Advanced Technologies in Pediatric Nephrology

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Pediatrics".

Deadline for manuscript submissions: 31 October 2025 | Viewed by 1863

Special Issue Editor


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Guest Editor
Department of Pediatrics, University of Florida College of Medicine, Gainesville, FL, USA
Interests: kidney; nephrology; transplantation; hypertension; UTI; glomerulonephritis

Special Issue Information

Dear Colleagues,

In this Special Issue, we plan to provide a practical source of information about the common topics in a format that is clear to understand and accessible to all health care professionals involved in treating children and adolescents with kidney diseases. We believe that the open access nature of the journal fulfills this mission. We also aim to refine the knowledge base in pediatric nephrology, where significant advances have been made, and highlight improvements in clinical management. The study areas that we aim to cover are glomerular diseases, advances in management of pediatric hypertension, childhood nephrotic syndrome, advances in lupus nephritis, different aspects of chronic kidney disease, advances in different modalities of renal replacement therapy, advances in kidney transplantation, voiding dysfunction in children, renal tubular diseases, and genetics in renal diseases.

We will solicit original research articles, systematic reviews, meta-analyses, and reviews pertaining to these topics. 

Dr. Kiran K. Upadhyay
Guest Editor

Manuscript Submission Information

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Keywords

  • pediatrics
  • kidney transplantation
  • dialysis
  • hypertension
  • nephrotic syndrome
  • glomerulonephritis
  • lupus nephritis
  • chronic kidney disease
  • voiding dysfunction
  • renal tubular disease

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Published Papers (2 papers)

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Review

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10 pages, 273 KiB  
Review
Pediatric Voiding Dysfunction: Definitions and Management
by Ciara Lusnia, Romano DeMarco and Cynthia Sharadin
Medicina 2025, 61(4), 594; https://doi.org/10.3390/medicina61040594 - 26 Mar 2025
Viewed by 150
Abstract
The prevalence of lower urinary tract symptoms or voiding dysfunction is significant in pediatric patients. Severe voiding dysfunction can cause serious medical issues, including impacting renal function. This review article aims to help provide an understanding of the variable presentations of voiding dysfunction [...] Read more.
The prevalence of lower urinary tract symptoms or voiding dysfunction is significant in pediatric patients. Severe voiding dysfunction can cause serious medical issues, including impacting renal function. This review article aims to help provide an understanding of the variable presentations of voiding dysfunction and the different methods of treatment in children. The symptoms vary widely and can often be associated with constipation. Etiologies vary from behavioral/habits to anatomic to psychological or neurologic. Occasionally, imaging is used in the workup, with ultrasound being the most common. Behavior changes are often employed first in treatment before introducing pharmacotherapies or other interventions. Given the variety of presentations and severities, along with the significant number of children who present with lower urinary tract complaints, it is important for all pediatric providers to be familiar with this common diagnosis and some management options. Full article
(This article belongs to the Special Issue Advanced Technologies in Pediatric Nephrology)

Other

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8 pages, 1046 KiB  
Case Report
Association of Oral Tobacco-Free Nicotine Delivery Product with Acute Renal Tubular Necrosis
by Ratna Acharya, William Clapp and Kiran Upadhyay
Medicina 2024, 60(11), 1846; https://doi.org/10.3390/medicina60111846 - 9 Nov 2024
Viewed by 1201
Abstract
Usage of novel non-tobacco oral nicotine delivery products (ONDPs) has been increasing among adolescents in the United States. It is presumed that they are less toxic than their tobacco-containing counterparts, but that has not been examined in controlled studies. Most of the studies [...] Read more.
Usage of novel non-tobacco oral nicotine delivery products (ONDPs) has been increasing among adolescents in the United States. It is presumed that they are less toxic than their tobacco-containing counterparts, but that has not been examined in controlled studies. Most of the studies have focused on non-renal manifestations of tobacco consumption via different means. The renal manifestations of non-tobacco ONDPs are not very well known, especially in immunocompromised patients. A 19-year-old male transplant recipient presented with flank pain and a few days’ history of intake of ZYNR pouches. Immunosuppression was with tacrolimus, mycophenolate, and steroids. Baseline serum creatinine was 1.1–1.3 mg/dL. Laboratory evaluation showed elevated C-reactive protein, increased serum creatinine and blood urea nitrogen, leukocytosis, neutrophilia, and increased lactate dehydrogenase (LDH). Infectious disease work-up was negative. A kidney transplant biopsy showed severe acute tubular injury/necrosis (ATN) without evidence of rejection. Donor-specific antibodies were negative. Other etiologies of hemolysis were negative. He did not require renal replacement therapy. Kidney function and LDH improved gradually. The most recent follow-up eight months after presentation showed a serum creatinine level of 2.6 mg/dL with stable electrolytes, with eGFR of 35 mL/min/1.73 m2. Here, we describe a 19-year-old adolescent with a kidney transplant who sustained ATN leading to advanced chronic disease apparently following the usage of non-tobacco ONDP. Further larger studies are needed to study ATN as a possible renal manifestation of these next-generation products to raise awareness among the public. Full article
(This article belongs to the Special Issue Advanced Technologies in Pediatric Nephrology)
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