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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue polices and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Innovative Biomarkers and Imaging Techniques for the Early Detection and Risk Stratification of Uro-Oncological Tumours

edited by

Magdalena Görtz

submission deadline 30 Jun 2025 | Viewed by 2 | Submission Open

Keywords: uro-oncological tumours; novel biomarkers; advanced imaging techniques; early detection; risk stratification; molecular diagnostics; multimodal data integration; personalized treatment

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Updates on Immune Checkpoint Inhibitors in Hepatocellular Carcinoma

edited by Luca Marzi and

Rodolfo Sacco

submission deadline 30 Jun 2025 | Submission Open

Keywords: hepatocellular carcinoma; immunotherapy; immuno-oncology; immune checkpoint inhibitors; clinical trial; immunological microenvironments

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Pediatric Brain Tumors: Symptoms, Diagnosis and Treatments

edited by Christian Ott and Julius Höhne

submission deadline 1 Jul 2025 | 1 articles | Viewed by 1165 | Submission Open

Keywords: MRI/CT scans; radiation therapy; chemotherapy; combined therapy

(This special issue belongs to the Section Cancer Therapy)

Advances in Therapeutic Strategies for Prostate Cancer

edited by Angelo Naselli and

Giacomo Maria Pirola

submission deadline 1 Jul 2025 | 1 articles | Viewed by 1057 | Submission Open

Keywords: immunotherapy; radiation therapy; hormone therapy; targeted therapies

(This special issue belongs to the Section Cancer Therapy)

The Role of Radiotherapy, Immunotherapy and New Surgical Techniques in the Treatment of Lung Neoplasms

edited by

Elisa Meacci

submission deadline 1 Jul 2025 | 1 articles | Viewed by 487 | Submission Open

Keywords: radiotherapy; immunotherapy; new surgical techniques; lung cancer

(This special issue belongs to the Section Cancer Therapy)

The Role of Imaging in Cervical Cancer

edited by

Andrea Giannini

, Emma R. Allanson and Ming Yin Lin

submission deadline 1 Jul 2025 | Viewed by 313 | Submission Open

Keywords: cervical cancer; staging; ultrasound; MRI; PET-CT; radiotherapy; image-guided brachytherapy

(This special issue belongs to the Section Methods and Technologies Development)

Radiomics in Gynaecological Cancers

edited by

Priya Bhosale

and

Mayur Virarkar

submission deadline 1 Jul 2025 | Viewed by 17 | Submission Open

Keywords: MRI; CT; PET; radiomics; gynecologic malignancies

(This special issue belongs to the Section Cancer Informatics and Big Data)

Breast Cancer: Tailored Rehabilitation Strategies to Address the Challenge of Survivorship Issues

edited by

Marco Invernizzi

and

Lorenzo Lippi

submission deadline 3 Jul 2025 | 4 articles | Viewed by 14521 | Submission Open

Keywords: breast cancer; rehabilitation; biomarkers; survivorship; precision medicine

(This special issue belongs to the Section Cancer Therapy)

Advances in Neurofibromatosis

edited by Yunjia Chen and Yulong Fu

submission deadline 5 Jul 2025 | Viewed by 33 | Submission Open

Keywords: neurofibromatosis; schwannomatosis; NF1; NF2; SMARCB1; LZTR1

(This special issue belongs to the Section Molecular Cancer Biology)

Challenges and Opportunities for Novel Therapeutic Strategies in Pediatric Oncology

edited by

Jeong A Park

and

Jaume Mora

submission deadline 6 Jul 2025 | 3 articles | Viewed by 2181 | Submission Open

Keywords: antibody-drug conjugate; bispecific antibody; cancer predisposition; CAR T cell; immunotherapy; leukemia; monoclonal antibody; neuroblastoma; pediatric cancer; photoimmunotherapy; precision medicine; sarcoma; translational research; tyrosine kinase inhibitor

(This special issue belongs to the Section Cancer Therapy)

Molecular Biology, Diagnosis and Management of Endometrial Cancer

edited by

Georgios Androutsopoulos

Georgios Michail

and Thomas Vrekoussis

submission deadline 12 Jul 2025 | 2 articles | Viewed by 2892 | Submission Open

Keywords: endometrial cancer; molecular biology; lymph node dissection; sentinel lymph node mapping; sentinel lymph node dissection; surgery; systemic therapy; radiotherapy; fertility preservation; molecular targeted therapies

(This special issue belongs to the Section Molecular Cancer Biology)

Applications of Different Knowledge Graphs and Large Language Models in Diagnosis Cancers

edited by

Ramin Ranjbarzadeh

submission deadline 12 Jul 2025 | Viewed by 469 | Submission Open

Keywords: deep learning; machine learning; large language models; cancer diagnosis; clinical decision support systems; image analysis; genomic data interpretation; biomedical literature mining; patient risk assessment; computational oncology; healthcare informatics; precision medicine; artificial intelligence; medical research; patient care

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Primary Central Nervous System Lymphoma: A Challenging Disease

edited by

Roser Velasco

submission deadline 15 Jul 2025 | Viewed by 17 | Submission Open

Keywords: primary central nervous system lymphoma (PCNSL); diffuse large B cell lymphoma (DLBCL); advanced imaging; novel therapies; prognostic markers

(This special issue belongs to the Section Clinical Research of Cancer)

EVs and EPS in Cancer: Cell-to-Cell Communication, Diagnosis, and Evaluation of Cancer Therapy Response

edited by Irina Nazarenko and

José Antonio López-Guerrero

submission deadline 20 Jul 2025 | 1 articles | Viewed by 1699 | Submission Open

Keywords: extracellular vesicles; EVs; particles; cancer; liquid biopsy; cell-cell communication

(This special issue belongs to the Section Tumor Microenvironment)

Advances in Spinal Tumoral Pathology: Surgical Perspectives and Multidisciplinary Therapeutic Approaches

edited by

Ştefan Florian

submission deadline 20 Jul 2025 | Viewed by 53 | Submission Open

Keywords: spinal tumors; oncological surgery; spinal oncology; minimally invasive techniques; multidisciplinary treatment; targeted therapy; patient outcomes in spinal surgery; imagine techniques in spinal tumors; surgical robotics in spinal tumor resection; neuromonitoring

(This special issue belongs to the Section Cancer Pathophysiology)

State of the Art: Cardiothoracic Tumors

edited by

Calvin Sze Hang Ng

and Panagiotis Tasoudis

submission deadline 25 Jul 2025 | 1 articles | Viewed by 516 | Submission Open

Keywords: lung cancer; non-small cell lung cancer; esophageal cancer; diagnostic imaging; robotic-assisted thoracoscopic surgery; video-assisted thoracoscopic surgery; immunotherapy; radiotherapy; molecular oncology; lung cancer screening

(This special issue belongs to the Section Cancer Therapy)

State of the Art and Novelties in Multidisciplinary Approach to Soft Tissue and Bone Sarcomas

edited by Ron Batash, Alberto Crimì, Moshe Schaffer and

Pietro Ruggieri

submission deadline 30 Jul 2025 | Viewed by 19 | Submission Open

Keywords: soft tissue sarcoma; bone sarcoma; treatment; diagnosis; radiation therapy; chemotherapy

(This special issue belongs to the Section Cancer Therapy)

Integrative Histopathology-Molecular and Computational Analysis of Primary Brain Tumors

edited by

Adriana Olar

submission deadline 31 Jul 2025 | Viewed by 151 | Submission Open

Keywords: brain tumor histopathology; neuropathology; molecular pathology; digital pathology; artificial intelligence; bioinformatics; computational pathology; deep learning

(This special issue belongs to the Section Cancer Informatics and Big Data)

The Pathologic Diagnosis and Clinical Therapy of Neuroendocrine Tumors

edited by

Annabella Di Mauro

Ottavia Clemente

and

Salvatore Tafuto

submission deadline 31 Jul 2025 | Viewed by 126 | Submission Open

Keywords: neuroendocrine neoplasms; molecular mechanisms; cancer pathogenesis; tumorigenesis; diagnosis; molecular and cellular heterogeneity; predictive biomarkers; animal models and of neuroendocrine cancer; diagnostic clinical oncology; genomic characterization; clinical biomarkers; biomarkers of drug response; epigenetic biomarkers; targeted therapy; tumor immunity; molecular oncology; clinical therapy

(This special issue belongs to the Section Cancer Therapy)

Emerging Research in Primary Brain Tumor

edited by Jacob S Young and Mitchel S. Berger

submission deadline 31 Jul 2025 | Viewed by 42 | Submission Open

Keywords: molecular biomarkers; drug delivery; immunotherapy; personalized medicine; targeted therapies; glioma

(This special issue belongs to the Section Cancer Therapy)

Novel Diagnosis and Treatment Approaches in Pancreatic Cancer

edited by

Atsushi Masamune

submission deadline 31 Jul 2025 | Viewed by 12 | Submission Open

Keywords: pancreatic cancer; pancreatic fibrosis; biomarker; risk factor; genetic testing; artificial intelligence; endoscopic ultrasound; stroma; cancer-associated fibroblasts; familial pancreatic cancer

(This special issue belongs to the Section Cancer Therapy)

Oncology: State-of-the-Art Research in Germany

edited by

Orlando Guntinas-Lichius

submission deadline 31 Aug 2025 | 17 articles | Viewed by 23769 | Submission Open

Keywords: cancer; oncology; research; Germany; cancer care

New Concepts and Recent Advances in the Management of Skin Cancer

edited by

Rafael Salido-Vallejo

and

Pedro Redondo

submission deadline 31 Aug 2025 | 10 articles | Viewed by 13480 | Submission Open

Keywords: skin cancer; basal cell carcinoma; cutaneous squamous cell carcinoma; melanoma; Merkel cell carcinoma; cutaneous sarcomas; treatment; checkpoint inhibitors; epidemiology; dermatologic surgery; extramammary paget's disease; cutaneous lymphoma

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Diagnosis and Treatment of Gastroenteropancreatic Neuroendocrine Neoplasms (Volume II)

edited by Peter Stålberg

submission deadline 31 Aug 2025 | 1 articles | Viewed by 1593 | Submission Open

Keywords: biomarkers; imaging; gastric NETs; pancreatic NETs; small intestinal NETs; receptor-based therapy

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Advancing Horizons in Colorectal Surgery: Innovative Approaches and Outcomes

edited by Petros I. Bangeas and Vasileios N. Papadopoulos

submission deadline 31 Aug 2025 | 1 articles | Viewed by 1522 | Submission Open

Keywords: colorectal surgery; postoperative pain; surgical site infections; anastomotic leaks; minimally invasive techniques; robotic surgery

(This special issue belongs to the Section Cancer Therapy)

Radiosurgery for Brain Tumors

edited by Anna Petoukhova

submission deadline 31 Aug 2025 | Viewed by 116 | Submission Open

Keywords: radiosurgery with photons and protons; stereotactic radiosurgery (SRS); brain tumors; gliomas; meningioma; pituitary adenoma; magnetic resonance imaging (MRI); magnetic resonance linac (MRL)

(This special issue belongs to the Section Cancer Therapy)

Cancer Genetics and Epigenetics: Their Roles and Clinical Implications

edited by

Armita Bahrami

and

Ying Qing

submission deadline 15 Sep 2025 | 3 articles | Viewed by 6549 | Submission Open

Keywords: cancer genetics; cancer epigenetics; carcinogenesis; cancer prognosis; cancer therapeutics; genetic mutations; DNA methylation; histone modifications; RNA methylation

(This special issue belongs to the Section Molecular Cancer Biology)

Giant-Cell-Containing Tumors of Bone—New Insights into Pathobiology, the Clinical Setting and Targeted Therapies

edited by

Ramses Forsyth

and

Pancras Hogendoorn

submission deadline 30 Sep 2025 | 11 articles | Viewed by 18101 | Submission Open

Keywords: giant-cell-containing tumors of bone (GCCTB); giant cell tumor of bone (GCTB); giant cell tumor in Paget's disease; malignant giant cell tumor; giant cell reparative granuloma; fibrohistiocytic tumors and lesions; chondroblastoma; brown tumor; non-ossifying fibroma; chrondromyxoid fibroma; aneurysmal bone cyst; langerhans cell histiocytosis; osteosarcoma; clear cell chondrosarcoma; metastatic carcinoma

(This special issue belongs to the Section Molecular Cancer Biology)

The Influence of Epigenetic Regulation on the Tumor Microenvironment: Mechanisms and Therapeutic Implications

edited by

Mariarosaria Conte

submission deadline 30 Sep 2025 | Submission Open

Keywords: tumor microenvironment; epigenetics; cancer; immune system; remodeling mechanisms; therapy; clinical application

(This special issue belongs to the Section Tumor Microenvironment)

What’s behind the Scenes? New Insights in Endometrial Cancer Management and Risk Stratification

edited by

Emanuele Perrone

submission deadline 20 Oct 2025 | 2 articles | Viewed by 6321 | Submission Open

Keywords: endometrial cancer; molecular classification; surgical staging; surgery; target therapy; gynecologic oncology; precision medicine; immunohistochemistry

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Gastrointestinal Cancer Surgery

edited by Florian Primavesi and

Daniel Neureiter

submission deadline 31 Oct 2025 | Viewed by 35 | Submission Open

Keywords: gastrointestinal cancer surgery; precision surgery; personalized medicine; robotics; pathology; colorectal cancer; stomach cancer; pancreatic cancer; hepatocellular cancer; biliary tract cancer

(This special issue belongs to the Section Cancer Therapy)

New Approaches in the Treatment of Hepatocellular Carcinoma and Liver Tumor

edited by Riccardo Inchingolo, Stavros Spiliopoulos and Riccardo Memeo

submission deadline 30 Nov 2025 | Viewed by 41 | Submission Open

Keywords: hepatocellular carcinoma; cirrhosis; liver; interventional oncology; trans-arterial chemo embolization; selective internal radiation therapy; ablation; radiology

(This special issue belongs to the Section Cancer Therapy)

Clinical and Translational Updates in Renal Cell Carcinoma

edited by

Irbaz Bin Riaz

submission deadline 15 Dec 2025 | 2 articles | Viewed by 4471 | Submission Open

Keywords: renal cell carcinoma; RCC; machine cearning; clinical; translational developments

(This special issue belongs to the Section Clinical Research of Cancer)

Outcome Analysis and Predictive Insights in Soft Tissue Sarcomas: Levergaing Clinical Data and Integrating Modelling

edited by

Bruno Fuchs

submission deadline 15 Dec 2025 | Viewed by 20 | Submission Open

Keywords: bone sarcomas; soft tissue sarcomas; outcome analysis; predictive modelling; prognostic biomarkers; therapeutic impact; clinical data integration; survivorship prediction; patient trajectories; sarcoma management

(This special issue belongs to the Section Methods and Technologies Development)

Advances in Clinical Trials: Outcome, Innovations, Challenges, and Ethical Practice in Cancer Research 2024–2025

edited by

Naoto T. Ueno

and David R. Gandara

submission deadline 31 Dec 2025 | Viewed by 852 | Submission Open

Keywords: phase I; phase II; phase III; phase IV; clinical trials; features; design; implementation; outcomes

(This special issue belongs to the Section Clinical Research of Cancer)

Fertility Preservation in Gynecological Cancer

edited by