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Medicina, Volume 56, Issue 7

2020 July - 46 articles

Cover Story: Functional dyspepsia (FD) is one of the most common gastrointestinal clinical syndromes and its etiology remains largely idiopathic. FD pharmacotherapy is difficult and often yields unsatisfactory results. Within this article, we investigate, for the first time, the efficacy and safety of trimebutine as monotherapy for FD. Trimebutine is a prokinetic drug, exhibiting also antimuscarinic and opiate receptor (mu, kappa and delta) agonist effects, as well as antibiotic properties. A multicenter, randomized, double-blind, placebo-controlled, prospective study was conducted; trimebutine was compared against placebo for a period of four weeks in patients diagnosed with FD. It was shown that trimebutine monotherapy is an effective and safe therapeutic approach for FD. This article is supplemented with additional information regarding the pathophysiology of FD and relevant additional pharmacological studies. View this paper
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Articles (46)

  • Case Report
  • Open Access
3 Citations
3,450 Views
7 Pages

21 July 2020

Rhabdomyosarcoma (RMS) is a common soft tissue sarcoma in childhood, however, it is very rare in the neonatal period (0.4–2% of cases). This case depicts a boy, who presented with RMS at two weeks of age, but officially diagnosed at the age of...

  • Article
  • Open Access
13 Citations
4,450 Views
11 Pages

21 July 2020

Background and objectives: Although treatment with novel oral non-vitamin K antagonist 3anticoagulants (NOACs) is associated with an overall decrease in hemorrhagic complications compared to warfarin, the incidence of gastrointestinal bleeding remain...

  • Review
  • Open Access
15 Citations
4,481 Views
27 Pages

The Impact of Artificial Intelligence in the Endoscopic Assessment of Premalignant and Malignant Esophageal Lesions: Present and Future

  • Daniela Cornelia Lazăr,
  • Mihaela Flavia Avram,
  • Alexandra Corina Faur,
  • Adrian Goldiş,
  • Ioan Romoşan,
  • Sorina Tăban and
  • Mărioara Cornianu

21 July 2020

In the gastroenterology field, the impact of artificial intelligence was investigated for the purposes of diagnostics, risk stratification of patients, improvement in quality of endoscopic procedures and early detection of neoplastic diseases, implem...

  • Article
  • Open Access
5 Citations
3,048 Views
10 Pages

18 July 2020

Background and Objectives: This study aimed to group diseases classified by the International Classification of Diseases using principal component analysis, and discuss a systematic approach to reducing the preventable death rate from a perspective o...

  • Article
  • Open Access
9 Citations
3,845 Views
11 Pages

18 July 2020

Background and Objectives: Dehydration might be an issue after hip fracture surgery, but the optimal tools to identify the dehydrated condition have not been determined. The aim of the present study was to compare the characteristics of elderly posto...

  • Article
  • Open Access
3 Citations
3,319 Views
13 Pages

Designers Drugs—A New Challenge to Emergency Departments—An Observational Study in Poland

  • Rakesh Jalali,
  • Paula Dmochowska,
  • Izabela Godlewska,
  • Justyna Balmas,
  • Katarzyna Młynarska,
  • Krzysztof Narkun,
  • Andrzej Zawadzki and
  • Marcin Wojnar

17 July 2020

Background and Objective: In the last decade, the phenomenon of using new psychoactive substances (NPS), called designer drugs, has been on rise. Though their production and marketing in Poland is prohibited, reports of the Supreme Audit Office noted...

  • Case Report
  • Open Access
4 Citations
4,022 Views
8 Pages

A Patient with Cryoglobulinemic Membranoproliferative GN (MPGN) Who Survived COVID-19 Disease: Case Presentation and Current Data of COVID-19 Infection in Dialysis and Transplanted Patients in Greece

  • Smaragdi Marinaki,
  • Stathis Tsiakas,
  • Chrysanthi Skalioti,
  • Panayiota Lourida,
  • Aikaterini Argyraki,
  • Konstantinos Grigorakos and
  • Ioannis Boletis

17 July 2020

The evolving pandemic of Coronavirus Disease 2019 has posed a substantial health risk worldwide. However, there is a paucity of data regarding the clinical course and the therapeutic management of patients with chronic kidney disease and COVID-19 inf...

  • Article
  • Open Access
14 Citations
5,617 Views
10 Pages

Effectiveness of 6-Week Nordic Walking Training on Functional Performance, Gait Quality, and Quality of Life in Parkinson’s Disease

  • Justyna Szefler-Derela,
  • Michal Arkuszewski,
  • Andrzej Knapik,
  • Dagmara Wasiuk-Zowada,
  • Agnieszka Gorzkowska and
  • Ewa Krzystanek

17 July 2020

Background and objectives: Motor rehabilitation improves physical mobility and quality of life in Parkinson’s disease (PD). As specialized rehabilitation is expensive and resource-consuming, there is a need for simpler, cost-effective methods....

  • Article
  • Open Access
7 Citations
3,138 Views
11 Pages

Intravenous r-tPA Dose Influence on Outcome after Middle Cerebral Artery Ischemic Stroke Treatment by Mechanical Thrombectomy

  • Marius Kurminas,
  • Andrius Berūkštis,
  • Nerijus Misonis,
  • Karmela Blank,
  • Algirdas Edvardas Tamošiūnas and
  • Dalius Jatužis

17 July 2020

Background and Objectives: Pretreatment with intravenous thrombolysis (IVT) is still recommended in all eligible acute ischemic stroke patients with large-vessel occlusion before mechanical thrombectomy (MTE). However, the added value and safety of b...

  • Article
  • Open Access
11 Citations
6,010 Views
10 Pages

17 July 2020

Background and objectives: Hypernatremia can be community or hospital-acquired, and there may be specific factors unique to the hospital environment, such as intravenous fluid treatment, which contribute to hypernatremia. The aim of this study was to...

  • Article
  • Open Access
5 Citations
3,327 Views
11 Pages

Expression Levels of Inflammatory and Oxidative Stress-Related Genes in Skin Biopsies and Their Association with Pityriasis Alba

  • Margarita L. Martinez-Fierro,
  • Griselda A. Cabral-Pacheco,
  • Idalia Garza-Veloz,
  • Andrés E. Campuzano-García,
  • Alma P. Díaz-Alonso,
  • Virginia Flores-Morales,
  • Iram P. Rodriguez-Sanchez,
  • Ivan Delgado-Enciso and
  • Jorge Rios-Jasso

17 July 2020

Background and objectives: Pytiriasis alba (PA) is a common skin disorder which affects 80% of children between six and 16 years. The etiology of PA is unclear, but hypo-pigmented patches in photo-exposed zones characterize the disease. Because the h...

  • Article
  • Open Access
6 Citations
2,703 Views
10 Pages

Factors Associated with Procedural Thromboembolisms after Mechanical Thrombectomy for Acute Ischemic Stroke

  • Taek Min Nam,
  • Ji Hwan Jang,
  • Young Zoon Kim,
  • Kyu Hong Kim and
  • Seung Hwan Kim

16 July 2020

Background and objective: Procedural thromboembolisms after mechanical thrombectomy (MT) for acute ischemic stroke has rarely been studied. We retrospectively evaluated factors associated with procedural thromboembolisms after MT using diffusion-weig...

  • Article
  • Open Access
16 Citations
3,916 Views
16 Pages

15 July 2020

Background and objectives: Patient-handling activities predispose women to chronic low back pain (CLBP), but sufficient evidence is not available on whether a 3D moving platform, made for core stability exercise, affects pain, trunk flexibility, and...

  • Review
  • Open Access
35 Citations
15,283 Views
19 Pages

Eating Disorders in Pregnant and Breastfeeding Women: A Systematic Review

  • María Martínez-Olcina,
  • Jacobo A. Rubio-Arias,
  • Cristina Reche-García,
  • Belén Leyva-Vela,
  • María Hernández-García,
  • Juan José Hernández-Morante and
  • Alejandro Martínez-Rodríguez

15 July 2020

Background and objectives: Pregnancy is a stage associated with various biopsychosocial changes. These changes, along with concerns about keeping an adequate weight, can modulate an individual’s risk for psychological disorders, especially eati...

  • Review
  • Open Access
3 Citations
3,072 Views
8 Pages

14 July 2020

Background and Objectives: This research attempts to provide a clear view of the literature on randomized clinical trials (RCTs) concerning the efficacy of topical dexamethasone, clobetasol and budesonide in oral graft versus host disease (GVHD). Mat...

  • Article
  • Open Access
16 Citations
3,144 Views
22 Pages

14 July 2020

Background and Objectives: Elevated oxidative stress has been shown to play an important role in the diagnosis and prognosis of stress and memory-related complications. Mukia madrespatana (M. madrespatana) has been reported to have various biological...

  • Article
  • Open Access
10 Citations
3,211 Views
10 Pages

Neurodevelopmental Aspects and Cortical Auditory Maturation in Children with Cochlear Implants

  • Cristina Pantelemon,
  • Violeta Necula,
  • Alexandra-Stefania Berghe,
  • Livia Livinț-Popa,
  • Steluța Palade,
  • Vitalie Văcăraș,
  • Ioana Anamaria Mureșanu,
  • Ștefan Strilciuc and
  • Fior-Dafin Mureșanu

13 July 2020

Background and objectives: The cochlear implant is not only meant to restore auditory function, but it also has a series of benefits on the psychomotor development and on the maturation of central auditory pathways. In this study, with the help of ne...

  • Article
  • Open Access
14 Citations
3,362 Views
13 Pages

13 July 2020

Background and objectives: The present study aims to elucidate the clinicopathologic significance of Epstein–Barr virus (EBV) infection in gastric carcinomas (GCs) through a meta-analysis. Materials and Methods: Sixty-one eligible studies were...

  • Article
  • Open Access
5 Citations
2,340 Views
8 Pages

13 July 2020

Background: The corpus uteri and ovarian cancers burden in Lithuania has remained high. The aim of this study was to investigate time trends in mortality rates of corpus uteri and ovarian cancer in Lithuania across age groups and time periods over a...

  • Article
  • Open Access
9 Citations
3,657 Views
11 Pages

Residential Links to Air Pollution and School Children with Asthma in Vilnius (Population Study)

  • Sarunas Alasauskas,
  • Ruta Ustinaviciene and
  • Mindaugas Kavaliauskas

13 July 2020

Background and objectives: Many studies have been carried out on the negative health effects of exposure to PM10, PM 2.5, NO2, CO, SO2 and B[a]P for small populations. The main purpose of this study was to explore the association of air pollution to...

  • Article
  • Open Access
4 Citations
3,372 Views
9 Pages

The Impact of Everolimus and Radiation Therapy on Pulmonary Fibrosis

  • Mehmet Fuat Eren,
  • Ayfer Ay Eren,
  • Mutlay Sayan,
  • Birsen Yücel,
  • Şahende Elagöz,
  • Yıldıray Özgüven,
  • Irina Vergalasova,
  • Ahmet Altun,
  • Saadettin Kılıçkap and
  • Nuran Beşe
  • + 1 author

13 July 2020

Background and objectives: Everolimus (EVE) is a mammalian target of the rapamycin (mTOR) inhibitor that is widely used in cancer patients. Pulmonary toxicity, usually manifesting as interstitial pneumonitis, is a serious adverse effect of this drug....

  • Article
  • Open Access
6 Citations
3,329 Views
11 Pages

Neck Dissection for Cervical Lymph Node Metastases from Remote Primary Malignancies

  • Shogo Shinohara,
  • Hiroyuki Harada,
  • Masahiro Kikuchi,
  • Shinji Takebayashi and
  • Kiyomi Hamaguchi

10 July 2020

Background and Objectives: Patients with cervical lymph node metastases from remote primary tumours have poor prognoses because of the advanced stage of their cancer. Owing to recent progress in the nonsurgical management of various cancer types, opt...

  • Article
  • Open Access
15 Citations
3,293 Views
8 Pages

Diagnostic Value of Circulating miR-202 in Early-Stage Breast Cancer in South Korea

  • Jungho Kim,
  • Sunyoung Park,
  • Dasom Hwang,
  • Seung Il Kim and
  • Hyeyoung Lee

Background and objectives: Breast cancer is the most common cancer among women worldwide. Early stage diagnosis is important for predicting increases in treatment success rates and decreases in patient mortality. Recently, circulating biomarkers such...

  • Article
  • Open Access
27 Citations
3,728 Views
10 Pages

Treatment Strategies for Pilonidal Sinus Disease in Switzerland and Austria

  • Tenzin Lamdark,
  • Raphael Nicolas Vuille-dit-Bille,
  • Isabella Naomi Bielicki,
  • Laura C. Guglielmetti,
  • Rashikh A Choudhury,
  • Nora Peters,
  • Dietrich Doll,
  • Markus M Luedi and
  • Michel Adamina

Background and objective: No current nationwide consensus exists on pilonidal disease (PD) treatment in Switzerland and Austria. The objective of this study was to assess and compare the spectrum of PD treatment strategies in Switzerland and Austria....

  • Article
  • Open Access
18 Citations
3,565 Views
11 Pages

Postoperative Delirium in Patients with Chronic Obstructive Pulmonary Disease after Coronary Artery Bypass Grafting

  • Aleksandra Szylińska,
  • Iwona Rotter,
  • Mariusz Listewnik,
  • Kacper Lechowicz,
  • Mirosław Brykczyński,
  • Sylwia Dzidek,
  • Maciej Żukowski and
  • Katarzyna Kotfis

Background and Objectives: The incidence of postoperative delirium (POD) in patients with chronic obstructive pulmonary disease (COPD) is unclear. It seems that postoperative respiratory problems that may occur in COPD patients, including prolonged m...

  • Article
  • Open Access
1 Citations
3,056 Views
9 Pages

The Effect of Muscle Exercise on Perforators Flow: A Prospective Cohort Study

  • Francesco Amendola,
  • Luca Vaienti,
  • Giuseppe Cottone,
  • Giovanna Zaccaria,
  • Zvi Steinberger,
  • Nicole Dereatti,
  • Michele Riccio,
  • Glenda Giorgia Caputo,
  • Francesco De Francesco and
  • Nicola Zingaretti

Background and objectives: The metabolic response after exercise causes a significant increase in the muscle blood flow. While these effects are demonstrated for intra-muscular vessels, there is no evidence about the inter-muscular vessels, such as t...

  • Article
  • Open Access
12 Citations
11,096 Views
12 Pages

Trimebutine Maleate Monotherapy for Functional Dyspepsia: A Multicenter, Randomized, Double-Blind Placebo Controlled Prospective Trial

  • Jannis Kountouras,
  • Emmanuel Gavalas,
  • Apostolis Papaefthymiou,
  • Ioannis Tsechelidis,
  • Stergios A. Polyzos,
  • Serhat Bor,
  • Mircea Diculescu,
  • Κhaled Jadallah,
  • Mazurek Tadeusz and
  • Michael Doulberis
  • + 8 authors

Background and Objectives: Functional dyspepsia (FD) is one of the most common functional gastrointestinal disorders; it has a great impact on patient quality of life and is difficult to treat satisfactorily. This study evaluates the efficacy and saf...

  • Review
  • Open Access
21 Citations
7,173 Views
12 Pages

Dysautonomia in Alzheimer's Disease

  • Delia Tulbă,
  • Liviu Cozma,
  • Bogdan Ovidiu Popescu and
  • Eugenia Irene Davidescu

Alzheimer's disease is the most common neurodegenerative disorder, and its prevalence increases with age. Although there is a large amount of scientific literature focusing on Alzheimer's disease cardinal cognitive features, autonomic nervous system...

  • Article
  • Open Access
5 Citations
3,922 Views
25 Pages

Background and Objectives: Oral health-related quality of life (OHRQOL) is compromised during the post-implant healing period, especially when vertical augmentation is required. A long-term trial sought to evaluate a short dental implant system with...

  • Article
  • Open Access
7 Citations
2,911 Views
9 Pages

Early Glottic Cancer Treated by Transoral Laser Surgery Using Toluidine Blue for the Definition of the Surgical Margins: A Pilot Study

  • Eugenia Allegra,
  • Maria Rita Bianco,
  • Chiara Mignogna,
  • Gaetano Davide Drago,
  • Domenico Michele Modica and
  • Lidia Puzzo

Background and objectives: Transoral laser microsurgery (TLM) is widely accepted for its advantages, which consist of a brief hospital stay, rapid functional recovery, low management costs and the fact that it can be easily repeated in cases of recur...

  • Article
  • Open Access
13 Citations
4,067 Views
9 Pages

Bilateral Comparisons of Quadriceps Thickness after Anterior Cruciate Ligament Reconstruction

  • Joo-Hyun Lee,
  • Soul Cheon,
  • Hyung-Pil Jun,
  • Yu-Lun Huang and
  • Eunwook Chang

Background and objectives: Anterior cruciate ligament reconstruction (ACLR) often results in quadricep atrophy. The purpose of this study was to compare the bilateral thickness of each quadricep component before and after ACLR. Materials and Methods:...

  • Review
  • Open Access
98 Citations
13,223 Views
19 Pages

Properties, Extraction Methods, and Delivery Systems for Curcumin as a Natural Source of Beneficial Health Effects

  • Aleksandra Zielińska,
  • Henrique Alves,
  • Vânia Marques,
  • Alessandra Durazzo,
  • Massimo Lucarini,
  • Thais F. Alves,
  • Margreet Morsink,
  • Niels Willemen,
  • Piotr Eder and
  • Eliana B. Souto
  • + 3 authors

This review discusses the impact of curcumin—an aromatic phytoextract from the turmeric (Curcuma longa) rhizome—as an effective therapeutic agent. Despite all of the beneficial health properties ensured by curcumin application, its pharma...

  • Article
  • Open Access
38 Citations
5,307 Views
13 Pages

Influence of Body Composition on Physical Fitness in Adolescents

  • María Mendoza-Muñoz,
  • José Carmelo Adsuar,
  • Jorge Pérez-Gómez,
  • Laura Muñoz-Bermejo,
  • Miguel Ángel Garcia-Gordillo and
  • Jorge Carlos-Vivas

Background and objectives: Childhood obesity is one of the main public health issues facing advanced societies. The Spanish population presents 28.6% overweight or obese adolescents, and Extremadura, 22.3%. Physical fitness is considered one of the m...

  • Article
  • Open Access
9 Citations
3,141 Views
9 Pages

Background and objectives: Persistent wheezing (PW) is defined as prolonged or recurrent episodes of wheezing despite regular treatment. Flexible bronchoscopy (FB) is recommended to determine the etiology of PW in children. This study aimed to determ...

  • Article
  • Open Access
21 Citations
5,225 Views
12 Pages

Exploring the Influencing Factors of Health Literacy among Older Adults: A Cross-Sectional Survey

  • Hsiao-Ting Chiu,
  • Han-Wei Tsai,
  • Ken N. Kuo,
  • Angela Y.M. Leung,
  • Yao-Mao Chang,
  • Pi-Hsia Lee and
  • Wen-Hsuan Hou

Background and Objectives: To investigate the health literacy (HL) among older adults in Taiwan, we referenced an existing integrated model of HL to confirm the influencing factors of HL in older adults. We propose this study to examine the personal,...

  • Article
  • Open Access
5 Citations
2,710 Views
10 Pages

Background and Objectives: The purpose of this study was to elucidate the effects of different exercise intensities in preventing the decline of cognitive function and lipolysis associated with a high-fat diet-induced obesity in growing mice. Materia...

  • Article
  • Open Access
7 Citations
4,030 Views
10 Pages

Sialolithiasis—Do Early Diagnosis and Removal Minimize Post-Operative Morbidity?

  • Gal Avishai,
  • Yehonatan Ben-Zvi,
  • Omar Ghanaiem,
  • Gavriel Chaushu and
  • Hanna Gilat

Background and objectives: Sialolithiasis is an inflammation of a salivary gland due to obstruction of salivary flow by a sialolith. We aim to assess potential factors that may predict lower morbidity following endoscopically assisted per-oral sialol...

  • Article
  • Open Access
10 Citations
8,823 Views
9 Pages

Vaginal Reconstruction in Patients with Mayer–Rokitansky–Küster–Hauser Syndrome—One Centre Experience

  • Adelaida Avino,
  • Laura Răducu,
  • Adrian Tulin,
  • Daniela-Elena Gheoca-Mutu,
  • Andra-Elena Balcangiu-Stroescu,
  • Cristina-Nicoleta Marina and
  • Cristian-Radu Jecan

Background and Objectives: The Mayer–Rokitansky–Küster–Hauser syndrome is a congenital condition in which patients are born with vaginal and uterus agenesis, affecting the ability to have a normal sexual life and to bear childr...

  • Article
  • Open Access
6 Citations
4,336 Views
7 Pages

Dupuytren’s Contracture: Incidence of Injury-Induced Cases and Specific Clinical Expression

  • Gediminas Samulėnas,
  • Rytis Rimdeika,
  • Kęstutis Braziulis,
  • Mantas Fomkinas and
  • Rokas Paškevičius

30 June 2020

Background and objectives: Dupuytren’s contracture is a chronic fibroproliferative hand disorder with a varying pattern of genetic predisposition across different regions and populations. Traumatic events have been found to have influence on th...

  • Article
  • Open Access
5 Citations
3,943 Views
13 Pages

30 June 2020

Background and Objectives: Patients undergoing mastectomy and implant-based breast reconstruction have significant acute postsurgical pain. The purpose of this study was to examine the efficacy of intercostal nerve blocks (ICNBs) for reducing pain af...

  • Article
  • Open Access
9 Citations
3,495 Views
7 Pages

Validity of the STOP-Bang Questionnaire in Identifying OSA in a Dental Patient Cohort

  • Letizia Lonia,
  • Marco Scalese,
  • Gianluca Rossato,
  • Giovanni Bruno,
  • Francesca Zalunardo,
  • Alberto De Stefani and
  • Antonio Gracco

30 June 2020

Background and objectives: Obstructive Sleep Apnea represents a widespread problem in the population, but it is often not diagnosed and not considered a true pathology. Different diagnostic tools are available for the diagnosis of sleep apnea. This s...

  • Case Report
  • Open Access
2 Citations
3,685 Views
19 Pages

Non-Autogenous Innovative Reconstruction Method Following Mandibulectomy

  • Bahaa Haj Yahya,
  • Eli Rosenfeld,
  • Gavriel Chaushu,
  • Ilana Kaplan,
  • Yehonantan Ben-Zvi and
  • Yafit Hamzani

30 June 2020

Plexiform ameloblastoma is a locally aggressive odontogenic tumor, rare in the anterior mandible. The treatment of choice is resection with 1–3 cm free margins. In most of reported cases, the affected mandible is reconstructed by autogenic bone...

  • Article
  • Open Access
21 Citations
4,572 Views
13 Pages

Acceleration of Skin Wound-Healing Reactions by Autologous Micrograft Tissue Suspension

  • Shiro Jimi,
  • Satoshi Takagi,
  • Francesco De Francesco,
  • Motoyasu Miyazaki and
  • Arman Saparov

29 June 2020

Background and objectives: Skin grafting is a method usually used in reconstructive surgery to accelerate skin regeneration. This method results frequently in unexpected scar formations. We previously showed that cutaneous wound-healing in normal mic...

  • Review
  • Open Access
19 Citations
3,182 Views
11 Pages

Prognostic Significance of ADAM17 for Gastric Cancer Survival: A Meta-Analysis

  • Peng Ni,
  • Mingyang Yu,
  • Rongguang Zhang,
  • Mengya He,
  • Haiyan Wang,
  • Shuaiyin Chen and
  • Guangcai Duan

29 June 2020

Background and objectives: The prognostic role of a disintegrin and metalloproteinase (ADAM) 17 has been widely assessed in gastric cancer. However, the results are inconsistent. We performed a meta-analysis to evaluate the prognostic significance of...

  • Review
  • Open Access
44 Citations
7,692 Views
11 Pages

Pharmacological Interactions in the Elderly

  • Emilia Błeszyńska,
  • Łukasz Wierucki,
  • Tomasz Zdrojewski and
  • Marcin Renke

28 June 2020

Pharmacological therapy in the elderly is particularly complicated and challenging. Due to coexistence of three main predisposing factors (advanced age, multiple morbidity and polypharmacotherapy), this group of patients is prone to occurrence of dru...

  • Article
  • Open Access
2 Citations
2,489 Views
12 Pages

Close Correlation between Frailty and Depressive State in Chronic Liver Diseases

  • Hiroki Nishikawa,
  • Kazunori Yoh,
  • Hirayuki Enomoto,
  • Yoshinori Iwata,
  • Yoshiyuki Sakai,
  • Kyohei Kishino,
  • Yoshihiro Shimono,
  • Naoto Ikeda,
  • Tomoyuki Takashima and
  • Hiroko Iijima
  • + 7 authors

27 June 2020

Background and objectives: Few data with regard to the relevance between depression and frailty in chronic liver disease (CLD) patients are currently available. We aimed to elucidate the relationship between frailty and depression as evaluated by the...

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Medicina - ISSN 1648-9144