plant Polysaccharides
edited by and
submission deadline 30 Apr 2025 | Viewed by 124 | Submission Open
Keywords: plant polysaccharides; identification; characterization; functional property; biological activity; health benefit; food packaging
(This special issue belongs to the Section Pharmaceutical Science)
Sleep and Sleep Disorders in Sports and Advanced Physical Exercise: 2nd Edition submission deadline 30 Apr 2025 | Viewed by 112 | Submission Open
Keywords: sleep; sport; performance; physical exercise; sleep disorders; sleep regimens; fractured sleep; sleep at altitude; sleep medications
(This special issue belongs to the Section Physiology and Pathology)
From Muscle to Fascia: Current Trends and Future Perspectives submission deadline 30 Apr 2025 | Viewed by 107 | Submission Open
Keywords: connective tissue; deep fascia; superficial fascia; retinacula; muscle stiffness; hyaluronan; densification; biomechanics; therapies
(This special issue belongs to the Section Physiology and Pathology)
The Interactions Between Cells and Their Microenvironment
edited by and
submission deadline 30 Apr 2025 | Viewed by 107 | Submission Open
Keywords: cell microenvironment; extracellular matrix; interstitial cells
(This special issue belongs to the Section Cell Biology and Tissue Engineering)
Traumatic Brain Injury (TBI)
edited by and Andrew J. Kobets
submission deadline 30 Apr 2025 | Viewed by 87 | Submission Open
Keywords: neurosurgery; neuroscience; Traumatic Brain Injury; TBI; head injury; imaging; prognosis; labaratory findings; quality of life
(This special issue belongs to the Section Medical Research)
New Perspectives and Innovations in Prosthetic Joint Infections
edited by Novella Cesta and
submission deadline 30 Apr 2025 | Viewed by 86 | Submission Open
Keywords: prosthetic joint infection; phage therapy; diagnostic tools in PJIs; antimicrobial resistance; biofilm-associated infections; antimicrobial therapy in PJIs; surgical outcomes; surgical management
Innovations in Dairy Cattle Health and Nutrition Management
edited by Rasa Želvytė and Ingrida Monkevičienė
submission deadline 30 Apr 2025 | Viewed by 79 | Submission Open
Keywords: innovations; dairy cattle; health; nutrition; rumen; metabolism; biomarkers
(This special issue belongs to the Section Animal Science)
Innovations, Utilization, and Safety of Psychiatric Drugs: Current Trends and Future Directions
edited by Josipa Bukić
submission deadline 30 Apr 2025 | Viewed by 71 | Submission Open
Keywords: psychiatric diseases; psychiatric medicine; psychiatric pharmacotherapy; psychiatric drugs
The Emerging Clinical Relevance of Artificial Intelligence, Data Science, and Wearable Devices in Headache
edited by , , Muneto Tatsumoto and Shingo Shimoda
submission deadline 30 Apr 2025 | Viewed by 61 | Submission Open
Keywords: headache; migraine; tension-type headache; trigeminal autonomic cephalalgias; medication-overuse headache; primary headaches; secondary headaches; raising awareness; calcitonin gene-related peptide (CGRP) monoclonal antibodies; artificial intelligence; wearable devices; data sciences
(This special issue belongs to the Section Medical Research)
Agri-Food Waste Extracts: Structural and Functional Characterization
edited by
submission deadline 30 Apr 2025 | Viewed by 34 | Submission Open
Keywords: agri-food waste; extracts; extraction techniques; chemical characterization; bioactivity; cytotoxicity and cytocompatibility; isolation of bioactive molecules
(This special issue belongs to the Section Plant Science)
Recent Advances in Non-Invasive Diagnosis Based on Volatile Metabolites
edited by Kiran Sankar Maiti
submission deadline 30 Apr 2025 | Viewed by 32 | Submission Open
Keywords: volatile metabolites; breath analysis; headspace analysis; biofluids; non-invasive; diagnosis
(This special issue belongs to the Section Medical Research)
Advances in Brain-Machine Interfaces
edited by
submission deadline 30 Apr 2025 | Viewed by 24 | Submission Open
Keywords: brain– machine interfaces; brain– computer interfaces; neurorehabilitation; neuroengineering; neurophysiology
(This special issue belongs to the Section Physiology and Pathology)
Advances in Non-Invasive Brain Stimulation
edited by Mariagiovanna Cantone and
submission deadline 1 May 2025 | Viewed by 45 | Submission Open
Keywords: translational neuroscience; clinical neurophysiology; neurodegeneration; neural plasticity; neurosonology; sleep disorders; cognitive decline; non-invasive brain stimulation; nutraceuticals; neurogenetics; transcranial magnetic stimulation; dementia; vascular cognitive impairment; stroke; depression; metaplasticity; motor cortex; motor learning; neurotrophins; transcranial-focused ultrasound
(This special issue belongs to the Section Medical Research)
Advances in the Biomedical Applications of Plants and Plant Extracts
edited by and Annamária Pallag
submission deadline 5 May 2025 | 9 articles | Viewed by 9383 | Submission Open
Keywords: herbals; plant extracts; polyphenols; anthocyanins; isolation; characterization; preparation; oxidative stress; apoptosis; inflammation; dermatitis; CNS; new target molecules
(This special issue belongs to the Section Pharmaceutical Science)
Obstructive Sleep Apnea and Related Disorders: Pathophysiological Traits and Strategies for Treatment
edited by
submission deadline 5 May 2025 | 5 articles | Viewed by 7178 | Submission Open
Keywords: obstructive sleep apnea; sleep fragmentation; cardiometabolic dysfunction; inflammation; co-morbidities
(This special issue belongs to the Section Physiology and Pathology)
Unravelling the Molecular Mechanisms of Different Stress Responses in Plants
edited by
submission deadline 9 May 2025 | Viewed by 98 | Submission Open
Keywords: biotic stresses; abiotic stresses; plant growth and development; crop productivity; molecular mechanisms
(This special issue belongs to the Section Plant Science)
MASLD and Its Comorbidities: From Pathophysiology Perspectives
edited by
submission deadline 9 May 2025 | Viewed by 51 | Submission Open
Keywords: MASLD; integrative physiology; pathogenesis; biomarkers; translational research
(This special issue belongs to the Section Physiology and Pathology)
MASLD and Its Comorbidities: From Epidemiology to Future Therapeutic Perspectives
edited by
submission deadline 9 May 2025 | Viewed by 46 | Submission Open
Keywords: MASLD and comorbidities/complications; diagnostic techniques and biomarkers; clinical trials; innovative therapies
(This special issue belongs to the Section Medical Research)
Ruminant Nutrition Strategies to Improve Feed Efficiency and Reduce Methane Emissions: 2nd Edition
edited by , Tongjun Guo and
submission deadline 15 May 2025 | Viewed by 148 | Submission Open
Keywords: ruminant nutrition; roughage utilization; unconventional feed materials; feed efficiency; production performance; methane emissions; feed additive
(This special issue belongs to the Section Animal Science)
Innovative Perspectives in Physical Therapy and Health submission deadline 22 May 2025 | Viewed by 38 | Submission Open
Keywords: physical therapy; health; pain management; musculoskeletal disorders; ultrasonography; rehabilitation; innovative therapies
(This special issue belongs to the Section Medical Research)
Pain and Therapy: Historical Perspectives and Future Directions submission deadline 22 May 2025 | Viewed by 24 | Submission Open
Keywords: pain; nociceptive pain; neuropathic pain; neoplastic pain; pain physiology; pain treatment
(This special issue belongs to the Section Medical Research)
Effects of Exercise Training on Muscle Function
edited by Marco Duca and
submission deadline 26 May 2025 | 4 articles | Viewed by 5905 | Submission Open
Keywords: exercise; training; muscle function; resistance training; HIIT
(This special issue belongs to the Section Physiology and Pathology)
Conservative Management of Chronic Disease
edited by
submission deadline 26 May 2025 | 3 articles | Viewed by 5116 | Submission Open
Keywords: chronic disease  ; conservative management; trial protocol; clinical research; interventions
(This special issue belongs to the Section Medical Research)
Feature Papers in Synthetic Biology and Systems Biology 2024
edited by
submission deadline 26 May 2025 | Viewed by 103 | Submission Open
Keywords: design and construction of synthetic biological systems; innovations in the creation of synthetic organisms; genetic circuits; and biomolecular devices; bottom-up synthetic biology; cell-free synthetic biology; tissue engineering and organoids; bioorthogonal parts; devices; systems; microcompartmentalized systems with soft or hard interfaces; theoretical considerations about synthetic biology; synthetic biology intersection with systems chemistry and bioorganic chemistry; computational modeling and simulation of biological processes; advances in computational tools and models that enhance our understanding of biological processes and systems; metabolic engineering and synthetic pathways; development of novel approaches for the production of biofuels; pharmaceuticals; and other valuable compounds; synthetic biology for approaching evolutionary problems; artificial evolution and in vitro evolution; optogenetics and related techniques; gene editing technologies; applications; and developments; education in synthetic and systems biology; cutting-edge techniques and applications of CRISPR and other gene editing tools; systems biology approaches to understanding complex biological networks; mathematical aspects of systems biology approaches; artificial photosynthesis; applications of synthetic biology in medicine; agriculture; and industry; practical applications of synthetic and systems biology in various sectors; including healthcare; agriculture; and industrial biotechnology; ethical; legal; and social implications of synthetic and systems biology; exploration of the broader implications of advancements in synthetic and systems biology; including ethical considerations and regulatory challenges and social implications
(This special issue belongs to the Section Synthetic Biology and Systems Biology)
Green Medicine: Unraveling the Medicinal Effects of Plant Extracts and Functional Foods submission deadline 28 May 2025 | 5 articles | Viewed by 4226 | Submission Open
Keywords: plant extracts; phytochemicals; inflammation; obesity; liver disease; oxidative stress; antioxidants; diabetes; skin damage; aging
(This special issue belongs to the Section Pharmaceutical Science)
Plant Biotic and Abiotic Stresses 2024
edited by and
submission deadline 30 May 2025 | 7 articles | Viewed by 6280 | Submission Open
Keywords: plant stress; abiotic stress; biotic stress
(This special issue belongs to the Section Plant Science)
Interdisciplinary Approach to Diabetes Mellitus: From Pathophysiology to Diagnosis and Therapeutic Challenges submission deadline 30 May 2025 | 3 articles | Viewed by 6020 | Submission Open
Keywords: cardiovascular disease; hyperlipidemia; neuropathy; nephropathy; retinopathy; skin conditions; impaired wound healing; hearing impairment; psychological effects; epigenetic imprinting; molecular profiling; biomarkers; targeted therapy; glucose control; conventional and complementary approaches; stem cell damage; vascular damage and regeneration; diabetes complications
(This special issue belongs to the Section Physiology and Pathology)
Fish Nutrition, Production, and Welfare
edited by Liviu-Dan Miron, , and
submission deadline 30 May 2025 | 2 articles | Viewed by 5015 | Submission Open
Keywords: aquaculture; fish nutrition; fish welfare; water quality; fish disease; feed additives; rearing systems; modern feeding technologies; waste management
(This special issue belongs to the Section Animal Science)
New Updates in Adipocytes and Adipose Tissue: 2nd Edition submission deadline 30 May 2025 | 2 articles | Viewed by 4408 | Submission Open
Keywords: adipose tissue; obesity; inflammation; thermogenesis; adipokines; insulin resistance
(This special issue belongs to the Section Physiology and Pathology)
Applications of EEG in Neural Rehabilitation: 2nd Edition submission deadline 30 May 2025 | 2 articles | Viewed by 4128 | Submission Open
Keywords: neurorehabilitation; neuroplasticity; EEG; ERPs; qEEG; EEG mediated patient-therapist interaction; BCI; exoskeleton; cognitive rehabilitation; brain rewiring
(This special issue belongs to the Section Radiobiology and Nuclear Medicine)
New Advances in Neuroimaging and Brain Functions: 2nd Edition submission deadline 30 May 2025 | 1 articles | Viewed by 3461 | Submission Open
Keywords: neuroimaging; brain functions; neurological diseases; humanities and social sciences; noninvasive methods; AI deep learning
(This special issue belongs to the Section Radiobiology and Nuclear Medicine)
Ecology and Conservation of Small Mammals: Exploring Biodiversity, Climate Resilience, and Ecosystem Dynamics through Small Mammal Monitoring and Research: 2nd Edition submission deadline 30 May 2025 | 1 articles | Viewed by 1266 | Submission Open
Keywords: small mammals; biodiversity; indicators; monitoring; assessment; communities
(This special issue belongs to the Section Diversity and Ecology)
Pain Management and Related Complications in the Orthopedics and Neurology
edited by Danilo Donati and
submission deadline 30 May 2025 | 1 articles | Viewed by 672 | Submission Open
Keywords: pain management of the upper and lower limb; pain management of the spine; orthopaedic rehabilitation; prevention of fall risks prevention and management infections; muscle; tendon; and joint diseases; neurological impacts on musculoskeletal health
(This special issue belongs to the Section Physiology and Pathology)
Role of Mitochondria in the Pathophysiology of Cardiovascular Diseases
edited by Yuriana Oropeza-Almazán and Héctor Chapoy-Villanueva
submission deadline 30 May 2025 | Viewed by 300 | Submission Open
Keywords: cardiovascular diseases (CVDs); mitochondria; mitochondrial dysfunction; ATP production; mitochondrial fission; mitochondrial fusion; electron transport chain; oxidative phosphorylation; mitophagy; cardiac hypertrophy; myocardial infarction; IR injury; mitochondrial ROS; ROS signaling; ion homeostasis; cardiac arrhythmias
(This special issue belongs to the Section Physiology and Pathology)
Diagnostic Imaging in Colorectal Cancer
edited by and Chiara Zanon
submission deadline 30 May 2025 | Viewed by 237 | Submission Open
Keywords: colorectal cancer; artificial intelligence; texture analysis; ultrasound; magnetic resonance imaging; PET/MRI
(This special issue belongs to the Section Radiobiology and Nuclear Medicine)
Microbial Diversity and Function in Aquatic Environments
edited by Xianglong Chen and
submission deadline 30 May 2025 | Viewed by 211 | Submission Open
Keywords: aquatic environment; microbial diversity and function; element biogeochemical cycle; interaction between microorganisms and aquatic environments; metaomic approaches
(This special issue belongs to the Section Microbiology)
Advances in Vascular Health and Metabolism
edited by Ana Blazquez-Medela
submission deadline 30 May 2025 | Viewed by 54 | Submission Open
Keywords: cardiovascular; cardiometabolic disease; adipogenesis; atherosclerosis; obesity; overweight; peripheral artery disease
(This special issue belongs to the Section Medical Research)
Cancer Genomics and Transcriptomics: Uncovering New Frontiers in Tumor Biology
edited by and Panagiotis Tsiakanikas
submission deadline 30 May 2025 | Viewed by 32 | Submission Open
Keywords: transcriptomic profiling; tumor heterogeneity; integrative omics; non-coding RNAs; oncogenes
(This special issue belongs to the Section Genetics and Genomics)
Advances in Knee Osteoarthritis and Photobiomodulation Therapy submission deadline 30 May 2025 | Viewed by 25 | Submission Open
Keywords: knee osteoarthritis; light-emitting diode therapy; low-level laser therapy; high-intensity laser therapy; photobiomodulation therapy
(This special issue belongs to the Section Medical Research)
Vision Science and Optometry submission deadline 31 May 2025 | 1 articles | Viewed by 806 | Submission Open
Keywords: clinical optometry; eye movements and binocular vision; aberrometry; accommodation; color vision; anterior and posterior poles; circadian light
(This special issue belongs to the Section Physiology and Pathology)
Advances in Emergency and Critical Care Medicine
edited by
submission deadline 31 May 2025 | Viewed by 281 | Submission Open
Keywords: emergency medicine; critical care; trauma; infectious diseases; elderly
(This special issue belongs to the Section Medical Research)
Topographic and Functional Anatomy of Musculoskeletal System: 2nd Edition submission deadline 31 May 2025 | Viewed by 51 | Submission Open
Keywords: muscle; bone; joint; peripheral nerve; motor innervation; proprioception; anatomical variant; radiologic imaging; development; comparative anatomy
(This special issue belongs to the Section Medical Research)
Microvascular and Macrovascular Response in Healthy and Critically III
edited by Andrius Pranskunas and
submission deadline 31 May 2025 | Viewed by 48 | Submission Open
Keywords: microcirculation; glycocalyx; peripheral perfusion; systemic hemodynamic; body temperature; dynamic maneuvers; remote ischemic conditioning; exercise; adaptation
(This special issue belongs to the Section Physiology and Pathology)
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