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Nutrients
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Clinical Nutrition and Oncologic Outcomes
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Clinical Nutrition and Oncologic Outcomes

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Clinical Nutrition".

Deadline for manuscript submissions: 5 December 2025 | Viewed by 1153

Special Issue Editors

Dr. Livia Silvia Augustin

E-Mail Website
Guest Editor
National Cancer Institute ‘Istituto Nazionale Tumori IRCCS Fondazione Giovanni Pascale’, Via Mariano Semmola, 80131 Naples, Italy
Interests: mediterranean diet; carbohydrates; dietary fiber; cancer risk; breast cancer survivorship; quality of life; cardiometabolic comorbidities
Special Issues, Collections and Topics in MDPI journals
Dr. Alessio Filippone

E-Mail Website
Guest Editor
Center for Integrative Oncology Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy
Interests: diet; breast cancer; microbiome; integrative oncology; body composition; nutritional screening; personalized medicine

Special Issue Information

Dear Colleagues,

The relationship between nutrition and cancer has been a focal point of extensive research. Growing evidence strongly suggests that dietary patterns, specific nutrients, and overall nutritional status can significantly influence an individual's risk of developing cancer, the progression of the disease, and ultimately, their response to treatment. This complex interplay highlights the critical role of nutrition at all stages of the cancer journey, from prevention and early detection to treatment and survivorship.

This Special Issue aims to explore the impact of various dietary factors, nutritional interventions, and nutritional status on cancer risk, prevention, treatment, and survivorship. We encourage the submission of manuscripts that investigate the role of macronutrients, micronutrients, dietary fiber, antioxidants, phytochemicals, microbiota interactions, and dietary patterns in cancer development and progression. Furthermore, we welcome studies examining the impact of obesity, including sarcopenic obesity, malnutrition, cachexia, and other nutrition-related complications on cancer prognosis and treatment outcomes.

This Special Issue of Nutrients entitled “Clinical Nutrition and Oncologic Outcomes” welcomes original research and reviews of the literature concerning this important topic.

Dr. Livia Silvia Augustin
Dr. Alessio Filippone
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • diet
  • nutrition
  • malnutrition
  • cancer
  • oncology
  • obesity
  • body composition
  • chemotherapy
  • prevention
  • survivorship
  • cachexia
  • microbiota

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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15 pages, 4414 KiB  
Article
Early Nutritional Intervention in Patients with Non-Small Cell Lung Cancer Receiving Concurrent Chemoradiotherapy: A Phase II Prospective Study
by Fangjie Liu, Qiaoting Luo, Yu Xi, Pengxin Zhang, Yingjia Wu, Suping Guo, Yaoling Dong, Daquan Wang, Qingping Wu, Hui Liu, Yuming Rong and Bo Qiu
Nutrients 2025, 17(8), 1389; https://doi.org/10.3390/nu17081389 - 21 Apr 2025
Abstract
Aims: This phase II study aimed to evaluate the impact of early nutritional intervention on the nutritional status and survival of locally advanced non-small cell lung cancer (LANSCLC) patients undergoing concurrent chemoradiotherapy (CCRT). Methods: LANSCLC patients treated with CCRT were enrolled in [...] Read more.
Aims: This phase II study aimed to evaluate the impact of early nutritional intervention on the nutritional status and survival of locally advanced non-small cell lung cancer (LANSCLC) patients undergoing concurrent chemoradiotherapy (CCRT). Methods: LANSCLC patients treated with CCRT were enrolled in the study group and received early nutritional intervention, including individualized nutrition counseling and oral nutritional supplements, from the initiation of CCRT to 2 weeks after its completion. The primary endpoint was the incidence of weight loss ≥5% during the CCRT. For comparison with the study group, a matched control group was retrieved from previous trials by the 1:1 propensity score matching method. Results: Sixty-seven patients were enrolled in the study group with a median follow-up of 52.4 months. Compared with the control group, the study group exhibited a lower incidence of weight loss ≥5% (p = 0.032), higher body mass index (p = 0.034) and prealbumin levels (p = 0.014) at the end of CCRT, as well as lower patient-generated subjective global assessments scores at the end of CCRT (p < 0.001) and 6 months after CCRT (p = 0.007). The study group also had a lower incidence of grade 2+ radiation pneumonitis (p = 0.023) and longer progression-free survival (13.5 vs. 11.3 months, p = 0.032). Patients who responded well to oral nutritional supplements had a higher Firmicutes/Bacteroidetes ratio at baseline (p = 0.036). Conclusions: Early nutritional intervention in LANSCLC patients undergoing CCRT improved nutritional status and reduced radiation pneumonitis. Gut microbiota was associated with the response to oral nutritional supplements. Full article
(This article belongs to the Special Issue Clinical Nutrition and Oncologic Outcomes)
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15 pages, 993 KiB  
Systematic Review
A Neutropenic Diet in Haemato-Oncological Patients Receiving High-Dose Therapy and Hematopoietic Stem Cell Transplantation: A Systematic Review
by Luise Jahns, Jutta Hübner, Christina Mensger and Viktoria Mathies
Nutrients 2025, 17(5), 768; https://doi.org/10.3390/nu17050768 - 21 Feb 2025
Viewed by 908
Abstract
Background/Objectives: Although the benefits of low-germ diets for patients are increasingly being questioned, their application in practice is widespread. The aim of this review is to summarise the current data and evaluate the effectiveness of the neutropenic diet (ND) in adult haemato-oncological patients [...] Read more.
Background/Objectives: Although the benefits of low-germ diets for patients are increasingly being questioned, their application in practice is widespread. The aim of this review is to summarise the current data and evaluate the effectiveness of the neutropenic diet (ND) in adult haemato-oncological patients to provide a basis for practical guidelines. Methods: A systematic search was conducted in four electronic databases (Medline (Ovid), CINAHL (EBSCO), EMBASE (Ovid) and Cochrane CENTRAL) to identify English and German randomised controlled trials (RCTs) concerning the effectiveness of an ND in adult haematological patients. The main endpoints were fever and systemic infections, gastrointestinal (GI) infections, mortality, nutritional status and hospitalisation length. Results: A total of five RCTs with 510 adult patients were included in this systematic review. All patients received high-dose chemotherapy in order to treat haemato-oncological malignancies. None of the analysed endpoints showed a significant advantage of the ND compared to the control group. Conclusions: An ND does not have a beneficial effect on infection rates, GI health, mortality or hospitalisation length for haemato-oncological patients. On the contrary, an ND tends to negatively affect the patient’s nutritional status; therefore, an adaption in clinical routine should take place. Full article
(This article belongs to the Special Issue Clinical Nutrition and Oncologic Outcomes)
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