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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Tumor Microenvironment in Bone Sarcoma submission deadline 31 Aug 2026 | Viewed by 189 | Submission Open
Keywords: osteosarcoma; microenvironment; oncogene; tumor suppressor; CAR cell therapy; epithelial– mesenchymal transition; metabolism; epigenetics
(This special issue belongs to the Section Tumor Microenvironment)
Advances in Surgery for Gynecologic Cancer submission deadline 31 Aug 2026 | Viewed by 182 | Submission Open
Keywords: sentinel lymph node mapping; cervical cancer; robotic-assisted laparoscopy; cytoreductive surgery; nerve-sparing techniques; image-guided surgery; enhanced recovery after surgery; molecular staging; individualized surgery; endometrial cancer
The Invasion and Metastasis in Skin Cancer
edited by Emanuela Passoni, and
submission deadline 31 Aug 2026 | Viewed by 178 | Submission Open
Keywords: melanoma; skin cancer; basal cell carcinoma; squamous cell carcinoma; Kaposi’ s sarcoma; dermoscopy; photoprotection; skin cancer prevention
Early Detection and Strategies for Overcoming Therapy Resistance in Lung Cancer and Mesothelioma
edited by
submission deadline 31 Aug 2026 | Viewed by 174 | Submission Open
Keywords: lung cancer; mesothelioma; screening; biomarker; molecular diagnostics; resistance
(This special issue belongs to the Section Cancer Therapy)
Liquid Biopsy Innovation: From ctDNA to RNA Modifications in Genitourinary Cancers
edited by , and Jacopo Venturini
submission deadline 31 Aug 2026 | Viewed by 170 | Submission Open
Keywords: liquid biopsy; cell-free DNA (cfDNA); circulating tumor DNA (ctDNA); RNA modification
(This special issue belongs to the Section Cancer Biomarkers)
Cancer Survivorship: Transforming Challenges into Quality Living
edited by and Tania Estapé
submission deadline 31 Aug 2026 | Viewed by 168 | Submission Open
Keywords: cancer survivorship; psychological adjustment; emotional well-being; coping; quality of life; family relationships; couple functioning; sexuality; return to work; psychosocial interventions; financial toxicity
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Clinical Outcomes in Urologic Cancers (2nd Edition)
edited by and Pierre Karakiewicz
submission deadline 31 Aug 2026 | Viewed by 164 | Submission Open
Keywords: bladder cancer; prostate cancer; kidney cancer; upper tract urothelial carcinoma; adrenocortical cancer
(This special issue belongs to the Section Clinical Research of Cancer)
Progress in Minimally Invasive Approaches in Gastrointestinal Cancer
edited by Florin Grama and
submission deadline 31 Aug 2026 | Viewed by 164 | Submission Open
Keywords: minimally invasive surgery; gastrointestinal cancer; endoscopic techniques; hybrid techniques
(This special issue belongs to the Section Methods and Technologies Development)
Pancreatic Cancer: Clinical Trials, Treatment Strategies, and Future Directions
edited by Brent Taiting Xia
submission deadline 31 Aug 2026 | Viewed by 160 | Submission Open
Keywords: pancreatic cancer; neoadjuvant therapy; clinical trials; pancreatectomy; chemoradiation
(This special issue belongs to the Section Clinical Research of Cancer)
Heat Shock Proteins in Metastatic Cancer: From Molecular Mechanisms to Clinical Targeting
edited by Daniel Jay and
submission deadline 31 Aug 2026 | Viewed by 160 | Submission Open
Keywords: HSPs and eHSPs (Hsp90; Hsp70; Hsp60; Hsp40 and Hsp27); HSF1; chaperone; cancer metastasis; EMT; tumor microenvironment; ECM remodelling; anoikis resistance; circulating tumor cell survival; premetastatic niche; metastatic colonisation; extracellular vesicles; exosomes; cancer stem cells; therapy resistance; metastatic biomarkers; immunotherapy; HSP-targeted therapy
Artificial Intelligence in Gastrointestinal Cancer Diagnosis and Treatment
edited by Eun Jeong Gong
submission deadline 31 Aug 2026 | Viewed by 156 | Submission Open
Keywords: artificial intelligence; gastrointestinal cancer; deep learning; precision oncology; clinical decision support; large language model; explainable artificial intelligence
(This special issue belongs to the Section Methods and Technologies Development)
Treatment Outcomes in Older Adults with Cancer (2nd Edition) submission deadline 31 Aug 2026 | Viewed by 154 | Submission Open
Keywords: older adults with cancer; geriatric oncology; geriatric assessment; supportive care; palliative care; cancer rehabilitation; nutrition; physical activity; functional status; survivorship
(This special issue belongs to the Section Cancer Therapy)
Advances in Drug Delivery for Cancer Therapy (2nd Edition) submission deadline 31 Aug 2026 | Viewed by 153 | Submission Open
Keywords: cancer; oncology; therapeutic target; drug resistance; immunotherapy; chemotherapy; small molecule inhibitors; drug delivery; nanoparticle
(This special issue belongs to the Section Cancer Drug Development)
Palliative and Supportive Care in Oncology
edited by and Heidrun Golla
submission deadline 31 Aug 2026 | Viewed by 145 | Submission Open
Keywords: screening; timely palliative care; caregivers; symptom control; digitalization; care structures; gender-specific aspects
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Applications of Computed Tomography in Lung Cancer
edited by Yukinori Sakao
submission deadline 31 Aug 2026 | Viewed by 144 | Submission Open
Keywords: lung cancer; computed tomography (CT); radiomics; artificial intelligence (AI); image-guided surgery
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Epigenetic Markers of Cancer Diseases
edited by and Jessica Puzzuoli
submission deadline 31 Aug 2026 | Viewed by 143 | Submission Open
Keywords: epigenetics; DNA methylation; histone modifications; tumor suppressor genes; oncogenes; cancer biomarkers; early detection; disease progression; epigenetic therapy; DNA methyltransferase inhibitors; histone deacetylase inhibitors; liquid biopsy; cancer risk assessment; clinical translation
(This special issue belongs to the Section Molecular Cancer Biology)
Integrating Immunotherapy, Novel Agents, and Their Combinations with Standard Treatments in the Management of Head and Neck Cancers
edited by , , and Laurent Muller
submission deadline 31 Aug 2026 | Viewed by 143 | Submission Open
Keywords: head and neck cancer; oropharyngeal cancer; chemotherapy; immunotherapy; biomarker; targeted therapies; checkpoint inhibitor
(This special issue belongs to the Section Cancer Therapy)
Head and Neck Cancer Surgery: Resection and Reconstruction
edited by , Kiyoto Shiga and Hisakazu Kato
submission deadline 31 Aug 2026 | Viewed by 138 | Submission Open
Keywords: head and neck cancer surgery; tumor resection; reconstructive surgery; microvascular free flap; functional reconstruction; oncologic outcomes; perioperative management; rehabilitation (speech and swallowing); imaging and surgical planning; multidisciplinary care
(This special issue belongs to the Section Methods and Technologies Development)
Diagnosis and Novel Therapies for Pediatric Solid Tumor
edited by and
submission deadline 31 Aug 2026 | Viewed by 138 | Submission Open
Keywords: pediatric solid tumors; diagnosis; targeted therapy; immunotherapy; sequencing
(This special issue belongs to the Section Pediatric Oncology)
Genomic Instability in Breast Cancer: Biomarkers, Resistance and Therapeutic Opportunities
edited by Melyssa R. Bratton
submission deadline 31 Aug 2026 | Viewed by 127 | Submission Open
Keywords: genomic instability; somatic mutation; DNA damage response; homologous recombination deficiency (HRD); tumor mutational burden (TMB); chromosomal instability (CIN); tumor evolution; therapeutic resistance
Paradigm Shifts in Gynaecological Oncology Surgery (2nd Edition)
edited by
submission deadline 31 Aug 2026 | Viewed by 125 | Submission Open
Keywords: gynecological surgery; genomic risk management; survivorship health economics
(This special issue belongs to the Section Cancer Therapy)
Clinical and Research Progress in the Resection of Gastro-Esophageal Cancer (2nd Edition)
edited by Biniam Kidane
submission deadline 31 Aug 2026 | Viewed by 123 | Submission Open
Keywords: gastro-esophageal cancer resection; multi-modal management; surgical morbidity and mortality; treatment-related toxicities; perioperative outcomes
(This special issue belongs to the Section Clinical Research of Cancer)
Advancements in Prostate Cancer Using Multi-Omics
edited by and Justin H. Hwang
submission deadline 31 Aug 2026 | Viewed by 121 | Submission Open
Keywords: prostate cancer; genomics; transcriptomics; proteomics; cancer immunology; translational research; single cell; spatial-omics
Precision Prediction of Cardiotoxicity: Imaging, Biomarkers, Genetics, Risk Models, and Digital Innovation in Cardio-Oncology
edited by Kalliopi Keramida
submission deadline 31 Aug 2026 | Viewed by 121 | Submission Open
Keywords: cardio-oncology; imaging; biomarkers; genetics; risk models; digital innovation
The Role of the Microbiome in Oral Tumorigenesis
edited by Elena Varoni
submission deadline 31 Aug 2026 | Viewed by 119 | Submission Open
Keywords: oral squamous cell carcinoma; oral potentially malignant disorders; leukoplakia; erythroplakia; oral microbiome; periodontal pathogens; immunotherapy
Digestive Tract Cancers: A State-of-the-Art Perspective on Epidemiology, Risk Factors, Molecular Mechanisms, Prevention, Diagnosis and Management
edited by Paraskevi A Farazi
submission deadline 31 Aug 2026 | Viewed by 118 | Submission Open
Keywords: colorectal; pancreatic; liver; biliary; esophageal; stomach cancers; epidemiology; risk factors; molecular mechanisms; prevention; diagnosis; treatment
Molecular Mechanisms and Therapeutic Resistance in Hematological Malignancies
edited by
submission deadline 31 Aug 2026 | Viewed by 111 | Submission Open
Keywords: genomic and epigenomic alterations; signaling pathway dysregulation; non-coding RNAs; metabolic reprogramming; antigen escape mechanisms; antigen presentation defects; interferon signaling impairment; T-cell exhaustion; memory T-cell dysfunction; myeloid-mediated immunosuppression; bone marrow immune microenvironment; spatial immune architecture; CAR-T cell therapy; next-generation CAR engineering; bispecific antibodies and T-cell engagers; antibody-drug conjugates; NK-cell and macrophage immunotherapy; immune checkpoint modulation; combination immunotherapy strategies; liquid biopsy– guided precision therapy
Advances in Laryngeal Cancer: Integrating Clinical Practice, Artificial Intelligence, Molecular Mechanisms, and Functional Rehabilitation
edited by Shuihong Zhou
submission deadline 31 Aug 2026 | Viewed by 110 | Submission Open
Keywords: laryngeal cancer; laryngeal carcinoma; head and neck cancer; artificial intelligence; radiomics; digital pathology; optical tumor imaging; voice rehabilitation; secondary prevention; multi-omics; biomarkers; precision oncology
Oncological Outcomes of Active Surveillance Versus Radical Treatment in Localized Prostate Cancer
edited by
submission deadline 31 Aug 2026 | Viewed by 104 | Submission Open
Keywords: active surveillance; molecular markers; multiparametric magnetic resonance imaging; prostate cancer
Emerging Therapies in the Management of Gastrointestinal Malignancies (3rd Edition) submission deadline 31 Aug 2026 | Viewed by 103 | Submission Open
Keywords: hepatocellular carcinoma; colorectal cancer; esophageal cancer; immunotherapy; targeted therapy
(This special issue belongs to the Section Cancer Therapy)
Immune–Genomic Interactions and Risk Stratification in Hormone-Receptor-Positive Breast Cancer
edited by Shinichiro Kashiwagi
submission deadline 31 Aug 2026 | Viewed by 102 | Submission Open
Keywords: hormone-receptor-positive breast cancer; oncotype DX; tumor-infiltrating lymphocytes; immune– genomic interaction; clinical– genomic discordance; tumor microenvironment; precision medicine
Advances in Brachytherapy in the Treatment of Tumors (2nd Edition)
edited by
submission deadline 31 Aug 2026 | Viewed by 101 | Submission Open
Keywords: brachytherapy; LDR; HDR; PDR; cervical cancer; prostate cancer; breast cancer
(This special issue belongs to the Section Cancer Therapy)
Advances in Minimally Invasive Surgery for Gastrointestinal Cancers: Laparoscopic and Robotic Approaches
edited by Beat Peter Müller-Stich and Alexander Wilhelm
submission deadline 31 Aug 2026 | Viewed by 95 | Submission Open
Keywords: minimally invasive surgery; gastrointestinal cancers; laparoscopic surgery; robotic-assisted surgery; surgical oncology; oncologic outcomes; artificial intelligence in surgery; learning curve and training; multimodal cancer care; image-guided surgery
(This special issue belongs to the Section Clinical Research of Cancer)
Detection and Management of Melanoma
edited by
submission deadline 31 Aug 2026 | Viewed by 91 | Submission Open
Keywords: mucosal melanoma; acral melanoma; rare subtypes
Cancer Therapy-Related Adverse Events (2nd Edition)
edited by and Pauline Funchain
submission deadline 1 Sep 2026 | 2 articles | Viewed by 8868 | Submission Open
Keywords: cancer; cancer therapy; toxicities; adverse events
(This special issue belongs to the Section Cancer Therapy)
Chronic Lymphocytic Leukemia: From Genetics to Therapy submission deadline 1 Sep 2026 | 6 articles | Viewed by 6484 | Submission Open
Keywords: chronic lymphocytic; leukemia treatment; biology
(This special issue belongs to the Section Cancer Therapy)
The Role of Minimally Invasive and Minimally Radical Surgery in Cervical and Endometrial Cancer
edited by , , Christophe Pomel, and Gwénaël Ferron
submission deadline 1 Sep 2026 | 1 articles | Viewed by 967 | Submission Open
Keywords: cervical cancer; endometrial cancer; laparoscopic surgery; minimally invasive surgery; surgical oncology; fertility-sparing surgery; non-radical surgery; conservative surgery
(This special issue belongs to the Section Cancer Therapy)
Prostatectomy Today: Surgical Advances in Prostate Cancer Management
edited by
submission deadline 1 Sep 2026 | 1 articles | Viewed by 834 | Submission Open
Keywords: prostate cancer; robot-assisted radical prostatectomy; robotic system; perioperative outcomes; sexual function; urinary continence; oncological outcomes
(This special issue belongs to the Section Clinical Research of Cancer)
Quality of Care for Patients with Head and Neck Cancer
edited by Khara Marissa Sauro
submission deadline 1 Sep 2026 | Viewed by 329 | Submission Open
Keywords: patient safety; treatment delays; healthcare resource use; effectiveness; health economics; continuity of care; outcomes research
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Clinical Update on Lung Cancer: Current Strategies and Outcome
edited by Antonio D'Andrilli
submission deadline 6 Sep 2026 | Viewed by 131 | Submission Open
Keywords: lung cancer; clinical outcomes; diagnosis; treatment
Study on Clinical Treatment of Brain Tumors
edited by Shinya Watanabe
submission deadline 9 Sep 2026 | 3 articles | Viewed by 9100 | Submission Open
Keywords: brain tumors; clinical treatment; anti-tumor drugs; clinical trials
(This special issue belongs to the Section Cancer Therapy)
Quality of Life and Side Effects Management in Cancer Treatment (3rd Edition)
edited by
submission deadline 10 Sep 2026 | 5 articles | Viewed by 14652 | Submission Open
Keywords: cancer treatment adverse events; quality of life in cancer patients; chemotherapy adverse events; target therapy adverse events; immunotherapy adverse events; hormonotherapy adverse events; chemotherapy-induced nausea and vomiting; cancer pain
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Exercise and Cancer Treatment: The Clinical Application of Exercise Oncology
edited by and Geovana Leite
submission deadline 10 Sep 2026 | 3 articles | Viewed by 3795 | Submission Open
Keywords: exercise oncology; cancer therapy; immunotherapy; patient outcomes
(This special issue belongs to the Section Clinical Research of Cancer)
Advances in Interventional Oncologic Therapies
edited by Edward W. Lee and
submission deadline 15 Sep 2026 | 4 articles | Viewed by 14479 | Submission Open
(This special issue belongs to the Section Cancer Therapy)
Advances in Artificial Intelligence Methodologies and Applications in Cancer
edited by Jennifer G. Le-Rademacher and
submission deadline 15 Sep 2026 | 4 articles | Viewed by 6538 | Submission Open
Keywords: artificial intelligence (AI); AI tools; cancer research; diagnostic tools; medical imaging; biomarkers; ethical considerations; patient care
(This special issue belongs to the Section Methods and Technologies Development)
First-Line Therapy in Thoracic Oncology
edited by Antonio D'Andrilli and
submission deadline 15 Sep 2026 | 4 articles | Viewed by 6392 | Submission Open
Keywords: thoracic oncology; lung cancer; thymoma; mediastinal tumors
(This special issue belongs to the Section Cancer Therapy)
Robot-Assisted Surgery for Urologic Cancer
edited by Gabriele Sorce, Francesco Pellegrino and Ettore Di Trapani
submission deadline 15 Sep 2026 | 3 articles | Viewed by 6207 | Submission Open
Keywords: robot-assisted surgery; urologic oncology; minimally invasive surgery; prostate cancer surgery; kidney cancer surgery; bladder cancer surgery; robotic platforms; robotic surgery training
(This special issue belongs to the Section Cancer Therapy)
Radiotherapy for Sarcoma
edited by Safia K. Ahmed and Miranda Lam
submission deadline 15 Sep 2026 | 3 articles | Viewed by 4698 | Submission Open
Keywords: soft tissue sarcoma; bone sarcoma; advanced sarcoma; radiation therapy; particle therapy; multidisciplinary sarcoma care
(This special issue belongs to the Section Cancer Therapy)
Treatment of Acute Kidney Injury in Cancer Patients: From Theory to Practice
edited by and Shveta S. Motwani
submission deadline 15 Sep 2026 | 1 articles | Viewed by 2186 | Submission Open
Keywords: immune check point inhibitor related nephritis; MGRS; CART cell therapy; stem cell transplant; TMA; BK nephropathy; cisplatin nephropathy
(This special issue belongs to the Section Cancer Therapy)
Endometrial Cancer Therapy: Foundations and Future Directions submission deadline 15 Sep 2026 | 1 articles | Viewed by 1905 | Submission Open
Keywords: pathology; surgery; radiotherapy; chemotherapy; new agents; immunotherapy; artificial intelligence
(This special issue belongs to the Section Cancer Therapy)
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