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Metabolites publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Unlocking Nature’s Toolbox: Advances in Plant Metabolites Identification: 2nd Edition

edited by

Ramona Paltinean

and

Irina Ielciu

submission deadline 30 Nov 2026 | Viewed by 232 | Submission Open

Keywords: natural compounds; plant metabolites; extraction methods; separation techniques; biological activities

(This special issue belongs to the Section Plant Metabolism)

Effects of Stress on Animal Metabolism—2nd Edition

edited by

Krystyna Pierzchala-Koziec

and Colin Scanes

submission deadline 30 Nov 2026 | Viewed by 167 | Submission Open

Keywords: stressors; ACTH; glucocorticoids; mineralocorticoids; opioids; glycemia; growth; development; lactation; pregnancy

(This special issue belongs to the Section Animal Metabolism)

Advances in NMR-Based Metabolomics for Biomedical Research

edited by

Chi-Jen Lo

and

Mei-Ling Cheng

submission deadline 1 Dec 2026 | Viewed by 241 | Submission Open

Keywords: metabolomics; NMR; biomedical research

(This special issue belongs to the Section Metabolomic Profiling Technology)

Molecular Mechanisms of Metabolic Pathway Regulation by Phytochemicals

edited by

Carlos Lopez-Ortiz

submission deadline 4 Dec 2026 | Viewed by 317 | Submission Open

Keywords: phytochemicals; plant metabolism; secondary metabolites; gene expression regulation; metabolomics

(This special issue belongs to the Section Plant Metabolism)

The Multifaceted Roles of Biomarkers in Metabolic Disorders: From Diagnosis and Monitoring to Prediction, Management, and Treatment, 2nd Edition

edited by

Prince Dadson

and

Miikka-Juhani Honka

submission deadline 5 Dec 2026 | 1 articles | Viewed by 1155 | Submission Open

Keywords: metabolism; dysmetabolism; tissue-specific metabolism; cardiometabolic disorders; nutritional disorders; functional biomarkers; metabolomics profiling; multi-omics data integration; biochemical pathways; personalized medicine

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Vitamin D Metabolism and Human Health, 2nd Edition

edited by

Magdalena Kowalówka

Marta Karaźniewicz-Łada

and

Ilona Górna

submission deadline 10 Dec 2026 | Viewed by 115 | Submission Open

Keywords: vitamin D; metabolites vitamin D; metabolic pathways; metabolic perturbations; vitamin D re-ceptor; enzymes; polymorphism; vitamin D deficiency; health; metabolic diseases; nutrition

(This special issue belongs to the Section Nutrition and Metabolism)

The Molecular Cargo of Extracellular Vesicles: A Key to Understanding Their Biological Role

edited by

Elisabetta Chiaradia

and

Sandra Buratta

submission deadline 11 Dec 2026 | 4 articles | Viewed by 7242 | Submission Open

Keywords: extracellular vesicles (EVs); intercellular communication; molecular cargo; proteins in EVs; lipids in EVs; metabolites in EVs; nucleic acids in EVs; horizontal gene transfer; bioactive molecules in EVs

(This special issue belongs to the Section Cell Metabolism)

Research on Biomarkers for Cardiometabolic Risk in Metabolic Syndrome—2nd Edition

edited by Antoaneta Trifonova Gateva and Yavor Sashov Assyov

submission deadline 15 Dec 2026 | 2 articles | Viewed by 1316 | Submission Open

Keywords: metabolic syndrome; vascular complications; biomarkers; carbohydrate disturbances; diabetes; pre-diabetes

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolic Signature of Type 2 Diabetes, Insulin Resistance, and Obesity Triad

edited by Simona Georgiana Popa

submission deadline 15 Dec 2026 | 1 articles | Viewed by 1071 | Submission Open

Keywords: cardiometabolic phenotypes of obesity; metabolomic profiles; microbiota; entero-insular axis; adipocytokines; precision therapy; insulin resistance; type 2 diabetes

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Effects of Nutrition Intake and Lifestyle Intervention on Human Metabolic Health

edited by

Katarzyna Dereń

Edyta Łuszczki

and

Magdalena Zielińska

submission deadline 15 Dec 2026 | 1 articles | Viewed by 676 | Submission Open

Keywords: dietary patterns; physical activity; sleep and circadian rhythms; insulin resistance; glycemic variability; cardiometabolic risk; energy expenditure; lipid metabolism; continuous glucose monitoring; wearable devices

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Toxicodynamics and Toxicokinetics of New Psychoactive Substances: From In Vitro Insights to In Vivo Impact

edited by

Lea Wagmann

submission deadline 15 Dec 2026 | 1 articles | Viewed by 499 | Submission Open

Keywords: forensic toxicology; clinical toxicology; absorption; metabolism; distribution; excretion; new psychoactive substances; toxicodynamics; toxicokinetics; metabolomics

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

Drug Metabolism and New Drug Development for Cancers—2nd Edition

edited by

Anna Jelińska

and

Szymon Tomczak

submission deadline 15 Dec 2026 | Viewed by 267 | Submission Open

Keywords: cancer; new drug development; metabolites; secondary plant metabolites; drug delivery; nanoformulation; anticancer treatment

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

Beyond the Ordinary: Mass Spectrometry-Based Detection of Unexpected Metabolites

edited by

Beate Fuchs

submission deadline 15 Dec 2026 | Viewed by 243 | Submission Open

Keywords: mass spectrometry; unexpected metabolites; data analysis; metabolomics; biological samples

(This special issue belongs to the Section Metabolomic Profiling Technology)

Signaling Pathways' Interplay and Crosstalk with Metabolism in Human Disease

edited by

Theodoros Karalis

, Emine Kazanc and

Karsten Hiller

submission deadline 15 Dec 2026 | Viewed by 240 | Submission Open

Keywords: human disease; obesity; diabetes; cancer; signaling; metabolism; metabolic rewiring; omics; precision medicine; bioinformatics

(This special issue belongs to the Section Cell Metabolism)

Immunometabolic Consequences of Aquatic Stress

edited by

Yanchun Sun

submission deadline 15 Dec 2026 | Viewed by 218 | Submission Open

Keywords: aquatic stress; metabolomics; immunometabolism; environmental immunology

(This special issue belongs to the Section Environmental Metabolomics)

Influence of Maternal Nutrition on Offspring Metabolic Health

edited by

Yoshinori Kubo

and

Hideoki Fukuoka

submission deadline 15 Dec 2026 | Viewed by 150 | Submission Open

Keywords: preconception care; pregnant women; 5-methyltetrahydrofolate; vitamin A; vitamin D; folic acid; trace elements; choline

(This special issue belongs to the Section Nutrition and Metabolism)

Metabolic Dysfunction-Associated Steatotic Liver Disease: From Pathophysiology to Prevention Strategies

edited by

Seong-Uk Baek

and

Caroline Rhéaume

submission deadline 20 Dec 2026 | Viewed by 259 | Submission Open

Keywords: steatotic liver disease; epidemiology; MASLD; MAFLD; non-alcoholic fatty liver disease (NAFLD); liver metabolism; liver diseases; hepatic steatosis

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Pharmacological Properties of Natural Products and Metabolites

edited by

Vanesa Sánchez-Martín

and

Maria Dolores del Castillo

submission deadline 20 Dec 2026 | Viewed by 92 | Submission Open

Keywords: natural products; bioactive metabolites; digestion; metabolic fate; bioavailability; gut microbiota; biotransformation; metabolomics; drug discovery; safety and toxicity

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

Nutrition, Metabolism and Physiology in Aquatic Animals, 2nd Edition

edited by

Renlei Ji

and Xueshan Li

submission deadline 20 Dec 2026 | Viewed by 28 | Submission Open

Keywords: nutrition; metabolism; physiology; aquaculture; metabolome; nutrients; hazardous materials

(This special issue belongs to the Section Animal Metabolism)

Nutritional Modulation in Metabolic Health

edited by Qi Zhang

submission deadline 20 Dec 2026 | Viewed by 17 | Submission Open

Keywords: nutrition; nutrigenomics; gut microbiota; dietary pattern; functional foods; metabolic syndrome

(This special issue belongs to the Section Nutrition and Metabolism)

SynBio-Driven Metabolic Engineering: From Novel Tools to Real-World Applications

edited by

Hao Wu

and

Jie Cheng

submission deadline 25 Dec 2026 | 1 articles | Viewed by 1033 | Submission Open

Keywords: synthetic biology; metabolic engineering; microbial cell factories; natural products; sustainable production

(This special issue belongs to the Section Microbiology and Ecological Metabolomics)

Chemical Composition and Therapeutic Potential Analysis of Plant Extracts

edited by

Aleksandar Ž. Kostić

and

Petar M. Batinić

submission deadline 25 Dec 2026 | Viewed by 107 | Submission Open

Keywords: lamiaceae; apiaceae; green extracts and solvents; residual process water after plant thermal carbonization; alkaloids; sesquiterpene lactones; metabolomics; acetylcholinesterase inhibitors; foodborne pathogens; antidiabetic activity

(This special issue belongs to the Section Plant Metabolism)

Application of Metabolomics in Chemistry and Biochemistry

edited by Nerilson Marques Lima,

Teresinha Andrade

and

Felipe de Almeida La Porta

submission deadline 25 Dec 2026 | Viewed by 90 | Submission Open

Keywords: metabolomics; analytical chemistry; biochemistry; mass spectrometry; nuclear magnetic resonance; chemometrics; metabolite annotation; pathway analysis; multi-omics

(This special issue belongs to the Section Advances in Metabolomics)

Nutritional Regulation of Gut Microbiome in Humans and Livestock

edited by Junquan Tian and

Qian Jiang

submission deadline 25 Dec 2026 | Viewed by 6 | Submission Open

Keywords: microbial metabolites; precision nutrition and synbiotics; multi-omics integration; livestock resilience optimization; dysbiosis-amended interventions

(This special issue belongs to the Section Nutrition and Metabolism)

Bioactive Secondary Metabolites from Marine Macro- and Microorganisms

edited by

Xiaowei Luo

and

Yonghong Liu

submission deadline 31 Dec 2026 | 1 articles | Viewed by 1421 | Submission Open

Keywords: secondary metabolites; bioactivity; marine natural products; marine microorganisms; marine organisms; drug discovery; lead compounds; pharmacological mechanism; marine drugs

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

Metabolic Regulation in Cancer Development and Progression

edited by Ovidiu Nicolae Pop and Carmen Pantiș

submission deadline 31 Dec 2026 | 1 articles | Viewed by 1026 | Submission Open

Keywords: cancer metabolism; metabolic reprogramming; tumor progression; glycolysis; lipid metabolism; amino acid metabolism; mitochondrial metabolism; tumor microenvironment; immunometabolism; therapeutic resistance

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Biomarkers in Obesity, Metabolic Syndrome, and Weight Loss: Advances in Diagnosis, Risk Stratification, and Personalized Management

edited by

Martina Gažarová

Petra Lenártová

and

Magdalena Górnicka

submission deadline 31 Dec 2026 | 1 articles | Viewed by 1010 | Submission Open

Keywords: obesity biomarkers; metabolic risk stratification; adipose tissue dysfunction; nutritional biomarkers; personalized nutrition; nutrition interventions; weight loss interventions; body composition analysis; emerging anthropometric indices

(This special issue belongs to the Section Nutrition and Metabolism)

Metabolic Research in Dairy Cattle Health

edited by

Wei Yang

submission deadline 31 Dec 2026 | 1 articles | Viewed by 877 | Submission Open

Keywords: dairy cow; nutrient metabolism; feed ingredients; additives; disease; microbes; metabolite biomarkers

(This special issue belongs to the Section Animal Metabolism)

Bioactive Compounds: Plant Stress Responses, Metabolic Regulation, and Therapeutic Insights

edited by

Periyasamy Rathinapriya

and

Theivanayagam Maharajan

submission deadline 31 Dec 2026 | Viewed by 399 | Submission Open

Keywords: abiotic stress adaptation; antioxidant potential; cytotoxic and therapeutic activity; plant-derived elicitors; plant metabolism

(This special issue belongs to the Section Plant Metabolism)

Open-Source Software in Metabolomics, 2nd Edition

edited by

Seongho Kim

submission deadline 31 Dec 2026 | Viewed by 329 | Submission Open

Keywords: GC- MS; LC-MS; mass spectrometry; metabolomics; open-source software

(This special issue belongs to the Section Bioinformatics and Data Analysis)

Plant-Derived Bioactive Metabolites and Their Applications

edited by

Irina Ielciu

and

Ramona Paltinean

submission deadline 31 Dec 2026 | Viewed by 188 | Submission Open

Keywords: plant metabolites; characterization methods; biological activities

(This special issue belongs to the Section Plant Metabolism)

Integrative OMICs Analyses of Cardiometabolic Dysfunction

edited by

Rui Wang-Sattler

and Makoto Harada

submission deadline 31 Dec 2026 | Viewed by 174 | Submission Open

Keywords: cardiometabolic disease; metabolic syndrome; OMICs integration; metabolomics; biomarker discovery; machine learning; explainable AI; metabolic stress; inflammation; fibrosis

(This special issue belongs to the Section Integrative Metabolomics)

The Effects of Functional Foods on Human Metabolism

edited by

Boqun Liu

submission deadline 31 Dec 2026 | Viewed by 129 | Submission Open

Keywords: functional foods; human metabolism; metabolic pathways; bioactive components; gut microbiota

(This special issue belongs to the Section Nutrition and Metabolism)

Microbial and Nutrition Metabolism in Animals

edited by

Zhiming Xu

and Xiaoge Sun

submission deadline 31 Dec 2026 | Viewed by 100 | Submission Open

Keywords: ruminant nutrition; microbial metabolism; lipid metabolism; rumen microbiota; microbial fermentation; microbiome; microbe– host; microorganisms and the environment

(This special issue belongs to the Section Animal Metabolism)

Fat and Glucose Metabolism: Mechanisms and Regulation

edited by

Getachew D. Belew

submission deadline 31 Dec 2026 | Viewed by 97 | Submission Open

Keywords: fat metabolism; glucose metabolism; intermediary metabolism; energy homeostasis; cardiometabolic diseases; obesity; MASLD/MASH; type 2 diabetes; metabolic regulation; therapeutic targets

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolic Factors in Neurodegenerative Diseases: Mechanisms, Biomarkers, and Therapy

edited by

Anna Serefko

and

Aleksandra Szopa

submission deadline 31 Dec 2026 | Viewed by 84 | Submission Open

Keywords: neurodegenerative diseases; metabolic dysfunction; insulin resistance; obesity; dyslipidemia; oxida-tive stress; glucose metabolism; lipid metabolism; gut– brain axis; biomarkers; therapeutic strategies

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Interplay Between Metabolism, Oxidative Stress, and Cellular Signaling in Health and Disease

edited by

Serena Castelli

and

Laura Mosca

submission deadline 15 Jan 2027 | 4 articles | Viewed by 5181 | Submission Open

Keywords: oxidative stress; metabolism; cellular signaling; lipid metabolism; ROS

(This special issue belongs to the Section Lipid Metabolism)

The Role of Diet and Nutrition in Relation to Metabolic Health

edited by

Ivana Šarac

Marija Paunovic

and

Marija Takić

submission deadline 15 Jan 2027 | 2 articles | Viewed by 4001 | Submission Open

Keywords: dietary patterns; nutrients; metabolic syndrome; diet; metabolic health; nutritional biochemistry; dietotherapy; functional food; nutraceuticals

(This special issue belongs to the Section Nutrition and Metabolism)

Mycotoxins and Fungal Secondary Metabolism

edited by

Guohua Yin

and Kayla K. Pennerman

submission deadline 20 Jan 2027 | 2 articles | Viewed by 1973 | Submission Open

Keywords: mycotoxins; aflatoxin; patulin; biocontrol; metabolites; fungi

(This special issue belongs to the Section Plant Metabolism)

Amino Acid Metabolism Affecting Obesity and Energy Balance

edited by Xuchao Lyu and

Teruo Miyazaki

submission deadline 31 Jan 2027 | Viewed by 285 | Submission Open

Keywords: metabolomics; enzymes; obesity; amino acids; non-protein amino acids; biomarkers; cell signals

(This special issue belongs to the Section Cell Metabolism)

Lipid Metabolism Dysregulation in Metabolic Disorders: Unraveling the Molecular Complexity: 2nd Edition

edited by

Joshua De Leon

submission deadline 31 Jan 2027 | Viewed by 72 | Submission Open

Keywords: lipid metabolism; dyslipidemia; atherosclerosis

(This special issue belongs to the Section Lipid Metabolism)

Metabolic Imaging and Biomarkers in Cancer and Metabolic Disorders

edited by Paul Begovatz and

Sean B. Fain

submission deadline 28 Feb 2027 | Viewed by 139 | Submission Open

Keywords: cancer; metabolism; imaging; quantitative MRI; hyperpolarized MRI; metabolomics; biomarkers; tumor microenvironment; immunotherapy; theranostics

(This special issue belongs to the Section Advances in Metabolomics)

Recent Advances in Metabolomics (IECM2026)

edited by

and

submission deadline 31 Mar 2027 | 1 articles | Viewed by 1065 | Submission Open

Keywords: lipidomics; nutrition metabolomics; environmental metabolomics; clinical metabolomics; metabolic modeling; metabolomics technology; data analysis and integration; drug metabolism

(This special issue belongs to the Section Advances in Metabolomics)

Application of Metabolomics, Lipidomics and Exposomics Based on LC-MS

edited by

Zhiqiang Pang

and

Jianguo (Jeff) Xia

submission deadline 31 Mar 2027 | Viewed by 33 | Submission Open

Keywords: metabolomics; lipidomics; exposomics; multi-omics; LC-MS

(This special issue belongs to the Section Advances in Metabolomics)

Brain Energy Metabolism and Substrate Utilization in Neuroinflammation and Neurodegenerative Diseases

edited by

Chandan Sona

submission deadline 1 Apr 2027 | Viewed by 125 | Submission Open

Keywords: brain energy metabolism; neurodegenerative diseases; mitochondrial dysfunction; substrate utilization; neuron– glia metabolic coupling; metabolic reprogramming

(This special issue belongs to the Section Cell Metabolism)

Metabolomics for Clinical Biomarkers Discovery

edited by

Cecília R.C. Calado

submission deadline 30 Apr 2027 | Viewed by 93 | Submission Open

Keywords: metabolomics; biomarkers discovery; precision medicine

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

From Environmental Exposures to Health: Metabolic Signatures in Exposome Research

edited by Xiangping Lin,

Xinyu Liu

and

Guozhu Ye

submission deadline 15 May 2027 | Viewed by 220 | Submission Open

Keywords: exposome; metabolomics; environmental exposure; air pollution; biomarker discovery; multi-omics integration; environmental epidemiology; metabolic signatures

(This special issue belongs to the Section Environmental Metabolomics)

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