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Metabolites publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Functional Foods and Metabolic Health

edited by

Lucas Fornari Laurindo

submission deadline 5 Jun 2026 | Viewed by 397 | Submission Open

Keywords: metabolomics; metabolic analyses; functional foods; metabolic health; chronic disease prevention; bioactive compounds; antioxidants; soluble fiber; probiotics; omega-3 fatty acids; diabetes; dyslipidemia; gut microbiota; obesity; cardiovascular disease; metabolic syndrome; personalized nutrition; nutritional interventions

(This special issue belongs to the Section Plant Metabolism)

Analysis of Specialized Metabolites in Natural Products—2nd Edition

edited by

Aikaterini Koutsaviti

and

Christos Petrou

submission deadline 5 Jun 2026 | Viewed by 261 | Submission Open

Keywords: structure elucidation; isolation; evaluation of activity; plant bioactive secondary metabolites; methodology development

(This special issue belongs to the Section Plant Metabolism)

Effects of Various Exercise Methods on Metabolic Health

edited by

Hun-Young Park

and Won-Sang Jung

submission deadline 8 Jun 2026 | 4 articles | Viewed by 15510 | Submission Open

Keywords: exercise physiology; metabolism; insulin sensitivity; energy expenditure; cardiovascular health; resistance training; high-intensity interval training; hypoxia; mitochondrial function; metabolic syndrome

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Obesity, Hormones, and Metabolic Complications in Pregnancy

edited by

Angélica Saraí Jiménez-Osorio

Diego Estrada-Luna

and

Jennifer W. Hill

submission deadline 15 Jun 2026 | 2 articles | Viewed by 3265 | Submission Open

Keywords: obesity; gestational weight gain; hormones; oxidative stress; inflammation; metabolic complications of pregnancy; neonatal complications; childhood health

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Effects of Phytochemicals on Human Metabolism

edited by

Henrique Cerqueira

and

Eric Gumpricht

submission deadline 15 Jun 2026 | Viewed by 402 | Submission Open

Keywords: phytochemistry; bioactive compounds; metabolism; nutritional interventions; energy balance; oxidative stress; inflammation

(This special issue belongs to the Section Nutrition and Metabolism)

Autophagy and Antioxidant Pathways in Neurodegenerative Diseases

edited by

Federica Armeli

and

Rita Businaro

submission deadline 15 Jun 2026 | Viewed by 346 | Submission Open

Keywords: neurodegeneration; Alzheimer’ s disease; Parkinson’ s disease; Huntington’ s disease; amyotrophic lateral sclerosis; autophagy; neuroinflammation; oxidative stress; antioxidant pathways; neuroprotection

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Rare Diseases: From Metabolism, Pathogenesis to Therapy

edited by

Vincenza Gragnaniello

submission deadline 15 Jun 2026 | Viewed by 223 | Submission Open

Keywords: rare disease; metabolism; metabolic pathway; biomarkers; precision medicine; disease mechanisms; diagnostic advances; omics technologies; pathogenesis; translational research

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Bioactive Compounds in Obesity and Its Metabolic Complications

edited by

Patricia Rios Chavez

and Héctor Eduardo Martínez-Flores

submission deadline 20 Jun 2026 | 2 articles | Viewed by 1840 | Submission Open

Keywords: antioxidant; obesity; inflammation; oxidative stress; metabolic syndrome

(This special issue belongs to the Section Plant Metabolism)

Lipidomic and Metabolomic Analysis of Neurodegenerative Diseases

edited by

Marios Krokidis

submission deadline 20 Jun 2026 | 1 articles | Viewed by 971 | Submission Open

Keywords: neurodegenerative diseases; metabolomics; lipidomics; biofluids and patient samples; cellular models; animal models; mass-spectrometry; nuclear magnetic resonance; biomarkers; artifical intelligence; multi-omics analysis; bioinformatics

(This special issue belongs to the Section Advances in Metabolomics)

Metabolomics: The Role of Natural Products in Drugs

edited by

Jeysson Sanchez-Suarez

and

Jennyfer Andrea Aldana Mejía

submission deadline 25 Jun 2026 | Viewed by 358 | Submission Open

Keywords: metabolomics; natural products; drug discovery; bioactive compounds; computational metabolism; pharmacology; secondary metabolites; therapeutic development

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

Metabolic Insights into Natural Health Products and Dietary Supplements for Human Health

edited by

Julia Solnier

and Mary Hardy

submission deadline 30 Jun 2026 | 2 articles | Viewed by 21522 | Submission Open

Keywords: bioactive natural compounds; traditional medicine; metabolic pathways; absorption; distribution; metabolism; and excretion (ADME); clinical efficacy; pharmacokinetics; nutritional supplements; health benefits; safety and toxicology; delivery systems

(This special issue belongs to the Section Nutrition and Metabolism)

Plant Biotic and Abiotic Stress Responses and Tolerance: Phytohormonal and Metabolic Insights

edited by

Tabibul Islam

and Md. Al Mamun

submission deadline 30 Jun 2026 | 6 articles | Viewed by 11072 | Submission Open

Keywords: biotic and abiotic stress; phytohormones: primary metabolism; secondary metabolites; plant– pathogen interactions; biostimulants; beneficial microbes; plant innate immunity; omics (genomics; transcriptomics; proteomics; metabolomics; etc.)

(This special issue belongs to the Section Plant Metabolism)

Metabolomics Approaches to Nutrition, Intestine and Farm Animal

edited by

Shu-cheng Huang

Lihong Zhang

and Aoyun Li

submission deadline 30 Jun 2026 | 1 articles | Viewed by 8636 | Submission Open

Keywords: farm animal; nutrition; metabolomics; metabolism; gut microbiota

(This special issue belongs to the Section Nutrition and Metabolism)

Metabolomics in Plant Natural Products Research, 2nd Edition

edited by

Junsong Wang

submission deadline 30 Jun 2026 | 5 articles | Viewed by 5374 | Submission Open

Keywords: natural products; metabolomics; plant– environment interactions; chemical markers; active principles; LC/MS; GC/MS; NMR

(This special issue belongs to the Section Plant Metabolism)

Proteomics and Metabolomics in Human Health and Disease

edited by

Michele Costanzo

and

Margherita Ruoppolo

submission deadline 30 Jun 2026 | 4 articles | Viewed by 5231 | Submission Open

Keywords: proteomics; metabolomics; lipidomics; multi-omics; disease mechanisms; machine learning; omics integrations; artificial intelligence

(This special issue belongs to the Section Advances in Metabolomics)

Exploring Pathological Mechanisms in Obesity, Diabetes, and Metabolic Syndrome: 2nd Edition

edited by

Tiemin Liu

Hongmei Yan

and

Qiongyue Zhang

submission deadline 30 Jun 2026 | 4 articles | Viewed by 4233 | Submission Open

Keywords: metabolic diseases: obesity; diabetes; NAFLD; MAFLD; NASH; metabolic syndrome; etc.; multi-omics: metabolomics; lipidomics; proteomics; etc.; pathogenesis: genetic predispositions; lifestyle factors; microbiome and environmental exposures; etc.

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Diabetes and Metabolic Diseases: From Prevention to Clinical Management, 2nd Edition

edited by

Davide Masi

and

Renata Risi

submission deadline 30 Jun 2026 | 4 articles | Viewed by 3918 | Submission Open

Keywords: obesity; nutritional ketosis; dietary manipulations; therapeutic inertia; type 2 diabetes; gut microbiome; incretins; hormone regulation

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Muscle Metabolic Response and Adaptation to Exercise, Diet, and Environment: 2nd Edition

edited by

Susumu Muroya

submission deadline 30 Jun 2026 | 4 articles | Viewed by 3624 | Submission Open

Keywords: skeletal muscle; metabolomics; mitochondria; energy metabolism; lipid metabolism; nutrition; feeding; environment; exercise; stress

(This special issue belongs to the Section Animal Metabolism)

Mitochondrial Metabolism in Health and Disease: A Clinical Perspective

edited by

Joao Pessoa

Ana Duarte

and

Susana P. Pereira

submission deadline 30 Jun 2026 | 1 articles | Viewed by 3618 | Submission Open

Keywords: mitochondrion; bioenergetics; oxidative stress; calcium homeostasis; apoptosis; cancer; metabolic diseases; cardiovascular diseases; neurodegenerative diseases

(This special issue belongs to the Section Cell Metabolism)

The Role of Lipid Metabolism in Health and Disease

edited by

Mónica Narváez-Rivas

submission deadline 30 Jun 2026 | 3 articles | Viewed by 3381 | Submission Open

Keywords: lipid metabolism; lipidomics; dyslipidemia; mass spectrometry; lipid biomarkers; lipid signaling; therapeutic targets; bioinformatics; clinical lipidomics

(This special issue belongs to the Section Lipid Metabolism)

Adipose Thermogenesis and Crosstalk: Signaling Networks in Obesity, Metabolic Disease and Beyond

edited by Lei Huang

submission deadline 30 Jun 2026 | 3 articles | Viewed by 2963 | Submission Open

Keywords: adipose thermogenesis; BAT; WAT browning; adipokines; batokines; UCP1; single-cell/spatial omics; metabolic disease; obesity; insulin resistance; cardiovascular risk

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Mitochondrial Metabolism, Redox State and Immunology in Cancer

edited by

Alfredo Cruz-Gregorio

and

Gladis Fragoso

submission deadline 30 Jun 2026 | 1 articles | Viewed by 2458 | Submission Open

Keywords: immune system; mitochondria; redox state; cancer

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Nutritional Interventions and Lipid Metabolism

edited by

Cecilia Bender

and

Mariano Stornaiuolo

submission deadline 30 Jun 2026 | 2 articles | Viewed by 2126 | Submission Open

Keywords: lipid metabolism; nutritional interventions; dietary fats; bioactive compounds; functional foods; chronic diseases; nutrigenomics; weight management; inflammation; personalized nutrition

(This special issue belongs to the Section Lipid Metabolism)

Advances on Metabolomics: Driving Innovation in Bio-Analysis and Natural Products Research

edited by

Natalia Drabińska-Fois

Daria Cicha-Wojciechowicz

Patrycja Mojsak

Eliza Matuszewska-Mach

and Martyna Pajewska-Szmyt

submission deadline 30 Jun 2026 | 1 articles | Viewed by 2040 | Submission Open

Keywords: metabolomics; bioanalysis; biomedical research; biomarkers; foodomics; lipidomics; volatilomics; natural products; clinical diagnosis; biomarker discovery; analytical approaches; method development; mass spectrometry; disease detection; microorganisms

(This special issue belongs to the Section Advances in Metabolomics)

Metabolic Adaptations to Exercise: Mechanisms, Modulators, and Health Impacts

edited by

Kiwon Lim

and

Jisu Kim

submission deadline 30 Jun 2026 | 3 articles | Viewed by 2034 | Submission Open

Keywords: exercise metabolism; metabolic adaptations; mitochondrial function; metabolic flexibility; energy substrate utilization; exercise-induced remodeling; skeletal muscle metabolism; metabolomics and multi-omics approaches

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

State-of-the-Art NMR-Based Metabolomics and Its Applications

edited by

Pau Nolis

submission deadline 30 Jun 2026 | 1 articles | Viewed by 1104 | Submission Open

Keywords: NMR spectroscopy; metabolomics; metabolic profiling; biomarker; multivariate analysis; high-throughput data analysis

Advancements in Mass Spectrometry Techniques for Metabolomic and Pharmaceutical Analysis

edited by

Xiaowei Song

and Fangling Wu

submission deadline 30 Jun 2026 | 1 articles | Viewed by 991 | Submission Open

Keywords: ambient ionization; mass spectrometry imaging; sample pretreatment; isomer analysis; marker discovery; ion annotation; structural identification; artificial intelligence; multi-omics

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

Microbial Metabolites and Host Health

edited by Weilan Wang

submission deadline 30 Jun 2026 | 1 articles | Viewed by 825 | Submission Open

Keywords: microbial metabolites; host– microbe interactions; host health; inflammatory bowel disease; chronic metabolic disorders; cancer; autoimmune diseases; neurodegenerative conditions; metabolism and immune status

(This special issue belongs to the Section Microbiology and Ecological Metabolomics)

The Interaction Between Metabolic Dysfunction and Hypothalamic Inflammation

edited by

Joana M. Gaspar

submission deadline 30 Jun 2026 | 1 articles | Viewed by 384 | Submission Open

Keywords: metabolic disorders; neuroinflammation; hypothalamus; energy homeostasis; feeding behavior; high-fat diets; obesity

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Veterinary Metabolomics: Emerging Tools for Animal Health

edited by

Ionela Hotea

Adrian Maximilian Macri

and Emil Tirziu

submission deadline 30 Jun 2026 | Viewed by 382 | Submission Open

Keywords: veterinary metabolomics; animal nutrition; nutrient utilization; feed efficiency; precision nutrition; metabolic health; microbiome– metabolome interactions; sustainable livestock production; multi-omics integration; animal welfare; one health

(This special issue belongs to the Section Animal Metabolism)

Advances in Translational Oncology and Oncometabolism

edited by Graham Pidgeon and

Zivile Useckaite

submission deadline 30 Jun 2026 | Viewed by 380 | Submission Open

Keywords: oncometabolism; obesity; clinical research; clinical trials; oncogenes; translational oncology

(This special issue belongs to the Section Cell Metabolism)

Lipidomics and Metabolic Biomarkers in Heart Disease

edited by

Davide Radaelli

and Matteo Scopetti

submission deadline 30 Jun 2026 | Viewed by 364 | Submission Open

Keywords: lipidomic; metabolomic; biomarkers; cardiovascular disease; risk stratification

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Endothelial Metabolism in Vascular Development and Diseases

edited by

Pengchun Yu

submission deadline 30 Jun 2026 | Viewed by 226 | Submission Open

Keywords: cellular metabolism; metabolites; metabolic network; blood endothelial cells; lymphatic endothelial cells; blood vessel development; lymphatic vascular development; vascular disease; cancer; ocular disorders

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Integrating Metabolism and Molecular Biology in Cancer Research and Therapeutics

edited by

Susmita Barman

submission deadline 30 Jun 2026 | Viewed by 210 | Submission Open

Keywords: cancer metabolism; metabolic reprogramming; tumor microenvironment; oncometabolites; immunometabolism; therapeutic resistance; microbiome-derived metabolites; metabolomics; molecular signaling pathways

(This special issue belongs to the Section Integrative Metabolomics)

Metabolic Studies in Urinary Diseases

edited by

Dechao Feng

submission deadline 30 Jun 2026 | Viewed by 209 | Submission Open

Keywords: metabolomics; lipidomics; biomarkers; chronic kidney disease (CKD); acute kidney injury (AKI); urolithiasis (kidney stones); bladder cancer; prostate cancer; diabetic nephropathy; polycystic kidney disease; metabolic pathways

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Dysbiosis and Metabolic Disorders of the Microbiota

edited by

Guozhu Ye

submission deadline 1 Jul 2026 | 6 articles | Viewed by 19679 | Submission Open

Keywords: metabolomics; metagenomics; metaproteomics; metatranscriptomics; Liquid Chromatograph-Mass Spectrometer; Gas Chromatography-Mass Spectrometer; gut microbiota; environmental microbiota; metabolism; metabolic disorders

(This special issue belongs to the Section Microbiology and Ecological Metabolomics)

Novel Methods of Mass Spectrometry Imaging Towards Biomedical and Environmental Applications

edited by

Xiaoxiao Ma

Zhaoying Wang

and

Yanhua Chen

submission deadline 1 Jul 2026 | 1 articles | Viewed by 1370 | Submission Open

Keywords: mass spectrometry imaging; molecular mapping; new techniques; biomedicine; materials science; environmental research; pharmaceutics

(This special issue belongs to the Section Advances in Metabolomics)

Mechanistic Insights into Metabolic Interactions with the Tumor Microenvironment

edited by

Jyoti Kaushal

submission deadline 5 Jul 2026 | 5 articles | Viewed by 7455 | Submission Open

Keywords: metabolism; tumor microenvironment; therapy; immune cells; clinical oncology; metabolic pathways

(This special issue belongs to the Section Cell Metabolism)

Biomarkers for Fibrotic Diseases

edited by

Chao He

and Jennifer L. Larson-Casey

submission deadline 10 Jul 2026 | Viewed by 235 | Submission Open

Keywords: fibrosis; biomarkers; multi-omics; machine learning

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Nutrition and Metabolism in Poultry

edited by

Catarina Stefanello

submission deadline 15 Jul 2026 | 2 articles | Viewed by 4736 | Submission Open

Keywords: ingredient; feed additive; feed quality; nutrient utilization; intestinal health

(This special issue belongs to the Section Animal Metabolism)

Expanding Boundaries in Spatial Metabolomics and Lipidomics: Advances in Mass Spectrometry Imaging

edited by

Vanna Denti

and

Simone Serrao

submission deadline 15 Jul 2026 | 1 articles | Viewed by 2100 | Submission Open

Keywords: spatial omics; mass spectrometry imaging; multimodal; imaging data analysis; spatial functional analysis; small-molecule biochemistry

(This special issue belongs to the Section Advances in Metabolomics)

Nutrition and Metabolic Diseases: Mechanistic Insights and Personalized Dietary Strategies

edited by

Silvia Tagliamonte

and

Marcelo Macedo Rogero

submission deadline 15 Jul 2026 | 1 articles | Viewed by 1307 | Submission Open

Keywords: personalized nutrition; metabolic diseases; metabolomics; food digestion; postprandial metabolism; biomarkers; gut microbiome; precision medicine; systems biology

(This special issue belongs to the Section Nutrition and Metabolism)

Multi-Omics Insights into Stress-Induced Metabolism of Bioactive Plant Compounds

edited by

Dan Gao

and

Junsong Wang

submission deadline 15 Jul 2026 | 1 articles | Viewed by 1033 | Submission Open

Keywords: stress-induced metabolism; plant secondary metabolites; bioactive phytochemicals; medicinal plant compounds; multi-omics integration; comparative metabolomics; plant stress biology; metabolic and regulatory networks; network pharmacology

(This special issue belongs to the Section Plant Metabolism)

Environmental Exposures and Metabolic Health in Vulnerable Populations

edited by

Sandra India-Aldana

and Lauren Petrick

submission deadline 15 Jul 2026 | 1 articles | Viewed by 762 | Submission Open

Keywords: exposomics; metabolic health; metabolic diseases; metabolomics; metabolome; susceptible populations; susceptible windows; children; women’ s health; minorities

(This special issue belongs to the Section Environmental Metabolomics)

Vitamin D Metabolism: Implications in Metabolic Health and Disease

edited by

Gar Yee Koh

and

Elena Planells

submission deadline 15 Jul 2026 | 1 articles | Viewed by 564 | Submission Open

Keywords: vitamin D; metabolic disease; micronutrient; obesity; diabetes; cardiovascular health; nutrition

(This special issue belongs to the Section Nutrition and Metabolism)

Effects of Exercise and Lifestyle on Cardiometabolic Health

edited by

Zacharias Papadakis

and

Alice S. Ryan

submission deadline 15 Jul 2026 | Viewed by 321 | Submission Open

Keywords: cardiovascular– kidney– metabolic (CKM) syndrome; lifestyle medicine; exercise prescription; metabolic perturbations; metabolites; metabolomics; high-intensity interval training (HIIT); moderate-intensity continuous training (MICT); resistance training (RT); metabolic dysfunction-associated steatotic liver disease (MASLD); insulin resistance; exerkines; mitochondrial function; cardiometabolic health

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Reactive Oxygen Species and Metabolic Dysregulation: From Bench to Bedside

edited by

Paola Maycotte

Álvaro Marín-Hernández

and Annie Joubert

submission deadline 15 Jul 2026 | Viewed by 222 | Submission Open

Keywords: cancer; ROS; glycolysis; mitochondria autophagy; antioxidant system; glutathione; oxidative phosphorylation

(This special issue belongs to the Section Cell Metabolism)

Tumoral Microenvironment and Metabolic Reprogramming in Cancer

edited by

Beatrice Dufrusine

submission deadline 15 Jul 2026 | Viewed by 196 | Submission Open

Keywords: tumoral microenvironment; inflammation; cancer; immune system; stromal cells; metabolic reprogramming; warburg effect; reverse warburg effect

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Exploring Metabolomic Signatures and the Metabolic Impact of Thyroid Dysfunction

edited by Janine Wirth

submission deadline 17 Jul 2026 | 3 articles | Viewed by 2518 | Submission Open

Keywords: thyroid function; hypothyroidism; hyperthyroidism; Hashimoto; metabolic health; metabolomics; inflammation; autoimmune

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Mass Spectrometry Imaging and Spatial Metabolomics—2nd Edition

edited by

Zhonghua Wang

and Chenglong Sun

submission deadline 20 Jul 2026 | 2 articles | Viewed by 997 | Submission Open

Keywords: mass spectrometry imaging (MSI); spatial metabolomics; biomarker discovery; disease diagnostics; drug development; technical advancements; interdisciplinary approaches; imaging techniques

(This special issue belongs to the Section Metabolomic Profiling Technology)

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