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Pharmaceutics publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue polices and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Trends in mRNA Vaccine Development and Applications

edited by

Janos Szebeni

submission deadline 30 Apr 2025 | 1 articles | Viewed by 1781 | Submission Open

Keywords: vaccines; vaccination; modified mRNA; lipid nanoparticles (LNPs); mRNA-LNP; COVID-19 pandemic; SARS-CoV-2; spike protein; immunogenicity; adverse reactions

(This special issue belongs to the Section Gene and Cell Therapy)

Recent Advances in Pharmaceutical Applications of Functionalized Polysaccharides and Their Derivatives, 2nd Edition

edited by

Peter Foot

Elena Polycarpou

and Federico Buonocore

submission deadline 30 Apr 2025 | 1 articles | Viewed by 1507 | Submission Open

Keywords: functionalized polysaccharides ; nanoparticle characterization; drug delivery; enhanced loading capacity; controlled release properties; anti-microbial and anti-cancer activities; wound management

(This special issue belongs to the Section Biopharmaceutics)

Mechanism-Based Pharmacokinetic and Pharmacodynamic Modeling

edited by

Artur Świerczek

submission deadline 30 Apr 2025 | 1 articles | Viewed by 1472 | Submission Open

Keywords: PK/PD modeling; disease progression modeling; quantitative system pharmacology; physiologically based modeling

(This special issue belongs to the Section Pharmacokinetics and Pharmacodynamics)

Therapeutic Drugs and Delivery Strategies for Gastrointestinal Diseases

edited by

Michael A. Firer

and

Hengqi Zheng

submission deadline 30 Apr 2025 | 1 articles | Viewed by 1123 | Submission Open

Keywords: targeted therapy in drug delivery; biologic therapies in inflammatory bowel disease (e.g.; special dosages; administration and delivery); biologic therapies in eosinophilic esophagitis (e.g.; special dosages; administration and delivery); eosinophilic gastrointestinal disease

(This special issue belongs to the Section Clinical Pharmaceutics)

Advanced In Silico Methods and Digital Platforms for the Prediction of ADMET and Pharmacokinetics Properties

edited by

Nicola Gambacorta

and

Daniela Trisciuzzi

submission deadline 30 Apr 2025 | 1 articles | Viewed by 878 | Submission Open

Keywords: ADMET properties prediction; physiologically based pharmacokinetic (PBPK) modeling; in silico digital platform; chemoinformatics; computer-aided drug discovery; predictive toxicology

(This special issue belongs to the Section Pharmacokinetics and Pharmacodynamics)

Advances in Formulation of Nanocarriers for Overcoming Biological Barriers

edited by

Sandra Elisa Haas

submission deadline 30 Apr 2025 | 1 articles | Viewed by 856 | Submission Open

Keywords: biological barriers; drug delivery; nanocarriers; pharmacokinetics; toxicology; pharmacodynamics

(This special issue belongs to the Section Nanomedicine and Nanotechnology)

Exploring the Versatility of Cyclodextrins in Pharmaceutical Formulations

edited by

Łukasz Szeleszczuk

submission deadline 30 Apr 2025 | Viewed by 532 | Submission Open

Keywords: cyclodextrins; CDs; inclusion complexes; cyclodextrin-based nanosponges; excipients; host– guest complexes; complexes

(This special issue belongs to the Section Physical Pharmacy and Formulation)

Cyclodextrin-Based Gene and Drug Delivery Applications

edited by

Francesco Trotta

and

Yousef Khazaei Monfared

submission deadline 30 Apr 2025 | Viewed by 465 | Submission Open

Keywords: cyclodextrin; gene delivery; drug delivery; nanocarriers; biocompatibility; controlled release; targeted therapy

(This special issue belongs to the Section Drug Delivery and Controlled Release)

Biotechnology Applications and Innovative Approaches for Cancer Prevention and Treatment (BIO-APP)

edited by

Luca Vanella

Antonino Mazzaglia

and

Giuseppe Nocito

submission deadline 30 Apr 2025 | Viewed by 460 | Submission Open

Keywords: applied biochemistry; biotechnologies; cancer; drug delivery; multitarget ligands; theranostics; biomarkers; point-of-care testing; sensitive nanomaterials

(This special issue belongs to the Section Biologics and Biosimilars)

Advanced Drug Delivery across the Blood–Brain Barrier

edited by

Kun Cheng

and Zhen Zhao

submission deadline 30 Apr 2025 | Viewed by 459 | Submission Open

Keywords: blood– brain barrier (BBB); central nervous system (CNS); drug delivery; neurological disease; nanotechnology; transport mechanism; targeted delivery; BBB permeability; glioblastoma

(This special issue belongs to the Section Drug Delivery and Controlled Release)

Nano-Based Technology for Glioblastoma

edited by

Maria João Ramalho

and Joana Peixoto

submission deadline 30 Apr 2025 | Viewed by 338 | Submission Open

Keywords: nanoparticles; glioblastoma; blood– brain barrier; diagnosis; therapy; drug delivery; nose-to-brain delivery; targeted delivery; surface modification

(This special issue belongs to the Section Nanomedicine and Nanotechnology)

Application of Silver Nanoparticles in Cancer Treatment

edited by

Serena Mazzucchelli

and Francesco Ragonese

submission deadline 30 Apr 2025 | Viewed by 329 | Submission Open

Keywords: silver nanoparticles; nanomedicine; nanotechnology; cancer therapy; cancer diagnostics; cancer theranostics; tumor targeting; drug delivery systems; in vitro studies; in vivo studies

(This special issue belongs to the Section Nanomedicine and Nanotechnology)

Gene Therapy with LNPs, Possibilities, Limitations, New Strategies

edited by Jason Duskey and

Ilaria Ottonelli

submission deadline 30 Apr 2025 | Viewed by 317 | Submission Open

Keywords: gene therapy; lipid nanoparticles; nucleic acid delivery; nuclear targeted LNPs; microfluidic production of LNPs

(This special issue belongs to the Section Gene and Cell Therapy)

Research on the Development of Semi-solid Pharmaceutical Dosage Forms and Self-Emulsifying Drug Delivery Systems

edited by

Pálma Fehér

and

Liza Józsa

submission deadline 30 Apr 2025 | Viewed by 298 | Submission Open

Keywords: semi-solid dosage forms; ointments; creams; gels; transdermal patches; self-emulsifying drug delivery systems; topical delivery; transdermal delivery

(This special issue belongs to the Section Drug Delivery and Controlled Release)

Microneedles for Drug and Vaccine Delivery

edited by

Hiep (Ben) Nguyen

submission deadline 30 Apr 2025 | Viewed by 191 | Submission Open

Keywords: physical enhancement technologies; fabrication; characterization; applications; drug delivery; cosmetic applications; diagnostic; vaccination

(This special issue belongs to the Section Drug Delivery and Controlled Release)

Enhancing Drug Delivery with Bioactive Substances and Solid Dispersion

edited by

Marco Chaud

and Fernanda Isadora Boni

submission deadline 30 Apr 2025 | Viewed by 140 | Submission Open

Keywords: solid dispersion; amorphous solid dispersion; solid dispersion bioavailability; solid dispersion characterization; ternary solid dispersion; binary solid dispersion

(This special issue belongs to the Section Drug Delivery and Controlled Release)

Nanoemulsions for Nose-to-Brain Drug Delivery

edited by Clóvis Orlando Pereira Da Fonseca and

Rubiana Mara Mainardes

submission deadline 30 Apr 2025 | Viewed by 87 | Submission Open

Keywords: nanoemulsion; intranasal; pharmacokinetics; nose-to-brain; neurology; olfactory; nanomedicine

(This special issue belongs to the Section Nanomedicine and Nanotechnology)

Cutting-Edge Drug Delivery and Nanomedicine: Innovations in Hybrid Systems, Theranostics and Targeted Therapies

edited by

Maria Natalia Calienni

and

Marcela Analia Moretton

submission deadline 30 Apr 2025 | Viewed by 84 | Submission Open

Keywords: drug delivery; nanomedicine; hybrid nanosystems; targeted therapies; theragnostic; drug repurposing; PDT; PTT

(This special issue belongs to the Section Drug Delivery and Controlled Release)

Innovations in Drug Delivery, Pharmacometrics, and Clinical Studies in Veterinary Medicine

edited by

Eryvaldo Sócrates Tabosa Do Egito

Frederico Severino Martins

and Marcos Ferrante

submission deadline 30 Apr 2025 | Viewed by 64 | Submission Open

Keywords: veterinary medicine; pharmacometrics; PK/PD modeling; drug delivery; dose optimization

(This special issue belongs to the Section Pharmacokinetics and Pharmacodynamics)

Hybrid Nanoparticles for Cancer Therapy

edited by Jacy Gameiro

submission deadline 30 Apr 2025 | Viewed by 63 | Submission Open

Keywords: hybrid nanoparticles; cancer therapy; targeted drug delivery; nanomedicine; tumor microenvironment; gene therapy; immunotherapy; diagnostics; nanomaterials

(This special issue belongs to the Section Nanomedicine and Nanotechnology)

Advancing Block Co-Polymer Nanomedicines: Innovations in Effective Drug Delivery

edited by

Giulia Bonacucina

and

Nisar Ul Khaliq

submission deadline 30 Apr 2025 | Viewed by 50 | Submission Open

Keywords: pluronic-based nanomedicines and hydrogels; gene delivery; advanced drug delivery systems; radiotherapy and photodynamic therapy; combination therapy; polymeric nanomedicines; immunotherapy; nanogels; small-molecule delivery systems; block co-polymers nanomedicines

(This special issue belongs to the Section Nanomedicine and Nanotechnology)

Multifunctional Hydrogels for Controlled Release of Bioactive Molecules

edited by

Diana C. Silva

Ana Paula Serro

and

Maria Vivero-Lopez

submission deadline 30 Apr 2025 | Viewed by 49 | Submission Open

Keywords: multifunctional hydrogels; biodegradable hydrogels; antimicrobial hydrogels; smart hydrogels; stimuli-responsive hydrogels; therapeutic hydrogels; nanogels; drug delivery; local drug delivery; controlled release; drug carriers; bioactive molecules; bioactive materials; biocompatible materials; hydrogel characterization; ex vivo and in vivo evaluation

(This special issue belongs to the Section Drug Delivery and Controlled Release)

Antibiotic Drug Delivery Systems

edited by

Aaron J. Courtenay

Deborah Lowry

and Jessica V. Moore

submission deadline 30 Apr 2025 | Viewed by 49 | Submission Open

Keywords: antibiotic drug delivery; antimicrobial resistance; targeted drug carriers; nanoparticles; liposomes; prodrug systems; drug solubility and stability; synergistic approaches; biofilm targeting; host– pathogen interaction; personalized antibiotic therapy

(This special issue belongs to the Section Drug Delivery and Controlled Release)

Application of PLGA Nanoparticles in Cancer Therapy

edited by

Daniele Rubert Nogueira-Librelotto

submission deadline 30 Apr 2025 | Viewed by 32 | Submission Open

Keywords: PLGA nanoparticles; cancer therapy; drug delivery; biocompatibility; controlled release; targeted therapy; theranostics; formulation strategies

(This special issue belongs to the Section Nanomedicine and Nanotechnology)

Recent Advances in Drug Formulation for Antiviral Therapy

edited by Chiara Medaglia

submission deadline 30 Apr 2025 | Viewed by 29 | Submission Open

Keywords: antiviral drugs development; infection; host-pathogen interactions; functional genomics

(This special issue belongs to the Section Drug Targeting and Design)

Design of Hydrogels for Drug Delivery

edited by

Luis Morales-Quintana

and

Bustos Daniel

submission deadline 30 Apr 2025 | Viewed by 28 | Submission Open

Keywords: drug delivery; controlled release; smart hydrogels; computational modelling of hydrogels; molecular simulations of hydrogels; bioresponsive systems; hydrogel fabrication techniques

(This special issue belongs to the Section Drug Delivery and Controlled Release)

Advances in Drug Delivery Systems for Leishmaniasis Therapy

edited by Elizabeth Igne Ferreira, Jeanine Giarolla and Soraya Da Silva Santos

submission deadline 30 Apr 2025 | Viewed by 27 | Submission Open

Keywords: delivery systems; leishmanicides; bioactive compounds in Leishmania sp.; advanced systems for drug delivery; oral and topical administration

(This special issue belongs to the Section Drug Targeting and Design)

Advance Drug Delivery Systems for the Treatment of Chronic Wound Healing

edited by Carolina Martinez and María Jimena Prieto

submission deadline 30 Apr 2025 | Viewed by 16 | Submission Open

Keywords: wound healing; chronic diseases; wound repair and regeneration; drug delivery; topical formulations; biomaterial; nanotechnology; wound dressing; scar

(This special issue belongs to the Section Drug Delivery and Controlled Release)

Advances and Challenges in Nasal Formulation Developments, 2nd Edition

edited by

Daisuke Inoue

submission deadline 10 May 2025 | 7 articles | Viewed by 16436 | Submission Open

Keywords: nasal formulations; intranasal dissolution and permeation; mucosal absorption; excipients for nasal formulations; in vitro dissolution system; in vivo nasal dissolution and absorption

(This special issue belongs to the Section Pharmaceutical Technology, Manufacturing and Devices)

Dosage Form Design for Oral Administration

edited by

Atheer Awad

and

Hend Abdelhakim

submission deadline 10 May 2025 | 4 articles | Viewed by 6992 | Submission Open

Keywords: controlled release; nanotechnology; peptide and protein; buccal; age-appropriate; taste; packaging; mini-tablets; quality by design; veterinary medicine

(This special issue belongs to the Section Physical Pharmacy and Formulation)

Development of Novel Tumor-Targeting Nanoparticles, 2nd Edition

edited by

Andrea Lancia

Alexander Zaboronok

and

Bryan Mathis

submission deadline 10 May 2025 | 4 articles | Viewed by 5690 | Submission Open

Keywords: nanoparticles; nanoliposomes; nanomicelles; tumor targeting; drug delivery system; cancer; theranostics

(This special issue belongs to the Section Nanomedicine and Nanotechnology)

Biopolymer-Based Nanosystem for Drug Delivery, 2nd Edition

edited by

Ildikó Bácskay

and

János Borbély

submission deadline 10 May 2025 | 2 articles | Viewed by 4709 | Submission Open

Keywords: nano-formulations of drugs; antibody drug conjugation (ADC); nanoformulated vaccines; delivery of biologics; biotech risk analysis; assessment of biocompatibility; drug delivery system formulation; characterization of dosage forms; in vitro dissolution studies; SEDDS

(This special issue belongs to the Section Drug Delivery and Controlled Release)

Phytocompounds-Based Formulations for Anti-Inflammatory Disorders

edited by Gustavo Costa

submission deadline 10 May 2025 | Viewed by 154 | Submission Open

Keywords: phytocompounds; natural compounds; phytotherapy; plant-based drugs; anti-inflammatory; pharmaceutical forms

(This special issue belongs to the Section Physical Pharmacy and Formulation)

Nanoparticle-Based Drug Formulation for Enhancing Nose-to-Brain Delivery

edited by

Jagdish Singh

and Richard Nii Lante Lamptey

submission deadline 10 May 2025 | Viewed by 44 | Submission Open

Keywords: nanoparticles; nose-to-brain drug delivery; blood– brain barrier (BBB); central nervous system (CNS); neurodegenerative diseases; targeted therapeutics; non-invasive delivery; intranasal administration

(This special issue belongs to the Section Drug Delivery and Controlled Release)

Advances in Physiologically Based Pharmacokinetic (PBPK) Modeling and Applications

edited by

Dong‑Gyun Han

submission deadline 15 May 2025 | Viewed by 39 | Submission Open

Keywords: physiologically based pharmacokinetic (PBPK) modeling; IVIVE; pharmacokinetics; ADME; modeling and simulation; PK/PD; biopharmaceutics; quantitative systems pharmacology

(This special issue belongs to the Section Pharmacokinetics and Pharmacodynamics)

Stability of Medicines and Novel Approaches for Predicting Drug Stability

edited by

Dolores R. Serrano

and

Juan José Torrado Durán

submission deadline 20 May 2025 | 9 articles | Viewed by 33861 | Submission Open

Keywords: stability; 3D printing; ICH; physical stability; biologicals

(This special issue belongs to the Section Physical Pharmacy and Formulation)

Nucleic-Acid-Based Strategies and Nanotechnology Applications for Targeted Therapy

edited by

Andrea Patrizia Falanga

Stefano D’Errico

and

Monica Terracciano

submission deadline 20 May 2025 | 8 articles | Viewed by 14564 | Submission Open

Keywords: nucleic acids; drug delivery; nanomedicine; biotechnology; material science.

(This special issue belongs to the Section Drug Targeting and Design)

Where Are We Now and Where Is Cell Therapy Headed?

edited by

Andrea Papait

and

Paola Chiodelli

submission deadline 20 May 2025 | 7 articles | Viewed by 11816 | Submission Open

Keywords: stem cells; mesenchymal stromal cells; cell therapy; CAR-T; CAR-NK; cancer; gene therapy; organoids and organ on a chip; extracellular vesicles; secretome

(This special issue belongs to the Section Gene and Cell Therapy)

Natural Pharmaceuticals Focused on Anti-inflammatory Activities

edited by

Katarina Šavikin

and

Aleksandra A. Jovanović

submission deadline 20 May 2025 | 4 articles | Viewed by 4376 | Submission Open

Keywords: anti-inflammatory properties; chemical identification of natural anti-inflammatory agents; delivery and controlled-release systems; natural extracts; mechanisms of natural anti-inflammatory agents; molecular docking; natural products; plants and fungi; structure– effect relationships

(This special issue belongs to the Section Drug Targeting and Design)

Precision Dosing in Clinical Therapeutics: The Application of Pharmacokinetics and Pharmacometrics

edited by

Raj Badhan

submission deadline 20 May 2025 | 2 articles | Viewed by 3475 | Submission Open

Keywords: pharmacokinetics; pharmacometrics; PBPK; drug– drug interactions; pediatrics; pregnancy; oral bioavailability; modelling and simulation; population pharmacokinetics

(This special issue belongs to the Section Pharmacokinetics and Pharmacodynamics)

The State-of-the-art in Improving the Antitumor Efficacy of Platinum Drugs

edited by

Mauro Ravera

and

Elisabetta Gabano

submission deadline 20 May 2025 | 2 articles | Viewed by 2500 | Submission Open

Keywords: bioinorganic chemistry; metal-based drugs; pt coordination compounds; pharmacodynamics; pharmacokinetics

(This special issue belongs to the Section Drug Targeting and Design)

New Nano-Systems for Imaging, Diagnostics, and Drug Delivery

edited by Iris Batalha, Daniel Gonzalez-Carter and Lorena Ruiz-Pérez

submission deadline 20 May 2025 | 2 articles | Viewed by 2413 | Submission Open

Keywords: nanomedicine; drug delivery; imaging; diagnostics

(This special issue belongs to the Section Nanomedicine and Nanotechnology)

Recent Advances in Nanodelivery Systems for Plant and Food Derivatives, 2nd Edition

edited by

Anna Rita Bilia

Giulia Vanti

and

Eleonora Truzzi

submission deadline 20 May 2025 | 1 articles | Viewed by 1558 | Submission Open

Keywords: nanodelivery system; liposome; nanovesicle; nanoparticle; nanoemulsion; food-macromolecule-based nanodelivery systems; bioavailability; controlled release; natural products; functional food; food supplements; plant derivatives; herbal drugs

(This special issue belongs to the Section Drug Delivery and Controlled Release)

Bioadhesive Nanocarriers: Innovations in Drug Release and Therapeutic Effectiveness

edited by

Luana Mota Ferreira

Marcel Henrique Marcondes Sari

and Reolon Jéssica Brandão

submission deadline 20 May 2025 | Viewed by 336 | Submission Open

Keywords: nanocarriers; bioadhesive materials; mucoadhesive materials; drug delivery; topic formulations; efficacy optimization

(This special issue belongs to the Section Drug Delivery and Controlled Release)

Drug Delivery and Pharmacokinetics in Oral Medicine and Dental Infection, 2nd Edition

edited by Igor Tsesis and

Milos Kojic

submission deadline 20 May 2025 | Submission Open

Keywords: oral drug delivery; dental infection/pain; oral medicine; drug delivery; pharmacokinetics; controlled release; periodontal and endodontic infections

(This special issue belongs to the Section Drug Delivery and Controlled Release)

Long Acting Drug Delivery Formulations

edited by

Thierry Vandamme

submission deadline 20 May 2025 | Submission Open

Keywords: improvement in patient adherence; steady state; drug bioavailability; reduced side effect; targeted delivery; long acting; sustained release; prolonged release; pulse release; compliance

(This special issue belongs to the Section Physical Pharmacy and Formulation)

Biocompatible Polymers for Drug Delivery

edited by

Nebojša Pavlović

submission deadline 22 May 2025 | Viewed by 352 | Submission Open

Keywords: biomaterials; biocompatible polymers; functional materials; natural polymers; polymeric composites; drug delivery systems; biohydrogels; formulation challenges; controlled release; biomedical applications

(This special issue belongs to the Section Drug Delivery and Controlled Release)

Exploring Solid Dosage Forms: Characterization, Dissolution, and Stability

edited by Magali B. Araújo

submission deadline 30 May 2025 | Viewed by 56 | Submission Open

Keywords: solid dosage forms; drug release kinetics; physicochemical properties; dissolution testing; stability assessment; crystalline forms; pharmaceutical formulations; analytical methods

(This special issue belongs to the Section Physical Pharmacy and Formulation)

Ultrasound-Mediated Brain Drug Delivery

edited by Muna Aryal

submission deadline 30 May 2025 | Viewed by 21 | Submission Open

Keywords: low-intensity transcranial focused ultrasound; blood-brain opening; neuromodulation; glymphatic perturbation; brain diseases: brain cancer; aging; and Alzheimer; ultrasound-sensitive biomaterials

(This special issue belongs to the Section Drug Delivery and Controlled Release)

Novel Carriers for Drug Delivery and Brain Disease Treatment across the Blood-Brain Barrier

edited by