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Brain Sciences, Volume 11, Issue 10

2021 October - 116 articles

Cover Story: Oxidative stress mechanisms may explain associations between perinatal acetaminophen exposure and childhood attention-deficit hyperactivity disorder (ADHD). We investigated whether the changes in umbilical cord plasma amino acids needed to synthesize the antioxidant glutathione and in the oxidative stress biomarker 8-hydroxy-deoxyguanosine may explain the association between cord plasma acetaminophen and ADHD in the Boston Birth Cohort (BBC). Mother–child dyads were followed at the Boston Medical Center between 1998 and 2018. Cord plasma analytes were measured from archived samples collected at birth. Physician diagnoses of childhood ADHD were obtained from medical records. View this paper.
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Articles (116)

  • Feature Paper
  • Article
  • Open Access
15 Citations
3,172 Views
10 Pages

Metacognitive Performance on Memory and Visuospatial Tasks in Functional Cognitive Disorder

  • Catherine Pennington,
  • Harriet Ball,
  • Marta Swirski,
  • Margaret Newson and
  • Elizabeth Coulthard

19 October 2021

Functional Cognitive Disorder (FCD) is a common diagnosis at the memory clinic. FCD is characterised by significant self-reported cognitive symptoms in the absence of external evidence of cognitive dysfunction. A potential explanation for this is a d...

  • Article
  • Open Access
8 Citations
4,368 Views
19 Pages

Prior Exposure and Toddlers’ Sleep-Related Memory for Novel Words

  • Emma L. Axelsson,
  • Jaclyn Swinton,
  • Isabel Y. Jiang,
  • Emma V. Parker and
  • Jessica S. Horst

18 October 2021

Children can easily link a novel word to a novel, unnamed object—something referred to as fast mapping. Despite the ease and speed with which children do this, their memories for novel fast-mapped words can be poor unless they receive memory supports...

  • Article
  • Open Access
4 Citations
3,575 Views
12 Pages

18 October 2021

Individuals in healthy romantic relationships gain significant benefits to their psychological wellbeing and physiological health. Notably, the majority of relationship research has focused on how adult attachment influences these relationship outcom...

  • Review
  • Open Access
18 Citations
7,734 Views
13 Pages

17 October 2021

The purpose of the study was to systematically review the evidence on the effects of an acute bout of exercise on concurrent performance of core executive function (EF) during exercise in adults. Four electronic databases (i.e., PubMed, Web of Scienc...

  • Article
  • Open Access
6 Citations
3,145 Views
13 Pages

Genotype- and Age-Dependent Differences in Ultrasound Vocalizations of SPRED2 Mutant Mice Revealed by Machine Deep Learning

  • Denis Hepbasli,
  • Sina Gredy,
  • Melanie Ullrich,
  • Amelie Reigl,
  • Marco Abeßer,
  • Thomas Raabe and
  • Kai Schuh

17 October 2021

Vocalization is an important part of social communication, not only for humans but also for mice. Here, we show in a mouse model that functional deficiency of Sprouty-related EVH1 domain-containing 2 (SPRED2), a protein ubiquitously expressed in the...

  • Article
  • Open Access
12 Citations
3,433 Views
11 Pages

Decreased Global EEG Synchronization in Amyloid Positive Mild Cognitive Impairment and Alzheimer’s Disease Patients—Relationship to APOE ε4

  • Una Smailovic,
  • Charlotte Johansson,
  • Thomas Koenig,
  • Ingemar Kåreholt,
  • Caroline Graff and
  • Vesna Jelic

16 October 2021

The apolipoprotein E (APOE) ε4 allele is a risk factor for Alzheimer’s disease (AD) that has been linked to changes in brain structure and function as well as to different biological subtypes of the disease. The present study aimed to investigate the...

  • Article
  • Open Access
7 Citations
3,725 Views
24 Pages

Diffusion Tensor Imaging Changes Do Not Affect Long-Term Neurodevelopment following Early Erythropoietin among Extremely Preterm Infants in the Preterm Erythropoietin Neuroprotection Trial

  • Janessa B. Law,
  • Bryan A. Comstock,
  • Todd L. Richards,
  • Christopher M. Traudt,
  • Thomas R. Wood,
  • Dennis E. Mayock,
  • Patrick J. Heagerty and
  • Sandra E. Juul

16 October 2021

We aimed to evaluate diffusion tensor imaging (DTI) in infants born extremely preterm, to determine the effect of erythropoietin (Epo) on DTI, and to correlate DTI with neurodevelopmental outcomes at 2 years of age for infants in the Preterm Erythrop...

  • Feature Paper
  • Review
  • Open Access
19 Citations
20,732 Views
11 Pages

16 October 2021

Background: Sleep disorders and sleep problems commonly occur in adults with ADHD and add to functional impairment. Evidence-based treatments for sleep could improve function in the adult ADHD population. Methods: A literature review was conducted to...

  • Article
  • Open Access
9 Citations
3,520 Views
14 Pages

Similar CNV Neurodynamic Patterns between Sub- and Supra-Second Time Perception

  • Mingming Zhang,
  • Keye Zhang,
  • Xing Zhou,
  • Bin Zhan,
  • Weiqi He and
  • Wenbo Luo

16 October 2021

In the field of time psychology, the functional significance of the contingent negative variation (CNV) component in time perception and whether the processing mechanisms of sub- and supra-second are similar or different still remain unclear. In the...

  • Case Report
  • Open Access
3 Citations
2,979 Views
16 Pages

Alterations in Leg Muscle Glucose Uptake and Inter-Limb Asymmetry after a Single Session of tDCS in Four People with Multiple Sclerosis

  • Alexandra C. Fietsam,
  • Justin R. Deters,
  • Craig D. Workman,
  • Laura L. Boles Ponto and
  • Thorsten Rudroff

16 October 2021

Asymmetrical lower limb weakness is an early symptom and significant contributor to the progressive worsening of walking ability in people with multiple sclerosis (PwMS). Transcranial direct current stimulation (tDCS) may effectively increase neural...

  • Article
  • Open Access
11 Citations
3,455 Views
15 Pages

15 October 2021

Background: Interoceptive accuracy and sensibility are decreased in depressive samples. However, different studies showed that cognitive-behavioural therapy (CBT) and mindfulness interventions are promising approaches to improve interoceptive abiliti...

  • Systematic Review
  • Open Access
16 Citations
3,541 Views
15 Pages

Emotional Processing and Experience in Amyotrophic Lateral Sclerosis: A Systematic and Critical Review

  • Laura Carelli,
  • Federica Solca,
  • Sofia Tagini,
  • Silvia Torre,
  • Federico Verde,
  • Nicola Ticozzi,
  • Monica Consonni,
  • Roberta Ferrucci,
  • Gabriella Pravettoni and
  • Vincenzo Silani
  • + 1 author

15 October 2021

Even though increasing literature describes changes in emotional processing in Amyotrophic Lateral Sclerosis (ALS), efforts to summarize relevant findings are lacking in the field. A systematic literature review was performed to provide a critical an...

  • Article
  • Open Access
14 Citations
3,666 Views
10 Pages

15 October 2021

The medial posterior parietal cortex (PPC) is involved in the complex processes of visuomotor integration. Its connections to the dorsal premotor cortex, which in turn is connected to the primary motor cortex (M1), complete the fronto-parietal networ...

  • Article
  • Open Access
17 Citations
3,904 Views
11 Pages

15 October 2021

Previous studies have found that transcranial alternating current stimulation (tACS) can significantly enhance individuals’ working memory performance. However, it is still unclear whether the memory performance enhancement was attributed to the quan...

  • Article
  • Open Access
3 Citations
4,471 Views
13 Pages

The Department of Veterans Affairs Gulf War Veterans’ Illnesses Biorepository: Supporting Research on Gulf War Veterans’ Illnesses

  • Christopher B. Brady,
  • Ian Robey,
  • Thor D. Stein,
  • Bertrand R. Huber,
  • Jessica Riley,
  • Nazifa Abdul Rauf,
  • Keith R. Spencer,
  • Gabriel Walt,
  • Latease Adams and
  • Neil W. Kowall
  • + 4 authors

14 October 2021

Aims: To introduce a resource supporting research on Gulf War illness (GWI) and related disorders, the Gulf War Veterans’ Illnesses Biorepository (GWVIB). Methods: Gulf War era veterans (GWVs) are recruited nationally and enrolled via telephone and e...

  • Feature Paper
  • Article
  • Open Access
12 Citations
4,415 Views
14 Pages

Short Digital Spatial Memory Test Detects Impairment in Alzheimer’s Disease and Mild Cognitive Impairment

  • Jackie M. Poos,
  • Ineke J. M. van der Ham,
  • Anna E. Leeuwis,
  • Yolande A. L. Pijnenburg,
  • Wiesje M. van der Flier and
  • Albert Postma

14 October 2021

Background: Impairment in navigation abilities and object location memory are often seen in early-stage Alzheimer’s Disease (AD), yet these constructs are not included in standard neuropsychological assessment. We investigated the differential abilit...

  • Systematic Review
  • Open Access
23 Citations
9,679 Views
15 Pages

Depressive Symptoms and Burnout in Football Players: A Systematic Review

  • Hugo Sarmento,
  • Roberta Frontini,
  • Adilson Marques,
  • Miguel Peralta,
  • Nestor Ordoñez-Saavedra,
  • João Pedro Duarte,
  • António Figueiredo,
  • Maria João Campos and
  • Filipe Manuel Clemente

14 October 2021

The purpose of this article was to systematically review and organise the available literature devoted to the topic of depressive symptoms and burnout in football players. A systematic search was conducted in Web of Science, Scopus, SPORTdiscus, PubM...

  • Feature Paper
  • Review
  • Open Access
13 Citations
3,333 Views
14 Pages

Mental Illness and Amyloid: A Scoping Review of Scientific Evidence over the Last 10 Years (2011 to 2021)

  • Gianluca Pandolfo,
  • Fiammetta Iannuzzo,
  • Giovanni Genovese,
  • Antonio Bruno,
  • Giovanni Pioggia,
  • Sergio Baldari and
  • Sebastiano Gangemi

14 October 2021

Amyloid precursor protein and its derivates represent a central factor in the process of neurodegeneration in Alzheimer’s disease (AD). Since mental illnesses share with AD cognitive impairment, amyloid indicators have been used to explore the unknow...

  • Feature Paper
  • Article
  • Open Access
9 Citations
4,490 Views
16 Pages

Reduced Axon Calibre in the Associative Striatum of the Sapap3 Knockout Mouse

  • Eliana Lousada,
  • Mathieu Boudreau,
  • Julien Cohen-Adad,
  • Brahim Nait Oumesmar,
  • Eric Burguière and
  • Christiane Schreiweis

14 October 2021

Pathological repetitive behaviours are a common feature of various neuropsychiatric disorders, including compulsions in obsessive–compulsive disorder or tics in Gilles de la Tourette syndrome. Clinical research suggests that compulsive-like symptoms...

  • Systematic Review
  • Open Access
9 Citations
4,001 Views
23 Pages

Relevance of CSF, Serum and Neuroimaging Markers in CNS and PNS Manifestation in COVID-19: A Systematic Review of Case Report and Case Series

  • Sanjiti Podury,
  • Samiksha Srivastava,
  • Erum Khan,
  • Mihir Kakara,
  • Medha Tandon,
  • Ashish K. Shrestha,
  • Kerri Freeland,
  • Sijin Wen and
  • Shitiz Sriwastava

14 October 2021

Background: The data on neurological manifestations in COVID-19 patients has been rapidly increasing throughout the pandemic. However, data on CNS and PNS inflammatory disorders in COVID-19 with respect to CSF, serum and neuroimaging markers is still...

  • Article
  • Open Access
8 Citations
4,490 Views
26 Pages

Reflexive Gaze Shifts and Fear Recognition Deficits in Children with Callous-Unemotional Traits and Impulsivity/Conduct Problems

  • Luna C. Muñoz Centifanti,
  • Timothy R. Stickle,
  • Jamila Thomas,
  • Amanda Falcón,
  • Nicholas D. Thomson and
  • Matthias Gamer

13 October 2021

The ability to efficiently recognize the emotions on others’ faces is something that most of us take for granted. Children with callous-unemotional (CU) traits and impulsivity/conduct problems (ICP), such as attention-deficit hyperactivity disorder,...

  • Article
  • Open Access
4 Citations
2,867 Views
9 Pages

Obstructive Apnea and Hypopnea Length in Normal Children and Adolescents

  • Lourdes M. DelRosso,
  • David Panek,
  • Greg Redding,
  • Maria Paola Mogavero,
  • Chris Ruth,
  • Nicole Sheldon,
  • Holly Blazier,
  • Candace Strong,
  • Maria Samson and
  • Raffaele Ferri
  • + 1 author

13 October 2021

(1) Background: Breathing is an essential function that requires both metabolic (or au-tomatic) and voluntary (behavioral) control during wakefulness but during sleep depends on metabolic control via peripheral and central chemoreceptors. Breathing d...

  • Article
  • Open Access
4 Citations
3,510 Views
12 Pages

Acoustic Identification of Sentence Accent in Speakers with Dysarthria: Cross-Population Validation and Severity Related Patterns

  • Viviana Mendoza Ramos,
  • Anja Lowit,
  • Leen Van den Steen,
  • Hector Arturo Kairuz Hernandez-Diaz,
  • Maria Esperanza Hernandez-Diaz Huici,
  • Marc De Bodt and
  • Gwen Van Nuffelen

13 October 2021

Dysprosody is a hallmark of dysarthria, which can affect the intelligibility and naturalness of speech. This includes sentence accent, which helps to draw listeners’ attention to important information in the message. Although some studies have invest...

  • Review
  • Open Access
15 Citations
7,455 Views
16 Pages

Watch and Learn: Vicarious Threat Learning across Human Development

  • Yael Skversky-Blocq,
  • Jan Haaker and
  • Tomer Shechner

13 October 2021

Vicarious threat learning is an important pathway in learning about safety and danger in the environment and is therefore critical for survival. It involves learning by observing another person’s (the demonstrator) fearful responses to threat and beg...

  • Article
  • Open Access
3 Citations
2,948 Views
13 Pages

13 October 2021

People with schizophrenia often experience a profound lack of motivation for social affiliation—a facet of negative symptoms that detrimentally impairs functioning. However, the mechanisms underlying social affiliative deficits remain poorly understo...

  • Article
  • Open Access
6 Citations
5,011 Views
15 Pages

13 October 2021

Previous research has shown that rope jumping improves physical health; however, little is known about its impact on brain-derived monoamine neurotransmitters associated with cognitive regulation. To address these gaps in the literature, the present...

  • Article
  • Open Access
8 Citations
3,075 Views
16 Pages

13 October 2021

Traumatic brain injury (TBI) is highly prevalent in children. Attention deficits are among the most common and persistent post-TBI cognitive and behavioral sequalae that can contribute to adverse outcomes. This study investigated the topological prop...

  • Article
  • Open Access
19 Citations
3,593 Views
19 Pages

11 October 2021

Inter-individual and sex differences in pain responses are recognized but their mechanisms are not well understood. This study was intended to provide the behavioral framework for analyses of pain mechanisms using fear extinction learning as a predic...

  • Article
  • Open Access
11 Citations
5,110 Views
15 Pages

Can the Addition of Maintenance Electroconvulsive Therapy to Pharmacotherapy Improve Relapse Prevention in Severe Major Depressive Disorder? A Randomized Controlled Trial

  • Erika Martínez-Amorós,
  • Narcís Cardoner,
  • Verònica Gálvez,
  • Aida de Arriba-Arnau,
  • Virginia Soria,
  • Diego J. Palao,
  • José M. Menchón and
  • Mikel Urretavizcaya

11 October 2021

Few systematic evaluations have been performed of the efficacy of electroconvulsive therapy (ECT) as a relapse prevention strategy in major depressive disorder (MDD). This is a single-blind, multicenter, randomized controlled trial to compare the eff...

  • Article
  • Open Access
8 Citations
2,889 Views
8 Pages

Safety and Efficacy of Eculizumab Therapy in Multiple Sclerosis: A Case Series

  • Marco Allinovi,
  • Angelo Bellinvia,
  • Francesco Pesce,
  • Sabrina Milan Manani,
  • Lorenzo Razzolini,
  • Brigida Brezzi,
  • Paolo Protopapa,
  • Vittorio Mantero,
  • Leonardo Caroti and
  • Lucia Del Vecchio
  • + 2 authors

11 October 2021

(1) Background: Complement system activation has been proposed as one of the different factors that contribute to Multiple Sclerosis (MS) pathogenesis. In this study, we aimed to describe the potential effects of eculizumab, an anticomplement therapy...

  • Correction
  • Open Access
1 Citations
1,427 Views
2 Pages

11 October 2021

The authors wish to make the following correction to [...]

  • Article
  • Open Access
7 Citations
3,174 Views
10 Pages

A New Approach to Assess Blinding for Transcranial Direct Current Stimulation Treatment in Patients with Fibromyalgia. A Randomized Clinical Trial

  • Rubén Arroyo-Fernández,
  • Juan Avendaño-Coy,
  • Rafael Velasco-Velasco,
  • Rocío Palomo-Carrión,
  • Elisabeth Bravo-Esteban and
  • Asunción Ferri-Morales

11 October 2021

Correct blinding is essential for preventing potential biases. The aim of this study was to assess the blinding of participants and a therapist following treatment with transcranial direct current stimulation in subjects with fibromyalgia using James...

  • Article
  • Open Access
25 Citations
5,208 Views
20 Pages

11 October 2021

There is evidence that abnormalities in eye movements exist during reading in dyslexic individuals. A few recent studies applied Machine Learning (ML) classifiers to such eye movement data to predict dyslexia. A general problem with these studies is...

  • Article
  • Open Access
2 Citations
3,749 Views
12 Pages

11 October 2021

Microglia, the immune cells in the brain involved in both homeostasis and injury/infection control, play a predominant role in neurodegenerative diseases. In vivo studies on microglia are limited due to the requirement of surgical intervention, which...

  • Article
  • Open Access
48 Citations
6,304 Views
10 Pages

11 October 2021

The restraining measures due to the COVID-19 outbreak deeply affected the general population’s sleep health and psychological status. The current literature proposes young and older people as two particularly at-risk groups. However, the differential...

  • Article
  • Open Access
17 Citations
2,735 Views
11 Pages

The Impact of Sex on the Neurocognitive Functions of Patients with Parkinson’s Disease

  • Mei-Ling Chen,
  • Chun-Hsiang Tan,
  • Hui-Chen Su,
  • Pi-Shan Sung,
  • Chia-Yi Chien and
  • Rwei-Ling Yu

9 October 2021

This study aimed to understand the impact of sex on the neurocognitive function of patients with Parkinson’s disease (PD). Ninety-four participants with idiopathic PD and 167 age-matched healthy individuals as normal controls (NCs) were recruited and...

  • Article
  • Open Access
17 Citations
8,926 Views
18 Pages

The Benefits of Music Listening for Induced State Anxiety: Behavioral and Physiological Evidence

  • Binxin Huang,
  • Xiaoting Hao,
  • Siyu Long,
  • Rui Ding,
  • Junce Wang,
  • Yan Liu,
  • Sijia Guo,
  • Jing Lu,
  • Manxi He and
  • Dezhong Yao

9 October 2021

Background: Some clinical studies have indicated that neutral and happy music may relieve state anxiety. However, the brain mechanisms by which these effective interventions in music impact state anxiety remain unknown. Methods: In this study, we sel...

  • Article
  • Open Access
3 Citations
3,302 Views
14 Pages

Forgiveness in the Modulation of Responsibility in a Sample of Italian Adolescents with a Tendency towards Conduct or Obsessive–Compulsive Problems

  • Carlo Buonanno,
  • Enrico Iuliano,
  • Giuseppe Grossi,
  • Francesco Mancini,
  • Emiliana Stendardo,
  • Fabrizia Tudisco and
  • Barbara Pizzini

9 October 2021

Although obsessive–compulsive disorder (OCD) and the conduct disorders (CD) express a contrasting symptomatology, they could represent different answers to a common matrix about morality. In the literature, some theoretical models describe people wit...

  • Case Report
  • Open Access
3 Citations
2,896 Views
11 Pages

A Pathogenic Presenilin-1 Val96Phe Mutation from a Malaysian Family

  • Eva Bagyinszky,
  • Gaik-Siew Ch’ng,
  • Mei-Yan Chan,
  • Seong Soo A. An and
  • SangYun Kim

8 October 2021

Presenilin-1 (PSEN1) is one of the causative genes for early onset Alzheimer’s disease (EOAD). Recently, emerging studies have reported several novel PSEN1 mutations among Asians. In this study, a PSEN1 Val96Phe mutation was discovered in two sibling...

  • Article
  • Open Access
8 Citations
3,221 Views
12 Pages

The Neural Markers of Self-Caught and Probe-Caught Mind Wandering: An ERP Study

  • Yong Liu,
  • Jia Zhao,
  • Xinqi Zhou,
  • Xiaolin Liu,
  • Hong Chen and
  • Hong Yuan

8 October 2021

Mind-wandering (MW) is a common phenomenon, defined as task-unrelated thoughts. This study is based on event-related potentials (ERPs), using modified sustained attention to response task (modified SART, mSART) to discuss the neural patterns of diffe...

  • Article
  • Open Access
5 Citations
4,112 Views
18 Pages

Simultaneous Normalization and Compensatory Changes in Right Hemisphere Connectivity during Aphasia Therapy

  • Tammar Truzman,
  • Elizabeth Rochon,
  • Jed Meltzer,
  • Carol Leonard and
  • Tali Bitan

8 October 2021

Changes in brain connectivity during language therapy were examined among participants with aphasia (PWA), aiming to shed light on neural reorganization in the language network. Four PWA with anomia following left hemisphere stroke and eight healthy...

  • Article
  • Open Access
18 Citations
10,621 Views
21 Pages

6 October 2021

Yogic and meditative traditions have long held that the fluctuations of the breath and the mind are intimately related. While respiratory modulation of cortical activity and attentional switching are established, the extent to which electrophysiologi...

  • Article
  • Open Access
10 Citations
3,545 Views
10 Pages

6 October 2021

The timing of transcranial direct current stimulation (tDCS) is essential for enhancing motor skill learning. Previously, tDCS, before or concurrently, with motor training was evaluated in healthy volunteers or elderly patients, but the optimal timin...

  • Article
  • Open Access
7 Citations
4,831 Views
14 Pages

Sleep-Related Rhythmic Movement Disorder in Young Children with Down Syndrome: Prevalence and Clinical Features

  • Ceren Kose,
  • Izabelle Wood,
  • Amy Gwyther,
  • Susiksha Basnet,
  • Chloe Gaskell,
  • Paul Gringras,
  • Heather Elphick,
  • Hazel Evans and
  • Catherine M. Hill

6 October 2021

Sleep-related Rhythmic Movement Disorder (RMD) affects around 1% of UK pre-school children. Little is known about RMD in Down syndrome (DS). We aimed to determine: (a) the prevalence of RMD in children with DS aged 1.5–8 years; (b) phenotypic and sle...

  • Article
  • Open Access
1 Citations
3,266 Views
14 Pages

6 October 2021

Background: Numerous data show a role for genetic polymorphisms in the development of epilepsy. Previously, the TT genotype of the MTHFR 677C>T polymorphism was found to be associated with a decreased leucocyte DNA methylation status. Polymorphism...

  • Feature Paper
  • Article
  • Open Access
11 Citations
5,022 Views
14 Pages

5 October 2021

Daytime napping contributes to retention of new word learning in children. Importantly, children transition out of regular napping between ages 3–5 years, and the impact of this transition on memory is unclear. Here, we examined the performance of bo...

  • Article
  • Open Access
7 Citations
3,819 Views
13 Pages

Revascularization Outcome Prediction for A Direct Aspiration-First Pass Technique (ADAPT) from Pre-Treatment Imaging and Machine Learning

  • Tatsat R. Patel,
  • Muhammad Waqas,
  • Seyyed M. M. J. Sarayi,
  • Zeguang Ren,
  • Cesario V. Borlongan,
  • Rimal Dossani,
  • Elad I. Levy,
  • Adnan H. Siddiqui,
  • Kenneth V. Snyder and
  • Vincent M. Tutino
  • + 2 authors

5 October 2021

A direct aspiration-first pass technique (ADAPT) has recently gained popularity for the treatment of large vessel ischemic stroke. Here, we sought to create a machine learning-based model that uses pre-treatment imaging metrics to predict successful...

  • Article
  • Open Access
10 Citations
3,079 Views
9 Pages

Sleep and White Matter in Adults with Down Syndrome

  • Victoria Fleming,
  • Brianna Piro-Gambetti,
  • Austin Bazydlo,
  • Matthew Zammit,
  • Andrew L. Alexander,
  • Bradley T. Christian,
  • Benjamin Handen,
  • David T. Plante and
  • Sigan L. Hartley

5 October 2021

Adults with Down syndrome are at a high risk for disordered sleep. These sleep problems could have marked effects on aging and Alzheimer’s disease, potentially altering white matter integrity. This study examined the associations between disordered s...

  • Article
  • Open Access
19 Citations
3,930 Views
11 Pages

Dealing with Headache: Sex Differences in the Burden of Migraine- and Tension-Type Headache

  • Maria Susanne Neumeier,
  • Heiko Pohl,
  • Peter S. Sandor,
  • Hans Gut,
  • Gabriele S. Merki-Feld and
  • Colette Andrée

5 October 2021

Objective: The aim of this study was to investigate sex differences in the burden of migraine and tension-type headache (TTH). Background: Migraine and TTH are more common in women than in men, with differences in comorbidities, treatment responses,...

  • Article
  • Open Access
10 Citations
3,328 Views
14 Pages

Sleep, Function, Behaviour and Cognition in a Cohort of Children with Down Syndrome

  • Jasneek K. Chawla,
  • Anne Bernard,
  • Helen Heussler and
  • Scott Burgess

4 October 2021

Objective: To describe the sleep problems experienced by children with Down syndrome attending a tertiary sleep clinic and relationship with behaviour, function and cognition. Methods: Data were collected from children with Down syndrome aged 3–18 ye...

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Brain Sci. - ISSN 2076-3425