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Research and Development of New Metal-Based Biomaterials

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A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: closed (20 February 2024) | Viewed by 12007

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Special Issue Editors

Prof. Dr. Ke Yang

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Guest Editor

Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China
Interests: biomaterials, including antibacterial metals for medical applications
Special Issues, Collections and Topics in MDPI journals

Prof. Dr. Diego Mantovani

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Guest Editor

Laboratory for Biomaterials & Bioengineering (CRC-I), Department Min-Met-Materials Engineering & Research Center CHU de Québec, Laval University, Québec, QC G1V 0A6, Canada
Interests: metal-based biomaterials
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Metal is an important member of biomaterial family, usually playing a role of mechanical support in human body and generally behaving bio-inert. With the development of material technologies, metal-based biomaterials are developing continuously. Many new metal-based biomaterials have been developed with prospective application potentials in recent years, providing better materials platform for design and manufacture of metal medical devices. This special issue will invite those working on research and application of metal-based biomaterials to contribute their research achievements or reviews on the new metal-based biomaterials in order to promote people to better understand and be involved in these studies. The topics of interest include (but are not limited to):

Additively manufactured metallic biomaterials
Multi-functional biomaterials
New metals and alloys for application in medicine and biology
Advanced production techniques for metallic biomaterials
Mechanical properties of metallic biomaterials
Anti-microbial and infection-resistant implants and metallic biomaterials
Biomaterial-tissue interfaces
Mechanical properties of metallic biomaterials
Coatings and surface treatments of metallic biomaterials
Biodegradable metallic biomaterials including magnesium, zinc, iron, and their alloys
New areas of application for metallic biomaterials
Surface patterning of metallic biomaterials

Prof. Dr. Ke Yang
Prof. Dr. Diego Mantovani
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

metallic biomaterial
metal medical material
low modulus
antibacterial
anti-infection
biodegradable
porous
3D printing
surface modification
composite
biocompatibility

Published Papers (5 papers)

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Research

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18 pages, 4137 KiB

Open AccessEditor’s ChoiceArticle

Characterization of a Magnesium Fluoride Conversion Coating on Mg-2Y-1Mn-1Zn Screws for Biomedical Applications

by Sofia Gambaro, M. Lucia Nascimento, Masoud Shekargoftar, Samira Ravanbakhsh, Vinicius Sales, Carlo Paternoster, Marco Bartosch, Frank Witte and Diego Mantovani

Materials 2022, 15(22), 8245; https://doi.org/10.3390/ma15228245 - 20 Nov 2022

Cited by 4 | Viewed by 1959

Abstract

MgF₂-coated screws made of a Mg-2Y-1Mn-1Zn alloy, called NOVAMag^® fixation screws (biotrics bioimplants AG), were tested in vitro for potential applications as biodegradable implants, and showed a controlled corrosion rate compared to non-coated screws. While previous studies regarding coated Mg-alloys have been carried out on flat sample surfaces, the present work focused on functional materials and final biomedical products. The substrates under study had a complex 3D geometry and a nearly cylindrical-shaped shaft. The corrosion rate of the samples was investigated using an electrochemical setup, especially adjusted to evaluate these types of samples, and thus, helped to improve an already patented coating process. A MgF₂/MgO coating in the µm-range was characterized for the first time using complementary techniques. The coated screws revealed a smoother surface than the non-coated ones. Although the cross-section analysis revealed some fissures in the coating structure, the electrochemical studies using Hanks’ salt solution demonstrated the effective role of MgF₂ in retarding the alloy degradation during the initial stages of corrosion up to 24 h. The values of polarization resistance (Rp) of the coated samples extrapolated from the Nyquist plots were significantly higher than those of the non-coated samples, and impedance increased significantly over time. After 1200 s exposure, the Rp values were 1323 ± 144 Ω.cm² for the coated samples and 1036 ± 198 Ω.cm² for the non-coated samples, thus confirming a significant decrease in the degradation rate due to the MgF₂ layer. The corrosion rates varied from 0.49 mm/y, at the beginning of the experiment, to 0.26 mm/y after 1200 s, and decreased further to 0.01 mm/y after 24 h. These results demonstrated the effectiveness of the applied MgF₂ film in slowing down the corrosion of the bulk material, allowing the magnesium-alloy screws to be competitive as dental and orthopedic solutions for the biodegradable implants market. Full article

(This article belongs to the Special Issue Research and Development of New Metal-Based Biomaterials)

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13 pages, 2870 KiB

Open AccessArticle

A Simple Replica Method as the Way to Obtain a Morphologically and Mechanically Bone-like Iron-Based Biodegradable Material

by Marlena Grodzicka, Gabriela Gąsior, Marek Wiśniewski, Michał Bartmański and Aleksandra Radtke

Materials 2022, 15(13), 4552; https://doi.org/10.3390/ma15134552 - 28 Jun 2022

Cited by 3 | Viewed by 1393

Abstract

Porous iron-based scaffolds were prepared by the simple replica method using polyurethane foam as a template and applying the sintering process in a tube furnace. Their surface morphology was characterized using scanning electron microscopy (SEM) and phase homogeneity was confirmed using X-ray diffraction (XRD). Corrosion behavior was determined using immersion and potentiodynamic polarization methods in phosphate buffered saline (PBS). The surface energy was calculated by studying the changes of enthalpy of calorimetric immersion. A preliminary biological test was also carried out and was done using the albumin adsorption procedure. Results of our work showed that in using the simple replica method it is possible to obtain iron biomaterial with morphology and mechanical properties almost identical to bones, and possessing adequate wettability, which gives the potential to use this material as biomaterial for scaffolds in orthopedics. Full article

(This article belongs to the Special Issue Research and Development of New Metal-Based Biomaterials)

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Review

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24 pages, 7093 KiB

Open AccessReview

An Overview on the Effect of Severe Plastic Deformation on the Performance of Magnesium for Biomedical Applications

by Mariana P. Medeiros, Debora R. Lopes, Megumi Kawasaki, Terence G. Langdon and Roberto B. Figueiredo

Materials 2023, 16(6), 2401; https://doi.org/10.3390/ma16062401 - 17 Mar 2023

Cited by 10 | Viewed by 1608

Abstract

There has been a great interest in evaluating the potential of severe plastic deformation (SPD) to improve the performance of magnesium for biological applications. However, different properties and trends, including some contradictions, have been reported. The present study critically reviews the structural features, mechanical properties, corrosion behavior and biological response of magnesium and its alloys processed by SPD, with an emphasis on equal-channel angular pressing (ECAP) and high-pressure torsion (HPT). The unique mechanism of grain refinement in magnesium processed via ECAP causes a large scatter in the final structure, and these microstructural differences can affect the properties and produce difficulties in establishing trends. However, the recent advances in ECAP processing and the increased availability of data from samples produced via HPT clarify that grain refinement can indeed improve the mechanical properties and corrosion resistance without compromising the biological response. It is shown that processing via SPD has great potential for improving the performance of magnesium for biological applications. Full article

(This article belongs to the Special Issue Research and Development of New Metal-Based Biomaterials)

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17 pages, 4844 KiB

Open AccessReview

Systems, Properties, Surface Modification and Applications of Biodegradable Magnesium-Based Alloys: A Review

by Junxiu Chen, Yu Xu, Sharafadeen Kunle Kolawole, Jianhua Wang, Xuping Su, Lili Tan and Ke Yang

Materials 2022, 15(14), 5031; https://doi.org/10.3390/ma15145031 - 20 Jul 2022

Cited by 20 | Viewed by 2632

Abstract

In recent years, biodegradable magnesium (Mg) alloys have attracted the attention of many researchers due to their mechanical properties, excellent biocompatibility and unique biodegradability. Many Mg alloy implants have been successfully applied in clinical medicine, and they are considered to be promising biological materials. In this article, we review the latest research progress in biodegradable Mg alloys, including research on high-performance Mg alloys, bioactive coatings and actual or potential clinical applications of Mg alloys. Finally, we review the research and development direction of biodegradable Mg alloys. This article has a guiding significance for future development and application of high-performance biodegradable Mg alloys, promoting the future advancement of the magnesium alloy research field, especially in biomedicine. Full article

(This article belongs to the Special Issue Research and Development of New Metal-Based Biomaterials)

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15 pages, 4059 KiB

Open AccessReview

Recent Advances on Development of Hydroxyapatite Coating on Biodegradable Magnesium Alloys: A Review

by Junxiu Chen, Yang Yang, Iniobong P. Etim, Lili Tan, Ke Yang, R. D. K. Misra, Jianhua Wang and Xuping Su

Materials 2021, 14(19), 5550; https://doi.org/10.3390/ma14195550 - 24 Sep 2021

Cited by 17 | Viewed by 3044

Abstract

The wide application of magnesium alloys as biodegradable implant materials is limited because of their fast degradation rate. Hydroxyapatite (HA) coating can reduce the degradation rate of Mg alloys and improve the biological activity of Mg alloys, and has the ability of bone induction and bone conduction. The preparation of HA coating on the surface of degradable Mg alloys can improve the existing problems, to a certain extent. This paper reviewed different preparation methods of HA coatings on biodegradable Mg alloys, and their effects on magnesium alloys’ degradation, biocompatibility, and osteogenic properties. However, no coating prepared can meet the above requirements. There was a lack of systematic research on the degradation of coating samples in vivo, and the osteogenic performance. Therefore, future research can focus on combining existing coating preparation technology and complementary advantages to develop new coating preparation techniques, to obtain more balanced coatings. Second, further study on the metabolic mechanism of HA-coated Mg alloys in vivo can help to predict its degradation behavior, and finally achieve controllable degradation, and further promote the study of the osteogenic effect of HA-coated Mg alloys in vivo. Full article

(This article belongs to the Special Issue Research and Development of New Metal-Based Biomaterials)

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