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Nutrients
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Nutritional Support for Pediatric Gastroenterology Patients
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Nutritional Support for Pediatric Gastroenterology Patients

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Pediatric Nutrition".

Deadline for manuscript submissions: 5 November 2024 | Viewed by 9151

Special Issue Editors

Dr. Víctor Manuel Navas-López

E-Mail Website
Guest Editor
Pediatric Gastroenterology and Nutrition Unit, Hospital Regional Universitario de Malaga, 29010 Málaga, Spain
Interests: inflammatory bowel disease; short bowel syndrome; cystic fibrosis; enteral nutrition; cerebral palsy
Dr. Rafael Martín-Masot

E-Mail Website
Co-Guest Editor
Pediatric Gastroenterology and Nutrition Unit, Hospital Regional Universitario de Malaga, 29010 Málaga, Spain
Interests: gastroenterology; pediatrics; nutrition; celiac disease; inflammatory bowel disease
Marta Herrador-López

E-Mail Website
Guest Editor Assistant
Pediatric Gastroenterology and Nutrition Unit, Hospital Regional Universitario de Malaga, 29010 Málaga, Spain
Interests: nutrition; celiac disease; crohn’s disease; enteral nutrition; pediatrics

Special Issue Information

Dear Colleagues,

We extend a warm invitation to contribute your research to the upcoming Special Issue “Nutritional Support for Pediatric Gastroenterology Patients” of the journal "Nutrients” which will focus on pediatric patients with gastrointestinal diseases. This field of study holds significant relevance due to the complex implications these diseases have on the development and well-being of the young recipients.

Understanding and improving nutritional support in this context is essential to optimize the quality of life and the recovery process for these patients. By submitting scientific articles based on robust research, we aim to delve into key aspects of nutritional support, including accurate assessment of nutritional needs, selection of appropriate diets, and monitoring of clinical response.

Your contribution could shed light on specific strategies to address challenges such as nutrient malabsorption, food intolerance, and other gastrointestinal issues in pediatric patients. By sharing your findings and insights, you will be strengthening the foundation of medical evidence and helping to inform clinical practices in this field.

We appreciate your interest and look forward to your valuable participation in this special issue. Your scientific work is pivotal in advancing the field of nutritional support in pediatric patients with gastrointestinal diseases, thus enhancing the medical care provided to these patients.

Dr. Víctor Manuel Navas-López
Dr. Rafael Martín-Masot
Guest Editors

Marta Herrador-López
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nutritional support
  • pediatric nutrition
  • gastrointestinal disorders
  • malabsorption
  • enteral nutrition
  • parenteral nutrition
  • nutrient deficiency
  • diet therapy
  • micronutrients
  • macronutrients
  • nutritional assessment
  • dietary interventions
  • nutritional guidelines
  • clinical nutrition
  • nutritional status
  • nutritional needs
  • nutritional management
  • growth and development
  • nutrient absorption
  • food intolerance

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Further information on MDPI's Special Issue polices can be found here.

Published Papers (4 papers)

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Research

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12 pages, 278 KiB  
Article
Nutritional Issues in Children with Dysphagia
by Pilar Ortiz Pérez, Inés Valero-Arredondo, Encarnación Torcuato-Rubio, Marta Herrador-López, Rafael Martín-Masot and Víctor Manuel Navas-López
Nutrients 2024, 16(11), 1590; https://doi.org/10.3390/nu16111590 - 23 May 2024
Viewed by 1235
Abstract
(1) Background: Pediatric dysphagia presents significant nutritional challenges, often impacting growth and development due to reduced oral intake, increased nutritional needs, and gastrointestinal complications; (2) Methods: This prospective quasi-experimental study assessed 117 children under 14 years old (20 patients were under 1 year [...] Read more.
(1) Background: Pediatric dysphagia presents significant nutritional challenges, often impacting growth and development due to reduced oral intake, increased nutritional needs, and gastrointestinal complications; (2) Methods: This prospective quasi-experimental study assessed 117 children under 14 years old (20 patients were under 1 year old, 80 were aged 1–7 years, and 17 were older than 7 years), diagnosed with swallowing disorders, to analyze their caloric, macro-, and micronutrient intake and identify potential deficiencies. The severity of dysphagia was established using functional oral intake scales, and dietary records were reviewed over a 3-day period; (3) Results: The study revealed that 39.8% of participants did not meet their total energy expenditure (TEE), highlighting a high prevalence of malnutrition among these children. Furthermore, patients using feeding devices exhibited a significantly lower caloric intake, and over half required significantly modified food textures. After individualized speech therapy and nutritional rehabilitation, participants showed significant improvements in caloric intake, with their energy coverage increasing from 958% to 1198% of the daily requirement. Rehabilitation also improved tolerance to a broader range of food textures; (4) Conclusions: This research underscores the importance of multidisciplinary, individualized nutritional strategies to address the specific challenges of pediatric dysphagia, emphasizing the role of enteral nutrition and therapeutic interventions in improving the quality of life and nutritional outcomes of these children. Further studies are recommended to assess the long-term impact of such strategies. Full article
(This article belongs to the Special Issue Nutritional Support for Pediatric Gastroenterology Patients)

Review

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14 pages, 732 KiB  
Review
Prebiotic Strategies to Manage Lactose Intolerance Symptoms
by Gloria Angima, Yunyao Qu, Si Hong Park and David C. Dallas
Nutrients 2024, 16(7), 1002; https://doi.org/10.3390/nu16071002 - 29 Mar 2024
Cited by 2 | Viewed by 3473
Abstract
Lactose intolerance, which affects about 65–75% of the world’s population, is caused by a genetic post-weaning deficiency of lactase, the enzyme required to digest the milk sugar lactose, called lactase non-persistence. Symptoms of lactose intolerance include abdominal pain, bloating and diarrhea. Genetic variations, [...] Read more.
Lactose intolerance, which affects about 65–75% of the world’s population, is caused by a genetic post-weaning deficiency of lactase, the enzyme required to digest the milk sugar lactose, called lactase non-persistence. Symptoms of lactose intolerance include abdominal pain, bloating and diarrhea. Genetic variations, namely lactase persistence, allow some individuals to metabolize lactose effectively post-weaning, a trait thought to be an evolutionary adaptation to dairy consumption. Although lactase non-persistence cannot be altered by diet, prebiotic strategies, including the consumption of galactooligosaccharides (GOSs) and possibly low levels of lactose itself, may shift the microbiome and mitigate symptoms of lactose consumption. This review discusses the etiology of lactose intolerance and the efficacy of prebiotic approaches like GOSs and low-dose lactose in symptom management. Full article
(This article belongs to the Special Issue Nutritional Support for Pediatric Gastroenterology Patients)
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11 pages, 1300 KiB  
Review
Lactose Intolerance versus Cow’s Milk Allergy in Infants: A Clinical Dilemma
by Andy Darma, Khadijah Rizky Sumitro, Juandy Jo and Nova Sitorus
Nutrients 2024, 16(3), 414; https://doi.org/10.3390/nu16030414 - 31 Jan 2024
Cited by 4 | Viewed by 3177
Abstract
Due to its very early introduction, cow’s milk is one of the first foods that can cause adverse reactions in human beings. Lactose intolerance (LI) and cow’s milk allergy (CMA) are the most common adverse reactions to cow’s milk. While LI is due [...] Read more.
Due to its very early introduction, cow’s milk is one of the first foods that can cause adverse reactions in human beings. Lactose intolerance (LI) and cow’s milk allergy (CMA) are the most common adverse reactions to cow’s milk. While LI is due to insufficient small intestinal lactase activity and/or a large quantity of ingested lactose, CMA is an aberrant immune reaction to cow’s milk proteins, particularly casein or β-lactoglobulin. However, the clinical manifestations of LI and CMA, particularly their gastrointestinal signs and symptoms, are very similar, which might lead to misdiagnosis or delayed diagnosis as well as nutritional risks due to inappropriate dietary interventions or unnecessary dietary restriction. Formula-fed infants with LI should be treated with formula with reduced or no lactose, while those with CMA should be treated with formula containing extensive hydrolyzed cow’s milk protein or amino acids. This review is therefore written to assist clinicians to better understand the pathophysiologies of LI and CMA as well as to recognize the similarities and differences between clinical manifestations of LI and CMA. Full article
(This article belongs to the Special Issue Nutritional Support for Pediatric Gastroenterology Patients)
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Other

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14 pages, 1431 KiB  
Study Protocol
Can Faecal Zonulin and Calprotectin Levels Be Used in the Diagnosis and Follow-Up in Infants with Milk Protein-Induced Allergic Proctocolitis?
by Grażyna Czaja-Bulsa, Karolina Bulsa, Monika Łokieć and Arleta Drozd
Nutrients 2024, 16(17), 2949; https://doi.org/10.3390/nu16172949 - 2 Sep 2024
Viewed by 570
Abstract
Objective: The aim of our study was to investigate whether a 1-month-long milk-free diet results in a reduction in faecal calprotectin (FC) and faecal-zonulin-related proteins (FZRP) in children with milk-protein-induced allergic proctocolitis (MPIAP). Materials and methods: This is a single-centre, prospective, observational cohort [...] Read more.
Objective: The aim of our study was to investigate whether a 1-month-long milk-free diet results in a reduction in faecal calprotectin (FC) and faecal-zonulin-related proteins (FZRP) in children with milk-protein-induced allergic proctocolitis (MPIAP). Materials and methods: This is a single-centre, prospective, observational cohort study involving 86 infants with MPIAP, aged 1–3 months, and 30 healthy controls of the same age. The FC and FZRP were marked using the ELISA method (IDK® Calprotectin or Zonulin ELISA Kit, Immunodiagnostik AG, Bensheim, Germany). The diagnosis of MPIAP was confirmed with an open milk challenge test. Results: FFC and FZRP proved useful in evaluating MPIAP treatment with a milk-free diet, and the resolution of allergic symptoms and a significant (p = 0.0000) decrease in the concentrations of both biomarkers were observed after 4 weeks on the diet. The FC and FZRP concentrations were still higher than in the control group. A high variability of FC concentrations was found in all the study groups. An important limitation is the phenomenon of FZRP not being produced in all individuals, affecting one in five infants. Conclusions: FC and FZRP can be used to monitor the resolution of colitis in infants with MPIAP treated with a milk-free diet, indicating a slower resolution of allergic inflammation than of allergic symptoms. The diagnosis of MPIAP on the basis of FC concentrations is subject to considerable error, due to the high individual variability of this indicator. FZRP is a better parameter, but this needs further research, as these are the first determinations in infants with MPIAP. Full article
(This article belongs to the Special Issue Nutritional Support for Pediatric Gastroenterology Patients)
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: A retrospective observational study of the current status and efficacy and safety of oral selenium solution preparation and administration in a pediatric patient population predominantly suffering from inflammatory bowel disease.
Author: Saito
Highlights: In Japan, oral selenium preparations have been prepared in hospitals from reagents, but their efficacy and safety are unknown. The oral selenium preparation was produced in a similar dosage as the injectable formulation, producing comparable blood concentrations. Oral administration of selenium below the upper tolerated dose limit was safe for children without increasing the frequency of adverse events.

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