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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Oncology: State-of-the-Art Research in Austria submission deadline 15 Apr 2026 | 3 articles | Viewed by 10561
Keywords: oncology; cancer; research; tumor; Austria
(This special issue belongs to the Section Cancer Therapy)
Detection of Breast Cancer with Mammography
edited by
submission deadline 15 Apr 2026 | 1 articles | Viewed by 2782
Keywords: mammography; breast cancer detection; imaging technologies; artificial intelligence; radiomics
(This special issue belongs to the Section Methods and Technologies Development)
Advances in Radiation Therapy for Brain Metastases
edited by Luis A. Pérez-Romasanta
submission deadline 15 Apr 2026 | 3 articles | Viewed by 2605
Keywords: brain metastasis; metastatic brain tumor; imaging; radiotherapy; stereotactic radiosurgery; radiomics; machine learning; magnetic resonance imaging; positron emission tomography
(This special issue belongs to the Section Cancer Therapy)
Recent Advances in Radiological Imaging for Head and Neck Squamous Cell Carcinoma
edited by Mintu Nath and
submission deadline 15 Apr 2026 | Viewed by 462
Keywords: head and neck squamous cell carcinoma; computed tomography (CT); positron emission tomography (PET); PET-CT; radiological imaging; image processing; image segmentation; diagnosis; treatment modalities; prediction and prognostic models; mathematical and statistical models; machine learning and deep learning techniques
(This special issue belongs to the Section Methods and Technologies Development)
Prostate Cancer: Molecular Imaging and Magnetic Resonance Imaging (MRI)
edited by Marco Paciotti and Davide Maffei
submission deadline 17 Apr 2026 | 5 articles | Viewed by 11933 | Submission Open
Keywords: prostate cancer; prostate imaging; diagnosis; clinical staging; magnetic resonance imaging (MRI); fusion biopsy; molecular imaging; positron emission tomography (PET); PSMA PET/CT; PSMA-based therapy
(This special issue belongs to the Section Methods and Technologies Development)
Unique Perspectives in Cancer Signaling (2nd Edition)
edited by
submission deadline 18 Apr 2026 | 2 articles | Viewed by 2539 | Submission Open
Keywords: oncogenesis; cancer signaling; technology; translational; clinical; epidemiology
(This special issue belongs to the Section Cancer Therapy)
Immune Landscape of Renal Cell Carcinoma
edited by and Yuexin Xu
submission deadline 20 Apr 2026 | 4 articles | Viewed by 18783 | Submission Open
Keywords: renal cell carcinoma; solid tumor; immunotherapy; immune checkpoint inhibitor; T cell; tumor microenvironment; biomarkers; tumor antigen; immune surveillance
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Advancements in Child, Adolescent, and Young Adult Cancer Survivorship submission deadline 20 Apr 2026 | 6 articles | Viewed by 14906 | Submission Open
Keywords: late effects; chronic diseases; prevention; rehabilitation; remediation; psychosocial factors; quality of life; lifestyles; surveillance; survivors; educational strategies
(This special issue belongs to the Section Pediatric Oncology)
Immunotherapy and Transplantation in the Era of Transplant Oncology (2nd Edition)
edited by
submission deadline 20 Apr 2026 | 1 articles | Viewed by 326 | Submission Open
Keywords: transplant oncology; liver transplantation; solid organ transplantation; hepatocellular carcinoma; immunotherapy; immune-checkpoint inhibitors; CTLA-4 inhibitors; PD-1 inhibitors; allograft rejection
(This special issue belongs to the Section Transplant Oncology)
Research on Current Progress in Penile Cancer
edited by Juan J. Chipollini and Ahmet Murat Aydin
submission deadline 25 Apr 2026 | 5 articles | Viewed by 17805 | Submission Open
(This special issue belongs to the Section Cancer Therapy)
Clinical Applications of Integrative Analysis of Validated Somatic and Germline Genomic Results in Oncology
edited by
submission deadline 25 Apr 2026 | 2 articles | Viewed by 6211 | Submission Open
Keywords: tumor and constitutional genome integration; clinical application of somatic and germline findings; precision oncology
(This special issue belongs to the Section Molecular Cancer Biology)
Hepatocellular Carcinoma: Current Treatment Strategies for Advanced Disease and Recurrence: 2nd Edition
edited by
submission deadline 25 Apr 2026 | 2 articles | Viewed by 5115 | Submission Open
Keywords: hepatocellular carcinoma; surgery; anticancer drugs; radiation therapy; recurrence
(This special issue belongs to the Section Cancer Therapy)
PD-1/PD-L1 Immune Checkpoint Therapy: From Predictive Biomarkers to Noninvasive Imaging 2nd Edition submission deadline 25 Apr 2026 | Viewed by 602 | Submission Open
Keywords: PD-1; PD-L1; anti-cancer immune response; immune checkpoint; immunotherapy; biomarker; immuno-PET radiotracers; drug combinations
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Surgical Treatment of Hepato-Pancreato-Biliary Cancers
edited by Mariano C. Giglio
submission deadline 27 Apr 2026 | 1 articles | Viewed by 2370 | Submission Open
Keywords: pancreatic cancer; hepatocellular carcinoma; colorectal liver metastases; liver surgery; pancreatic surgery; hepato-biliary cancers
(This special issue belongs to the Section Cancer Therapy)
Head and Neck Cancer: Advanced PET/CT and MRI Imaging with a Focus on Current and Emerging Molecular Theranostics
edited by Bennett Chin, Jorge Oldan and Steven P. Rowe
submission deadline 28 Apr 2026 | 6 articles | Viewed by 23224 | Submission Open
Keywords: head and neck cancer; thyroid cancer; PET/SPECT/CT molecular imaging; radionuclide therapy; nuclear medicine
(This special issue belongs to the Section Cancer Therapy)
Immune Biomarkers in Solid Tumors: From Peripheral Blood Parameters to Tissue-Based Indicators for Prognosis and Therapy Response submission deadline 28 Apr 2026 | 4 articles | Viewed by 6654 | Submission Open
Keywords: immune biomarkers; solid tumors; peripheral blood immune parameters; circulating immune cells; cytokines; tissue-based biomarkers; immune checkpoint molecules; prognostic biomarkers; predictive biomarkers; tumor microenvironment; immunotherapy response; translational oncology
(This special issue belongs to the Section Cancer Biomarkers)
Novel Therapeutic Strategies in Salivary Gland Tumor submission deadline 30 Apr 2026 | 9 articles | Viewed by 25704 | Submission Open
Keywords: parotid gland; parotid tumors; facial nerve; novel therapeutic options; distant metastasis; liquid biopsy; prognostic factors; parotid robotic surgery; microRNA; imaging
(This special issue belongs to the Section Cancer Therapy)
Advancements in Molecular Research of Prostate Cancer
edited by
submission deadline 30 Apr 2026 | 8 articles | Viewed by 22027 | Submission Open
Keywords: prostate cancer; molecular targets; tumor heterogeneity; targeted interception and therapies; noninvasive biomarkers; precision oncology
(This special issue belongs to the Section Molecular Cancer Biology)
Immune Microenvironment and Immunotherapy in Malignant Brain Tumors
edited by Masaki Terabe and
submission deadline 30 Apr 2026 | 5 articles | Viewed by 20311 | Submission Open
Keywords: glioma; brain metastasis; primary brain cancer; tumor immunity; neuroimmunology; immune microenvi-ronment; T cells; myeloid cells; cancer neuroscience
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Advances in Uveal Melanoma
edited by and
submission deadline 30 Apr 2026 | 10 articles | Viewed by 18901 | Submission Open
Keywords: uveal melanoma; eye cancer; liver metastasis; Gα q/11 mutations; BAP1; SF3B1; PRAME; dormancy; liver-directed treatment; T-cell engager
(This special issue belongs to the Section Molecular Cancer Biology)
Targeted Therapy in Head and Neck Cancer
edited by , Angelo Camaioni and Luca de Campora
submission deadline 30 Apr 2026 | 7 articles | Viewed by 16898 | Submission Open
Keywords: salivary glands; thyroid; laryngeal cancer; molecular oncology; reconstruction; microsurgery; oral cancer; HPV; oropharyngeal cancer
(This special issue belongs to the Section Cancer Therapy)
The Future of Machine Learning in Predicting the Treatment Responses of Cancers
edited by Alfredo Vellido, and
submission deadline 30 Apr 2026 | 5 articles | Viewed by 15416 | Submission Open
Keywords: cancer treatment response; medical decision support systems; cancer outcome prediction; personalized medicine; pre-clinical models; artificial intelligence; machine learning; deep learning; progression-free survival; disease-free survival; event-free survival; overall survival; adverse event; quality of life; surrogate endpoint
(This special issue belongs to the Section Methods and Technologies Development)
Quality of Life and Management of Pediatric Cancer submission deadline 30 Apr 2026 | 6 articles | Viewed by 14236 | Submission Open
Keywords: pediatric palliative care; oncology; quality of life; early management
(This special issue belongs to the Section Pediatric Oncology)
Human Microbiome, Diet and Cancerogenesis
edited by Ewa Brzeziańska-Lasota
submission deadline 30 Apr 2026 | 3 articles | Viewed by 13683 | Submission Open
Keywords: microbiota; dysbiosis; oncobiome; cell disruptors; cell signaling; epigenetics; diet; dietary intervention; microbiota disorders; cancerogenesis
(This special issue belongs to the Section Tumor Microenvironment)
Epidemiology of Cancer and Risk Factors: Pushing Boundaries in Public Health Research and Policy
edited by
submission deadline 30 Apr 2026 | 5 articles | Viewed by 11894 | Submission Open
Keywords: cancer epidemiology; risk factors; public health policy; cancer prevention; early detection; genetic determinants; environmental exposures; behavioral health; interdisciplinary approaches; innovative methodologies
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Prognosis and Treatment of Cutaneous Melanoma (2nd Edition)
edited by
submission deadline 30 Apr 2026 | 3 articles | Viewed by 11063 | Submission Open
Keywords: prognosis; melanoma; adjuvant; germline; somatic; genetic; epigenetic; neoadjuvant
(This special issue belongs to the Section Cancer Therapy)
Surgical Oncology for Hepato-Pancreato-Biliary Cancer
edited by Zaed Z. R. Hamady
submission deadline 30 Apr 2026 | 6 articles | Viewed by 10219 | Submission Open
Keywords: pancreatic cancer; liver cancer; liver metastases; surgical oncology; multidisciplinary approach
(This special issue belongs to the Section Clinical Research of Cancer)
Neuroblastoma: Molecular Insights and Clinical Implications
edited by Mary Beth Madonna
submission deadline 30 Apr 2026 | 3 articles | Viewed by 9445 | Submission Open
Keywords: neuroblastoma; molecular mechanisms; targeted therapies; immunotherapies; small molecule therapies
(This special issue belongs to the Section Molecular Cancer Biology)
Chemo-Radio-Immunotherapy for Colorectal Cancer
edited by Shoichi Hazama
submission deadline 30 Apr 2026 | 5 articles | Viewed by 6327 | Submission Open
Keywords: colorectal cancer; immunotherapy; chemotherapy; radiotherapy; combination therapy; neoadjuvant therapy; biomarkers for treatment response; anal cancer; squamous cell carcinoma; minimally invasive surgery; conversion surgery
(This special issue belongs to the Section Cancer Therapy)
Interrogating Molecular Regulators and Chemical Agents in Brain Tumor Progression
edited by Shilpi Singh
submission deadline 30 Apr 2026 | 2 articles | Viewed by 5449 | Submission Open
Keywords: brain tumor progression; molecular mechanisms; small molecule inhibitors; natural compounds; synthetic drugs; biomarkers; oncogenic pathways; metabolic reprogramming
(This special issue belongs to the Section Tumor Microenvironment)
Advances in Molecular and Genetic Biomarkers in Head and Neck Squamous Cell Carcinoma
edited by and Michal Masternak
submission deadline 30 Apr 2026 | 2 articles | Viewed by 5436 | Submission Open
Keywords: head and neck squamous cell carcinoma (HNSCC); molecular biomarkers; genetic biomarkers; multi-omics approaches; HNSCC carcinogenesis; prognostic biomarkers; translational medicine; molecular pathology
(This special issue belongs to the Section Molecular Cancer Biology)
Acute Myeloid Leukemia: Updates on Diagnosis, Treatment and Management submission deadline 30 Apr 2026 | 2 articles | Viewed by 5287 | Submission Open
Keywords: acute myeloid leukemia; treatment; targeted therapy; molecular profiling; resistance
(This special issue belongs to the Section Methods and Technologies Development)
Mesothelioma Epidemiology, Pathogenesis, Emerging Treatments and Pre-Clinical Models submission deadline 30 Apr 2026 | 3 articles | Viewed by 5189 | Submission Open
Keywords: mesothelioma; epidemiology; pathogenesis; emerging treatments; risk factors; biomarkers; surgical techniques; targeted therapies; immunotherapies; pre-clinical models
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Molecular PET Imaging in Cancer Metabolic Studies submission deadline 30 Apr 2026 | 1 articles | Viewed by 4801 | Submission Open
Keywords: PET imaging; PET/CT; PET/MRI; cancer metabolism; tumor microenvironment; cancer antigens; radiotracers
(This special issue belongs to the Section Methods and Technologies Development)
Health Disparities and Outcomes in Cancer Survivors submission deadline 30 Apr 2026 | 4 articles | Viewed by 4500 | Submission Open
Keywords: cancer survivorship; quality of life; social behavioral determinants of health (SBDH); health disparities; symptom management
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
CT/MRI/PET in Cancer submission deadline 30 Apr 2026 | 3 articles | Viewed by 4452 | Submission Open
Keywords: PET imaging; CT; MRI; cancer; characterization; treatment monitoring; biomarkers; predictive value; AI integration
(This special issue belongs to the Section Methods and Technologies Development)
Integrating Bioinformatics, AI, Imaging, and Clinical Informatics in Cancer Research
edited by Jason Li
submission deadline 30 Apr 2026 | 1 articles | Viewed by 4378 | Submission Open
Keywords: bioinformatics; multiomics; genomics; transcriptomics artificial intelligence; deep learning; clinical informatics; medical imaging; functional genomics; multi-discipline
(This special issue belongs to the Section Cancer Informatics and Big Data)
Real-World Evidence and Emerging Therapeutic Strategies in Refractory Metastatic Colorectal Cancer
edited by
submission deadline 30 Apr 2026 | 3 articles | Viewed by 4263 | Submission Open
Keywords: real-world evidence; refractory metastatic colorectal cancer; treatment resistance; third-line and beyond therapies; targeted therapies; immunotherapy; patient outcomes; clinical practice; biomarkers; precision oncology
(This special issue belongs to the Section Cancer Metastasis)
Myeloma: Pathogenesis and Targeted Therapies
edited by Fenghuang (Frank) Zhan, Gang An and Cody Ashby
submission deadline 30 Apr 2026 | 2 articles | Viewed by 4209 | Submission Open
Keywords: multiple myeloma; drug resistance; car-t cell therapy; immunotherapy targets; biomarkers; genetic alterations; molecular pathogenesis
(This special issue belongs to the Section Tumor Microenvironment)
Image-Guided Treatment of Liver Tumors
edited by and Niek Wijnen
submission deadline 30 Apr 2026 | 5 articles | Viewed by 4186 | Submission Open
Keywords: liver; thermal ablation; radioembolization; TACE; yttrium-90; portal vein embolization; radiation oncology; interventional oncology
(This special issue belongs to the Section Cancer Therapy)
Advances in the Treatment of Urological Cancer
edited by Anna Patrikidou
submission deadline 30 Apr 2026 | 1 articles | Viewed by 3641 | Submission Open
Keywords: urological oncology; chemotherapy; hormone therapy; immunotherapy; targeted therapy; radioligand therapy; antibody-drug conjugates; novel therapeutics
(This special issue belongs to the Section Cancer Therapy)
Prostate Cancer Epidemiology and Genetics: 2nd Edition
edited by
submission deadline 30 Apr 2026 | 2 articles | Viewed by 3625 | Submission Open
Keywords: prostate cancer; epidemiology; clinical genetics; aging; population-level databases
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
The Latest Advancements in Cutaneous Melanoma
edited by Zhenyu Ji
submission deadline 30 Apr 2026 | 2 articles | Viewed by 3399 | Submission Open
Keywords: cutaneous melanoma; skin cancer; immunotherapy; targeted therapy; melanoma biomarkers
(This special issue belongs to the Section Cancer Therapy)
G Protein-Coupled Receptors in Cancer Progression
edited by
submission deadline 30 Apr 2026 | 1 articles | Viewed by 3362 | Submission Open
Keywords: GPCRs; heterotrimeric G proteins; signal transduction; mutations; cancer development
(This special issue belongs to the Section Tumor Microenvironment)
Exosomes in Cancer Metastasis (2nd Edition) submission deadline 30 Apr 2026 | 2 articles | Viewed by 3082 | Submission Open
Keywords: exosomes; biomarkers; cancer metastasis
(This special issue belongs to the Section Cancer Metastasis)
Radical Pelvic Surgery and Reconstructive Innovations in Pelvic Oncology
edited by Evrim Erdemogľu
submission deadline 30 Apr 2026 | 4 articles | Viewed by 2978 | Submission Open
Keywords: pelvic exenteration; LEER; radical pelvic surgery; reconstruction; flap surgery; multivisceral resection; gynecologic oncology; pelvic cancer; surgical outcomes; minimally invasive surgery
(This special issue belongs to the Section Clinical Research of Cancer)
Prostate Cancer: Contemporary Standards and Challenges submission deadline 30 Apr 2026 | 2 articles | Viewed by 2976 | Submission Open
Keywords: prostate cancer; molecular pathogenesis; precision oncology; biomarkers; treatment de-escalation
(This special issue belongs to the Section Cancer Therapy)
Immune Checkpoint Therapy in Liver Cancer: Current Evidence, Underlying Biology, and What's Next
edited by and
submission deadline 30 Apr 2026 | 3 articles | Viewed by 2959 | Submission Open
Keywords: hepatocellular carcinoma; immunotherapy; immuno-oncology; immune checkpoint inhibitors; clinical trial; immunological microenvironments
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Genetic Screening and Personalized Prevention in Hereditary Gastrointestinal Cancer Syndromes
edited by and Vittoria Disciglio
submission deadline 30 Apr 2026 | 1 articles | Viewed by 2791 | Submission Open
Keywords: hereditary gastrointestinal cancer syndromes; NGS multigene panel tests; pathogenic variant (PV); variant of uncertain significance (VUS); mismatch repair (MMR) genes; gastrointestinal cancer susceptibility; personalized medicine; genetic risk assessment; germline variants; genetic counseling; functional impact of the genetic variant
(This special issue belongs to the Section Cancer Pathophysiology)
Immune Biomarkers and Checkpoint Inhibitors: Advancing Immunotherapy in Gynecologic Cancers
edited by Ting-Tai Yen and Eugene Patrick Toy
submission deadline 30 Apr 2026 | 2 articles | Viewed by 2623 | Submission Open
Keywords: immune checkpoints; checkpoint inhibitors; PD-1/PD-L1 pathway; immune biomarkers; tumor microenvironment; immunosuppressive pathways; T-cell activation in solid tumors; gynecologic tumors
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
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