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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in Precision Medicine: Targeting Known and Emerging Oncogenic Targets in Lung Cancer (2nd Edition)

edited by

Tianhong Li

submission deadline 15 Aug 2026 | 3 articles | Viewed by 4702 | Submission Open

Keywords: precision oncology; lung cancer; oncogenic target; targeted therapy; biomarker; diagnosis

(This special issue belongs to the Section Molecular Cancer Biology)

The Elderly Multiple Myeloma Patient in the Era of Quad Therapy and CAR-T Cells

edited by James J. Ignatz-Hoover and Koen Van Besien

submission deadline 15 Aug 2026 | 1 articles | Viewed by 3020 | Submission Open

Keywords: multiple myeloma; quad therapy; CAR-T; elderly

(This special issue belongs to the Section Cancer Therapy)

Clinical Applications of Advanced MRI Technologies for Cancers

edited by

Nicolò Cardobi

submission deadline 15 Aug 2026 | 2 articles | Viewed by 1868 | Submission Open

Keywords: advanced MRI techniques; multiparametric imaging; quantitative biomarkers; artificial intelligence; treatment response assessment; precision oncology; radiomics; cancer diagnosis; functional imaging; molecular imaging

(This special issue belongs to the Section Methods and Technologies Development)

Rare Genitourinary Cancers

edited by

Luis G Medina

and

Philippe E. Spiess

submission deadline 15 Aug 2026 | 1 articles | Viewed by 945 | Submission Open

Keywords: rare genitourinary tumors; penile cancer; testicular cancer; urethral cancer; adrenal cancer; variant histology; upper tract urothelial carcinoma; extramammary Paget’ s disease; urologic oncology; rare cancers

(This special issue belongs to the Section Clinical Research of Cancer)

Advances in Immunotherapy for Acute Myeloid Leukemia

edited by

Pau Montesinos

submission deadline 15 Aug 2026 | 1 articles | Viewed by 788 | Submission Open

Keywords: acute myeloid leukemia; immunotherapy; immune response; T-cell; cellular therapies; immune checkpoint inhibitors; treatment

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Prostate-Specific Membrane Antigen (PSMA)-Targeted Radionuclide Therapy in Cancer

edited by

Ning Zhou

and

Sashi Debnath

submission deadline 15 Aug 2026 | Viewed by 377 | Submission Open

Keywords: PSMA-TRNT; radioligand therapy; radionuclide therapy; theranostics; prostate-specific membrane antigen (PSMA); PSMA targeted; PSMA ligands; prostate cancer (PCa); metastatic castration-resistant prostate cancer (mCRPC)

(This special issue belongs to the Section Methods and Technologies Development)

Epigenetics and Non-Coding RNAs in Multiple Myeloma

edited by

Rui Bergantim

submission deadline 15 Aug 2026 | Viewed by 315 | Submission Open

Keywords: multiple myeloma; epigenetics; non-coding RNAs; microRNAs (miRNAs); long non-coding RNAs (lncRNAs); circular RNAs (circRNAs); DNA methylation; histone modifications; drug resistance; precision medicine

(This special issue belongs to the Section Cancer Biomarkers)

Immunotherapy for Hematologic Malignancies

edited by Rajesh Ramakrishnan Nair

submission deadline 15 Aug 2026 | Viewed by 300 | Submission Open

Keywords: immune evasion; immunotherapy; CAR-T cell therapy; BiTEs; immunomodulators; checkpoint; inhibitors; bone marrow microenvironment; refractory/relapsed; drug resistance; gene editing

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

How to Properly Diagnose and Treat Immune-Related Adverse Events During Immunotherapy in Patients with Cancer: Discussion Between Specialists (2nd Edition)

edited by

Angioletta Lasagna

and

Paolo Sacchi

submission deadline 15 Aug 2026 | Viewed by 253 | Submission Open

Keywords: ICIs; immune-related adverse effects (irAEs); infectious complications; immune reconstitution; inflammatory syndrome (IRIS); microbiota; vaccines; molecular mimicry

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Cancer and Solid Organ Transplantation

edited by

Georgios Tsoulfas

submission deadline 15 Aug 2026 | Viewed by 186 | Submission Open

Keywords: post-transplant malignancy; transplant oncology; liver transplantation; multidisciplinary care; artificial intelligence; precision medicine; immunosuppression; transplant immunology; cancer immunology; cancer diagnosis

(This special issue belongs to the Section Transplant Oncology)

Neuroimaging of Adult-Type Diffuse Gliomas

edited by

Hirohito Yano

submission deadline 15 Aug 2026 | Viewed by 155 | Submission Open

Keywords: glioma; image diagnosis; molecular diagnosis; MRI; MRS; SPECT; PET

(This special issue belongs to the Section Methods and Technologies Development)

Pancreaticoduodenectomy in the Treatment of Pancreatic Cancer

edited by Piero Chirletti and Roberto L. Meniconi

submission deadline 15 Aug 2026 | Viewed by 118 | Submission Open

Keywords: pancreatic ductal adenocarcinoma (PDAC); surgical treatment; R0 exeresis; mesopancreas; lymphadenectomy; reconstruction technique

(This special issue belongs to the Section Clinical Research of Cancer)

Genetic Changes in CNS Neoplasms

edited by Kimberly Bojanowski Hoang

submission deadline 16 Aug 2026 | Viewed by 250 | Submission Open

Keywords: primary brain tumor; secondary brain tumor; metastasis; glioma; genetics; genomics; CNS; neoplasms

(This special issue belongs to the Section Cancer Biomarkers)

Chronic Intestinal Inflammation and Cancers (2nd Edition)

edited by Livia Biancone and David Laharie

submission deadline 20 Aug 2026 | 3 articles | Viewed by 9494 | Submission Open

Keywords: colorectal cancer; chronic inflammation; inflammatory bowel disease; inflammation-associated dysplasia; outcomes; cancer molecular pathways

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Diagnosis and Therapeutic Management of Gastrointestinal Cancers: 2nd Edition

edited by

Christian Sebesta

and

Harald Rosen

submission deadline 20 Aug 2026 | 2 articles | Viewed by 6498 | Submission Open

Keywords: esophagus tumor; stomach tumor; liver tumor; colon tumor; rectum tumor; pancreato-biliary tumor; targeted immune and/or chemotherapy; surgical technology; multimodal approach; diagnosis; therapeutic management

(This special issue belongs to the Section Cancer Therapy)

Breast Cancer Biomarkers and Clinical Translation: 2nd Edition

edited by

Cristian Scatena

and Carmine De Angelis

submission deadline 20 Aug 2026 | 4 articles | Viewed by 5417 | Submission Open

Keywords: breast cancer diagnosis; cancer risk; cell reprogramming; biomarkers; resistance; precision therapy

(This special issue belongs to the Section Cancer Biomarkers)

Rare Cancers, Diagnostic Challenges and Personalized Therapeutic Approaches in the 21st Century (2nd Edition)

edited by

Jason Roszik

submission deadline 20 Aug 2026 | 2 articles | Viewed by 4126 | Submission Open

Keywords: rare cancer; biology; diagnosis; classification; personalized therapeutics; markers

(This special issue belongs to the Section Cancer Therapy)

Pain and Palliative Care in Patients with Cancers

edited by

Arpad Szallasi

and

Anna Horváth

submission deadline 20 Aug 2026 | 1 articles | Viewed by 1470 | Submission Open

Keywords: cancer pain; palliative care; opioid tolerance

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Advances in Surgery for Endocrine Cancers

edited by

Michael Bouvet

and Eren Berber

submission deadline 20 Aug 2026 | 1 articles | Viewed by 1418 | Submission Open

Keywords: thyroid cancer; thyroid surgery; hyperparathyroidism; adrenal tumors; adrenal surgery; pancreatic neuroendocrine tumors; fluorescence guided surgery; intraoperative imaging; surgical navigation; technological innovation

(This special issue belongs to the Section Methods and Technologies Development)

Next-Generation Biomarkers and AI-Enhanced Digital Pathology Alliance: Revolutionizing Therapeutic Strategies and Prognostic Assessment in Colorectal Cancer

edited by

Τaxiarchis Κonstantinos Νikolouzakis

submission deadline 20 Aug 2026 | 1 articles | Viewed by 1225 | Submission Open

Keywords: liquid biopsy; precision oncology; predictive prognostication

Socio-Demographic Factors and Cancer Research: 2nd Edition

edited by

Mitchell S. Fourman

and Amanda N. Goldin

submission deadline 20 Aug 2026 | 1 articles | Viewed by 900 | Submission Open

Keywords: socio-economic disparity; cancer delivery; cancer survival; metastatic cancer; culture-specific cancer outcomes; AI; machine learning

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Novel Drugs for Treating Gynecologic Cancers: 2nd Edition

edited by

Tadahiro Shoji

and

Hiroaki Itamochi

submission deadline 20 Aug 2026 | 1 articles | Viewed by 657 | Submission Open

Keywords: gynecological cancers; novel treatment strategies; cytotoxic chemotherapeutic agents; molecularly targeted agents; immune-checkpoint inhibitors

(This special issue belongs to the Section Cancer Drug Development)

Advances in Clinical, Diagnostic and Neurosurgical Management in Pediatric Neuro-Oncology

edited by

John Ross Crawford

and Michael Levy

submission deadline 20 Aug 2026 | Viewed by 329 | Submission Open

Keywords: neuro-oncology; brain tumors; neuroradiology; proton therapy; pediatric; neurosurgery; treatment; chemotherapy; targeted agents; molecular subtypes; immunotherapy; late effects; radiation therapy

(This special issue belongs to the Section Pediatric Oncology)

Multidisciplinary Strategies in Challenging Neuro-Oncological Surgery

edited by

Eiichi Ishikawa

submission deadline 20 Aug 2026 | Viewed by 215 | Submission Open

Keywords: neuro-oncology; surgery; awake craniotomy; intraoperative MRI; MRI navigation system; intraoperative photodynamic diagnosis/therapy; intraoperative pathological diagnosis

(This special issue belongs to the Section Clinical Research of Cancer)

Advances in Surgery of Liver Cancer

edited by Ho-Seong Han and Roberto Ivan Troisi

submission deadline 20 Aug 2026 | Viewed by 127 | Submission Open

Keywords: liver cancer surgery; hepatocellular carcinoma; minimally invasive liver resection; laparoscopic surgery; robotic surgery; anatomical resection; surgical oncology; precision surgery

(This special issue belongs to the Section Methods and Technologies Development)

Precision Imaging and Radiomics in Thoracic Oncology

edited by Sharyn Katz

submission deadline 20 Aug 2026 | Viewed by 122 | Submission Open

Keywords: thoracic oncology; radiomics; artificial intelligence; molecular imaging; precision medicine

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Photodynamic Therapy in Solid Tumors

edited by

Yu Wen

submission deadline 20 Aug 2026 | Viewed by 100 | Submission Open

Keywords: photodynamic therapy; solid tumors; photosensitizers; light delivery; combination therapy; translational research; clinical trials; biomarkers; treatment optimization; cancer treatment

(This special issue belongs to the Section Cancer Therapy)

Diagnostic Biomarkers in Cancers Study

edited by Zejuan Li and

Xin Yi

submission deadline 21 Aug 2026 | 8 articles | Viewed by 14786 | Submission Open

Keywords: cancer; diagnostics; biomarker

(This special issue belongs to the Section Cancer Biomarkers)

New Insights into Cancer Radiotherapy

edited by

Michael L. F. Lerch

submission deadline 21 Aug 2026 | 3 articles | Viewed by 4565 | Submission Open

Keywords: radiotherapy; X-rays; gamma rays; external beam radiation therapy; brachytherapy; palliative care; intensity-modulated radiotherapy (IMRT); stereotactic body radiotherapy (SBRT); proton therapy

(This special issue belongs to the Section Cancer Therapy)

Contemporary Diagnosis and Management of Prostate Cancer (2nd Edition)

edited by Thomas Jang

submission deadline 22 Aug 2026 | 1 articles | Viewed by 3185 | Submission Open

Keywords: prostate cancer; diagnosis; management; radical prostatectomy; biomarkers

(This special issue belongs to the Section Cancer Therapy)

Treatment of Bone and Soft Tissue Sarcomas

edited by

Minggui Pan

submission deadline 22 Aug 2026 | Viewed by 165 | Submission Open

Keywords: sarcoma; bone sarcoma; soft tissue sarcoma; therapy; chemotherapy; immunotherapy; targeted therapy

(This special issue belongs to the Section Methods and Technologies Development)

The Molecular Pathogenesis of Lung Cancer: From Oncogenic Drivers to Tumor Microenvironment

edited by

Bin Xu

submission deadline 24 Aug 2026 | Viewed by 165 | Submission Open

Keywords: lung cancer; oncogenic drivers; tumor microenvironment; immune checkpoint inhibitors; immunotherapy resistance; predictive biomarkers

(This special issue belongs to the Section Cancer Pathophysiology)

Contemporary Advances and Challenges in Multimodal Management of Gastric Cancer

edited by

Karol Rawicz-Pruszyński

and Zuzanna Pelc

submission deadline 25 Aug 2026 | 1 articles | Viewed by 870 | Submission Open

Keywords: gastric cancer; multimodal therapy; perioperative chemotherapy; immunotherapy; minimally invasive surgery/robotic gastrectomy; surgical escalation and de-escalation; conversion surgery; patient selection/prognostic factors; biomarkers (her2; pd-l1; msi; ctdna); perioperative nutrition/eras

(This special issue belongs to the Section Cancer Therapy)

Understanding HTLV-1 Induced Cancer: From Molecular Pathways to Treatment Strategies

edited by

George Eric Blair

and Suchitra Mohanty

submission deadline 25 Aug 2026 | Viewed by 284 | Submission Open

Keywords: HTLV-1; adult T-cell leukemia/lymphoma (ATLL); tax protein; HBZ protein; epigenetic regulation; immune evasion; chronic inflammation; host– pathogen interactions; viral oncogenesis; translational research

(This special issue belongs to the Section Infectious Agents and Cancer)

Clinical Studies of Colorectal Cancer Surgery

edited by

Konstantinos Perivoliotis

and Ioannis Baloyiannis

submission deadline 25 Aug 2026 | Viewed by 195 | Submission Open

Keywords: colon; rectal; cancer; clinical; trials; evidence; open; laparoscopic; robotic; surgery

(This special issue belongs to the Section Clinical Research of Cancer)

Neoadjuvant Therapy of Breast Cancer: 2nd Edition

edited by

Hiroyuki Takei

and Takaaki Fujii

submission deadline 25 Aug 2026 | Viewed by 162 | Submission Open

Keywords: neoadjuvant systemic therapy; chemotherapy; endocrine therapy; molecular targeted therapy; molecular subtypes; response-guided therapy; clinical trials

(This special issue belongs to the Section Cancer Therapy)

Risk of Skin Cancer: Non-Melanoma/Melanoma

edited by

Eggert Stockfleth

submission deadline 28 Aug 2026 | 2 articles | Viewed by 2015 | Submission Open

Keywords: melanoma; non-melanoma skin cancer; keratinocyte cancer; Merkel cell carcinoma; UV exposure; immunosuppression; skin cancer prevention

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Modern Approach to Oral Cancer

edited by

Maria Maddalena Marrapodi

and

Giuseppe Minervini

submission deadline 30 Aug 2026 | 12 articles | Viewed by 60873 | Submission Open

Keywords: oral cancer; neoplasm; oral surgery oncogenesis; dentistry oral health

(This special issue belongs to the Section Cancer Therapy)

Long-Term Health Outcomes and Quality of Life in Survivors of Childhood Cancer

edited by

Esteban Orenes-Piñero

submission deadline 30 Aug 2026 | 2 articles | Viewed by 3225 | Submission Open

Keywords: acute lymphoblastic leukemia; brain tumors; childhood cancer survivors; pollutants; environment; quality of life; nutrition; chemotherapy; air and water purification

(This special issue belongs to the Section Pediatric Oncology)

Neoantigen Vaccines for Cancer Therapy

edited by Takashi Morisaki

submission deadline 30 Aug 2026 | 1 articles | Viewed by 2902 | Submission Open

Keywords: neoantigens; vaccine; dendritic cells; cancer; immunotherapy; priming; CTL; helper T cells

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Tumor Suppressor and Targeted Therapy in Hepatocellular Carcinoma: From Diagnosis to Treatment (2nd Edition)

edited by

Ching-Sheng Hsu

Po-Heng Chuang

and I-Cheng Lee

submission deadline 30 Aug 2026 | 2 articles | Viewed by 2794 | Submission Open

Keywords: tumor suppressor; targeted therapy; hepatocellular carcinoma

(This special issue belongs to the Section Tumor Microenvironment)

Smart Nanotechnology for Drug Delivery in Cancer Therapy

edited by

Stefano Leporatti

submission deadline 30 Aug 2026 | 1 articles | Viewed by 1521 | Submission Open

Keywords: nanotechnology; drug delivery; cancer therapy; nanocarriers; nanoparticles; nano-devices; nano-channels

(This special issue belongs to the Section Methods and Technologies Development)

Pathology of Acute Myeloid Leukemia (AML)

edited by Olga K. Weinberg

submission deadline 30 Aug 2026 | Viewed by 1448 | Submission Open

(This special issue belongs to the Section Cancer Pathophysiology)

Pathology of Gynecological Cancers (2nd Edition)

edited by

Mohamed Desouki

submission deadline 30 Aug 2026 | 1 articles | Viewed by 1147 | Submission Open

Keywords: endometrial cancer; ovarian cancer; vulvar cancer; cervical cancer; vaginal cancer

(This special issue belongs to the Section Cancer Pathophysiology)

Proteometabolomics in Cancer

edited by

Samir M. Hanash

and

Johannes Fahrmann

submission deadline 30 Aug 2026 | Viewed by 377 | Submission Open

Keywords: proteomics; metabolomics; cancer biology; tumor microenvironment; biomarkers; therapeutics

(This special issue belongs to the Section Molecular Cancer Biology)

Robotic and Laparoscopic Surgery in Colorectal Cancer: Current Trends and Future Perspectives

edited by

Felix Aigner

, Quentin Denost and Barbara Noiret

submission deadline 30 Aug 2026 | Viewed by 324 | Submission Open

Keywords: robotic surgery; laparoscopic surgery; colorectal cancer; minimally invasive surgery; comparative outcomes (perioperative; oncologic; functional); conversion rates; open surgery; learning curve and surgical training; cost‐effectiveness and health economics; technological innovations (e.g.; AI; imaging; instrumentation); quality of life and long‐term patient‐reported outcomes

(This special issue belongs to the Section Cancer Therapy)

Innovations in Imaging and Endoscopic Diagnosis of Esophageal Cancer: From Early Detection to Clinical Decision Support

edited by

Hsiang-Chen Wang

Riya Karmakar

and Mahendra Bhatu Gawali

submission deadline 30 Aug 2026 | Viewed by 206 | Submission Open

Keywords: esophageal cancer; endoscopic imaging; early detection; image-enhanced endoscopy; optical imaging; artificial intelligence; computer-aided diagnosis; multimodal imaging; risk stratification; clinical decision support systems

(This special issue belongs to the Section Methods and Technologies Development)

Transcription Factors and Their Involvement in Carcinogenesis

edited by