Formulation Strategies for Suitable and Effective Drug Delivery Systems in Pediatrics

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: 31 May 2024 | Viewed by 848

Special Issue Editor


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Guest Editor
Department of Chemistry, University of Florence, via Schiff 6, Sesto Fiorentino, 50019 Florence, Italy
Interests: cyclodextrins; drug delivery systems; drug-in-cyclodextrin-in-nanolipid carriers; oral administration; pediatric formulations; topical delivery
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Dear Colleagues,

The development of pediatric drug formulations is challenging since they must be adapted to children’s needs depending on their age, requiring constant dosing adjustments according to their weight and physiological conditions, as well as requiring different administration routes and dosage forms. The lack of specific formulations results in a large use of extemporaneous preparations leading to poor dosing accuracy and the need to develop suitable dosage forms.

Acceptability, namely, the ability and willingness of the patient to use and their caregiver to administer the medicine as intended, is the main issue to consider in the development of pediatric formulations to assure adherence to therapy. Other critical issues are the stability of the formulations and the choice of suitable excipients for a safe and effective treatment.

Original research papers, communication papers and review articles focused on formulation strategies for the development of suitable and effective pediatric formulations are welcome in this Special Issue.

Dr. Marzia Cirri
Guest Editor

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Keywords

  • pediatric formulation
  • children
  • dosage form
  • pediatric drug delivery systems
  • formulation strategies
  • dosing accuracy
  • acceptability
  • safety
  • stability
  • excipients

Published Papers (1 paper)

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Research

15 pages, 2284 KiB  
Article
Questionnaire Study to Investigate the Preferences of Children, Parents, and Healthcare Professionals for Different Formulations of Oral Medicinal Products
by Manfred Wargenau, Felicitas Baase, Kristin Eckardt, Lucas-Sebastian Spitzhorn, Sibylle Reidemeister, Ingrid Klingmann and Viviane Klingmann
Pharmaceutics 2024, 16(4), 515; https://doi.org/10.3390/pharmaceutics16040515 - 8 Apr 2024
Viewed by 533
Abstract
Since the acceptability of a medicine can significantly impact therapeutic outcomes, this study aimed to determine and compare the preferences of children, parents, and healthcare professionals for the most commonly used pediatric oral medicine formulations (syrup, mini-tablets, oblong tablets, round tablets) addressing all [...] Read more.
Since the acceptability of a medicine can significantly impact therapeutic outcomes, this study aimed to determine and compare the preferences of children, parents, and healthcare professionals for the most commonly used pediatric oral medicine formulations (syrup, mini-tablets, oblong tablets, round tablets) addressing all pediatric age groups, 0–<18 years (y). This survey study employed sex-, age-, and participant group-adapted questionnaires for eight cohorts of participants, i.e., children 6–<12 y, adolescents 12–<18 y, parents of children in four age groups (0–<2 y, 2–<6 y, 6–<12 y, and 12–<18 y), nurses, and pediatricians. Descriptive statistics were used for data analysis. In the age groups 0–<2 y and 2–<6 y, mini-tablets were preferred over syrup by all participants. In the age group 6–12 y, solid dosage forms were also preferred over syrup by all participants. In the age group 12–<18 y, healthcare professionals preferred solid dosage forms over syrup. Parents preferred higher amounts of mini-tablets and syrup compared to round and oblong tablets, while adolescents’ preferences did not differentiate between these formulations. Based on the study results and in contrast to current practice, it is suggested to consider solid dosage forms for future age-appropriate medicinal products already for younger age groups. Full article
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