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Metabolites publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue polices and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Lipidomics in Health and Disease

edited by

Paul Wood

submission deadline 30 Mar 2025 | 2 articles | Viewed by 3561 | Submission Open

Keywords: lipidomics; high-resolution mass spectrometry; lipid derivatization; lipid chromatography; diagnostics; therapeutics

(This special issue belongs to the Section Lipid Metabolism)

Advances in Food Sciences: Metabolomics to Unravel the Complexity of Food Metabolites

edited by

José Iván Serrano-Contreras

submission deadline 30 Mar 2025 | 1 articles | Viewed by 3270 | Submission Open

Keywords: foodomics; nutrimetabolomics; phytochemicals; food chemistry; food analysis; dark matter in diet; nutritional dark matter; nutritional hormesis; untargeted/targeted analysis

(This special issue belongs to the Section Food Metabolomics)

Exploring Potential Diagnostic and Prognostic Salivary Biomarkers in Cancer—2nd Edition

edited by

Lyudmila Bel'skaya

and

Martin Grootveld

submission deadline 31 Mar 2025 | 2 articles | Viewed by 6706 | Submission Open

Keywords: salivary biomarkers; metabolomics; salivaomics; diagnosis; prognosis; cancer

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Obesity and Metabolic Dysfunction: Disease Development and Breaking the Cycle

edited by Paulo Cezar de Freitas Mathias, Lucas Paulo Jacinto Saavedra and

Rodrigo Mello Gomes

submission deadline 31 Mar 2025 | 3 articles | Viewed by 5340 | Submission Open

Keywords: obesity; diabetes; DOHaD; metabolic programming; treatment; intervention; cardiovascular disease; metabolic syndrome

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolic Biomarkers and Nutrition in Degenerative Conditions and Gastrointestinal Cancer Surgery

edited by

Irene Lidoriki

Dimitrios Schizas

and Maximos Frountzas

submission deadline 31 Mar 2025 | 3 articles | Viewed by 3658 | Submission Open

Keywords: biomarkers; nutrition; metabolism; metabolomics; degenerative disease; Parkinson’ s disease; Alzheimer’ s disease; cardiovascular disease; gastrointestinal cancer surgery

(This special issue belongs to the Section Nutrition and Metabolism)

Metabolic Research in Animal Nutrition and Production

edited by Tietao Zhang and Qingkui Jiang

submission deadline 31 Mar 2025 | 4 articles | Viewed by 2926 | Submission Open

Keywords: special economic animals; companion animals; nutrition; metabolomics; microbiome; metabolites; animal nutrition; animal production; animal health and disease; metabolic phenotypes

(This special issue belongs to the Section Animal Metabolism)

Plant Biotic and Abiotic Stress Responses and Tolerance: Phytohormonal and Metabolic Insights

edited by

Tabibul Islam

and Md. Al Mamun

submission deadline 31 Mar 2025 | 2 articles | Viewed by 2605 | Submission Open

Keywords: biotic and abiotic stress; phytohormones: primary metabolism; secondary metabolites; plant– pathogen interactions; biostimulants; beneficial microbes; plant innate immunity; omics (genomics; transcriptomics; proteomics; metabolomics; etc.)

(This special issue belongs to the Section Plant Metabolism)

The Interplay Between Inflammation and Metabolism in Disease

edited by

Elena Planells

submission deadline 31 Mar 2025 | 2 articles | Viewed by 1617 | Submission Open

Keywords: critically ill patients; micronutrients; vitamins; minerals; nutritional assessment; requirements; biomarkers; antioxidants; oxidative stress; inflammation; infection; supplementation; metabolism

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Nutritional and Metabolic Influences on Animal Growth and Reproduction

edited by

Zhipeng Li

and

Baichuan Deng

submission deadline 31 Mar 2025 | 2 articles | Viewed by 1113 | Submission Open

Keywords: metabolites; nutritional and metabolic influences; animal development; meat quality; dairy science; animal reproduction

(This special issue belongs to the Section Animal Metabolism)

Metabolic Responses to Environmental Challenges: Insights into Cellular Mechanism and Protective Strategy

edited by

Xiaohua Teng

, Hong Lan,

Lu Kang

and Zan Li

submission deadline 31 Mar 2025 | 1 articles | Viewed by 1103 | Submission Open

Keywords: environmental challenge; metabolic response; cellular mechanism; protective strategy; environmental adaptability; oxidative stress; environmental pollution; antioxidant defense; natural compounds; ecosystem protection

(This special issue belongs to the Section Microbiology and Ecological Metabolomics)

Advances in Phytomedicine Intervention on Metabolic Disorders

edited by

Hong Qin

submission deadline 31 Mar 2025 | 1 articles | Viewed by 607 | Submission Open

Keywords: metabolic disorders; glucose and lipid metabolism; insulin resistance; non-communicable diseases; energy imbalance; nutrients; phytochemicals; plant ac-tive components; inflammation; signaling pathway

(This special issue belongs to the Section Nutrition and Metabolism)

Natural Products and Dietary Supplements in Weight Loss: Metabolomic Perspectives

edited by

Eric Gumpricht

and

Alex Mohr

submission deadline 31 Mar 2025 | Viewed by 304 | Submission Open

Keywords: metabolomics; weight loss; fat loss; nutraceuticals; obesity; natural products; dietary sup-plements; phytochemicals

(This special issue belongs to the Section Integrative Metabolomics)

Proteomics and Metabolomics in Veterinary and Animal Health

edited by

Anita Horvatić

and

Andrea Gelemanović

submission deadline 31 Mar 2025 | Viewed by 289 | Submission Open

Keywords: metabolomics; proteomics; bioinformatics; omics data integration; mass spectrometry; veterinary medicine; animal health; biomarker discovery; metabolic pathways; molecular interactions

(This special issue belongs to the Section Integrative Metabolomics)

Glucose Metabolism in Cardiovascular Diseases

edited by Hidenori Komiyama and

Kuniya Asai

submission deadline 31 Mar 2025 | Viewed by 240 | Submission Open

Keywords: glucose metabolism; insulin resistance; statin use; mitochondrial function; heart failure; IoT devices; daily activity; skeletal muscle

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Research on Lipid Metabolism in Animals

edited by

Bing Han

Lihong Zhao

and Zhenlong Wang

submission deadline 31 Mar 2025 | Viewed by 196 | Submission Open

Keywords: lipid metabolism; bile acid; gut microbiota; obesity; meat quality

(This special issue belongs to the Section Animal Metabolism)

Advances in LC-MS-Based Metabolomics: From (Un)targeted Screening to Structural Elucidation

edited by Andrea Castellaneta and

Ilario Losito

submission deadline 31 Mar 2025 | Viewed by 183 | Submission Open

Keywords: liquid chromatography; high-resolution and multi-stage mass spectrometry; lipidomics; structure elucidation; LC-MS methods for metabolite screening; quantitative method development

(This special issue belongs to the Section Metabolomic Profiling Technology)

Lichen Secondary Metabolites in Cancer Research

edited by

Michal Goga

and

Martin Kello

submission deadline 31 Mar 2025 | Viewed by 181 | Submission Open

Keywords: identification of lichen substances; extraction; purification; methodology; anti-cancer effects; epigenetics; apoptosis pathways modulation; resistance mechanisms; tumor microenvironment modulation

(This special issue belongs to the Section Plant Metabolism)

Metabolomics Approaches to Nutrition, Intestine and Farm Animal

edited by

Shu-cheng Huang

Lihong Zhang

and Aoyun Li

submission deadline 31 Mar 2025 | Viewed by 163 | Submission Open

Keywords: farm animal; nutrition; metabolomics; metabolism; gut microbiota

(This special issue belongs to the Section Nutrition and Metabolism)

Role of Ceramides in Determining an Increased Cardiovascular and Renal Risk

edited by

Alessandro Mantovani

submission deadline 31 Mar 2025 | Viewed by 148 | Submission Open

Keywords: ceramides; cardiovascular risk; renal disease; biomarkers; sphingolipids; atherosclerosis; chronic kidney disease (CKD); cardiovascular disease (CVD); lipids

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Mechanistic Insights into Metabolic Interactions with the Tumor Microenvironment

edited by

Jyoti Kaushal

submission deadline 31 Mar 2025 | Viewed by 116 | Submission Open

Keywords: metabolism; tumor microenvironment; therapy; immune cells; clinical oncology; metabolic pathways

(This special issue belongs to the Section Cell Metabolism)

The Role of Isotope Tracers in Investigating Metabolic Disorders

edited by Nadezda Khodorova

submission deadline 31 Mar 2025 | Viewed by 112 | Submission Open

Keywords: kinetics effect; isotope ratio mass spectrometry; biomarker; fluxomics; metabolomics; stable isotope; tracing experiments; mass spectrometry; breath tests

(This special issue belongs to the Section Integrative Metabolomics)

The Digital Revolution in Livestock Production and Metabolism: Foodomics for a Viable Future and Beyond

edited by

Shuji Ueda

and

Salma Mohamad Yusop

submission deadline 31 Mar 2025 | Viewed by 93 | Submission Open

Keywords: metabolomics; foodomics; blockchain; nutritional genomics; smart farming; sustainable food production; Industry 4.0; precision livestock farming; food safety; genetic modification experiments

(This special issue belongs to the Section Food Metabolomics)

Research on Pharmacotherapy of Metabolic-Associated Fatty Liver Disease

edited by Aleksandra Bołdys

submission deadline 1 Apr 2025 | Viewed by 469 | Submission Open

Keywords: liver diseases; metabolomics; metabolic diseases; metabolic dysregulation; targeted therapies; MASLD

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

New Insights on the Role of Lipid Metabolism in the Development of Cardiac Dysfunction

edited by

Stephen C. Kolwicz

submission deadline 1 Apr 2025 | Viewed by 410 | Submission Open

(This special issue belongs to the Section Lipid Metabolism)

Intestinal Health and Metabolites in Farm Animals

edited by

Qian Jiang

and Junquan Tian

submission deadline 1 Apr 2025 | Viewed by 182 | Submission Open

Keywords: metabolites; intestinal health; oxidative stress; inflammation; epithelial barrier

(This special issue belongs to the Section Animal Metabolism)

Metabolic Biomarkers in Type 2 Diabetes: From Discovery to Application

edited by Eiji Kutoh and

Shengshuai Shan

submission deadline 2 Apr 2025 | Viewed by 453 | Submission Open

Keywords: metabolic biomarkers; type 2 diabetes (T2DM); glucose metabolism; insulin resistance; lipid profiles; diagnosis and prognosis

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolic Pathways of Nutrition Intake in Obese Children

edited by

Edyta Łuszczki

Katarzyna Dereń

and

Anna Bartosiewicz

submission deadline 7 Apr 2025 | 1 articles | Viewed by 916 | Submission Open

Keywords: children and adolescents; dietary habits; Mediterranean diet; metabolic pathways; metabolic diseases; nutrition; obesity; Western-type diet

(This special issue belongs to the Section Nutrition and Metabolism)

Metabolic Changes during Pre- and Post-harvest Fruit and Vegetable Decay, Ripening and Senescence

edited by

Analía Concellón

and

María José Zaro

submission deadline 8 Apr 2025 | 5 articles | Viewed by 5321 | Submission Open

Keywords: pre- and post-harvest technology; bio-stimulants and abiotic stress; nutritional quality; metabolic pathway; bioactive compounds; chilling injury

(This special issue belongs to the Section Plant Metabolism)

Metabolites and Regenerative Medicine: Perspectives and Updates

edited by Reggiani Vilela Gonçalves, Mariáurea Sarandy and Rômulo Dias Novaes

submission deadline 10 Apr 2025 | Viewed by 236 | Submission Open

Keywords: oxidative stress; inflammasome; cytokines; angiogenesis; tissue repair; molecular biology; cellular and molecu-lar mechanisms; diabetes; tissue repair

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

Method Development in Metabolomics and Exposomics

edited by Facundo M. Fernandez

submission deadline 15 Apr 2025 | 5 articles | Viewed by 3717 | Submission Open

Keywords: metabolomics; exposomics; lipidomics; metabolite; environmental exposure

(This special issue belongs to the Section Bioinformatics and Data Analysis)

Future Trends and Emerging Applications in Metabolomics

edited by

Lenard Farczadi

Ionela Hotea

and Chengguo Xing

submission deadline 15 Apr 2025 | 1 articles | Viewed by 1015 | Submission Open

Keywords: metabolomics; metabolism; interaction studies; pharmacokinetics; bioavailability; mass spectrometry; bioanalysis; biomarkers; nutrients; animal studies enzymes

(This special issue belongs to the Section Nutrition and Metabolism)

Mechanism of Metabolic Diseases

edited by

Dipsikha Biswas

and Logan Slade

submission deadline 15 Apr 2025 | Viewed by 586 | Submission Open

Keywords: metabolic diseases; nutrient signaling; metabolite profiling; genetic regulation; metabolomics; proteomics; organ crosstalk

(This special issue belongs to the Section Cell Metabolism)

Nutrition and Metabolic Changes in Aging and Age-Related Diseases

edited by Qi Zhang

submission deadline 15 Apr 2025 | Viewed by 168 | Submission Open

Keywords: senescence; metabolism; nutrient homeostasis; aging; SASP (senescence-associated secretory phenotype)

(This special issue belongs to the Section Nutrition and Metabolism)

Food Additives in Gut Microbiota and Metabolic Health

edited by Ran An, Jing Zhang and Heng Wang

submission deadline 15 Apr 2025 | Viewed by 114 | Submission Open

Keywords: food additives; emulsifier; carbohydrates; intestine; microbiota

(This special issue belongs to the Section Nutrition and Metabolism)

Energy Metabolism in Brown Adipose Tissue

edited by

Chuanhai Zhang

submission deadline 25 Apr 2025 | Viewed by 94 | Submission Open

Keywords: energy metabolism; thermogenic fat tissue; metabolites; mitochondrial function; ER stress

(This special issue belongs to the Section Cell Metabolism)

Mass Spectrometry Imaging and Spatial Metabolomics

edited by

Zhonghua Wang

and Chenglong Sun

submission deadline 28 Apr 2025 | 1 articles | Viewed by 1541 | Submission Open

Keywords: mass spectrometry imaging (MSI); spatial metabolomics; biomarker discovery; disease diagnostics; drug development; technical advancements; interdisciplinary approaches; imaging techniques

(This special issue belongs to the Section Metabolomic Profiling Technology)

Environmental Exposure and Its Effects on Cardio-Respiratory and Metabolic Health

edited by

Kristine McGrath

and Tatt Jhong Haw

submission deadline 28 Apr 2025 | Viewed by 170 | Submission Open

Keywords: environmental factors; pollution; cardiovascular; cardiometabolic risk factor; biomarkers; mechanisms; cardio-oncology; cardio-respiratory

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolic Syndrome and Non-Alcoholic Liver Disease

edited by

Mircea-Catalin Fortofoiu

and

Luigi Boccuto

submission deadline 30 Apr 2025 | 3 articles | Viewed by 4869 | Submission Open

Keywords: metabolic syndrome; non-alcoholic fatty liver disease (NAFLD); insulin resistance; obesity; type 2 diabetes; liver cirrhosis; dyslipidemia; NAFLD treatment; hepatic steatosis; cardiovascular risk

(This special issue belongs to the Section Lipid Metabolism)

Effects of Chemical Exposure on Endocrine and Reproductive Functions

edited by Renata Marino Romano and Caroline Serrano-Nascimento

submission deadline 30 Apr 2025 | 2 articles | Viewed by 3075 | Submission Open

Keywords: endocrine-disrupting chemicals exposure impact on metabolic diseases; reproductive failure; infertility; endocrine disorders

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Mitochondrial Metabolism and Oxidative Stress in Hypertension, Diabetes and Related Complications

edited by

Christian Cortés-Rojo

submission deadline 30 Apr 2025 | 2 articles | Viewed by 2771 | Submission Open

Keywords: diabetes; hypertension; ROS; oxidative stress; cell death; inflammation; mitochondrial control quality; mitochondrial dynamics; mitochondria-targeted molecules; nutraceuticals and functional foods

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolism and Nutrition in Fish

edited by

Lei Wang

, Peng Tan and Rantao Zuo

submission deadline 30 Apr 2025 | 2 articles | Viewed by 2638 | Submission Open

Keywords: fish; metabolism; nutrition; feed additives; lipid; protein; requirements

(This special issue belongs to the Section Animal Metabolism)

Enriching the Gut Microbial Functionality through Daily Meals

edited by Michihiro Fukushima and

Samanthi Pelpolage

submission deadline 30 Apr 2025 | 1 articles | Viewed by 2386 | Submission Open

Keywords: dietary-resistant food components; intestinal fermentation; gut microbial modulation; metabolic pathways; postbiotics; food processing methods; characterization of new prebiotic substances; structure– function relationships; in vitro studies; in vivo studies; metabolic disorders

(This special issue belongs to the Section Food Metabolomics)

New Analytical Techniques and Applications of Metabolomics and Lipidomics

edited by

Xinyu Liu

, Chunxiu Hu and Xianzhe Shi

submission deadline 30 Apr 2025 | 3 articles | Viewed by 1979 | Submission Open

Keywords: metabolomics; lipidomics; applications of metabolomics and/or lipidomics

(This special issue belongs to the Section Advances in Metabolomics)

Metabolism of Bioactives and Natural Products

edited by Kamila Misiakiewicz-Has, Barbara Wiszniewska and

Sylwia Rzeszotek

submission deadline 30 Apr 2025 | Viewed by 522 | Submission Open

Keywords: natural products; bioactive; medicinal plants; phytochemicals; isoflavones; triterpenes; coumarins; alkaloids; prebiotics; carotenoids; polyphenols; organosulfur compounds

(This special issue belongs to the Section Nutrition and Metabolism)

Integrative Metabolomic Biomarkers for Neurodegeneration

edited by Robert Logan

submission deadline 30 Apr 2025 | Viewed by 363 | Submission Open

Keywords: integrative metabolomics; multi-omics; biomarkers; neurodegeneration; bioinformatics; machine learning; Parkinson’ s disease; Alzheimer’ s disease

(This special issue belongs to the Section Integrative Metabolomics)

Metabolites as Biomarkers for Inherited Disorders

edited by Jennifer Saville

submission deadline 30 Apr 2025 | Viewed by 305 | Submission Open

Keywords: biomarkers; metabolites; inherited disorders; diagnostics; metabolomics; lipidomics

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolic Regulation of Reproductive Physiology in Livestock Species

edited by

Gabriele Brecchia

Giulio Curone

and Stella Agradi

submission deadline 30 Apr 2025 | Viewed by 227 | Submission Open

Keywords: metabolic regulation; reproductive physiology; livestock reproduction; energy balance; nutrient me-tabolism; fertility biomarkers; hormonal regulation; metabolic disorders; reproductive efficiency

(This special issue belongs to the Section Animal Metabolism)

NMR-Metabolomics in Peptide and Antibody Drug Discovery

edited by

Michela Buonocore

Anna Maria D’Ursi

Angelo Santoro

and Carmen Marino

submission deadline 30 Apr 2025 | Viewed by 223 | Submission Open

Keywords: NMR metabolomics; peptides; antibodies; drug discovery; metabolomic profiles; biomarkers; mechanisms of action

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

Nutritional Metabolism in Model Organisms: Phytochemicals and Genetic Responses

edited by

Carlos Lopez-Ortiz

submission deadline 30 Apr 2025 | Viewed by 212 | Submission Open

Keywords: phytochemicals; nutritional metabolism; gene expression; model organisms; genetic response; epigenetics

(This special issue belongs to the Section Nutrition and Metabolism)

Mitochondrial Metabolism in Health and Disease: A Clinical Perspective

edited by

Joao Pessoa

Ana Duarte

and

Susana P. Pereira

submission deadline 30 Apr 2025 | Viewed by 185 | Submission Open

Keywords: mitochondrion; bioenergetics; oxidative stress; calcium homeostasis; apoptosis; cancer; metabolic diseases; cardiovascular diseases; neurodegenerative diseases

(This special issue belongs to the Section Cell Metabolism)

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