Genomic Instability and the DNA Damage Repair Response in Malignant Brain Tumors: Factors Underpinning Cancer Progression, Treatment Resistance, and Inter/Intra-Tumoral Heterogeneity

Dear Colleagues,

Although comprising a small percentage (~2%) of all cancer types, malignant brain tumors affect both young and old, are often lethal, and account for a high degree of worldwide cancer mortality. Pediatric brain tumors, including gliomas and embryonal tumors, are the leading cause of cancer-related death among children and adolescents, while gliomas and meningiomas account for significant mortality in adults. Whereas precision medicine approaches are emerging, these tumors are usually treated with combinations of radiation; chemotherapy; and, more recently, immunotherapy. Recurrence of these malignant tumors is pervasive due to resistance to anticancer therapeutics, which may involve pronounced genomic instability or alteration in DNA damage repair responses elicited by chemoradiotherapy.

This Special Issue invites short reports, original research, and review articles that highlight recent advances using in vitro, in vivo, animal models, and clinical studies that expand our understanding of how genomic instability and DNA damage repair responses affect brain tumor initiation, progression, heterogeneity and treatment resistance.

Dr. Sachin Katyal
Guest Editor

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