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Assessment of Vitamin D Status in Human Health

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition Methodology & Assessment".

Deadline for manuscript submissions: closed (25 September 2024) | Viewed by 2237

Special Issue Editor


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Guest Editor
Department of Internal Medicine and Oncology, Semmelweis University Faculty of Medicine, 2/a Korányi S. Str, 1083, Budapest, Hungary
Interests: calcium metabolism; bone metabolism; genetics of bone diseases; vitamin D metabolism; pathophysiology; genetic of thyroid diseases; general health sciences; theoretical medicine
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Special Issue Information

Dear Colleagues,

Vitamin D deficiency has a prevalence high worldwide. Endeavors to ameliorate this public health problem are challenged mostly by the heterogeneity of nutritional and clinical vitamin D guidelines. The importance of vitamin D goes far beyond musculoskeletal health. As the vitamin D receptor (VDR) is expressed in the majority of human cells, it has been proposed that vitamin D may have a more widespread role in general health. This is supported by several experimental and epidemiological studies. The general dilemma regarding the potential extra-skeletal health benefits of vitamin D is that the vitamin D requirements for skeletal health may be fulfilled at lower or higher 25(OH)D concentrations than the requirements for certain extra-skeletal health benefits. Recent large vitamin D RCTs failed to document significant benefits regarding their primary outcomes, including mortality, cancer, or cardiovascular diseases, but these trials enrolled populations that were, by a vast majority, not vitamin D deficient.

This Special Issue will include manuscripts that focus on the assessment of vitamin D status (i.e., deficiency/normal/high level) and investigate the associations or causal relationships with any health benefit or disease outcome. Additionally, we accept studies regarding the investigation of vitamin D supplementation in healthy individuals or in patient populations with vitamin D deficiency compared to those of normal vitamin D status.

Dr. Istvan Takacs
Guest Editor

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Keywords

  • 25(OH)D level
  • 1,25(OH)2D level
  • vitamin D deficiency
  • vitamin D supplementation
  • treatment
  • prevention

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Published Papers (1 paper)

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Research

23 pages, 1627 KiB  
Article
Effects of High Dose Bolus Cholecalciferol on Free Vitamin D Metabolites, Bone Turnover Markers and Physical Function
by Simon D. Bowles, Richard Jacques, Thomas R. Hill, Richard Eastell and Jennifer S. Walsh
Nutrients 2024, 16(17), 2888; https://doi.org/10.3390/nu16172888 - 29 Aug 2024
Viewed by 1925
Abstract
High dose bolus cholecalciferol supplementation has been associated with falls and fracture, and this does not appear to be due to hypercalcaemia. The primary aim of this study was to determine the change in free vitamin D and metabolites after high dose bolus [...] Read more.
High dose bolus cholecalciferol supplementation has been associated with falls and fracture, and this does not appear to be due to hypercalcaemia. The primary aim of this study was to determine the change in free vitamin D and metabolites after high dose bolus supplementation. This was a single centre, double-blinded, randomised, controlled trial of three different oral bolus doses of vitamin D3 (50,000 IU, 150,000 IU, and 500,000 IU) in otherwise healthy, vitamin D deficient (total 25-hydroxylated vitamin 25(OH)D < 30 nmol/L) postmenopausal women. Thirty-three women were randomized to one of the three treatment groups. Twenty-seven vitamin D sufficient (25(OH)D > 50 nmol/L) postmenopausal women were recruited as a concurrent control group. Participants attended five study visits over three months. We measured total 25(OH)D3 and free 25(OH)D, total and free 1,25(OH)2D, parathyroid hormone, fibroblast-growth factor-23, serum calcium, ionised calcium, urinary calcium excretion, and bone turnover markers (procollagen I N-propeptide (PINP), serum C-telopeptides of type I collagen (CTX-I) and Osteocalcin (OC)). We assessed muscle strength and function with grip strength and a short physical performance battery. Postural blood pressure and aldosterone:renin ratio (ARR) was also measured. Total 25(OH)D3 and free 25(OH)D increased in response to dose, and there were proportionate increases in total and free metabolites. Treatment did not affect serum calcium, postural blood pressure, ARR, or physical function. Bone turnover markers increased transiently one week after administration of 500,000 IU. High dose bolus cholecalciferol supplementation does not cause disproportionate increases in free vitamin D or metabolites. We did not identify any effect on blood pressure regulation or physical function that would explain increased falls after high dose treatment. A transient increase in bone turnover markers one week after a 500,000 IU bolus suggests that very high doses can have acute effects on bone metabolism, but the clinical significance of this transient increase is uncertain. Full article
(This article belongs to the Special Issue Assessment of Vitamin D Status in Human Health)
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