Bioreactors: Control, Optimization and Applications - 2nd Volume

Dear Colleagues,

Bioreactor are the core of biological processes. The variety of bioprocesses is tremendous, and many different designs of bioreactors have been developed to meet different needs. The success of a bioprocess depends critically on the good design and operation of the bioreactor. The biological systems involved include enzymes, microorganisms, animal cells, plant cells, and tissues. To design an appropriate bioreactor for a particular bioprocess, intensive studies on the biological system, such as cell growth, metabolism, genetic manipulation, and protein or other product expression, are needed to understand the cells’ requirement on their physical and chemical environment. It is also necessary to control and optimize the bioreactor environment via operating variables in order to favor the desired functions of the cells and achieve cost-effective large-scale manufacture. Bioreactor operation strategies include fed-batch, continuous, semicontinuous, and perfusion cultures. For the industrial application of bioreactors, bioreactor scale-up, multiscale study, and bioprocess monitoring, modeling, and simulation are also very important. Moreover, qualitative and quantitative descriptions of a production process through the analysis of various parameters via automatic or manual methods are necessary for process control and optimization. The objects of process monitoring can be the environmental status or the varied values of operational variables. Through analysis, the cellular or engineering problems of a bioreactor on different scales can be identified. Interscale observation and operation are crucial in bioprocess optimization. In this context, there is the necessity for research on “Bioreactors: Control, Optimization and Applications”. The objective of this Topic is to showcase the diversity and advances in research that contribute to developing effective systems for microorganism culture and biochemical production. Original papers are solicited on experimental/theoretical studies on bioreactor systems. We are particularly interested in manuscripts that integrate biology and engineering research and/or experimental and theoretical studies. We invite researchers from all areas of bioengineering to submit manuscripts for this important Topic.

Dr. Francesca Raganati
Dr. Alessandra Procentese
Topic Editors