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Nutrients
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Nutrition, Physical Activity and Alternative Therapies in Diabetes and Obesity
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Nutrition, Physical Activity and Alternative Therapies in Diabetes and Obesity

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Diabetes".

Deadline for manuscript submissions: closed (25 October 2024) | Viewed by 3927

Special Issue Editor

Dr. Maurício Da Silva Krause

E-Mail Website
Guest Editor
Laboratory of Inflammation, Metabolism and Exercise Research (LAPIMEX) and Laboratory of Cellular Physiology, Department of Physiology, Institute of Basic Health Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
Interests: exercise; metabolism; obesity; diabetes; nutrition
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

I am pleased to invite you to contribute to this Special Issue, titled “Nutrition, Physical Activity and Alternative Therapies in Diabetes and Obesity”.

Diet and physical activity are modifiable lifestyle factors associated with metabolic health. In fact, exercise is the most effective non-pharmacological tool to prevent and treat metabolic diseases such as obesity and diabetes. The present Special Issue will help to improve understanding of the effects of exercise, whether alone or in combination with nutritional interventions, in obese and type I and type 2 diabetes patients mellitus. In addition to exercise and nutrition, this Special Issue will look at other potential alternative therapies, such as heat therapy, multidisciplinary interventions, etc. Papers describing the effects of exercise, nutrition and alternative therapies on health, as well as their impacts on changes in metabolism, inflammation, oxidative stress, microbiota, gene and protein expression, body composition, and cardiovascular function, are welcome. 

We encourage all researchers to submit original research papers, reviews, systematic reviews, and meta-analyses for publication in this Special Issue to broaden our knowledge and open new research avenues.

Prof. Dr. Maurício Da Silva Krause
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • exercise
  • nutrition
  • obesity
  • diabetes
  • alternative therapies

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

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16 pages, 2718 KiB  
Article
Subacute Effects of Moderate-Intensity Aerobic Exercise in the Fasted State on Cell Metabolism and Signaling in Sedentary Rats
by Layane Ramos Ayres, Éverton Lopes Vogt, Helena Trevisan Schroeder, Mariana Kras Borges Russo, Maiza Cristina Von Dentz, Débora Santos Rocha, Jorge Felipe Argenta Model, Lucas Stahlhöfer Kowalewski, Samir Khal de Souza, Vitória de Oliveira Girelli, Jerônimo da Rosa Coelho, Nathalia de Souza Vargas, Alvaro Reischak-Oliveira, Paulo Ivo Homem de Bittencourt, Jr., Eurico Nestor Wilhelm, Anapaula Sommer Vinagre and Mauricio Krause
Nutrients 2024, 16(20), 3529; https://doi.org/10.3390/nu16203529 - 18 Oct 2024
Viewed by 1653
Abstract
Background: Physical inactivity induces insulin resistance (IR) and metabolic imbalances before any significant changes in adiposity. Recent studies suggest that the beneficial effects of exercise can be potentiated if performed while fasting. This work aimed to compare the subacute effects of fed- and [...] Read more.
Background: Physical inactivity induces insulin resistance (IR) and metabolic imbalances before any significant changes in adiposity. Recent studies suggest that the beneficial effects of exercise can be potentiated if performed while fasting. This work aimed to compare the subacute effects of fed- and fasted-state single-bout exercise on biochemical parameters and cellular signaling in the metabolism. Methods: The animals were allocated into fed rest (FER), fasting rest (FAR), fed exercise (FEE), and fasting exercise (FAE) groups. The exercise protocol was a 30 min treadmill session at 60% of V˙O2max. The fasting groups fasted for 8 h before exercise and were killed after 12 h post-exercise. Results: Soleus glycogen concentration increased only in the fasting groups, whereas the triglyceride (TGL) content increased in brown adipose tissue (BAT) and liver in the FAE. The FAE showed decreased plasma total cholesterol concentration compared withthe FAR group. Immunocontent of HSP70, SIRT1, UCP-1, and PGC1-α did not change in any tissue investigated. Conclusions: Our results indicate that physical exercise while fasting can have beneficial metabolic effects on sedentary animals. Remarkably, in the FAE group, there was a reduction in total plasma cholesterol and an increase in the capacity of BAT to metabolize and store nutrients in the form of TGLs. Full article
(This article belongs to the Special Issue Nutrition, Physical Activity and Alternative Therapies in Diabetes and Obesity)
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Review

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28 pages, 1325 KiB  
Review
Managing Type 2 Diabetes Mellitus via the Regulation of Gut Microbiota: A Chinese Medicine Perspective
by Chester Yan Jie Ng, Linda Zhong, Han Seong Ng, Kia Seng Goh and Yan Zhao
Nutrients 2024, 16(22), 3935; https://doi.org/10.3390/nu16223935 - 18 Nov 2024
Cited by 1 | Viewed by 1791
Abstract
Background: Type 2 Diabetes Mellitus (T2DM) is a metabolic disorder characterized by insulin resistance and inadequate insulin production. Given the increased frequency of T2DM and the health issues it can cause, there is an increasing need to develop alternative T2DM management strategies. One [...] Read more.
Background: Type 2 Diabetes Mellitus (T2DM) is a metabolic disorder characterized by insulin resistance and inadequate insulin production. Given the increased frequency of T2DM and the health issues it can cause, there is an increasing need to develop alternative T2DM management strategies. One such approach is Chinese Medicine (CM), a complementary therapy widely used in T2DM treatment. Given the emphasis on gut microbiota in current research, studying CM in the treatment of T2DM via gut microbiota modulation could be beneficial. Scope and approach: The use of various CM methods for managing T2DM via gut microbiota modulation is highlighted in this review. Following an introduction of the gut microbiota and its role in T2DM pathogenesis, we will review the potential interactions between gut microbiota and T2DM. Thereafter, we will review various CM treatment modalities that modulate gut microbiota and provide perspectives for future research. Key findings and discussion: In T2DM, Akkermansia, Bifidobacterium, and Firmicutes are examples of gut microbiota commonly imbalanced. Studies have shown that CM therapies can modulate gut microbiota, leading to beneficial effects such as reduced inflammation, improved metabolism, and improved immunity. Among these treatment modalities, Chinese Herbal Medicine and acupuncture are the most well-studied, and several in vivo studies have demonstrated their potential in managing T2DM by modulating gut microbiota. However, the underlying biomolecular mechanisms of actions are not well elucidated, which is a key area for future research. Future studies could also investigate alternate CM therapies such as moxibustion and CM exercises and conduct large-scale clinical trials to validate their effectiveness in treatment. Full article
(This article belongs to the Special Issue Nutrition, Physical Activity and Alternative Therapies in Diabetes and Obesity)
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