Powder Processing in Pharmaceutical Applications
A special issue of Pharmaceutics (ISSN 1999-4923).
Deadline for manuscript submissions: closed (29 February 2020) | Viewed by 49799
Special Issue Editors
Interests: particle comminution; particle formulation; product design; bulk solids handling; battery process engineering; pharmaceutical engineering; battery recycling
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
In all production processes of solid dosage forms, powders with a multitude of distributed properties must be processed. Starting with the handling for dispensing and weighing, over blending, dosing, comminution, and granulation, up to capsule filling or tableting, powder properties crucially determine the process performance and product quality. In any case, each powder in pharmaceutical formulations brings along distributions of various microscopic properties such as particle size, morphology, and surface energies as well as macroscopic properties such as flow behavior and bulk densities. Along the process chain, multiple powders are blended or more fundamentally change their properties, e.g. by granulation, causing complex changes that will affect their behavior in subsequent processes. Additionally, transportation and packaging of intermediates and final products can cause changes due to aeration, abrasion, or compaction. The determination of powder properties such as particle, surface, and flow properties require sophisticated, methodologic approaches to measure meaningful parameters under representative conditions. The deep knowledge of powder properties and quick and reliable measurement techniques become a prerequisite in the context of continuous process chains that need to immediately respond to material property changes to keep processes and product quality stable within specified ranges. To achieve this, well-developed model approaches need to be derived to predict and control any complex powder processing operation.
This special issue is dedicated to in-depth studies and reviews, presenting fundamental advancement in the scientific field of powder processing in pharmaceutical applications. Contributions addressing thorough insight into unit operations, innovative measurement methods for powder properties, model approaches providing prediction of effects such as demixing, segregation, overmixing, abrasion, deagglomeration, particle breakage, and residence time distribution based on material properties and process parameters, as well as research on continuous process chains are especially encouraged.
Prof. Dr. Arno Kwade
Dr. Jan Henrik Finke
Guest Editors
Manuscript Submission Information
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Keywords
- Powder processing/handling
- Process modelling
- Powder properties
- Flow behavior
- Process performance
- Continuous processes
- Demixing/Segregation
- Granulation
- Tableting
- Capsule filling
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