Table of Contents
Viruses, Volume 9, Issue 8 (August 2017)
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Cover Story A newly identified partially hidden hydrophobic motif determines the subcellular localisation of [...] Read more. A newly identified partially hidden hydrophobic motif determines the subcellular localisation of the rabbit calicivirus polymerase and its ability to change the Golgi network. Molecular dynamics’ simulations revealed that neighbouring structural elements are highly labile and could give way upon an association with membranes. Three collinear lysines on the surface of the polymerase may not only attract the protein to negatively-charged membranes, but also position it such that the emerging hydrophobic motif would face the membrane and immerse itself into the outer leaflet. View the paper