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Nutrients
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Fat-Soluble Vitamins for Disease Prevention and Management (2nd Edition)
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Fat-Soluble Vitamins for Disease Prevention and Management (2nd Edition)

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Micronutrients and Human Health".

Deadline for manuscript submissions: 15 November 2025 | Viewed by 2726

Special Issue Editor

Prof. Dr. Caroline S. Stokes

E-Mail Website
Guest Editor
1. Food and Health Research Group, Faculty of Life Sciences, Humboldt University of Berlin, 14195 Berlin, Germany
2. Department of Molecular Toxicology, German Institute of Human Nutrition, 14558 Potsdam-Rehbruecke, Germany
Interests: vitamin D metabolism; fat-soluble vitamins; microbiome; liver diseases; depression; sustainable nutrition
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Considering the success of the previous Special Issue, entitled “Fat-Soluble Vitamins for Disease Prevention and Management” (from which we published 10 papers), we are pleased to announce that we are launching a second Special Issue on this topic.

In this Special Issue of Nutrients, we would like to bring together papers focusing on the topic of the influence of fat-soluble vitamins (A, D, E, and K) on health outcomes. Fat-soluble micronutrient deficiencies have been associated with unfavorable health outcomes and various diseases, such as cancer, diabetes, and cardiovascular and liver diseases.

Fat-soluble vitamins have a multitude of functions, including important immunomodulatory, inflammatory, and antioxidant-related processes, and deficiencies in these vitamins can contribute to, amongst others, the weakening of the immune system. Fat-soluble vitamins are stored in the body and, unlike water-soluble vitamins, cannot easily be excreted. Consequently, higher than required concentrations of such vitamins can be harmful. There is growing interest in the influence of fat-soluble micronutrients in both the prevention and management of disease. This interest is driven not only by the knowledge of the many biochemical functions of these essential nutrients but also by emerging pleiotropic processes.

These considerations warrant a Special Issue on fat-soluble vitamins to highlight recent developments in basic and applied research into their role in health maintenance as well as shed more light on any controversial issues. Manuscripts presenting basic, applied, and clinical research, observational and meta-analysis studies, and analytical reviews in the fat-soluble vitamin area are encouraged for this Special Issue.

Prof. Dr. Caroline S. Stokes
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • fat-soluble vitamins
  • neuropsychiatry
  • aging
  • vitamin A
  • vitamin D
  • vitamin E
  • vitamin K
  • non-alcoholic fatty liver disease
  • cancer
  • diabetes
  • immune function
  • CVD

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Published Papers (2 papers)

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Research

14 pages, 650 KiB  
Article
Vitamin D Status Determines Cardiometabolic Effects of Testosterone Replacement Therapy in Men with Late-Onset Hypogonadism
by Robert Krysiak, Karolina Kowalcze, Witold Szkróbka and Bogusław Okopień
Nutrients 2025, 17(6), 1013; https://doi.org/10.3390/nu17061013 - 13 Mar 2025
Viewed by 1274
Abstract
Background/Objectives: Low testosterone levels and low vitamin D status are associated with increased cardiometabolic risk. The purpose of this study was to investigate whether vitamin D status determines the cardiometabolic effects of testosterone replacement therapy. Methods: The study population consisted of [...] Read more.
Background/Objectives: Low testosterone levels and low vitamin D status are associated with increased cardiometabolic risk. The purpose of this study was to investigate whether vitamin D status determines the cardiometabolic effects of testosterone replacement therapy. Methods: The study population consisted of three groups of men with late-onset hypogonadism: vitamin D-naive individuals with 25-hydroxyvitamin D levels between 20 and 30 ng/mL (group I), males with 25-hydroxyvitamin D levels between 30 and 60 ng/mL receiving vitamin D supplementation because of previous low vitamin D status (group II), and vitamin D-naïve subjects with 25-hydroxyvitamin D levels between 30 and 60 ng/mL (group III). Circulating levels of total testosterone, 25-hydroxyvitamin D, glucose, insulin, lipids, uric acid, high-sensitivity C-reactive protein (hsCRP), homocysteine, fibrinogen, and urinary albumin-to-creatinine ratio (UACR) were assessed before and six months after intramuscular testosterone administration (250 mg every three weeks). Results: Group I differed from the remaining groups in baseline values of 25-hydroxyvitamin D, hsCRP, homocysteine, fibrinogen, UACR, and the Framingham Risk Score. In all three groups, testosterone injections increased plasma testosterone levels and had a neutral effect on 25-hydroxyvitamin D concentration. In groups II and III, the drug improved insulin sensitivity and reduced LDL cholesterol, uric acid, hsCRP, homocysteine, fibrinogen, and UACR. In group I, the impact of testosterone was limited to a small decrease in HDL cholesterol and hsCRP. Only in groups II and III did testosterone reduce the Framingham Risk Score. There were no differences in the strength of testosterone action between both groups. In groups II and III, the replacement-induced changes in insulin sensitivity, LDL cholesterol, uric acid, hsCRP, homocysteine, fibrinogen, UACR, and the Framingham Risk Score positively correlated with 25-hydroxyvitamin D concentration. Conclusions: The study results suggest that the cardiometabolic effects of exogenous testosterone in men with testosterone deficiency may be determined by vitamin D status. Full article
(This article belongs to the Special Issue Fat-Soluble Vitamins for Disease Prevention and Management (2nd Edition))
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13 pages, 3979 KiB  
Article
Vitamin K1 Administration Increases the Level of Circulating Carboxylated Osteocalcin in Critically Ill Patients
by Nadide Aydin, Thomas Kander, Ulf Schött and Sassan Hafizi
Nutrients 2025, 17(2), 348; https://doi.org/10.3390/nu17020348 - 19 Jan 2025
Viewed by 1075
Abstract
Background/Objectives: Vitamin K-dependent proteins (VKDPs) all commonly possess specially modified γ-carboxyglutamic acid residues created in a vitamin K-dependent manner. Several liver-derived coagulation factors are well characterised VKDPs. However, much less is known about extrahepatic VKDPs, which are more diverse in their molecular structures [...] Read more.
Background/Objectives: Vitamin K-dependent proteins (VKDPs) all commonly possess specially modified γ-carboxyglutamic acid residues created in a vitamin K-dependent manner. Several liver-derived coagulation factors are well characterised VKDPs. However, much less is known about extrahepatic VKDPs, which are more diverse in their molecular structures and functions, and some of which have been implicated in inflammatory disorders. Vitamin K metabolism was shown to be impaired in critically ill patients, in whom systemic inflammation and sepsis are common features. Therefore, the aim of this study was to investigate the effect of vitamin K administration to these patients on their circulating levels of selected VKDPs. A particular novelty of this study was the measurement of specifically carboxylated forms of these proteins in addition to their overall levels. Methods: Blood samples were taken from 47 patients in the intensive care unit before and approximately 24 h after intravenous vitamin K1 (10 mg) administration, and proteins were analysed by specific immunoassay. Results: Vitamin K1 induced increases in plasma levels of carboxylated osteocalcin and total Gas6 (p = 0.0002 and p = 0.0032, respectively). No changes were detected in levels of carboxylated Gas6 or PIVKA-II (undercarboxylated prothrombin), although the latter positively correlated with undercarboxylated osteocalcin (r = 0.38). Conclusion: Injected vitamin K1 increases the blood levels of two distinct VKDPs in critically ill patients, both of which have been implicated in inflammation regulation, including the increased carboxylation of one of them. Full article
(This article belongs to the Special Issue Fat-Soluble Vitamins for Disease Prevention and Management (2nd Edition))
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