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Metabolites publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue polices and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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The Role of Hepatic Insulin Clearance in Obesity and Type 2 Diabetes

edited by

Morvarid Kabir

and Richard N. Bergman

submission deadline 31 Jan 2025 | Viewed by 327 | Submission Open

Keywords: insulin clearance; insulin resistance; type 2 diabetes; obesity; hyperinsulinemia

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Effects of Diet on Metabolic Health of Obese People

edited by

Magdalena Górnicka

Marta Jeruszka-Bielak

and Irena Keser

submission deadline 31 Jan 2025 | Viewed by 272 | Submission Open

Keywords: diet; dietary pattern; bioactive food compounds; body composition; nutrition-related biomarkers; metabolites; metabolic disorders; obesity

(This special issue belongs to the Section Nutrition and Metabolism)

The Roles of Diet, Gut Microbiome and Microbial Metabolome in Precision Nutrition

edited by Renny S. Lan and

Jiangjiang Zhu

submission deadline 31 Jan 2025 | Viewed by 198 | Submission Open

Keywords: metabolomics; gut microbiome; precision nutrition; diet; integration; integrative; lipidomic; person-alized nutrition; probiotics; prebiotics; microbiota

(This special issue belongs to the Section Nutrition and Metabolism)

Secondary Metabolites and Their Activities: From the Identification to the Biological Investigation

edited by Valeria Cavalloro and

Emanuela Martino

submission deadline 31 Jan 2025 | Viewed by 138 | Submission Open

Keywords: active metabolites; green extraction; bioactivity; natural products; structural elucidation

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

Application of NMR in Food Metabolomics

edited by Charalambos Fotakis and

Maria Zervou

submission deadline 31 Jan 2025 | Viewed by 129 | Submission Open

Keywords: food items; NMR; food metabolomics; quality assurance; geographical origin; authenticity

(This special issue belongs to the Section Metabolomic Profiling Technology)

Cell Death and Cancer Metabolism

edited by

Zhengrong Yuan

submission deadline 31 Jan 2025 | Viewed by 117 | Submission Open

Keywords: cancer metabolism; metabolic reprogramming; tumor growth; metabolic biomarkers; therapeutic strategies; metabolic regulation; cancer treatment

Metabolic Responses to Abiotic Stress in Plants: Latest Advances and Prospects

edited by

Ghulam Hasnain

submission deadline 31 Jan 2025 | Viewed by 104 | Submission Open

Keywords: abiotic stress; plant metabolism; compatible solutes; antioxidant systems; energy metabolism; lipid metabolism; osmotic stress; drought stress; heat stress; salinity stress; heavy metal stress; crop productivity; stress tolerance; gene expression; proteomics; metabolomics; signaling pathways; transcription factors; reactive oxygen species

(This special issue belongs to the Section Plant Metabolism)

Lipid Metabolism Dysregulation in Metabolic Disorders: Unraveling the Molecular Complexity

edited by

Joshua De Leon

submission deadline 31 Jan 2025 | Viewed by 103 | Submission Open

Keywords: lipid metabolism; dyslipidemia; atherosclerosis

(This special issue belongs to the Section Lipid Metabolism)

Metabolic Impacts of Toxic Exposures on Human Health and Potential Biomarkers

edited by Leiliane Coelho Andre,

Isarita Martins Sakakibara

, Maria José Nunes de Paiva and

Solange Cristina Garcia

submission deadline 31 Jan 2025 | Viewed by 91 | Submission Open

Keywords: metabolomics; biomarkers; environmental toxicology; environmental exposure; environmental health

(This special issue belongs to the Section Environmental Metabolomics)

Microalgae Bioactive Compounds with Therapeutical Properties

edited by Miguel Martín-Pérez and

Sergio Balzano

submission deadline 31 Jan 2025 | Viewed by 80 | Submission Open

Keywords: microalgae; bioactive compounds; therapeutical properties; cancer; neurodegenerative diseases

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

Exploring the Depth of Metabolic Marvels: Innovation in Large-Scale Analysis of Small Molecules

edited by

Beate Fuchs

submission deadline 31 Jan 2025 | Viewed by 76 | Submission Open

Keywords: mass spectrometry; NMR spectroscopy; large-scale metabolomics; sample preparation; data ac-quisition; data repeatability; data integration; metabolite identification; biological explanation

(This special issue belongs to the Section Advances in Metabolomics)

The Comorbidity of Neurodegenerative and Metabolic Diseases

edited by

Anna Serefko

and

Aleksandra Szopa

submission deadline 31 Jan 2025 | Viewed by 64 | Submission Open

Keywords: neurodegenerative diseases; metabolic diseases; depression; dementia; Parkinson’ s disease; Alzheimer’ s disease; Huntington’ s disease; obesity; diabetes

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

Metabolic Changes in Diet-Mediated Inflammatory Diseases

edited by

Beatrice Dufrusine

submission deadline 31 Jan 2025 | Viewed by 60 | Submission Open

Keywords: nutrition; Westernized diet; inflammation; immune system; cancer; metabolic reprogramming; au-toimmune disease; obesity; allergies; inflammatory bowel diseases; celiac disease

(This special issue belongs to the Section Nutrition and Metabolism)

Lipid Metabolism in Age-Related Diseases

edited by

Simona Fenizia

Elettra Barberis

and

Marcello Manfredi

submission deadline 31 Jan 2025 | Viewed by 47 | Submission Open

Keywords: lipid metabolism; metabolic diseases; high-throughput mass spectrometry-based lipidomics; aging; lipid biomarkers; precision medicine

(This special issue belongs to the Section Lipid Metabolism)

Energy Metabolism and Its Application in Obesity and Diabetes Research

edited by

Domenico Sergi

and

Angelina Passaro

submission deadline 5 Feb 2025 | 1 articles | Viewed by 2289 | Submission Open

Keywords: energy metabolism; metabolic health; insulin resistance; metabolomics; lipidomics

(This special issue belongs to the Section Nutrition and Metabolism)

Metabolomics Analysis in Food Authentication and Traceability

edited by

Hui-Wen Gu

, Haiyan Fu and

Jiukai Zhang

submission deadline 8 Feb 2025 | Viewed by 389 | Submission Open

Keywords: food fraud; authentication and traceability; metabolomics; chemometrics; LC-MS; GC-MS

(This special issue belongs to the Section Food Metabolomics)

Nutrition, Metabolism and Physiology in Aquatic Animals

edited by

Renlei Ji

and Xueshan Li

submission deadline 10 Feb 2025 | 2 articles | Viewed by 1325 | Submission Open

Keywords: nutrition; metabolism; physiology; metabolism; aquaculture; metabolome; nutrients; hazardous materials

(This special issue belongs to the Section Nutrition and Metabolism)

Metabolic Responses of Seeds Development and Germination

edited by

Li Li

and

Mingxun Chen

submission deadline 10 Feb 2025 | 1 articles | Viewed by 760 | Submission Open

Keywords: stress; seeds; seedling; metabolism; hormone regulation; development

(This special issue belongs to the Section Plant Metabolism)

Research on Biomarkers for Cardiometabolic Risk in Metabolic Syndrome

edited by Antoaneta Trifonova Gateva and Yavor Sashov Assyov

submission deadline 10 Feb 2025 | Viewed by 132 | Submission Open

Keywords: metabolic syndrome; vascular complications; biomarkers; carbohydrate disturbances; diabetes; pre-diabetes

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Identification of Plant Metabolites: Characterization and Biological Activities, 2nd Edition

edited by

Irina Ielciu

and

Ramona Paltinean

submission deadline 14 Feb 2025 | Viewed by 131 | Submission Open

Keywords: natural compounds; plant metabolites; separation techniques; biological activities

(This special issue belongs to the Section Plant Metabolism)

New Insights in Plant Metabolism and Chemodiversity

edited by João Henrique Frota Cavalcanti and Diego S. Batista

submission deadline 15 Feb 2025 | 1 articles | Viewed by 655 | Submission Open

Keywords: plant metabolism; chemodiversity; abiotic stress; biotic elicitors; secondary metabolites; metabolic pathways

(This special issue belongs to the Section Plant Metabolism)

Diet and Nutrition in Relation to Metabolic Health

edited by

Marta P. Silvestre

submission deadline 20 Feb 2025 | 1 articles | Viewed by 525 | Submission Open

Keywords: diet; dietary interventions; foods; metabolism; nutrients; polyphenols

(This special issue belongs to the Section Nutrition and Metabolism)

Interplay between Metabolic Adaptations to Physical Activity

edited by

Olga Scudiero

and Cristina Mennitti

submission deadline 20 Feb 2025 | Viewed by 99 | Submission Open

Keywords: physical activity; biomarkers; metabolic adaptations; exercise; performance; athletes

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Biosynthesis, Metabolism, and Physiological Functions of Gamma-Aminobutyric Acid (2nd Edition)

edited by

Haixing Li

and

Dandan Gao

submission deadline 20 Feb 2025 | Viewed by 95 | Submission Open

Keywords: gamma-aminobutyric acid; metabolism and metabolomics; biotechnology and bioengineering; biosynthesis; physiological function; gamma-aminobutyric-acid-producing microbes; methodology

(This special issue belongs to the Section Microbiology and Ecological Metabolomics)

Lipid Metabolism and Atherosclerosis: Cell Specific Functions and Molecular Mechanism of the Disease

edited by Pablo Fernández-Tussy

submission deadline 20 Feb 2025 | Viewed by 94 | Submission Open

Keywords: lipid metabolism; lipoproteins; atherosclerosis; cardiovascular disease; macrophages; vascular smooth muscle cells; endothelial cells

(This special issue belongs to the Section Lipid Metabolism)

Immunometabolism and Metabolomics in Lung Disease

edited by Claudio Tirelli and Stefano Centanni

submission deadline 20 Feb 2025 | Viewed by 40 | Submission Open

Keywords: metabolomics; lung physiopathology; biomarkers; COPD; ILD; nuclear magnetic resonance spectroscopy; mass spectrometry; exhaled breath condensate; metabolites; immunometabolism

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Cancer Metabolomics 2024

edited by

Bénédicte Elena-Herrmann

submission deadline 25 Feb 2025 | 1 articles | Viewed by 1235 | Submission Open

Keywords: metabolomics approaches and technologies; cancer and chronic diseases; diagnosis or predictive metabolic biomarkers; multi-omics studies; tumor metabolism; molecular epidemiology of cancer

(This special issue belongs to the Section Cell Metabolism)

Unlocking the Mysteries of Muscle Metabolism in the Animal Sciences

edited by

David E. Gerrard

and

Sally E. Johnson

submission deadline 28 Feb 2025 | 5 articles | Viewed by 4757 | Submission Open

Keywords: muscle; amino acid metabolism; energy metabolism; metabolites; protein; growth

(This special issue belongs to the Section Animal Metabolism)

Impact of Food and Bioactive Compounds on Metabolic Diseases

edited by

Bungo Shirouchi

and

Hayato Maeda

submission deadline 28 Feb 2025 | 3 articles | Viewed by 3020 | Submission Open

Keywords: food factors; bioactive compounds; food function; metabolism; metabolites; gut microbiota (flora); metabolic syndrome; metabolic diseases (disorders)

(This special issue belongs to the Section Nutrition and Metabolism)

Nutrition and Metabolism in Human Diseases 2nd Edition

edited by

Xinhui Wang

submission deadline 28 Feb 2025 | 1 articles | Viewed by 1444 | Submission Open

Keywords: nutrition; metabolism; nutrient; metabolite; disease

(This special issue belongs to the Section Nutrition and Metabolism)

Reactive Oxygen Species and Energy Metabolic Alterations in Health and Disease

edited by

Paola Maycotte

and

Álvaro Marín-Hernández

submission deadline 28 Feb 2025 | 1 articles | Viewed by 1177 | Submission Open

Keywords: cancer; ROS; glycolysis; mitochondria; autophagy; antioxidant system; glutathione; oxidative phosphorylation

(This special issue belongs to the Section Cell Metabolism)

Environmental Metabolites Insights into Health and Disease

edited by

Yu Sun

submission deadline 28 Feb 2025 | Viewed by 99 | Submission Open

Keywords: environmental metabolites; probiotics; health; disease; toxic metabolites; protective metabolites; metabolomics; environmental exposure; molecular mechanisms; metabolic pathways

(This special issue belongs to the Section Environmental Metabolomics)

Metabolic Interaction between Gut Microbiota and Dietary Bioactive Compounds: Lipids, Carbohydrates, and Phytochemicals

edited by

Han Peng

submission deadline 28 Feb 2025 | Viewed by 95 | Submission Open

Keywords: food prebiotics; gut– organ axes; bioactive supplements; lipids; carbohydrates; phytochemicals; purification/processing technology; supplement formulation; alternative proteins/lipids

(This special issue belongs to the Section Nutrition and Metabolism)

Adrenal Neuroendocrine System and Cardiometabolic Health

edited by

Moe Thuzar

submission deadline 28 Feb 2025 | Viewed by 65 | Submission Open

Keywords: adrenal; metabolic syndrome; cardiovascular health; glucocorticoid; mineralocorticoid

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Lifestyle Medicine for Chronic Diseases

edited by

Caroline Rhéaume

and

Abu Hena Mostafa Kamal

submission deadline 28 Feb 2025 | Viewed by 48 | Submission Open

Keywords: lifestyle medicine; chronic diseases; metabolomics

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Myostatin: A Key Regulator of Skeletal Muscle Metabolism and Development

edited by

Emiliano Lasagna

and

Ishaku L. Haruna

submission deadline 28 Feb 2025 | Viewed by 22 | Submission Open

Keywords: myostatin; MSTN; GDF8; muscle development; muscular hypertrophy; metabolites and metabolism; omics sciences; myostatin pathways

(This special issue belongs to the Section Animal Metabolism)

Role of Metabolic Factors and Their Interactions on Diabetes and Its Complications

edited by Yun Shen

submission deadline 28 Feb 2025 | Viewed by 10 | Submission Open

Keywords: metabolic risk factors; diabetes comorbidities; bioinformatics; machine learning; multi-omics integration; cardiovascular disease; dyslipidemia; insulin resistance; biomarkers

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Adipose Tissue, Reproduction and Metabolic Health in Women

edited by

Aldo Ferreira-Hermosillo

and Renata Saucedo

submission deadline 5 Mar 2025 | 1 articles | Viewed by 1673 | Submission Open

Keywords: adiposity; gestational diabetes; preeclampsia; pregnancy; obesity; polycystic ovarian syndrome; infertility; reproductive health

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Exploring and Expanding Horizons in Secondary Metabolites: Biosynthesis, Identification, Regulation and Biological Activity

edited by

Alberto Jorge Oliveira Lopes

Antônio Cantanhede Filho

and Claúdia Quintino Da Rocha

submission deadline 10 Mar 2025 | 1 articles | Viewed by 1689 | Submission Open

Keywords: secondary metabolites; biosynthesis; regulation; identification; plants; microorganisms; marine organisms; animals; bioactivity; drug discovery; natural products

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

Expanding Boundaries in Spatial Lipidomics: Advances in Mass Spectrometry Imaging

edited by

Vanna Denti

and

Simone Serrao

submission deadline 10 Mar 2025 | Viewed by 86 | Submission Open

Keywords: spatial lipidomics; mass spectrometry imaging; multimodal; imaging data analysis; spatial functional analysis; lipids biochemistry

(This special issue belongs to the Section Lipid Metabolism)

Metabolomics and Bioinformatics Approaches to Studying Human Gut Microbiota-Derived Metabolites

edited by Zhiwei Zhou, Shipei Xing and Xiaotao Shen

submission deadline 15 Mar 2025 | Viewed by 80 | Submission Open

Keywords: metabolomics; bioinformatics; databases; gut microbiota; microbiome; host– microbe interaction; microbial metabolism; multiomics

(This special issue belongs to the Section Microbiology and Ecological Metabolomics)

Advances in Carotenoid Metabolism

edited by

Robin Ghosh

submission deadline 15 Mar 2025 | Viewed by 48 | Submission Open

Keywords: carotenoids; metabolism; systems biology; nutrigenomics; apocarotenoids

Metabolic Research in Bladder Cancer

edited by

Dechao Feng

submission deadline 15 Mar 2025 | Viewed by 25 | Submission Open

Keywords: bladder cancer; metabolic biomarkers; metabolic reprogramming; tumor microenvironment; molecular mechanisms

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Interactions of Diet, Exercise, and Metabolism

edited by

Raphael Gonçalves de Oliveira

, Dartagnan Pinto Guedes and Laís Campos de Oliveira

submission deadline 19 Mar 2025 | Viewed by 42 | Submission Open

Keywords: physical exercise; physical fitness; physical activity; diet; food; and nutrition; feeding behavior; me-tabolism; metabolic process

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Analysis of Specialized Metabolites in Natural Products

edited by

Aikaterini Koutsaviti

and

Christos Petrou

submission deadline 20 Mar 2025 | Viewed by 74 | Submission Open

Keywords: structure elucidation; isolation; evaluation of activity; plant bioactive secondary metabolites; methodology development

(This special issue belongs to the Section Plant Metabolism)

Lipidomics in Health and Disease

edited by

Paul Wood

submission deadline 30 Mar 2025 | 2 articles | Viewed by 2357 | Submission Open

Keywords: lipidomics; high-resolution mass spectrometry; lipid derivatization; lipid chromatography; diagnostics; therapeutics

(This special issue belongs to the Section Lipid Metabolism)

Plant Biotic and Abiotic Stress Responses and Tolerance: Phytohormonal and Metabolic Insights

edited by

Tabibul Islam

and Md. Al Mamun

submission deadline 31 Mar 2025 | 1 articles | Viewed by 1161 | Submission Open

Keywords: biotic and abiotic stress; phytohormones: primary metabolism; secondary metabolites; plant– pathogen interactions; biostimulants; beneficial microbes; plant innate immunity; omics (genomics; transcriptomics; proteomics; metabolomics; etc.)

(This special issue belongs to the Section Plant Metabolism)

Lichen Secondary Metabolites in Cancer Research

edited by

Michal Goga

and

Martin Kello

submission deadline 31 Mar 2025 | Viewed by 87 | Submission Open

Keywords: identification of lichen substances; extraction; purification; methodology; anti-cancer effects; epigenetics; apoptosis pathways modulation; resistance mechanisms; tumor microenvironment modulation

Advances in Phytomedicine Intervention on Metabolic Disorders

edited by

Hong Qin

submission deadline 31 Mar 2025 | Viewed by 83 | Submission Open

Keywords: metabolic disorders; glucose and lipid metabolism; insulin resistance; non-communicable diseases; energy imbalance; nutrients; phytochemicals; plant ac-tive components; inflammation; signaling pathway

(This special issue belongs to the Section Nutrition and Metabolism)

Metabolomics Approaches to Nutrition, Intestine and Farm Animal

edited by

Shu-cheng Huang

Lihong Zhang

and Aoyun Li

submission deadline 31 Mar 2025 | Viewed by 54 | Submission Open

Keywords: farm animal; nutrition; metabolomics; metabolism; gut microbiota

(This special issue belongs to the Section Nutrition and Metabolism)

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