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Journal of Clinical Medicine, Volume 14, Issue 4

February-2 2025 - 363 articles

Cover Story: Neuroblastoma is a common childhood malignancy, and high-risk presentations, including an amplified MYCN status, continue to result in poor survival. Difluoromethylornithine (DFMO) is a new and well-tolerated treatment for high-risk neuroblastoma. This review article discusses preclinical and clinical data that resulted in the establishment of DFMO as a treatment for neuroblastoma. The review of preclinical data includes a summary of the contribution of polyamine synthetic pathways to high-risk neuroblastoma, the effect that MYCN has on polyamine synthetic pathways, and the proposed mechanism by which DFMO inhibits tumorigenesis. This understanding has led to the discussion of various preclinical combination therapies that may result in a synergistic therapeutic response for high-risk neuroblastoma. View this paper
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Articles (363)

  • Article
  • Open Access
1,014 Views
15 Pages

Right Ventricular Diastolic Dysfunction Before Coronary Artery Bypass Grafting: Impact on 5-Year Follow-Up Outcomes

  • Alexey N. Sumin,
  • Anna V. Shcheglova,
  • Nazeli D. Oganyan,
  • Evgeniya Yu. Romanenko and
  • Tatjana Yu. Sergeeva

19 February 2025

Background: The aim of this study was to assess the effect of right ventricular diastolic dysfunction on the results of 5-year follow-up of patients after coronary artery bypass grafting (CABG). Methods: Patients were enrolled in this prospective obs...

  • Article
  • Open Access
1,198 Views
12 Pages

Cost-Effectiveness of Routine X-Rays After Central Venous Catheter Removal: A Value-Based Analysis of Post-Removal Complications

  • Martin Breitwieser,
  • Teresa Wiesner,
  • Vanessa Moore,
  • Florian Wichlas and
  • Christian Deininger

19 February 2025

Background: Healthcare systems worldwide are increasingly burdened by rising costs, growing patient demand, and limited resources. In this context, cost-effectiveness analysis (CEA) plays a vital role in evaluating the clinical value of medical inter...

  • Article
  • Open Access
1,059 Views
10 Pages

Factors Associated with Driving Ability and Changes After Immobilization of the Right Lower Limb: A Driving Simulator Study

  • Young Cheol Kim,
  • Moo Sik Lee,
  • Byung Hak Oh,
  • Youn Moo Heo,
  • Tae Gyun Kim,
  • Se Jong Yoo and
  • Hyun Jin Yoo

19 February 2025

Introduction: Patients with orthopedic injuries often require cast immobilization therapy using casts. Driving with a cast on the right lower limb restricts many things. This study aimed to investigate the factors associated with driving capacity aft...

  • Review
  • Open Access
1,446 Views
18 Pages

Benefits and Pitfalls of Uraemic Toxin Measurement in Peritoneal Dialysis

  • Aruni Malaweera,
  • Louis Huang and
  • Lawrence McMahon

19 February 2025

Chronic kidney disease is a global health burden with a rising incidence and prevalence in developed and developing nations. Once established, it results in a progressive accumulation of a myriad of uraemic toxins. Peritoneal dialysis (PD) uses the b...

  • Article
  • Open Access
1 Citations
4,157 Views
16 Pages

Decoding Prejudice: Understanding Patterns of Adolescent Mental Health Stigma

  • Sara Albuquerque,
  • Ana Carvalho,
  • Bárbara de Sousa,
  • Leonor Pereira da Costa and
  • Ana Beato

19 February 2025

Background/Objectives: Mental health problems are a major cause of disability, impacting nearly 20% of adolescents. Nevertheless, they are hesitant to seek help because of stigma and fear of being labelled. Adolescents often have low mental health li...

  • Article
  • Open Access
2 Citations
1,436 Views
11 Pages

19 February 2025

Background: Recently, the lateralization shoulder angle (LSA) and distalization shoulder angle (DSA) have been proposed to assess lateralization and distalization in reverse shoulder arthroplasty (RSA). However, there is insufficient evidence about t...

  • Article
  • Open Access
3 Citations
1,695 Views
10 Pages

Endometriosis in Adolescents: A Closer Look at the Pain Characteristics and Atypical Symptoms: A Prospective Cohort Study

  • Maria Federica Viscardi,
  • Ilaria Piacenti,
  • Angela Musella,
  • Laura Cacciamani,
  • Maria Grazia Piccioni,
  • Lucia Manganaro,
  • Ludovico Muzii and
  • Maria Grazia Porpora

19 February 2025

Background/Objectives: Endometriosis affects up to 10% of women of reproductive age and about 47% of adolescents with pelvic pain. Symptoms include dysmenorrhea, dyspareunia, and chronic pelvic pain (CPP). Adolescents often present atypical symptoms...

  • Article
  • Open Access
2,512 Views
11 Pages

Course of General Fatigue in Patients with Post-COVID-19 Conditions Who Were Prescribed Hochuekkito: A Single-Center Exploratory Pilot Study

  • Kazuki Tokumasu,
  • Nobuyoshi Matsuki,
  • Yuki Otsuka,
  • Yoko Sakamoto,
  • Keigo Ueda,
  • Yui Matsuda,
  • Yasue Sakurada,
  • Hiroyuki Honda,
  • Yasuhiro Nakano and
  • Toru Hasegawa
  • + 3 authors

19 February 2025

Background: After the start of the COVID-19 pandemic, general fatigue in patients with long COVID and post-COVID-19 conditions (PCC) became a medical issue. Although there is a lack of evidence-based treatments, Kampo medicine (traditional Japanese m...

  • Article
  • Open Access
2 Citations
1,662 Views
11 Pages

19 February 2025

Background/Objectives: The aim was to develop a Japanese version of the Obstetric Quality of Recovery-11 questionnaire (ObsQoR-11J), assess its feasibility, reliability, and validity, and investigate its association with postpartum depression and fun...

  • Article
  • Open Access
4 Citations
3,001 Views
12 Pages

Diabetes in Peripheral Artery Disease: Prevalence, Complications, and Polypharmacy

  • Mason Baty,
  • Ritesh Chimoriya,
  • Sophie James,
  • Leonard Kritharides,
  • Samim Behdasht,
  • Avinash Suryawanshi and
  • Sarah J. Aitken

19 February 2025

Background: Patients with peripheral artery disease (PAD) and diabetes face high risks of comorbidities, tissue loss, and cardiovascular events. As global type 2 diabetes (T2DM) prevalence rises, so does its incidence in symptomatic patients with PAD...

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J. Clin. Med. - ISSN 2077-0383Creative Common CC BY license